Marios Hadjivassiliou

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. ncbi request reprint A case of celiac disease mimicking amyotrophic lateral sclerosis
    Martin R Turner
    Department of Neurology, John Radcliffe Hospital, Oxford, UK
    Nat Clin Pract Neurol 3:581-4. 2007
  2. ncbi request reprint The humoral response in the pathogenesis of gluten ataxia
    M Hadjivassiliou
    Department of Clinical Neurology, The Royal Hallamshire Hospital, Sheffield, UK
    Neurology 58:1221-6. 2002
  3. pmc Neuropathy associated with gluten sensitivity
    M Hadjivassiliou
    Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    J Neurol Neurosurg Psychiatry 77:1262-6. 2006
  4. pmc Screening for coeliac disease: But where does it take us?
    David S Sanders
    BMJ 336:9. 2008
  5. ncbi request reprint Clinical, radiological, neurophysiological, and neuropathological characteristics of gluten ataxia
    M Hadjivassiliou
    Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK
    Lancet 352:1582-5. 1998
  6. pmc Can head trauma trigger celiac disease? Nation-wide case-control study
    Jonas F Ludvigsson
    Department of Pediatrics, Orebro University Hospital, Orebro, Sweden
    BMC Neurol 13:105. 2013
  7. doi request reprint Transglutaminase 6 antibodies in the diagnosis of gluten ataxia
    Marios Hadjivassiliou
    Departments of Neurology, Royal Hallamshire Hospital, Sheffield, UK
    Neurology 80:1740-5. 2013
  8. doi request reprint MR spectroscopy and atrophy in Gluten, Friedreich's and SCA6 ataxias
    M Hadjivassiliou
    Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK
    Acta Neurol Scand 126:138-43. 2012
  9. pmc Spectrum of gluten-related disorders: consensus on new nomenclature and classification
    Anna Sapone
    Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    BMC Med 10:13. 2012
  10. ncbi request reprint Dietary treatment of gluten neuropathy
    Marios Hadjivassiliou
    Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    Muscle Nerve 34:762-6. 2006

Collaborators

Detail Information

Publications49

  1. ncbi request reprint A case of celiac disease mimicking amyotrophic lateral sclerosis
    Martin R Turner
    Department of Neurology, John Radcliffe Hospital, Oxford, UK
    Nat Clin Pract Neurol 3:581-4. 2007
    ..The thigh muscle in the affected leg showed signs of wasting. The patient had a remote family history of celiac disease...
  2. ncbi request reprint The humoral response in the pathogenesis of gluten ataxia
    M Hadjivassiliou
    Department of Clinical Neurology, The Royal Hallamshire Hospital, Sheffield, UK
    Neurology 58:1221-6. 2002
    ..To characterize humoral response to cerebellum in patients with gluten ataxia...
  3. pmc Neuropathy associated with gluten sensitivity
    M Hadjivassiliou
    Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    J Neurol Neurosurg Psychiatry 77:1262-6. 2006
    ....
  4. pmc Screening for coeliac disease: But where does it take us?
    David S Sanders
    BMJ 336:9. 2008
  5. ncbi request reprint Clinical, radiological, neurophysiological, and neuropathological characteristics of gluten ataxia
    M Hadjivassiliou
    Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK
    Lancet 352:1582-5. 1998
    ..The sole manifestation of disease in such patients may be ataxia. We describe the clinical, radiological, and neurophysiological features of this disorder...
  6. pmc Can head trauma trigger celiac disease? Nation-wide case-control study
    Jonas F Ludvigsson
    Department of Pediatrics, Orebro University Hospital, Orebro, Sweden
    BMC Neurol 13:105. 2013
    ..We hypothesized that earlier brain injury due to head trauma may be more common in patients with CD, potentially through trauma-induced TG6 leading to interaction with TG2...
  7. doi request reprint Transglutaminase 6 antibodies in the diagnosis of gluten ataxia
    Marios Hadjivassiliou
    Departments of Neurology, Royal Hallamshire Hospital, Sheffield, UK
    Neurology 80:1740-5. 2013
    ..The previous finding of an immunologic response primarily directed against transglutaminase (TG)6 in patients with gluten ataxia (GA) led us to investigate the role of TG6 antibodies in diagnosing GA...
  8. doi request reprint MR spectroscopy and atrophy in Gluten, Friedreich's and SCA6 ataxias
    M Hadjivassiliou
    Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK
    Acta Neurol Scand 126:138-43. 2012
    ..Previous work using proton MR spectroscopy ((1)H-MRS) of the cerebellum in the ataxias suggested that (1)H-MRS abnormalities and atrophy do not necessarily occur concurrently...
