Genomes and Genes
Affiliation: University of Aberdeen
- The influence of birth weight and genetic factors on lipid levels: a study in adult twinsChuluuntulga Tuya
Clinical Research Unit, NHS Grampian, Westburn House, Foresterhill, Aberdeen, UK
Br J Nutr 95:504-10. 2006..The results suggest that the in utero growth restriction and early catch-up growth experienced by twins does not increase the risk of an atherogenic lipid profile in adult life...
- Folate in pregnancy and imprinted gene and repeat element methylation in the offspringPaul Haggarty
Lifelong Health, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, United Kingdom
Am J Clin Nutr 97:94-9. 2013..Epigenetic regulation of imprinted genes and transposable elements has been implicated in human disease and may be affected by maternal diet...
- Human intelligence and polymorphisms in the DNA methyltransferase genes involved in epigenetic markingPaul Haggarty
Nutrition and Epigenetics Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, United Kingdom
PLoS ONE 5:e11329. 2010..We believe that the role of epigenetics in the normal variation in human intelligence merits further study and that this novel finding should be tested in other cohorts...
- Fatty acid supply to the human fetusPaul Haggarty
Nutrition and Epigenetics Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, AB21 9SB, Scotland, United Kingdom
Annu Rev Nutr 30:237-55. 2010..An appreciation of these adaptations is important in any nutritional strategy designed to improve the availability of fatty acids to the fetus...
- Diet and deprivation in pregnancyPaul Haggarty
Nutrition and Epigenetics Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Br J Nutr 102:1487-97. 2009..Improving the nutrient intake of disadvantaged women of childbearing age may potentially improve pregnancy outcome...
- Folic acid use in pregnancy and embryo selectionP Haggarty
Nutrition and Epigenetics Group, Rowett Research Institute, Aberdeen, UK
BJOG 115:851-6. 2008..Our aim was to test for this effect...
- B-vitamins, genotype and disease causalityPaul Haggarty
Nutrition and Epigenetics Group, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, UK
Proc Nutr Soc 66:539-47. 2007..Graphical representation of diet-genotype-health data greatly assists in the elucidation of the nature of genetic effects, their interaction with nutrition and the implications for nutrition policy...
- Effect of B vitamins and genetics on success of in-vitro fertilisation: prospective cohort studyP Haggarty
Nutrition and Epigenetics Group, Rowett Research Institute, Bucksburn, Aberdeen, UK
Lancet 367:1513-9. 2006..Our aim was to assess the role of B vitamins and genetics...
- Fatty acid metabolism in human preimplantation embryosP Haggarty
Embryonic Programming Group, Rowett Research Institute, Bucksburn, Aberdeen, UK
Hum Reprod 21:766-73. 2006..Little is known of fatty acid metabolism in human embryos. This information would be useful in developing metabolic tests of embryo quality and improving embryo culture media...
- Effect of placental function on fatty acid requirements during pregnancyP Haggarty
Rowett Research Institute, Aberdeen, UK
Eur J Clin Nutr 58:1559-70. 2004....
- The effect of maternal smoking and ethanol on fatty acid transport by the human placentaP Haggarty
Rowett Research Institute, Aberdeen, Scotland, UK
Br J Nutr 87:247-52. 2002..05) in the clearance of H2(18)O. These results suggest that the presence of ethanol at a concentration of 2mg/ml may reduce the availability of polyunsaturated fatty acids to the developing fetus...
- Effect of maternal polyunsaturated fatty acid concentration on transport by the human placentaP Haggarty
Rowett Research Institute, Aberdeen University, Aberdeen, UK
Biol Neonate 75:350-9. 1999..These results suggest that the maternal concentration of individual fatty acids, and hence the composition of the maternal diet, can have large effects on polyunsaturated/long-chain polyunsaturated fatty acids delivery to the fetus...
- Placental regulation of fatty acid delivery and its effect on fetal growth--a reviewPaul Haggarty
Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Placenta 23:S28-38. 2002....
