Thilo Hagen

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Expression and characterization of GSK-3 mutants and their effect on beta-catenin phosphorylation in intact cells
    Thilo Hagen
    Systems Research Kinase Biology Discovery Research, GlaxoSmithKline Pharmaceuticals, Harlow, Essex, CM19 5AD, United Kingdom
    J Biol Chem 277:23330-5. 2002
  2. ncbi Characterisation of the phosphorylation of beta-catenin at the GSK-3 priming site Ser45
    Thilo Hagen
    The Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK
    Biochem Biophys Res Commun 294:324-8. 2002
  3. ncbi FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A
    Thilo Hagen
    Discovery Research Biology, Neurology Centre of Excellence in Drug Discovery, Computational, Analytical, and Structural Sciences, GlaxoSmithKline Pharmaceuticals, Harlow, Essex CM19 5AD, United Kingdom
    J Biol Chem 281:35021-9. 2006
  4. ncbi Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha
    Thilo Hagen
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Science 302:1975-8. 2003
  5. ncbi Inhibition of cellular respiration by endogenously produced carbon monoxide
    Gabriela D'Amico
    Wolfson Institute for Biomedical Research, University College London, UK
    J Cell Sci 119:2291-8. 2006
  6. ncbi Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol
    Thilo Hagen
    The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Biochem Biophys Res Commun 322:923-9. 2004
  7. ncbi Signalling activity of beta-catenin targeted to different subcellular compartments
    Thilo Hagen
    Wolfson Digestive Diseases Centre, University Hospital, Nottingham NG7 2UH, UK
    Biochem J 379:471-7. 2004
  8. ncbi Substrate-mediated regulation of cullin neddylation
    Eng Hui Chew
    Wolfson Digestive Diseases Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom
    J Biol Chem 282:17032-40. 2007

Collaborators

Detail Information

Publications8

  1. ncbi Expression and characterization of GSK-3 mutants and their effect on beta-catenin phosphorylation in intact cells
    Thilo Hagen
    Systems Research Kinase Biology Discovery Research, GlaxoSmithKline Pharmaceuticals, Harlow, Essex, CM19 5AD, United Kingdom
    J Biol Chem 277:23330-5. 2002
    ....
  2. ncbi Characterisation of the phosphorylation of beta-catenin at the GSK-3 priming site Ser45
    Thilo Hagen
    The Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK
    Biochem Biophys Res Commun 294:324-8. 2002
    ..Priming of GSK-3 dependent phosphorylation of beta-catenin by a different kinase could have important implications for the regulation of Wnt signalling...
  3. ncbi FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A
    Thilo Hagen
    Discovery Research Biology, Neurology Centre of Excellence in Drug Discovery, Computational, Analytical, and Structural Sciences, GlaxoSmithKline Pharmaceuticals, Harlow, Essex CM19 5AD, United Kingdom
    J Biol Chem 281:35021-9. 2006
    ..In conclusion, PKA phosphorylates FRAT1 in vitro as well as in intact cells and may play a role in regulating the inhibitory activity of FRAT1 toward GSK-3...
  4. ncbi Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha
    Thilo Hagen
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Science 302:1975-8. 2003
    ..Thus, the signaling consequences of hypoxia may be profoundly modified by nitric oxide...
  5. ncbi Inhibition of cellular respiration by endogenously produced carbon monoxide
    Gabriela D'Amico
    Wolfson Institute for Biomedical Research, University College London, UK
    J Cell Sci 119:2291-8. 2006
    ..Inhibition of cell respiration by endogenous CO through its interaction with cytochrome c oxidase might have an important role in inflammatory and hypoxic conditions...
  6. ncbi Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol
    Thilo Hagen
    The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Biochem Biophys Res Commun 322:923-9. 2004
    ..Since these actions of 2ME2 occur at higher concentrations than those known to inhibit cell proliferation, it remains to be established whether they contribute to its therapeutic effect...
  7. ncbi Signalling activity of beta-catenin targeted to different subcellular compartments
    Thilo Hagen
    Wolfson Digestive Diseases Centre, University Hospital, Nottingham NG7 2UH, UK
    Biochem J 379:471-7. 2004
    ..Our results suggest that cytosolic accumulation of beta-catenin is a prerequisite for the activation of TCF/LEF-dependent transcription in the nucleus...
  8. ncbi Substrate-mediated regulation of cullin neddylation
    Eng Hui Chew
    Wolfson Digestive Diseases Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom
    J Biol Chem 282:17032-40. 2007
    ..These findings suggest a mechanism through which availability of substrate recognition subunits and substrates can regulate the ubiquitin ligase activity...