  9. pmc Spectrum of gluten-related disorders: consensus on new nomenclature and classification
    Anna Sapone
    Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    BMC Med 10:13. 2012
    ....
  10. ncbi request reprint Dietary treatment of gluten neuropathy
    Marios Hadjivassiliou
    Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    Muscle Nerve 34:762-6. 2006
    ..Gluten-free diet may thus be a useful therapeutic intervention for patients with gluten neuropathy...
  11. ncbi request reprint Myopathy associated with gluten sensitivity
    Marios Hadjivassiliou
    Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    Muscle Nerve 35:443-50. 2007
    ..Myopathy may be another manifestation of gluten sensitivity and is likely to have an immune-mediated pathogenesis. A gluten-free diet may be a useful therapeutic intervention...
  12. ncbi request reprint Gluten sensitivity: from gut to brain
    Marios Hadjivassiliou
    Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK
    Lancet Neurol 9:318-30. 2010
    ....
  13. ncbi request reprint Cerebellar ataxia as a possible organ-specific autoimmune disease
    Marios Hadjivassiliou
    Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield, UK
    Mov Disord 23:1370-7. 2008
    ....
  14. doi request reprint Gluten ataxia
    Marios Hadjivassiliou
    Department of Neurology, The Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK
    Cerebellum 7:494-8. 2008
    ..IgA deposits against TG2 in the small bowel and at extraintestinal sites are proving to be additional reliable and perhaps more specific markers of the whole spectrum of gluten sensitivity. They may also hold the key to its pathogenesis...
  15. doi request reprint PET scan in clinically suspected paraneoplastic neurological syndromes: a 6-year prospective study in a regional neuroscience unit
    M Hadjivassiliou
    Department of Neurology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals, NHS Trust, Sheffield, UK
    Acta Neurol Scand 119:186-93. 2009
    ..The role of PET in the diagnosis of paraneoplastic neurological syndromes (PNS) has previously been reported in retrospective studies, from specialized neuro-oncology units, often selecting patients with positive paraneoplastic antibodies...
  16. doi request reprint GAD antibody-associated neurological illness and its relationship to gluten sensitivity
    M Hadjivassiliou
    Department of Neurology, The Royal Hallamshire Hospital, Sheffield, UK
    Acta Neurol Scand 123:175-80. 2011
    ..The high prevalence of gluten sensitivity in patients with stiff-person syndrome (SPS) lead us to investigate the relationship between gluten sensitivity and GAD-antibody-associated diseases...
  17. doi request reprint Sensory ganglionopathy due to gluten sensitivity
    M Hadjivassiliou
    Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK
    Neurology 75:1003-8. 2010
    ..The commonest type of neuropathy seen in the context of gluten sensitivity is sensorimotor axonal. We report 17 patients with sensory ganglionopathy associated with gluten sensitivity...
  18. doi request reprint Immune-mediated acquired ataxias
    Marios Hadjivassiliou
    Department of Neurology, The Royal Hallamshire Hospital, Sheffield, UK
    Handb Clin Neurol 103:189-99. 2012
    ..The pathophysiology leading to cerebellar damage, loss of Purkinje cells, and the development of ataxia remains speculative, but existing clues are discussed in detail...
  19. ncbi request reprint Autoantibody targeting of brain and intestinal transglutaminase in gluten ataxia
    M Hadjivassiliou
    Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK
    Neurology 66:373-7. 2006
    ....
  20. pmc Gluten sensitivity masquerading as systemic lupus erythematosus
    M Hadjivassiliou
    Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    Ann Rheum Dis 63:1501-3. 2004
    ..The correct diagnosis of gluten sensitivity was made after years of treatment with steroids and other immunosuppressive drugs...
  21. ncbi request reprint The immunology of gluten sensitivity: beyond the gut
    Marios Hadjivassiliou
    Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield, UK, S10 2JF
    Trends Immunol 25:578-82. 2004
  22. ncbi request reprint Gluten ataxia in perspective: epidemiology, genetic susceptibility and clinical characteristics
    Marios Hadjivassiliou
    Department of Neurology, The Royal Hallamshire Hospital, Sheffield, UK
    Brain 126:685-91. 2003
    ..HLA DQ2 was present in 72% of patients. Gluten ataxia is therefore the single most common cause of sporadic idiopathic ataxia. Antigliadin antibody testing is essential at first presentation of patients with sporadic ataxia...
  23. pmc Dietary treatment of gluten ataxia
    M Hadjivassiliou
    Department of Clinical Neurology, The Royal Hallamshire Hospital, Sheffield, UK
    J Neurol Neurosurg Psychiatry 74:1221-4. 2003
    ..No systematic study of the effect of gluten-free diet on gluten ataxia has ever been undertaken...
