Research Topics
| Jason C G HalfordSummaryAffiliation: University of Liverpool Country: UK Publications
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Publications
Clinical pharmacotherapy for obesity: current drugs and those in advanced developmentJason C G Halford
Kissileff Laboratory for the Study of Human Ingestive Behaviour, School of Psychology, University of Liverpool, Eleanor Rathbone Building, Liverpool, L69 7ZA, UK
Curr Drug Targets 5:637-46. 2004..Wider use of pharmacotherapy and enhanced efficacy for the next generation of anti-obesity drugs certainly promise to reduce obesity related illness if not halt the rise in obesity per se...- Beyond-brand effect of television food advertisements on food choice in children: the effects of weight statusJason Cg Halford
Kissileff Laboratory for the Study of Human Ingestive Behaviour, School of Psychology, Eleanor Rathbone Building, Bedford Street South, University of Liverpool, Liverpool L69 7ZA, UK
Public Health Nutr 11:897-904. 2008..To investigate the effect of television food advertising on children's food intake, specifically whether childhood obesity is related to a greater susceptibility to food promotion... 
Serotonergic anti-obesity agents: past experience and future prospectsJason C G Halford
Experimental Psychology, University of Liverpool, Liverpool, UK
Drugs 71:2247-55. 2011..The serotonergic system remains a viable target for anti-obesity treatment. In this review, we examine the limited behavioural data available on these two new CNS-acting appetite suppressants...- Satiety-enhancing products for appetite control: science and regulation of functional foods for weight managementJason C G Halford
Department of Experimental Psychology, University of Liverpool, Eleanor Rathbone Building, Liverpool L69 7ZA, UK
Proc Nutr Soc 71:350-62. 2012..Nonetheless, we possess the methodological tools, which when employed in appropriate designs, are sufficient to support health claims... 
The effect of Korean pine nut oil (PinnoThin) on food intake, feeding behaviour and appetite: a double-blind placebo-controlled trialGeorgina M Hughes
School of Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool, L69 7ZA, UK
Lipids Health Dis 7:6. 2008..Collectively, these data suggest that PinnoThin may exert satiating effects consistent with its known action on CCK and GLP-1 release, and previously observed effects on self-reported appetite ratings...- Pharmacotherapy for obesityJason C G Halford
Kissileff Laboratory for the Study of Human Ingestive Behaviour, School of Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool L69 7ZA, UK
Appetite 46:6-10. 2006..Despite this, in the XENDOS trial, the modest placebo-subtract weight loss produced by orlistat (2.8 kg) reduced the incidence of diabetes by over a third. Recent data on the potential anti-obesity drug rimonabant are also reviewed... - Obesity drugs in clinical developmentJason C G Halford
University of Liverpool, Kissileff Laboratory for the Study of Human Ingestive Behaviour, School of Psychology, Eleanor Rathbone Building, Bedford Street South, Liverpool, UK
Curr Opin Investig Drugs 7:312-8. 2006..Of these, only rimonabant has got as far as completing phase III clinical trials. This review will provide an overview of the most prominent drugs currently undergoing clinical development as potential anti-obesity therapies... - Serotonergic drugs : effects on appetite expression and use for the treatment of obesityJason C G Halford
Kissileff Laboratory for the Study of Human Ingestive Behaviour, School of Psychology, University of Liverpool, Liverpool, UK
Drugs 67:27-55. 2007..The hope is that these drugs will not only be free of their predecessors' adverse effect profiles, but will also be equally or more effective at regulating appetite and controlling bodyweight... - Beyond-brand effect of television (TV) food advertisements/commercials on caloric intake and food choice of 5-7-year-old childrenJason C G Halford
Kissileff Laboratory for the Study of Human Ingestive Behaviour, School of Psychology, Eleanor Rathbone Building, Bedford Street South, University of Liverpool, Liverpool L69 7ZA, UK
Appetite 49:263-7. 2007..Beyond their effects on brand choice, exposure to food advertisements (commercials) promotes over-consumption in younger children... - Children's food preferences: effects of weight status, food type, branding and television food advertisements (commercials)Jason C G Halford
Kissileff Laboratory for the Study of Human Ingestive Behaviour, School of Psychology, University of Liverpool, UK
Int J Pediatr Obes 3:31-8. 2008..This suggests that television food advertisement exposure can produce the same 'obesigenic' food preference response found in overweight and obese children in their normal weight counterparts... - From Claude Bernard to Walter Cannon. Emergence of the concept of homeostasisSteven J Cooper