- Placental nutrient transfer capacity and fetal growthP Haggarty
Rowett Research Institute, Aberdeen, AB2 9SB, UK
Placenta 23:86-92. 2002..It is proposed that the fetus itself may regulate placental nutrient transport in vivo via the fetal cardiac output and the rate of fetal nutrient utilization...
- Free and esterified fatty acid and cholesterol synthesis in adult males and its effect on the doubly-labelled water methodP Haggarty
Rowett Research Institute, Bucksburn, Aberdeen, UK
Br J Nutr 83:227-34. 2000....
- Blood pressure in relation to birth weight in twins and singleton controls matched for gestational ageGeraldine McNeill
Faculty of Medicine and Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
Am J Epidemiol 158:150-5. 2003..9 (95% CI: -6.4, 4.6) mmHg/kg for systolic pressure and -0.2 (95% CI: -4.1, 3.7) mmHg/kg for diastolic pressure. The results suggest that in-utero growth restriction in twins is not a major determinant of their blood pressure as adults...
- Leptin secretion to both the maternal and fetal circulation in the ex vivo perfused human term placentaN Hoggard
ACERO, Department of Molecular Physiology, Rowett Research Institute, Aberdeen, Scotland, UK
Placenta 22:347-52. 2001..7 per cent) but no corresponding relationship for fetal leptin production. It is proposed that such a mechanism would allow the placenta to modulate fat supply to the fetus in response to the fetal demand relative to placental supply...
- High omega-3:omega-6 fatty acid ratios in culture medium reduce endometrial-cell survival in combined endometrial gland and stromal cell cultures from women with and without endometriosisM R Gazvani
Department of Obstetrics and Gynaecology, University of Aberdeen, Aberden Hospital, Foresterhill, Aberdeen, AB25 2ZD, UK
Fertil Steril 76:717-22. 2001..To study the effects of omega-3 and omega-6 polyunsaturated fatty acid (PUFA) on in vitro proliferation of endometrial cells and their production of the cytokine interleukin-8 (IL-8)...
- The measurement of fetal liver T(*)(2) in utero before and after maternal oxygen breathing: progress towards a non-invasive measurement of fetal oxygenation and placental functionS I Semple
Department of Bio medical Physics, University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, AB25 2ZD Scotland
Magn Reson Imaging 19:921-8. 2001..This technique may potentially be applied to the identification and understanding of placental dysfunction in intra-uterine growth retardation...
- Changes in foetal liver T2* measurements by MRI in response to maternal oxygen breathing: application to diagnosing foetal growth restrictionDavid M Morris
Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen AB25 2ZD, UK
Physiol Meas 31:1137-46. 2010..Future studies on the use of oxygen-challenge MRI to investigate foetal growth restriction may therefore need to control for gestational age at the time of MR scanning in order to observe any underlying foetal growth-related effects...
- Leptin expression in placental and fetal tissues: does leptin have a functional role?N Hoggard
ACERO, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, U K
Biochem Soc Trans 29:57-63. 2001..In this review we will address these and other issues related to the expression of both placental and fetal leptin...
- Nutrition and the epigenomePaul Haggarty
Lifelong Health, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK
Prog Mol Biol Transl Sci 108:427-46. 2012..The promise of nutritional epigenetics is that it will help elucidate the way in which nutrition can influence health through direct effects on the genome...
- Ponderal index is a poor predictor of in utero growth retardationP Haggarty
Rowett Research Institute, Aberdeen, UK
BJOG 111:113-9. 2004..The inclusion of a length term generally reduced the predictive ability with the highest powers resulting in the poorest prediction...
- Estimation of energy expenditure in free-living red deer (Cervus elaphus) with the doubly-labelled water methodP Haggarty
Rowett Research Institute, Bucksburn, Aberdeen, UK
Br J Nutr 80:263-72. 1998..75 per d, one third higher than the value of 570 kJ/kg0.75 per d for stags penned indoors (Key et al. 1984)...
- A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesisJoel B Mason
Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Cancer Epidemiol Biomarkers Prev 16:1325-9. 2007..Further work is needed to definitively establish the nature of this relationship. In the meantime, deliberations about the institution or enhancement of fortification programs should be undertaken with these considerations in mind...