  24. ncbi request reprint Headache and CNS white matter abnormalities associated with gluten sensitivity
    M Hadjivassiliou
    Department of Clinical Neurology, The Royal Hallamshire Hospital, Sheffield, UK
    Neurology 56:385-8. 2001
    ..MRI abnormalities varied from confluent areas of high signal throughout the white matter to foci of high signal scattered in both hemispheres. Symptomatic response to gluten-free diet was seen in nine patients...
  25. doi request reprint Autoantibodies in gluten ataxia recognize a novel neuronal transglutaminase
    Marios Hadjivassiliou
    Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK
    Ann Neurol 64:332-43. 2008
    ..We have identified a novel neuronal transglutaminase isozyme and investigated whether this enzyme is the target of the immune response in patients with neurological dysfunction...
  26. ncbi request reprint A UK study assessing the population prevalence of self-reported gluten sensitivity and referral characteristics to secondary care
    Imran Aziz
    Departments of aGastroenterology bNeurology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals, Sheffield, UK
    Eur J Gastroenterol Hepatol 26:33-9. 2014
    ..Reports suggest that gluten sensitivity (GS) exists in the absence of coeliac disease (CD). This clinical entity has been termed noncoeliac gluten sensitivity (NCGS)...
  27. doi request reprint What is the role of serologic testing in celiac disease? A prospective, biopsy-confirmed study with economic analysis
    Andrew D Hopper
    Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield, United Kingdom
    Clin Gastroenterol Hepatol 6:314-20. 2008
    ..We also assessed whether tissue transglutaminase (tTG) antibody is a quantitative marker for histologic severity...
  28. pmc Pre-endoscopy serological testing for coeliac disease: evaluation of a clinical decision tool
    Andrew D Hopper
    Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield
    BMJ 334:729. 2007
    ..To determine an effective diagnostic method of detecting all cases of coeliac disease in patients referred for gastroscopy without performing routine duodenal biopsy...
  29. ncbi request reprint Making the diagnosis of coeliac disease: is there a role for push enteroscopy?
    Barbara S Höroldt
    Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield, UK
    Eur J Gastroenterol Hepatol 16:1143-6. 2004
    ..Push enteroscopy is used in the assessment of refractory coeliac disease. However, its value in making the diagnosis of coeliac disease is still not defined...
  30. doi request reprint Magnetic resonance imaging biomarkers in patients with progressive ataxia: current status and future direction
    Stuart Currie
    Academic Unit of Radiology, Floor C, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK
    Cerebellum 12:245-66. 2013
    ..Finally, discussion will turn to the feasibility of applying these biomarkers in routine clinical practice...
  31. ncbi request reprint A primary care cross-sectional study of undiagnosed adult coeliac disease
    David S Sanders
    Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, UK
    Eur J Gastroenterol Hepatol 15:407-13. 2003
    ..To establish the prevalence of coeliac disease in the general population and in specific conditions, such as irritable bowel syndrome, iron deficiency anaemia, fatigue and other coeliac-related conditions...
  32. pmc Antibody negative coeliac disease presenting in elderly people--an easily missed diagnosis
    David S Sanders
    Royal Hallamshire Hospital, Sheffield S10 2JF
    BMJ 330:775-6. 2005
  33. doi request reprint Magnetic resonance spectroscopy of the brain
    Stuart Currie
    Academic Unit of Radiology, University of Sheffield, Floor C, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    Postgrad Med J 89:94-106. 2013
    ..In this review we discuss the issues regarding MR spectroscopy in the brain with particular attention paid to its technique. Key examples of current clinical applications are provided and future directions are discussed...
  34. doi request reprint Should we be 'nervous' about coeliac disease? Brain abnormalities in patients with coeliac disease referred for neurological opinion
    Stuart Currie
    Academic Unit of Radiology, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    J Neurol Neurosurg Psychiatry 83:1216-21. 2012
    ....
  35. pmc High prevalence of microvascular complications in adults with type 1 diabetes and newly diagnosed celiac disease
    John S Leeds
    Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, UK
    Diabetes Care 34:2158-63. 2011
    ..We identified CD in adults with type 1 diabetes and investigated the effect of a GFD on diabetes-related complications...
  36. pmc Adult coeliac disease
    Andrew D Hopper
    Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield S10 2JF
    BMJ 335:558-62. 2007
  37. ncbi request reprint Are lower gastrointestinal investigations necessary in patients with coeliac disease?
    Andrew D Hopper
    Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield, UK
    Eur J Gastroenterol Hepatol 17:617-21. 2005
    ..However, there are limited data to support this approach...