School of Psychology, University of Liverpool, Bedford Street South, Liverpool, UK
Appetite 51:419-27. 2008.... - Neuropharmacology of human appetite expressionJason C G Halford
Kissileff Laboratory for the Study of Human Ingestive Behaviour, School of Psychology, University of Liverpool, Liverpool, United Kingdom
Dev Disabil Res Rev 14:158-64. 2008..All these drugs act by modifying the expression of human appetite. An assessment of a drug's effects on caloric intake and feelings of hunger and satiety is necessary before they can be considered for clinical use... - Separate systems for serotonin and leptin in appetite controlJ C Halford
Department of Psychology, University of Liverpool, UK
Ann Med 32:222-32. 2000..At a conceptual level, these may represent the distinction between 'satiety' and 'drive'. Interestingly, both 5-HT and leptin modulate the action of NPY, which may form a part of a common output pathway for the expression of appetite... - Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesityJason C G Halford
School of Psychology, University of Liverpool, Liverpool L69 7ZA, UK
Curr Drug Targets 6:201-13. 2005..Hopefully, such drugs will be as or even more effective at regulating appetite and controlling body weight, and will also be free of their predecessors' side effect... - Pharmacology of appetite suppression: implication for the treatment of obesityJ C Halford
Department of Psychology, University of Liverpool, UK
Curr Drug Targets 2:353-70. 2001..Such compounds used in combination with life style changes and dietary intervention may be critical in dealing with the rising world epidemic of obesity... - 5-HT(2C) Receptor Agonists and the Control of AppetiteJason C G Halford
Kissileff Laboratory for the Study of Human Ingestive Behaviour, School of Psychology, University of Liverpool, Liverpool, L69 7ZA, UK
Handb Exp Pharmacol 209:349-56. 2012..The effects of lorcaserin on eating behaviour remain to be characterised as does its behavioural specificity... - Pharmacological management of appetite expression in obesityJason C G Halford
School of Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool L69 7ZA, UK
Nat Rev Endocrinol 6:255-69. 2010..Rational interventions designed specifically to modulate these processes could limit the normally aversive consequences of caloric restriction and maximize an individual's capacity to successfully gain control over their appetite... - Food commercials increase preference for energy-dense foods, particularly in children who watch more televisionEmma J Boyland
Kissileff Laboratory for the Study of Human Ingestive Behaviour, Department of Experimental Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool L69 7ZA, United Kingdom
Pediatrics 128:e93-100. 2011..Our aim was to determine if levels of television viewing (a proxy measure for habitual commercial exposure) affect children's food preference responses to television food commercials... - The hypothalamus and obesityJoanne A Harrold
School of Psychology, University of Liverpool, Liverpool, L69 7ZA, UK
Recent Pat CNS Drug Discov 1:305-14. 2006..The true relevance of many of these to the regulation of human energy balance remains uncertain, but some novel anti-obesity drugs aimed at these targets are likely to emerge in the next few years... - The pharmacology of human appetite expressionJason C G Halford
Kissileff Laboratory for the Study of Human Ingestive Behaviour, Department of Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool, L69 7ZA, UK
Curr Drug Targets 5:221-40. 2004..However, such an understanding must be based on knowledge of the effect of the treatment on meal size, eating rate, meal pattern, food choice and the subjective experience of appetite flux (hunger and satiety), and notjust food intake... - Effect of television advertisements for foods on food consumption in childrenJason C G Halford
Department of Psychology, Kissileff Laboratory for the Study of Human Ingestive Behaviour, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool L69 7ZA, UK
Appetite 42:221-5. 2004..As suggested the relationship between TV viewing and childhood obesity appears not merely a matter of excessive sedentary activity. Exposure to food adverts promotes consumption... - Persuasive techniques used in television advertisements to market foods to UK childrenEmma J Boyland
Kissileff Laboratory for the Study of Human Ingestive Behaviour, Department of Experimental Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool L69 7ZA, UK
Appetite 58:658-64. 2012..Further studies should incorporate an analysis of the content of websites promoted during food adverts... - CNS regulation of appetiteJoanne A Harrold
