Research Topics
| Anthony D HallSummaryAffiliation: University of Kent Country: UK Publications
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Detail Information
Publications
Is the Y chromosome disappearing?--both sides of the argumentDarren K Griffin
University of Kent, Canterbury, UK
Chromosome Res 20:35-45. 2012..The issue was put to the vote with an exact 50/50 split among the opinion of the audience; an interesting (though perhaps not entirely unexpected) skew however was noted in the sex ratio of those for and against the notion...
The association between male infertility and sperm disomy: evidence for variation in disomy levels among individuals and a correlation between particular semen parameters and disomy of specific chromosome pairsHelen G Tempest
Cell and Chromosome Biology Group, Department of Biological Sciences, Brunel University, Uxbridge, UK
Reprod Biol Endocrinol 2:82. 2004..The relationship between individual semen parameters and segregation of specific chromosome pairs is however less well reported as is the variation of disomy levels in individual men...
Evolution of the chicken Toll-like receptor gene family: a story of gene gain and gene lossNicholas D Temperley
Department of Genomics and Genetics, Roslin Institute Edinburgh, Roslin, Midlothian EH25 9PS, UK
BMC Genomics 9:62. 2008..This study takes advantage of the recently sequenced chicken genome to determine the complete chicken TLR repertoire and place it in context of vertebrate genomic evolution...
Gene duplication and fragmentation in the zebra finch major histocompatibility complexChristopher N Balakrishnan
Department of Organismic and Evolutionary Biology, Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA
BMC Biol 8:29. 2010....
Whole genome comparative studies between chicken and turkey and their implications for avian genome evolutionDarren K Griffin
Department of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK
BMC Genomics 9:168. 2008..No molecular study has yet examined conservation of avian microchromosomes, nor differences in copy number variants (CNVs) between birds...
The evolution of the avian genome as revealed by comparative molecular cytogeneticsD K Griffin
University of Kent, Department of Biosciences, Canterbury, UK
Cytogenet Genome Res 117:64-77. 2007..We conclude by speculating as to the reasons for the strange behaviour of these chromosomes as well as the role of telomeres and nuclear organisation in avian evolution...
The 15th International Chromosome Conference (ICCXV), 5-10 September 2004, Brunel University, UK (Meeting Report)Darren K Griffin
Department of Biosciences, University of Kent, Canterbury CT2 7NZ, UK
Chromosoma 114:204-11. 2005
Comparative genomics in chicken and Pekin duck using FISH mapping and microarray analysisBenjamin M Skinner
Department of Biosciences, University of Kent, Canterbury CT2 7NJ, UK
BMC Genomics 10:357. 2009..Here, we extend this approach to the Pekin duck (Anas platyrhynchos), an obvious target for comparative genomic studies due to its agricultural importance and resistance to avian flu...
Practicable approaches to facilitate rapid and accurate molecular cytogenetic mapping in birds and mammalsW B Morris
Department of Biosciences, University of Kent, Canterbury, UK
Cytogenet Genome Res 117:36-42. 2007..Simple, practicable means often provide preferable solutions than complex alternatives (e.g. m-FISH) to the solution of scientific problems. Such is the case for the approaches described here...
The cytogenetics of preimplantation human development: insights provided by traditional and novel techniquesHelen G Tempest
Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
Chromosoma 114:295-9. 2005..This review discusses the use of these techniques in assessing chromosome abnormalities in this, the earliest of human developmental stages. In addition, the prospects for the clinical use of CGH are discussed...
Nuclear organization in human sperm: preliminary evidence for altered sex chromosome centromere position in infertile malesK A Finch
Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
Hum Reprod 23:1263-70. 2008..The purpose of this study was to test the hypothesis that altered chromosome position in the sperm head is associated with male infertility...
An appraisal of nuclear organisation in interphase embryonic fibroblasts of chicken, turkey and duckB M Skinner
Department of Biosciences, University of Kent, Canterbury, UK
Cytogenet Genome Res 126:156-64. 2009..Observations were consistent with those seen in chicken (although, less well-defined in duck), providing preliminary evidence of conservation throughout evolution...
Array comparative genomic hybridisation on first polar bodies suggests that non-disjunction is not the predominant mechanism leading to aneuploidy in humansA S Gabriel
School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK
J Med Genet 48:433-7. 2011..An alternative model (precocious separation of sister chromatids) has thus been proposed, but recurring criticism of this model purports that technical issues may have led to interpretation errors...
Multicolour interphase cytogenetics: 24 chromosome probes, 6 colours, 4 layersD Ioannou
School of Biosciences, University of Kent, Giles Lane, CT2 7NJ, Canterbury, UK
Mol Cell Probes 25:199-205. 2011..Applications of this technique are in the investigation of chromosome copy number and the assessment of nuclear organisation for a range of different cell types including human sperm, cancer cells and preimplantation embryos...
Quantum dots as new-generation fluorochromes for FISH: an appraisalDimitris Ioannou
Department of Biosciences, University of Kent, Canterbury, UK
Chromosome Res 17:519-30. 2009....
Nuclear organisation in totipotent human nuclei and its relationship to chromosomal abnormalityKatie A Finch
Department of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK
J Cell Sci 121:655-63. 2008..Our results provide clues to the nature of totipotency in human cells and might have future applications for preimplantation diagnosis and nuclear transfer...
