Affiliation: University of Liverpool
- The genome of the African trypanosome Trypanosoma bruceiMatthew Berriman
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Science 309:416-22. 2005..brucei and the greatest in L. major. Horizontal transfer of genes of bacterial origin has contributed to some of the metabolic differences in these parasites, and a number of novel potential drug targets have been identified...
- Advanced sequencing technologies and their wider impact in microbiologyNeil Hall
School of Biological Sciences, Biosciences Building, Crown Street, University of Liverpool, Liverpool L69 7ZB, UK
J Exp Biol 210:1518-25. 2007..While this review will concentrate on microorganisms, many of the important arguments about the need to measure and understand variation at the species, population and ecosystem level will hold true for many other biological systems...
- Genetic characterization indicates that a specific subpopulation of Pseudomonas aeruginosa is associated with keratitis infectionsRosalind M K Stewart
Institute of Infection and Global Health, University of Liverpool, Duncan Building, Daulby Street, Liverpool, L69 3GA, United Kingdom
J Clin Microbiol 49:993-1003. 2011..Thus, the keratitis isolates were associated with specific characteristics, indicating that a subpopulation of P. aeruginosa is adapted to cause corneal infection...
- Comparative genomics and transduction potential of Enterococcus faecalis temperate bacteriophagesAzra Yasmin
School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom
J Bacteriol 192:1122-30. 2010..The eight phages were tested for their ability to package host DNA, and three were shown to be very effective for generalized transduction of naive host cells of the laboratory strains OG1RF and JH2-2...
- A genome sequence survey of the filarial nematode Brugia malayi: repeats, gene discovery, and comparative genomicsClaire Whitton
Ashworth Laboratories, Institution of Cell, Animal and Polulation Biology, School of Biological Sciences, University of Edinburgh, King s Buildings, Edinburgh EH9 3JT, UK
Mol Biochem Parasitol 137:215-27. 2004..B. malayi is estimated to have over 18,500 protein-coding genes...
- Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytesMalcolm J Gardner
Institute for Genomic Research TIGR, 9712 Medical Center Drive, Rockville, MD 20850, USA
Science 309:134-7. 2005..Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated...
- Comparative genomics of trypanosomatid parasitic protozoaNajib M El-Sayed
Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
Science 309:404-9. 2005..Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont...
- Comparative genomics of malaria parasitesNeil Hall
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20851, USA
Curr Opin Genet Dev 15:609-13. 2005..Recent research has led to the description of a motif that is conserved across Plasmodium species and which plays a central role in protein export into the host cell...
- Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatusWilliam C Nierman
The Institute for Genomic Research, Rockville, Maryland 20850, USA
Nature 438:1151-6. 2005..The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus...
- Meeting report: the fourth Genomic Standards Consortium (GSC) workshopDawn Field
NERC Centre for Ecology and Hydrology, Mansfield Road, Oxford, OX1 3SR United Kingdom
OMICS 12:101-8. 2008..g., compliant with MIGS/MIMS), but also be extended to include a variety of data processing and calculations. Further information about the Genomic Standards Consortium and its range of activities can be found at http://gensc.org...
- Genome of the host-cell transforming parasite Theileria annulata compared with T. parvaArnab Pain
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Science 309:131-3. 2005....
- Gene arrays at Pneumocystis carinii telomeresScott P Keely
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267, USA
Genetics 170:1589-600. 2005..Long mononucleotide tracts were present in some MSR genes. These unstable sequences can be expected to suffer frequent frameshift mutations, providing P. carinii with another mechanism to generate antigen variation...
- An ancestral oomycete locus contains late blight avirulence gene Avr3a, encoding a protein that is recognized in the host cytoplasmMiles R Armstrong
Plant Pathogen Interactions Programme, Scottish Crop Research Institute, Invergowrie, DD2 5DA Dundee, UK
Proc Natl Acad Sci U S A 102:7766-71. 2005..We suggest that Avr3a has undergone gene duplication and that an allele evading recognition by R3a arose under positive selection...
- Genome sequence of the human malaria parasite Plasmodium falciparumMalcolm J Gardner
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nature 419:498-511. 2002..The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria...
- The DNA sequence of chromosome I of an African trypanosome: gene content, chromosome organisation, recombination and polymorphismNeil Hall
The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Nucleic Acids Res 31:4864-73. 2003..Genetic polymorphisms are exceptionally rare in sequences located within and around the strand-switches between several gene clusters...
- GeneDB: a resource for prokaryotic and eukaryotic organismsChristiane Hertz-Fowler
The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Nucleic Acids Res 32:D339-43. 2004..The current release stores 11 datasets of which six are curated and maintained by biologists, who review and incorporate information from the scientific literature, public databases and the respective research communities...
- Insight into the genome of Aspergillus fumigatus: analysis of a 922 kb region encompassing the nitrate assimilation gene clusterArnab Pain
The Pathogen Sequencing Unit, The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Fungal Genet Biol 41:443-53. 2004..We observed large scale synteny between A. fumigatus and Aspergillus nidulans by comparing this sequence to the A. nidulans genetic map of linkage group VIII...
- Gene synteny and evolution of genome architecture in trypanosomatidsElodie Ghedin
Parasity Genomics, The Institute for Genomics Research, 9712 Medical Center Dr Rockville, MD 20850, USA
Mol Biochem Parasitol 134:183-91. 2004..major by examining the regions near breakage points of the synteny. This is the first such element found in L. major suggesting that retroelements were found in the common ancestor of all three species...
- A transcriptomic analysis of the phylum NematodaJohn Parkinson
Hospital for Sick Children, 555 University Avenue, Departments of Biochemistry and Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5G 1X8, Canada
Nat Genet 36:1259-67. 2004..Nematode-specific families are particularly interesting as drug and vaccine targets...
- The genome of model malaria parasites, and comparative genomicsJane Carlton
The Institute for Genomic Research, Rockville, MD 20850, USA
Curr Issues Mol Biol 7:23-37. 2005..This is a stimulating time for comparative genomics of model and human malaria parasites, which promises to produce useful results for the development of antimalarial drugs and vaccines...
- A case for a Glossina genome projectSerap Aksoy
Yale University School of Medicine, 60 College Street, 606 LEPH, New Haven, CT 06520, USA
Trends Parasitol 21:107-11. 2005..An international consortium is now in place to further efforts to lead to a full genome project...
- The architecture of variant surface glycoprotein gene expression sites in Trypanosoma bruceiMatthew Berriman
The Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
Mol Biochem Parasitol 122:131-40. 2002..Unexpected conservation of sequences, including pseudogenes, indicates that the multiple ESs could have arisen through a relatively recent amplification of a single ES...