Human Ingestive Behaviour Laboratory, Department of Experimental Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool L69 7ZA, UK
Neuropharmacology 63:3-17. 2012..This article is part of a Special Issue entitled 'Central Control of Food Intake'... - Effects of insulin-induced hypoglycaemia on energy intake and food choice at a subsequent test mealShivani Dewan
Diabetes and Endocrinology Research Group, University Hospital Aintree, Liverpool, UK
Diabetes Metab Res Rev 20:405-10. 2004..High-fat foods can lead to passive overconsumption and have a low glycaemic index, which may prolong hypoglycaemia. Both factors could ultimately promote weight gain in individuals with recurrent hypoglycaemia... - Food neophobia and 'picky/fussy' eating in children: a reviewTerence M Dovey
Department of Psychology, Staffordshire University, College Road, Stoke on Trent, Staffordshire ST4 2DE, UK
Appetite 50:181-93. 2008..Behavioural interventions, focusing on early life exposure, could be developed to attenuate food neophobia and 'picky/fussy' eating in children, so promoting the ready acceptance and independent choice of fruits and vegetables... - The extent of food advertising to children on UK television in 2008Emma J Boyland
Department of Experimental Psychology, Institute of Psychology, Health and Society, University of Liverpool, Liverpool, UK
Int J Pediatr Obes 6:455-61. 2011..To provide the most comprehensive analysis to date of the extent of food advertising on UK television channels popular with young people following regulatory reform of this type of marketing activity... - Characterization of olanzapine-induced weight gain in ratsAndrew J Goudie
Psychology Department, Eleanor Rathbone Building, Liverpool University, Liverpool, UK
J Psychopharmacol 16:291-6. 2002..However, it remains to be determined how closely rodent models mimic the clinical situation and whether the mechanism(s) involved in the weight gain we have observed are the same as those involved in the clinical use of these drugs... - Autoradiographic analysis of ghrelin receptors in the rat hypothalamusJoanne A Harrold
School of Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool L69 7ZA, U K
Brain Res 1196:59-64. 2008..We suggest that this may relate to the paradigm employed to modify nutritional status in the study or could indicate that peripheral ghrelin is unlikely to be the major source of ghrelin that acts in many hypothalamic sites... - Orphan G-protein-coupled receptors : strategies for identifying ligands and potential for use in eating disordersJoanne A Harrold
Kissileff Laboratory for the Study of Human Ingestive Behaviour, School of Psychology, University of Liverpool, Liverpool, UK
Drugs R D 8:287-99. 2007..Consequently, hypophagic treatments may be of potential benefit in normal, overweight or obese individuals displaying aberrant (out of control) eating behaviour... - Adolescence and the diet-dieting disparity: healthy food choice or risky health behaviour?Paul J Lattimore
Department of Psychology, Chester College of Higher Education, UK
Br J Health Psychol 8:451-63. 2003..It was predicted that dieters would make healthier food choices compared to non-dieters and that measures of eating psychopathology would be associated with food choice... - Television advertising and branding. Effects on eating behaviour and food preferences in childrenEmma J Boyland
Department of Experimental Psychology, Institute of Psychology, Health and Society, University of Liverpool, Liverpool L69 7ZA, United Kingdom Electronic address
Appetite 62:236-41. 2013.... - A preliminary investigation into the relationship between anabolic-androgenic steroid use and the symptoms of reverse anorexia in both current and ex-usersJon C Cole
Psychology Department, Liverpool University, Liverpool, L69 7ZA, UK
Psychopharmacology (Berl) 166:424-9. 2003..To establish whether the symptoms of reverse anorexia continue with the cessation of anabolic-androgenic steroid (AAS) use in male body builders... - Is there a role for ghrelin and peptide-YY in the pathogenesis of obesity in adults with acquired structural hypothalamic damage?Christina Daousi
University Hospital Aintree, Diabetes and Endocrinology Research Group, Clinical Sciences Center, Longmoor Lane, Liverpool L9 7AL, United Kingdom
J Clin Endocrinol Metab 90:5025-30. 2005..Obesity is a common sequel to hypothalamic tumors and their treatment, but the underlying mechanisms are not fully established... - EditorialJason C G Halford
Curr Drug Targets 6:143-4. 2005 - H(1)-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugsAndrew J Goudie
Neuropsychopharmacology 28:2209; author reply 2210-11. 2003