Ian P Hall
Affiliation: University of Nottingham
Hall I, Fowler A, Gupta A, Tetzlaff K, Nivens M, Sarno M, et al
. Efficacy of BI 671800, an oral CRTH2 antagonist, in poorly controlled asthma as sole controller and in the presence of inhaled corticosteroid treatment. Pulm Pharmacol Ther. 2015;32:37-44 pubmed publisher
..37% (1.57%) for montelukast (p = 0.0050 and p = 0.0657, respectively). These findings suggest that BI 671800 is associated with a small improvement in FEV1 in symptomatic controller-naÃ¯ve asthma patients, and in patients on ICS. ..
Hall I. Pharmacogenetics of asthma. Chest. 2006;130:1873-8 pubmed
..A number of examples of possible pharmacogenetic approaches that may prove of value in the management of asthma are discussed. ..
Hall I. Stratified medicine: drugs meet genetics. Eur Respir Rev. 2013;22:53-7 pubmed publisher
..This knowledge can then potentially be used to stratify patient groups within (or even across) disease boundaries and then to target therapy more effectively. ..
Singh S, Billington C, Sayers I, Hall I. Clonally expanded human airway smooth muscle cells exhibit morphological and functional heterogeneity. Respir Res. 2014;15:57 pubmed publisher
..8 - 5.2 fold cf basal. In summary we show for the first time that primary human ASM cells are capable of clonal expansion and that the resulting clonal populations themselves exhibit phenotypic plasticity. ..
Billington C, Penn R, Hall I. ?2 Agonists. Handb Exp Pharmacol. 2017;237:23-40 pubmed publisher
..Finally we comment on what the future may hold for the use of ? agonists in respiratory disease. ..
Wain L, Shrine N, Miller S, Jackson V, Ntalla I, Soler Artigas M, et al
. Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. Lancet Respir Med. 2015;3:769-81 pubmed publisher
..Medical Research Council. ..
Kheirallah A, de Moor C, Faiz A, Sayers I, Hall I. Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways. BMC Genomics. 2017;18:248 pubmed publisher
..This study provides a detailed analysis of INTS12 activities on a genome-wide scale and contributes to the biology behind the genetic association for lung function at 4q24. ..