I P Hall

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi request reprint Severe hyponatraemia in medical in-patients: aetiology, assessment and outcome
    J A Clayton
    Division of Therapeutics and Molecular Medicine, Queen s Medical Centre, Nottingham NG7 2UH
    QJM 99:505-11. 2006
  2. pmc Thiazide diuretic prescription and electrolyte abnormalities in primary care
    J A Clayton
    Division of Therapeutics and Molecular Medicine, University Hospital, Queen s Medical Centre, Nottingham, UK
    Br J Clin Pharmacol 61:87-95. 2006
  3. pmc The future of asthma
    I P Hall
    Department of Therapeutics, University Hospital, Nottingham
    BMJ 314:45-9. 1997
  4. pmc Pharmacogenetic characterization of indacaterol, a novel beta 2-adrenoceptor agonist
    I Sayers
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK
    Br J Pharmacol 158:277-86. 2009
  5. ncbi request reprint Pharmacogenetics and asthma: false hope or new dawn?
    I P Hall
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, NG7 2UH, UK
    Eur Respir J 29:1239-45. 2007
  6. doi request reprint A biomechanical model of agonist-initiated contraction in the asthmatic airway
    B S Brook
    School of Mathematical Sciences, University Park, University of Nottingham, Nottingham, UK
    Respir Physiol Neurobiol 170:44-58. 2010
  7. pmc Expression profiling: fishing and chips
    I P Hall
    Division of Therapeutics and Molecular Medicine, D Floor, South Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Gut 53:917-8. 2004
  8. ncbi request reprint Asthma
    A E Tattersfield
    Division of Respiratory Medicine, Clinical Sciences Building, City Hospital, Nottingham, UK
    Lancet 360:1313-22. 2002
  9. ncbi request reprint Effects of growth factors and extracellular matrix on survival of human airway smooth muscle cells
    A M Freyer
    Division of Therapeutics and Institute of Cell Signalling, University Hospital, Nottingham, United Kingdom
    Am J Respir Cell Mol Biol 25:569-76. 2001
  10. pmc Interleukin-4 receptor alpha gene variants and allergic disease
    I P Hall
    Division of Therapeutics, University Hospital of Nottingham, Nottingham, UK
    Respir Res 1:6-8. 2000

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Severe hyponatraemia in medical in-patients: aetiology, assessment and outcome
    J A Clayton
    Division of Therapeutics and Molecular Medicine, Queen s Medical Centre, Nottingham NG7 2UH
    QJM 99:505-11. 2006
    ..Hyponatraemia is the most commonly identified electrolyte abnormality. Published data on severe hyponatraemia in general medical in-patients is lacking...
  2. pmc Thiazide diuretic prescription and electrolyte abnormalities in primary care
    J A Clayton
    Division of Therapeutics and Molecular Medicine, University Hospital, Queen s Medical Centre, Nottingham, UK
    Br J Clin Pharmacol 61:87-95. 2006
    ..Thiazide diuretics have a number of well-documented metabolic adverse effects. The aim of this study was to estimate the frequency of hyponatraemia and hypokalaemia amongst patients taking a thiazide diuretic in primary care...
  3. pmc The future of asthma
    I P Hall
    Department of Therapeutics, University Hospital, Nottingham
    BMJ 314:45-9. 1997
    ..I have tried to explain the thinking behind some of the approaches under study. I discuss the potential contributions of genetic studies, immunological approaches, and new therapeutic approaches...
  4. pmc Pharmacogenetic characterization of indacaterol, a novel beta 2-adrenoceptor agonist
    I Sayers
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK
    Br J Pharmacol 158:277-86. 2009
    ..The aim of this study was to investigate the comparative pharmacology of indacaterol in recombinant cells expressing the common polymorphic variants of the human beta(2)-adrenoceptor and in human primary airway smooth muscle (ASM) cells...
  5. ncbi request reprint Pharmacogenetics and asthma: false hope or new dawn?
    I P Hall
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, NG7 2UH, UK
    Eur Respir J 29:1239-45. 2007
    ..In addition, there is a shortage of well-designed, adequately powered clinical studies in this area. This series summarises the current state of knowledge and identifies areas for further research...