Copy number variation, chromosome rearrangement, and their association with recombination during avian evolutionMartin Völker
School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
Genome Res 20:503-11. 2010..The results thus provide support for the notion of recombination-based processes playing a major role in avian genome evolution...
Male fertility, chromosome abnormalities, and nuclear organizationD Ioannou
School of Biosciences, University of Kent, Canterbury, UK
Cytogenet Genome Res 133:269-79. 2011..A small handful of studies have addressed this issue; however, to date it remains an exciting avenue for future research with possible implications for diagnosis and therapy...
Is there a paternal age effect for aneuploidy?K G L Fonseka
School of Biosciences, University of Kent, Canterbury, UK
Cytogenet Genome Res 133:280-91. 2011..Array-based approaches may well supersede FISH in addressing the question of a paternal age effect; for now, however, the jury is still out...
Intrachromosomal rearrangements in avian genome evolution: evidence for regions prone to breakpointsB M Skinner
School of Biosciences, University of Kent, Canterbury, UK
Heredity (Edinb) 108:37-41. 2012..This agrees with our previous hypothesis that mechanisms of genome evolution are driven by hotspots of non-allelic homologous recombination...
Significant reduction of sperm disomy in six men: effect of traditional Chinese medicine?Helen G Tempest
Department of Biosciences, University of Kent, Canterbury CT2 7NJ, UK
Asian J Androl 7:419-25. 2005..To test the hypothesis that levels of sperm disomy fell significantly in six men treated by traditional Chinese medicine (TCM)...
Molecular cytogenetic definition of the chicken genome: the first complete avian karyotypeJulio S Masabanda
Cell and Chromosome Biology Group, Department of Biological Sciences, Brunel University, Uxbridge, Middlesex UB8 3PH, United Kingdom
Genetics 166:1367-73. 2004....
A mapping and evolutionary study of porcine sex chromosome genesClaire R Quilter
Human Molecular Genetics Group, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
Mamm Genome 13:588-94. 2002..This suggests that the order of the X/Y homologous genes of the porcine X and Y Chrs may closely resemble the ancestral gene order of the eutherian sex chromosomes...
The molecular basis of chromosome orthologies and sex chromosomal differentiation in palaeognathous birdsChizuko Nishida Umehara
Laboratory of Animal Cytogenetics, Division of Genome Dynamics, Creative Research Initiative Sousei, Hokkaido University, North 10 West 8, Kita ku, Sapporo, 060 0810, Japan
Chromosome Res 15:721-34. 2007....
Non-random chromosome positioning in mammalian sperm nuclei, with migration of the sex chromosomes during late spermatogenesisHelen A Foster
Laboratory of Nuclear and Genomic Health, Cell and Chromosome Biology Group, Division of Biosciences, School of Health Sciences and Social Care, Brunel University, Uxbridge, UB8 3PH, UK
J Cell Sci 118:1811-20. 2005..This study reveals the temporal repositioning of chromosome territories in spermatogenesis...
Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolutionLadeana W Hillier
Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
Nature 432:695-716. 2004..The distinctive properties of avian microchromosomes, together with the inferred patterns of conserved synteny, provide additional insights into vertebrate chromosome architecture...
Generation of chromosome paints: approach for increasing specificity and intensity of signalsJulio S Masabanda
Department of Biological Sciences, Brunel University, Uxbridge, Middlesex, UB8 3PH, UK
Biotechniques 34:530-2, 534, 536. 2003..Biotinylated DNA fragments captured on streptavidin-coated paramagnetic beads are eluted and amplified by PCR using a single primer complementary to the linker arm...
Coordinated transcriptional regulation patterns associated with infertility phenotypes in menPeter J I Ellis
Mammalian Molecular Genetics Group, University of Cambridge Department of Pathology, Tennis Court Rd, Cambridge, UK
J Med Genet 44:498-508. 2007..Here we present the results of an initial screen of 33 patients with differing spermatogenic phenotypes...
The genetic basis of infertilityKavita Shah
Cell and Chromosome Biology Group, Department of Biological Sciences, Brunel University, Uxbridge, Middlesex UB8 3PH, UK
Reproduction 126:13-25. 2003..This article reviews current research in the genetic basis of infertility; gender-specific disorders and those affecting both sexes are considered...
Computer simulations improve university instructional laboratoriesNicola J Gibbons
Cell and Chromosome Biology Group, Department of Biological Sciences, School of Business and Management, Brunel University, Uxbridge, Middlesex UB8 3PH, United Kingdom
Cell Biol Educ 3:263-9. 2004..In addition, they can offer significant benefits to teaching staff...
Characterization of chromosome structures of Falconinae (Falconidae, Falconiformes, Aves) by chromosome painting and delineation of chromosome rearrangements during their differentiationChizuko Nishida
Hokkaido University, North 10 West 8, Kita ku, Sapporo, 060 0810, Japan
Chromosome Res 16:171-81. 2008..These karyotypic features of Falconinae were relatively different from those of Accipitridae, indicating that the drastic chromosome rearrangements occurred independently in the lineages of Accipitridae and Falconinae...
