Research Topics
Genomes and Genes
| A HallSummaryAffiliation: University College London Country: UK Publications
| Collaborators
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Detail Information
Publications
Rho GTPases and the control of cell behaviourA Hall
MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, Cancer Research UK Oncogene and Signal Transduction Group, University College London, London WC1E 6BT, UK
Biochem Soc Trans 33:891-5. 2005..We have been analysing the biochemical contributions of Rho GTPases in cell movement and have found that Rac controls cell protrusion, while Cdc42 controls cell polarity...
Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeletonA Hall
Medical Research Council Laboratory for Molecular Cell Biology, University College London, UK
Philos Trans R Soc Lond B Biol Sci 355:965-70. 2000....- Rho GTPases and the actin cytoskeletonA Hall
Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
Science 279:509-14. 1998.... - A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathwaysN Tapon
MRC Laboratory for Molecular Cell Biology, CRC Oncogene and Signal Transduction Group, University College London, London WC1E 6BT, UK
EMBO J 17:1395-404. 1998..When overexpressed in fibroblasts, POSH is a strong inducer of apoptosis. We propose that POSH acts as a scaffold protein and contributes to Rac-induced signal transduction pathways leading to diverse gene transcriptional changes... - Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complexS Krugmann
MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, CRC Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, United Kingdom
Curr Biol 11:1645-55. 2001..Cdc42 controls the formation of actin bundle-containing filopodia at the cellular periphery. The molecular mechanism for this remains as yet unclear... - CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and RacN Lamarche-Vane
Medical Research Council Laboratory for Molecular Cell Biology, CRC Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, United Kingdom
J Biol Chem 273:29172-7. 1998..Thus, CdGAP is a novel GAP that is likely to participate in Cdc42- and Rac-induced signaling pathways leading to actin reorganization... - Role of actin polymerization and adhesion to extracellular matrix in Rac- and Rho-induced cytoskeletal reorganizationL M Machesky
Department of Molecular Medicine, Medical Research Council Laboratory for Molecular Cell Biology, University College London, United Kingdom
J Cell Biol 138:913-26. 1997..It appears, therefore, that the assembly of large integrin complexes is not required for most of the actin reorganization or cell morphology changes induced by Rac or Rho activation in Swiss 3T3 fibroblasts... - Lipopolysaccharide-induced activation of beta2-integrin function in macrophages requires Irak kinase activity, p38 mitogen- activated protein kinase, and the Rap1 GTPaseA Schmidt
MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, United Kingdom
Mol Cell Biol 21:438-48. 2001..Together, our results suggest that beta2-integrin-dependent spreading of macrophages in response to LPS is controlled by a linear signaling pathway via MyD88, Irak, p38, and Rap1... - Rho GTPases control polarity, protrusion, and adhesion during cell movementC D Nobes
MRC Laboratory for Molecular Cell Biology, CRC Oncogene and Signal Transduction Group, University College London, London WC1E 6BT, United Kingdom
J Cell Biol 144:1235-44. 1999..We conclude that the signal transduction pathways controlled by the four small GTPases, Rho, Rac, Cdc42, and Ras, cooperate to promote cell movement... - Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectinL Kjøller
Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, United Kingdom
J Cell Biol 152:1145-57. 2001..This mechanism may play a role in uPAR-mediated regulation of cell motility at sites where VN and uPAR are co-expressed, such as malignant tumors... - A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesionC D Nobes
Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group and Department of Biochemistry, University College London, London WC1E 7BT, United Kingdom
J Cell Biol 141:187-97. 1998..We suggest that these proteins control rearrangements of the actin cytoskeleton and changes in cell adhesion... - The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase RhoR F Lamb
MRC Laboratory for Molecular Cell Biology and Department of Biochemistry, University College London, UK
Nat Cell Biol 2:281-7. 2000.... - Analysis of R-Ras signalling pathwaysA J Self
MRC Laboratory for Molecular Cell Biology, CRC Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
J Cell Sci 114:1357-66. 2001..These results indicate that R-Ras has an important role in the regulation of cell growth and adhesion, but that this is mediated through downstream signals distinct from those used by Ras... - The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contactsV M Braga
Medical Research Council Laboratory for Molecular Cell Biology, University College London, WC1E 6BT, London, United Kingdom