  38. doi request reprint Gluten-related neurologic dysfunction
    Marios Hadjivassiliou
    Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK Electronic address
    Handb Clin Neurol 120:607-19. 2014
    ..In this chapter we review the spectrum of neurologic manifestations in GRD, discuss recent advances in their diagnosis, and look at their possible pathophysiologic mechanisms. ..
  39. doi request reprint Magnetic resonance spectroscopy of the normal cerebellum: what degree of variability can be expected?
    Stuart Currie
    Academic Unit of Radiology, University of Sheffield, Floor C, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK
    Cerebellum 12:205-11. 2013
    ..The regional variations of Cho/Cr and NAA/Cho within the hemisphere and vermis should be considered when performing studies of diseases, which may preferentially target a particular cerebellar location...
  40. doi request reprint Understanding MRI: basic MR physics for physicians
    Stuart Currie
    Academic Unit of Radiology, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Postgrad Med J 89:209-23. 2013
    ..Examples provided are primarily referenced to neuroradiology reflecting the subspecialty for which MR currently has the greatest clinical application...
  41. doi request reprint A novel MPZ gene mutation in exon 2 causing late-onset demyelinating Charcot-Marie-Tooth disease
    Govindsinh Chavada
    Department of Neurology, Royal Hallamshire Hospital, Sheffield, United Kingdom
    J Clin Neuromuscul Dis 13:206-8. 2012
    ..We subsequently identified another affected member of the same family with the same genotype leading to the correct diagnosis. Both the affected individuals had an 8-base pair deletion, c.160_167delTCCCGGGT in MPZ exon 2...
  42. pmc A novel amyloidogenic transthyretin variant, Gly53Ala, associated with intermittent headaches and ataxia
    C Douglass
    Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    J Neurol Neurosurg Psychiatry 78:193-5. 2007
    ..Serum amyloid P component scintigraphy did not show visceral amyloid in extra-cardiac sites, but magnetic resonance imaging indicated diffuse leptomeningeal amyloidosis...
  43. ncbi request reprint Coeliac disease: noncoeliac gluten sensitivity--food for thought
    Imran Aziz
    Department of Gastroenterology, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    Nat Rev Gastroenterol Hepatol 11:398-9. 2014
    ..NCGS-associated depression might share similar pathophysiological mechanisms to other neurological manifestations observed in gluten-related disorders, such as ataxia and encephalopathy...
  44. doi request reprint Coeliac disease, epilepsy, and cerebral calcifications: association with TG6 autoantibodies
    Alexandra M Johnson
    Department of Neurology, Sydney Children s Hospital, Sydney, NSW, Australia
    Dev Med Child Neurol 55:90-3. 2013
    ..The positive response to the diet, TG6 antibodies, and neuronal antibody binding suggest that CEC might be autoimmune in nature, as in other extra-intestinal manifestations of gluten-related diseases, such as gluten ataxia...
  45. pmc Changing face of adult coeliac disease: experience of a single university hospital in South Yorkshire
    D S Sanders
    Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, UK
    Postgrad Med J 78:31-3. 2002
    ..To determine the incidence and presenting features of adult coeliac disease in a single university hospital in South Yorkshire...
  46. ncbi request reprint Choreic syndrome and coeliac disease: a hitherto unrecognised association
    Anthony C Pereira
    Sobell Dept of Motor Neuroscience and Movement Disorders, Institute of Neurology, United Kingdom
    Mov Disord 19:478-82. 2004
    ..Unexpectedly, most of these patients showed a notable improvement in their motor symptoms after the introduction of a gluten-free diet...
  47. ncbi request reprint Gluten ataxia: passive transfer in a mouse model
    Sabrina Boscolo
    BRAIN Centre for Neuroscience, Department of Biology, University of Trieste, Via Giorgieri 10, 34127 Trieste, Italy
    Ann N Y Acad Sci 1107:319-28. 2007
    ..The aim of the present article is to review the knowledge on animal models of gluten sensitivity, as well as reviewing the role of anti-neural antibodies in GA...
  48. ncbi request reprint Multiple sclerosis and occult gluten sensitivity
    Marios Hadjivassiliou
    Neurology 64:933-4; author reply 933-4. 2005
  49. ncbi request reprint Detection of anti-brain serum antibodies using a semi-quantitative immunohistological method
    Sabrina Boscolo
    BRAIN Centre for Neuroscience, Department of Biology, University of Trieste, Via L Giorgieri, 10, 34127 Trieste, Italy
    J Immunol Methods 309:139-49. 2006
    ..In conclusion, this standardised semi-quantitative procedure makes immunohistochemistry a reliable diagnostic test for autoimmune neuropathologies and represents an excellent exclusion test for anti-neural autoimmunity...