A Hall

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Rho GTPases and the actin cytoskeleton
    A Hall
    Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
    Science 279:509-14. 1998
  2. pmc Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectin
    L Kjøller
    Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, United Kingdom
    J Cell Biol 152:1145-57. 2001
  3. pmc Ral GTPases regulate neurite branching through GAP-43 and the exocyst complex
    Giovanna Lalli
    Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, England, UK
    J Cell Biol 171:857-69. 2005
  4. pmc Cdc42 and Par6-PKCzeta regulate the spatially localized association of Dlg1 and APC to control cell polarization
    Sandrine Etienne-Manneville
    Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 68T, UK
    J Cell Biol 170:895-901. 2005
  5. ncbi Rho GTPases and the control of cell behaviour
    A Hall
    MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, Cancer Research UK Oncogene and Signal Transduction Group, University College London, London WC1E 6BT, UK
    Biochem Soc Trans 33:891-5. 2005
  6. pmc Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton
    A Hall
    Medical Research Council Laboratory for Molecular Cell Biology, University College London, UK
    Philos Trans R Soc Lond B Biol Sci 355:965-70. 2000
  7. pmc The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3
    K i Nagata
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
    EMBO J 17:149-58. 1998
  8. ncbi Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho
    M H Driessens
    MRC Laboratory for Molecular Cell Biology, Department of Biochemistry and Molecular Biology, University College London, London, WC1E 6BT, United Kingdom
    Curr Biol 11:339-44. 2001
  9. ncbi Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex
    S Krugmann
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, CRC Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Curr Biol 11:1645-55. 2001
  10. pmc A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways
    N Tapon
    MRC Laboratory for Molecular Cell Biology, CRC Oncogene and Signal Transduction Group, University College London, London WC1E 6BT, UK
    EMBO J 17:1395-404. 1998

Collaborators

Detail Information

Publications46

  1. ncbi Rho GTPases and the actin cytoskeleton
    A Hall
    Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
    Science 279:509-14. 1998
    ....
  2. pmc Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectin
    L Kjøller
    Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, United Kingdom
    J Cell Biol 152:1145-57. 2001
    ..This mechanism may play a role in uPAR-mediated regulation of cell motility at sites where VN and uPAR are co-expressed, such as malignant tumors...
  3. pmc Ral GTPases regulate neurite branching through GAP-43 and the exocyst complex
    Giovanna Lalli
    Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, England, UK
    J Cell Biol 171:857-69. 2005
    ..These findings highlight an important role for Ral in the regulation of neuronal morphology...
  4. pmc Cdc42 and Par6-PKCzeta regulate the spatially localized association of Dlg1 and APC to control cell polarization
    Sandrine Etienne-Manneville
    Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 68T, UK
    J Cell Biol 170:895-901. 2005
    ..Biochemical analysis and total internal reflection fluorescence microscopy reveal that the subsequent physical interaction between APC and Dlg1 is required for polarization of the microtubule cytoskeleton...
  5. ncbi Rho GTPases and the control of cell behaviour
    A Hall
    MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, Cancer Research UK Oncogene and Signal Transduction Group, University College London, London WC1E 6BT, UK
    Biochem Soc Trans 33:891-5. 2005
    ..We have been analysing the biochemical contributions of Rho GTPases in cell movement and have found that Rac controls cell protrusion, while Cdc42 controls cell polarity...
  6. pmc Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton
    A Hall
    Medical Research Council Laboratory for Molecular Cell Biology, University College London, UK
    Philos Trans R Soc Lond B Biol Sci 355:965-70. 2000
    ....
  7. pmc The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3
    K i Nagata
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
    EMBO J 17:149-58. 1998
    ....
  8. ncbi Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho
    M H Driessens
    MRC Laboratory for Molecular Cell Biology, Department of Biochemistry and Molecular Biology, University College London, London, WC1E 6BT, United Kingdom
    Curr Biol 11:339-44. 2001
    ..Our findings that plexin-B signaling to the cytoskeleton is both Rac and Rho dependent form a starting point for unraveling the mechanism by which semaphorins and plexins control axon guidance and cell migration...
