Research Topics
| I P HallSummaryAffiliation: University of Nottingham Country: UK Publications
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Detail Information
Publications
Severe hyponatraemia in medical in-patients: aetiology, assessment and outcomeJ A Clayton
Division of Therapeutics and Molecular Medicine, Queen s Medical Centre, Nottingham NG7 2UH
QJM 99:505-11. 2006..Hyponatraemia is the most commonly identified electrolyte abnormality. Published data on severe hyponatraemia in general medical in-patients is lacking...
Thiazide diuretic prescription and electrolyte abnormalities in primary careJ A Clayton
Division of Therapeutics and Molecular Medicine, University Hospital, Queen s Medical Centre, Nottingham, UK
Br J Clin Pharmacol 61:87-95. 2006..Thiazide diuretics have a number of well-documented metabolic adverse effects. The aim of this study was to estimate the frequency of hyponatraemia and hypokalaemia amongst patients taking a thiazide diuretic in primary care...- The future of asthmaI P Hall
Department of Therapeutics, University Hospital, Nottingham
BMJ 314:45-9. 1997..I have tried to explain the thinking behind some of the approaches under study. I discuss the potential contributions of genetic studies, immunological approaches, and new therapeutic approaches... - Pharmacogenetic characterization of indacaterol, a novel beta 2-adrenoceptor agonistI Sayers
Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK
Br J Pharmacol 158:277-86. 2009..The aim of this study was to investigate the comparative pharmacology of indacaterol in recombinant cells expressing the common polymorphic variants of the human beta(2)-adrenoceptor and in human primary airway smooth muscle (ASM) cells... - Pharmacogenetics and asthma: false hope or new dawn?I P Hall
Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, NG7 2UH, UK
Eur Respir J 29:1239-45. 2007..In addition, there is a shortage of well-designed, adequately powered clinical studies in this area. This series summarises the current state of knowledge and identifies areas for further research... 
A biomechanical model of agonist-initiated contraction in the asthmatic airwayB S Brook
School of Mathematical Sciences, University Park, University of Nottingham, Nottingham, UK
Respir Physiol Neurobiol 170:44-58. 2010..Such patterns of stress are likely to have important implications, from a mechano-transduction perspective, on contractility, short-term cytoskeletal adaptation and long-term airway remodelling in asthma...- Expression profiling: fishing and chipsI P Hall
Division of Therapeutics and Molecular Medicine, D Floor, South Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
Gut 53:917-8. 2004..However, there are many pitfalls which need to be considered in the design of experiments of this kind and in considering interpretation of data from such studies. Some of these are discussed... - AsthmaA E Tattersfield
Division of Respiratory Medicine, Clinical Sciences Building, City Hospital, Nottingham, UK
Lancet 360:1313-22. 2002..However, a better understanding of the mechanisms underlying asthma and the genetic and environmental factors that predispose individuals to asthma should lead to better preventative strategies and new therapeutic approaches... - Effects of growth factors and extracellular matrix on survival of human airway smooth muscle cellsA M Freyer
Division of Therapeutics and Institute of Cell Signalling, University Hospital, Nottingham, United Kingdom
Am J Respir Cell Mol Biol 25:569-76. 2001.... - Interleukin-4 receptor alpha gene variants and allergic diseaseI P Hall
Division of Therapeutics, University Hospital of Nottingham, Nottingham, UK
Respir Res 1:6-8. 2000.... - Regulation of proliferation of human colonic subepithelial myofibroblasts by mediators important in intestinal inflammationT M Jobson
Division of Therapeutics, University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
J Clin Invest 101:2650-7. 1998..2-fold over control and produces a dose-related inhibition of platelet-derived growth factor-driven proliferation with a maximum inhibition of 33% at 1 microM... - Contribution of ADAM33 polymorphisms to the population risk of asthmaJ Blakey
Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK
Thorax 60:274-6. 2005..It has a postulated role in myogenesis, airway modelling, and signalling via protein shedding. Concerns over the methodology of the initial study have led to several attempts at replication, with inconsistent results... - Beta(2)-adrenoceptor polymorphism determines vascular reactivity in humansJ R Cockcroft
School of Medical and Surgical Sciences, Division of Therapeutics, University of Nottingham Medical School, Queen s Medical Centre, Nottingham, UK
Hypertension 36:371-5. 2000..Further studies are necessary to establish whether beta(2)-adrenoceptor polymorphisms are important in the genesis of hypertension... - Beta2 adrenoceptor promoter polymorphisms: extended haplotypes and functional effects in peripheral blood mononuclear cellsB Lipworth
Asthma and Allergy Research Group, Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
Thorax 57:61-6. 2002..The aim of this study was to investigate the potential for genetic variation at this locus to influence the expression of beta2 adrenoceptors on circulating peripheral blood mononuclear cells (PBMCs)... - Comparison of asthma treatment given in addition to inhaled corticosteroids on airway inflammation and responsivenessR H Green
Institute for Lung Health, Dept of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Groby Road, Leicester LE3 9PQ, UK
Eur Respir J 27:1144-51. 2006..In conclusion, treatment given in addition to low-dose inhaled corticosteroids results in modest benefits. Formoterol and high-dose budesonide have contrasting effects on eosinophilic airway inflammation... - The effect of beta2-adrenoceptor haplotypes on bronchial hyper-responsiveness in patients with asthmaA M Wilson
Biomedicine Group, School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK
Allergy 61:254-9. 2006..The combined effect of these genotypes, or the haplotype, has not been fully characterized in terms of BHR... - Natriuretic peptides and asthma: is there a connection?I P Hall
Clin Exp Allergy 38:1068-70. 2008 - Mutation screening of the muscarinic M(2) and M(3) receptor genes in normal and asthmatic subjectsA G Fenech
Department of Clinical Pharmacology and Therapeutics, University of Malta, Msida MSD 06, Malta
Br J Pharmacol 133:43-8. 2001..The potential functional significance of the muscarinic M(2) receptor 3' UTR polymorphism (bp 1696) remains to be determined...