J Cell Biol 137:1421-31. 1997..Our results provide new insights into the role of the small GTPases in the cadherin-dependent cell- cell contact formation and the remodelling of actin filaments in epithelial cells... - Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzetaS Etienne-Manneville
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
Cell 106:489-98. 2001..Localized PKCzeta activity, acting through the microtubule motor protein dynein, is required for all aspects of induced polarity in these cells... - Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16H Daub
Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, and the Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, United Kingdom
J Biol Chem 276:1677-80. 2001..Because stathmin destabilizes microtubules, and this process is inhibited by phosphorylation at residue 16, Rac and Cdc42 can potentially regulate both F-actin and microtubule dynamics... - The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3K i Nagata
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
EMBO J 17:149-58. 1998.... - Rho GTPases and their effector proteinsA L Bishop
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, U K
Biochem J 348:241-55. 2000..The main focus of this review will be Rho, Rac and Cdc42, the three best characterized mammalian Rho GTPases, though the genetic analysis of Rho GTPases in lower eukaryotes is making increasingly important contributions to this field... - Oligodendrocyte lineage and the motor neuron connectionW D Richardson
MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, London, United Kingdom
Glia 29:136-42. 2000..We decide in favour of a single embryonic lineage with regional variations along the anterior-posterior neuraxis... - Teaching senior oncologists communication skills: results from phase I of a comprehensive longitudinal program in the United KingdomL Fallowfield
Department of Oncology, University College London Medical School, United Kingdom
J Clin Oncol 16:1961-8. 1998..To determine the communication difficulties experienced by clinicians in cancer medicine and to develop, implement, and evaluate communication skills training courses... - Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activityD Diekmann
Medical Research Council Laboratory for Molecular Cell Biology, University College London, UK
Science 265:531-3. 1994..Modified forms of Rac with mutations in the effector site did not stimulate oxidase activity or bind to p67phox. Thus, p67phox appears to be the Rac effector protein in the NADPH oxidase complex... - A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPasesP D Burbelo
Medical Research Council Laboratory for Molecular Cell Biology, University College London, United Kingdom
J Biol Chem 270:29071-4. 1995..These results indicate that proteins containing the CRIB motif bind to Cdc42 and/or Rac in a GTP-dependent manner, and they may, therefore, participate in downstream signaling... - The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathwayZ Zhou
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Dev Cell 1:477-89. 2001..We propose that through interactions with membranes and with a CED-2/CED-5 protein complex, CED-12 regulates Rho/Rac GTPase signaling and leads to cytoskeletal reorganization by an evolutionarily conserved mechanism... - Purification and N-terminal sequence of the p21rho GTPase-activating protein, rho GAPM D Garrett
Institute of Cancer Research, Chester Beatty Laboratories, London, U K
Biochem J 276:833-6. 1991..These results suggest that there is a family of sequence-related GAP proteins, which to date includes ras GAP and its yeast counterparts IRA1 and IRA2, rho GAP and the Neurofibromatosis gene product NF1... - A role for Rho-like GTPases in the polarisation of mouse eight-cell blastomeresL Clayton
Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, United Kingdom
Dev Biol 205:322-31. 1999..These results suggest that Rho family GTPases are involved in the polarisation of early mouse blastomeres... - Isolation, characterization, and mapping of the mouse Fgd3 gene, a new Faciogenital Dysplasia (FGD1; Aarskog Syndrome) gene homologueN G Pasteris
Department of Pediatrics, University of Michigan Medical School, Ann Arbor 48109 0688, USA
Gene 242:237-47. 2000..We conclude that Fgd3 is a new and novel member of the FGD1 family of RhoGEF proteins... - Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating RhoM H Driessens
MRC Laboratory for Molecular Cell Biology, Department of Biochemistry and Molecular Biology, University College London, London, WC1E 6BT, United Kingdom
Curr Biol 11:339-44. 2001..Our findings that plexin-B signaling to the cytoskeleton is both Rac and Rho dependent form a starting point for unraveling the mechanism by which semaphorins and plexins control axon guidance and cell migration... - PRK1 is targeted to endosomes by the small GTPase, RhoBH Mellor
Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
J Biol Chem 273:4811-4. 1998..Translocation of PRK1 to the endosomal compartment by RhoB is accompanied by a shift in the electrophoretic mobility of the kinase indicative of an accompanying activation... - Post-translational modifications of p21rho proteinsP Adamson