  9. ncbi Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex
    S Krugmann
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, CRC Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Curr Biol 11:1645-55. 2001
    ..Cdc42 controls the formation of actin bundle-containing filopodia at the cellular periphery. The molecular mechanism for this remains as yet unclear...
  10. pmc A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways
    N Tapon
    MRC Laboratory for Molecular Cell Biology, CRC Oncogene and Signal Transduction Group, University College London, London WC1E 6BT, UK
    EMBO J 17:1395-404. 1998
    ..When overexpressed in fibroblasts, POSH is a strong inducer of apoptosis. We propose that POSH acts as a scaffold protein and contributes to Rac-induced signal transduction pathways leading to diverse gene transcriptional changes...
  11. ncbi CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and Rac
    N Lamarche-Vane
    Medical Research Council Laboratory for Molecular Cell Biology, CRC Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Biol Chem 273:29172-7. 1998
    ..Thus, CdGAP is a novel GAP that is likely to participate in Cdc42- and Rac-induced signaling pathways leading to actin reorganization...
  12. pmc Role of actin polymerization and adhesion to extracellular matrix in Rac- and Rho-induced cytoskeletal reorganization
    L M Machesky
    Department of Molecular Medicine, Medical Research Council Laboratory for Molecular Cell Biology, University College London, United Kingdom
    J Cell Biol 138:913-26. 1997
    ..It appears, therefore, that the assembly of large integrin complexes is not required for most of the actin reorganization or cell morphology changes induced by Rac or Rho activation in Swiss 3T3 fibroblasts...
  13. pmc Lipopolysaccharide-induced activation of beta2-integrin function in macrophages requires Irak kinase activity, p38 mitogen- activated protein kinase, and the Rap1 GTPase
    A Schmidt
    MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, United Kingdom
    Mol Cell Biol 21:438-48. 2001
    ..Together, our results suggest that beta2-integrin-dependent spreading of macrophages in response to LPS is controlled by a linear signaling pathway via MyD88, Irak, p38, and Rap1...
  14. ncbi Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta
    S Etienne-Manneville
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
    Cell 106:489-98. 2001
    ..Localized PKCzeta activity, acting through the microtubule motor protein dynein, is required for all aspects of induced polarity in these cells...
  15. pmc Rho GTPases control polarity, protrusion, and adhesion during cell movement
    C D Nobes
    MRC Laboratory for Molecular Cell Biology, CRC Oncogene and Signal Transduction Group, University College London, London WC1E 6BT, United Kingdom
    J Cell Biol 144:1235-44. 1999
    ..We conclude that the signal transduction pathways controlled by the four small GTPases, Rho, Rac, Cdc42, and Ras, cooperate to promote cell movement...
  16. pmc A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion
    C D Nobes
    Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group and Department of Biochemistry, University College London, London WC1E 7BT, United Kingdom
    J Cell Biol 141:187-97. 1998
    ..We suggest that these proteins control rearrangements of the actin cytoskeleton and changes in cell adhesion...
  17. ncbi The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho
    R F Lamb
    MRC Laboratory for Molecular Cell Biology and Department of Biochemistry, University College London, UK
    Nat Cell Biol 2:281-7. 2000
    ....
  18. ncbi Analysis of R-Ras signalling pathways
    A J Self
    MRC Laboratory for Molecular Cell Biology, CRC Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
    J Cell Sci 114:1357-66. 2001
    ..These results indicate that R-Ras has an important role in the regulation of cell growth and adhesion, but that this is mediated through downstream signals distinct from those used by Ras...
  19. pmc The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts
    V M Braga
    Medical Research Council Laboratory for Molecular Cell Biology, University College London, WC1E 6BT, London, United Kingdom
    J Cell Biol 137:1421-31. 1997
    ..Our results provide new insights into the role of the small GTPases in the cadherin-dependent cell- cell contact formation and the remodelling of actin filaments in epithelial cells...
  20. ncbi Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16
    H Daub
    Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, and the Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Biol Chem 276:1677-80. 2001
    ..Because stathmin destabilizes microtubules, and this process is inhibited by phosphorylation at residue 16, Rac and Cdc42 can potentially regulate both F-actin and microtubule dynamics...