  6. doi request reprint A biomechanical model of agonist-initiated contraction in the asthmatic airway
    B S Brook
    School of Mathematical Sciences, University Park, University of Nottingham, Nottingham, UK
    Respir Physiol Neurobiol 170:44-58. 2010
    ..Such patterns of stress are likely to have important implications, from a mechano-transduction perspective, on contractility, short-term cytoskeletal adaptation and long-term airway remodelling in asthma...
  7. pmc Expression profiling: fishing and chips
    I P Hall
    Division of Therapeutics and Molecular Medicine, D Floor, South Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Gut 53:917-8. 2004
    ..However, there are many pitfalls which need to be considered in the design of experiments of this kind and in considering interpretation of data from such studies. Some of these are discussed...
  8. ncbi request reprint Asthma
    A E Tattersfield
    Division of Respiratory Medicine, Clinical Sciences Building, City Hospital, Nottingham, UK
    Lancet 360:1313-22. 2002
    ..However, a better understanding of the mechanisms underlying asthma and the genetic and environmental factors that predispose individuals to asthma should lead to better preventative strategies and new therapeutic approaches...
  9. ncbi request reprint Effects of growth factors and extracellular matrix on survival of human airway smooth muscle cells
    A M Freyer
    Division of Therapeutics and Institute of Cell Signalling, University Hospital, Nottingham, United Kingdom
    Am J Respir Cell Mol Biol 25:569-76. 2001
    ....
  10. pmc Interleukin-4 receptor alpha gene variants and allergic disease
    I P Hall
    Division of Therapeutics, University Hospital of Nottingham, Nottingham, UK
    Respir Res 1:6-8. 2000
    ....
  11. pmc Regulation of proliferation of human colonic subepithelial myofibroblasts by mediators important in intestinal inflammation
    T M Jobson
    Division of Therapeutics, University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    J Clin Invest 101:2650-7. 1998
    ..2-fold over control and produces a dose-related inhibition of platelet-derived growth factor-driven proliferation with a maximum inhibition of 33% at 1 microM...
  12. pmc Contribution of ADAM33 polymorphisms to the population risk of asthma
    J Blakey
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK
    Thorax 60:274-6. 2005
    ..It has a postulated role in myogenesis, airway modelling, and signalling via protein shedding. Concerns over the methodology of the initial study have led to several attempts at replication, with inconsistent results...
  13. ncbi request reprint Beta(2)-adrenoceptor polymorphism determines vascular reactivity in humans
    J R Cockcroft
    School of Medical and Surgical Sciences, Division of Therapeutics, University of Nottingham Medical School, Queen s Medical Centre, Nottingham, UK
    Hypertension 36:371-5. 2000
    ..Further studies are necessary to establish whether beta(2)-adrenoceptor polymorphisms are important in the genesis of hypertension...
  14. pmc Beta2 adrenoceptor promoter polymorphisms: extended haplotypes and functional effects in peripheral blood mononuclear cells
    B Lipworth
    Asthma and Allergy Research Group, Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Thorax 57:61-6. 2002
    ..The aim of this study was to investigate the potential for genetic variation at this locus to influence the expression of beta2 adrenoceptors on circulating peripheral blood mononuclear cells (PBMCs)...
  15. ncbi request reprint Comparison of asthma treatment given in addition to inhaled corticosteroids on airway inflammation and responsiveness
    R H Green
    Institute for Lung Health, Dept of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Groby Road, Leicester LE3 9PQ, UK
    Eur Respir J 27:1144-51. 2006
    ..In conclusion, treatment given in addition to low-dose inhaled corticosteroids results in modest benefits. Formoterol and high-dose budesonide have contrasting effects on eosinophilic airway inflammation...
  16. ncbi request reprint The effect of beta2-adrenoceptor haplotypes on bronchial hyper-responsiveness in patients with asthma
    A M Wilson
    Biomedicine Group, School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK
    Allergy 61:254-9. 2006
    ..The combined effect of these genotypes, or the haplotype, has not been fully characterized in terms of BHR...
  17. ncbi request reprint Natriuretic peptides and asthma: is there a connection?
    I P Hall
    Clin Exp Allergy 38:1068-70. 2008
  18. pmc Mutation screening of the muscarinic M(2) and M(3) receptor genes in normal and asthmatic subjects
    A G Fenech
    Department of Clinical Pharmacology and Therapeutics, University of Malta, Msida MSD 06, Malta
    Br J Pharmacol 133:43-8. 2001
    ..The potential functional significance of the muscarinic M(2) receptor 3' UTR polymorphism (bp 1696) remains to be determined...