Section of Cell and Molecular Biology, Chester Beatty Laboratories, London, United Kingdom
J Biol Chem 267:20033-8. 1992..We conclude that there are different populations of post-translationally modified p21rhoB in the cell and that the sequence specificity for geranylgeranyl- and farnesyltransferases may be more complicated than previously proposed... - The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factorsA J Ridley
Institute for Cancer Research, Chester Beatty Laboratories, London, England
Cell 70:389-99. 1992..These data imply that rho is essential specifically for the coordinated assembly of focal adhesions and stress fibers induced by growth factors... - The small GTP-binding protein rac regulates growth factor-induced membrane rufflingA J Ridley
Institute for Cancer Research, Chester Beatty Laboratories, London, England
Cell 70:401-10. 1992..We propose that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin... - Bcr encodes a GTPase-activating protein for p21racD Diekmann
Chester Beatty Beatty Laboratories, Institute of Cancer Research, London, UK
Nature 351:400-2. 1991..This result suggest that Bcr could be a target for regulation by Rac and has important new implications for the role of bcr translocations in leukaemia... - Ultrastructural localization of ras-related proteins using epitope-tagged plasmidsD Robertson
Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, UK
J Histochem Cytochem 43:471-80. 1995..These experiments demonstrate the successful use of this approach for detection of de novo synthesized proteins from microinjected plasmids by both light and electron microscopy on a small (< 50 cells) sample size... - A novel type of myosin implicated in signalling by rho family GTPasesJ Reinhard
Friedrich Miescher Laboratorium der Max Planck Gesellschaft, Tubingen, Germany
EMBO J 14:697-704. 1995..It is also the first unconventional myosin for which a tail binding partner(s), namely members of the rho family, has been identified... - Small GTP-binding proteins and the regulation of the actin cytoskeletonA Hall
MRC Laboratory for Molecular Cell Biology, University College London, England
Annu Rev Cell Biol 10:31-54. 1994 - Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPasesM F Olson
CRC Oncogene and Signal Transduction Group, MRC Laboratory for Molecular Cell Biology, London, UK
Curr Biol 6:1628-33. 1996..Homozygous Vav-/- knockout mice embryos are not viable past the blastocyst stage, indicating an essential role of Vav in embryonic implantation... - Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndromeP Aspenstrom
Department of Zoological Cell Biology, Wenner Gren Institute, Stockholm, Sweden
Curr Biol 6:70-5. 1996..In order to examine more closely the mechanisms underlying the diverse functions of Rho GTPases in mammalian cells, we searched for downstream targets of these proteins... - p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linkingP D Burbelo
Laboratory of Developmental Biology, NIDR, National Institutes of Health, Bethesda, Maryland 20892 4370, USA
J Biol Chem 270:30919-26. 1995..These results identify a novel second member of the p190 family and establish the existence of a novel transmembrane link between integrins and a new protein p190-B and Rho... - IgA antibodies of coeliac disease patients recognise a dominant T cell epitope of A-gliadinE A L Bateman
Department of Clinical Immunology, Churchill Hospital, Oxford Radcliffe Hospitals, Oxford OX3 7LJ, UK
Gut 53:1274-8. 2004..This peptide sequence is also located within a 33-mer protease resistant gliadin fragment and therefore is likely to play an important role in the pathogenesis of CD... - Sam68 from an immortalised B-cell line associates with a subset of SH3 domainsP M Finan
Yamanouchi Research Institute, Littlemore Hospital, Oxford, UK
FEBS Lett 389:141-4. 1996.... - Interaction of the human insulin receptor with the ras oncogene product p21K Siddle
FEBS Lett 217:253-9. 1987..After denaturation of p21Ha-ras with urea it became a substrate, but then failed to inhibit receptor autophosphorylation even in the presence of added GDP... - A novel role for RhoGDI as an inhibitor of GAP proteinsJ F Hancock
Onyx Pharmaceuticals, Richmond, CA 94806
EMBO J 12:1915-21. 1993..Thus GDI, by complexing with Rac-GTP and preventing GAP stimulated GTP hydrolysis, may allow transit of the activated form of the Rac protein between physically separated activator and effector proteins in the cell... - Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPasesC A Lancaster
Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom
J Biol Chem 269:1137-42. 1994..In vitro GTPase assays, however, reveal that G25K/CDC42 is the preferred substrate. RhoGAP contains a proline-rich sequence, suggesting that it is an SH3-binding protein... - Intracellular localization of the P21rho proteinsP Adamson
Section of Cell and Molecular Biology, Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom
J Cell Biol 119:617-27. 1992....