  21. ncbi Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity
    D Diekmann
    Medical Research Council Laboratory for Molecular Cell Biology, University College London, UK
    Science 265:531-3. 1994
    ..Modified forms of Rac with mutations in the effector site did not stimulate oxidase activity or bind to p67phox. Thus, p67phox appears to be the Rac effector protein in the NADPH oxidase complex...
  22. pmc Rho GTPases and their effector proteins
    A L Bishop
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, U K
    Biochem J 348:241-55. 2000
    ..The main focus of this review will be Rho, Rac and Cdc42, the three best characterized mammalian Rho GTPases, though the genetic analysis of Rho GTPases in lower eukaryotes is making increasingly important contributions to this field...
  23. ncbi Teaching senior oncologists communication skills: results from phase I of a comprehensive longitudinal program in the United Kingdom
    L Fallowfield
    Department of Oncology, University College London Medical School, United Kingdom
    J Clin Oncol 16:1961-8. 1998
    ..To determine the communication difficulties experienced by clinicians in cancer medicine and to develop, implement, and evaluate communication skills training courses...
  24. ncbi Oligodendrocyte lineage and the motor neuron connection
    W D Richardson
    MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, London, United Kingdom
    Glia 29:136-42. 2000
    ..We decide in favour of a single embryonic lineage with regional variations along the anterior-posterior neuraxis...
  25. ncbi A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases
    P D Burbelo
    Medical Research Council Laboratory for Molecular Cell Biology, University College London, United Kingdom
    J Biol Chem 270:29071-4. 1995
    ..These results indicate that proteins containing the CRIB motif bind to Cdc42 and/or Rac in a GTP-dependent manner, and they may, therefore, participate in downstream signaling...
  26. ncbi Bcr encodes a GTPase-activating protein for p21rac
    D Diekmann
    Chester Beatty Beatty Laboratories, Institute of Cancer Research, London, UK
    Nature 351:400-2. 1991
    ..This result suggest that Bcr could be a target for regulation by Rac and has important new implications for the role of bcr translocations in leukaemia...
  27. ncbi Post-translational modifications of p21rho proteins
    P Adamson
    Section of Cell and Molecular Biology, Chester Beatty Laboratories, London, United Kingdom
    J Biol Chem 267:20033-8. 1992
    ..We conclude that there are different populations of post-translationally modified p21rhoB in the cell and that the sequence specificity for geranylgeranyl- and farnesyltransferases may be more complicated than previously proposed...
  28. ncbi The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    A J Ridley
    Institute for Cancer Research, Chester Beatty Laboratories, London, England
    Cell 70:389-99. 1992
    ..These data imply that rho is essential specifically for the coordinated assembly of focal adhesions and stress fibers induced by growth factors...
  29. ncbi The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway
    Z Zhou
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Dev Cell 1:477-89. 2001
    ..We propose that through interactions with membranes and with a CED-2/CED-5 protein complex, CED-12 regulates Rho/Rac GTPase signaling and leads to cytoskeletal reorganization by an evolutionarily conserved mechanism...
  30. ncbi Ultrastructural localization of ras-related proteins using epitope-tagged plasmids
    D Robertson
    Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, UK
    J Histochem Cytochem 43:471-80. 1995
    ..These experiments demonstrate the successful use of this approach for detection of de novo synthesized proteins from microinjected plasmids by both light and electron microscopy on a small (< 50 cells) sample size...
  31. pmc Purification and N-terminal sequence of the p21rho GTPase-activating protein, rho GAP
    M D Garrett
    Institute of Cancer Research, Chester Beatty Laboratories, London, U K
    Biochem J 276:833-6. 1991
    ..These results suggest that there is a family of sequence-related GAP proteins, which to date includes ras GAP and its yeast counterparts IRA1 and IRA2, rho GAP and the Neurofibromatosis gene product NF1...
  32. ncbi The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
    A J Ridley
    Institute for Cancer Research, Chester Beatty Laboratories, London, England
    Cell 70:401-10. 1992
    ..We propose that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin...
  33. ncbi Small GTP-binding proteins and the regulation of the actin cytoskeleton
    A Hall
    MRC Laboratory for Molecular Cell Biology, University College London, England
    Annu Rev Cell Biol 10:31-54. 1994
  34. ncbi Isolation, characterization, and mapping of the mouse Fgd3 gene, a new Faciogenital Dysplasia (FGD1; Aarskog Syndrome) gene homologue
    N G Pasteris
    Department of Pediatrics, University of Michigan Medical School, Ann Arbor 48109 0688, USA
    Gene 242:237-47. 2000
    ..We conclude that Fgd3 is a new and novel member of the FGD1 family of RhoGEF proteins...
  35. ncbi A role for Rho-like GTPases in the polarisation of mouse eight-cell blastomeres
    L Clayton
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, United Kingdom
    Dev Biol 205:322-31. 1999
    ..These results suggest that Rho family GTPases are involved in the polarisation of early mouse blastomeres...
  36. pmc A novel type of myosin implicated in signalling by rho family GTPases
    J Reinhard
    Friedrich Miescher Laboratorium der Max Planck Gesellschaft, Tubingen, Germany
    EMBO J 14:697-704. 1995
    ..It is also the first unconventional myosin for which a tail binding partner(s), namely members of the rho family, has been identified...
  37. ncbi Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome
    P Aspenstrom
    Department of Zoological Cell Biology, Wenner Gren Institute, Stockholm, Sweden
    Curr Biol 6:70-5. 1996
    ..In order to examine more closely the mechanisms underlying the diverse functions of Rho GTPases in mammalian cells, we searched for downstream targets of these proteins...
  38. ncbi Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases
    M F Olson
    CRC Oncogene and Signal Transduction Group, MRC Laboratory for Molecular Cell Biology, London, UK
    Curr Biol 6:1628-33. 1996
    ..Homozygous Vav-/- knockout mice embryos are not viable past the blastocyst stage, indicating an essential role of Vav in embryonic implantation...
  39. ncbi PRK1 is targeted to endosomes by the small GTPase, RhoB
    H Mellor
    Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    J Biol Chem 273:4811-4. 1998
    ..Translocation of PRK1 to the endosomal compartment by RhoB is accompanied by a shift in the electrophoretic mobility of the kinase indicative of an accompanying activation...
  40. ncbi p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking
    P D Burbelo
    Laboratory of Developmental Biology, NIDR, National Institutes of Health, Bethesda, Maryland 20892 4370, USA
    J Biol Chem 270:30919-26. 1995
    ..These results identify a novel second member of the p190 family and establish the existence of a novel transmembrane link between integrins and a new protein p190-B and Rho...
  41. pmc IgA antibodies of coeliac disease patients recognise a dominant T cell epitope of A-gliadin
    E A L Bateman
    Department of Clinical Immunology, Churchill Hospital, Oxford Radcliffe Hospitals, Oxford OX3 7LJ, UK
    Gut 53:1274-8. 2004
    ..This peptide sequence is also located within a 33-mer protease resistant gliadin fragment and therefore is likely to play an important role in the pathogenesis of CD...
  42. pmc A novel role for RhoGDI as an inhibitor of GAP proteins
    J F Hancock
    Onyx Pharmaceuticals, Richmond, CA 94806
    EMBO J 12:1915-21. 1993
    ..Thus GDI, by complexing with Rac-GTP and preventing GAP stimulated GTP hydrolysis, may allow transit of the activated form of the Rac protein between physically separated activator and effector proteins in the cell...
  43. ncbi Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases
    C A Lancaster
    Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom
    J Biol Chem 269:1137-42. 1994
    ..In vitro GTPase assays, however, reveal that G25K/CDC42 is the preferred substrate. RhoGAP contains a proline-rich sequence, suggesting that it is an SH3-binding protein...
  44. ncbi Interaction of the human insulin receptor with the ras oncogene product p21
    R M O'Brien
    FEBS Lett 217:253-9. 1987
    ..After denaturation of p21Ha-ras with urea it became a substrate, but then failed to inhibit receptor autophosphorylation even in the presence of added GDP...
  45. pmc Intracellular localization of the P21rho proteins
    P Adamson
    Section of Cell and Molecular Biology, Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom
    J Cell Biol 119:617-27. 1992
    ....
  46. ncbi Sam68 from an immortalised B-cell line associates with a subset of SH3 domains
    P M Finan
    Yamanouchi Research Institute, Littlemore Hospital, Oxford, UK
    FEBS Lett 389:141-4. 1996
    ....