Research Topics
Species | Marios HadjivassiliouSummaryAffiliation: University of Sheffield Country: UK Publications
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Detail Information
Publications
The humoral response in the pathogenesis of gluten ataxiaM Hadjivassiliou
Department of Clinical Neurology, The Royal Hallamshire Hospital, Sheffield, UK
Neurology 58:1221-6. 2002..To characterize humoral response to cerebellum in patients with gluten ataxia...
Neuropathy associated with gluten sensitivityM Hadjivassiliou
Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
J Neurol Neurosurg Psychiatry 77:1262-6. 2006....- A case of celiac disease mimicking amyotrophic lateral sclerosisMartin R Turner
Department of Neurology, John Radcliffe Hospital, Oxford, UK
Nat Clin Pract Neurol 3:581-4. 2007..The thigh muscle in the affected leg showed signs of wasting. The patient had a remote family history of celiac disease... - Screening for coeliac disease: But where does it take us?David S Sanders
BMJ 336:9. 2008 
MR spectroscopy and atrophy in Gluten, Friedreich's and SCA6 ataxiasM Hadjivassiliou
Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK
Acta Neurol Scand 126:138-43. 2012..Previous work using proton MR spectroscopy ((1)H-MRS) of the cerebellum in the ataxias suggested that (1)H-MRS abnormalities and atrophy do not necessarily occur concurrently...- Spectrum of gluten-related disorders: consensus on new nomenclature and classificationAnna Sapone
Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
BMC Med 10:13. 2012.... - GAD antibody-associated neurological illness and its relationship to gluten sensitivityM Hadjivassiliou
Department of Neurology, The Royal Hallamshire Hospital, Sheffield, UK
Acta Neurol Scand 123:175-80. 2011..The high prevalence of gluten sensitivity in patients with stiff-person syndrome (SPS) lead us to investigate the relationship between gluten sensitivity and GAD-antibody-associated diseases... - Sensory ganglionopathy due to gluten sensitivityM Hadjivassiliou
Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK
Neurology 75:1003-8. 2010..The commonest type of neuropathy seen in the context of gluten sensitivity is sensorimotor axonal. We report 17 patients with sensory ganglionopathy associated with gluten sensitivity... - Autoantibody targeting of brain and intestinal transglutaminase in gluten ataxiaM Hadjivassiliou
Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK
Neurology 66:373-7. 2006.... - Gluten ataxiaMarios Hadjivassiliou
Department of Neurology, The Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK
Cerebellum 7:494-8. 2008..IgA deposits against TG2 in the small bowel and at extraintestinal sites are proving to be additional reliable and perhaps more specific markers of the whole spectrum of gluten sensitivity. They may also hold the key to its pathogenesis... - Dietary treatment of gluten neuropathyMarios Hadjivassiliou
Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
Muscle Nerve 34:762-6. 2006..Gluten-free diet may thus be a useful therapeutic intervention for patients with gluten neuropathy... - Myopathy associated with gluten sensitivityMarios Hadjivassiliou
Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
Muscle Nerve 35:443-50. 2007..Myopathy may be another manifestation of gluten sensitivity and is likely to have an immune-mediated pathogenesis. A gluten-free diet may be a useful therapeutic intervention... - Clinical, radiological, neurophysiological, and neuropathological characteristics of gluten ataxiaM Hadjivassiliou
Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK
Lancet 352:1582-5. 1998..The sole manifestation of disease in such patients may be ataxia. We describe the clinical, radiological, and neurophysiological features of this disorder... - Gluten sensitivity: from gut to brainMarios Hadjivassiliou
Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK
Lancet Neurol 9:318-30. 2010.... - The immunology of gluten sensitivity: beyond the gutMarios Hadjivassiliou
Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield, UK, S10 2JF
Trends Immunol 25:578-82. 2004 - Headache and CNS white matter abnormalities associated with gluten sensitivityM Hadjivassiliou
Department of Clinical Neurology, The Royal Hallamshire Hospital, Sheffield, UK
Neurology 56:385-8. 2001..MRI abnormalities varied from confluent areas of high signal throughout the white matter to foci of high signal scattered in both hemispheres. Symptomatic response to gluten-free diet was seen in nine patients... - PET scan in clinically suspected paraneoplastic neurological syndromes: a 6-year prospective study in a regional neuroscience unitM Hadjivassiliou
Department of Neurology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals, NHS Trust, Sheffield, UK
Acta Neurol Scand 119:186-93. 2009..The role of PET in the diagnosis of paraneoplastic neurological syndromes (PNS) has previously been reported in retrospective studies, from specialized neuro-oncology units, often selecting patients with positive paraneoplastic antibodies... - Gluten ataxia in perspective: epidemiology, genetic susceptibility and clinical characteristicsMarios Hadjivassiliou
Department of Neurology, The Royal Hallamshire Hospital, Sheffield, UK
Brain 126:685-91. 2003..HLA DQ2 was present in 72% of patients. Gluten ataxia is therefore the single most common cause of sporadic idiopathic ataxia. Antigliadin antibody testing is essential at first presentation of patients with sporadic ataxia... - Cerebellar ataxia as a possible organ-specific autoimmune diseaseMarios Hadjivassiliou
Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield, UK
Mov Disord 23:1370-7. 2008.... - Dietary treatment of gluten ataxiaM Hadjivassiliou
Department of Clinical Neurology, The Royal Hallamshire Hospital, Sheffield, UK
J Neurol Neurosurg Psychiatry 74:1221-4. 2003..No systematic study of the effect of gluten-free diet on gluten ataxia has ever been undertaken... - Gluten sensitivity masquerading as systemic lupus erythematosusM Hadjivassiliou
Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
Ann Rheum Dis 63:1501-3. 2004..Knowledge of the diverse manifestations of gluten sensitivity is essential in avoiding such misdiagnosis... - Immune-mediated acquired ataxiasMarios Hadjivassiliou
Department of Neurology, The Royal Hallamshire Hospital, Sheffield, UK
Handb Clin Neurol 103:189-99. 2012..The pathophysiology leading to cerebellar damage, loss of Purkinje cells, and the development of ataxia remains speculative, but existing clues are discussed in detail... - What is the role of serologic testing in celiac disease? A prospective, biopsy-confirmed study with economic analysisAndrew D Hopper
Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield, United Kingdom
Clin Gastroenterol Hepatol 6:314-20. 2008..We also assessed whether tissue transglutaminase (tTG) antibody is a quantitative marker for histologic severity... - Autoantibodies in gluten ataxia recognize a novel neuronal transglutaminaseMarios Hadjivassiliou
Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK
Ann Neurol 64:332-43. 2008..We have identified a novel neuronal transglutaminase isozyme and investigated whether this enzyme is the target of the immune response in patients with neurological dysfunction... - Pre-endoscopy serological testing for coeliac disease: evaluation of a clinical decision toolAndrew D Hopper
Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield
BMJ 334:729. 2007..To determine an effective diagnostic method of detecting all cases of coeliac disease in patients referred for gastroscopy without performing routine duodenal biopsy... - Making the diagnosis of coeliac disease: is there a role for push enteroscopy?Barbara S Höroldt
Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield, UK
Eur J Gastroenterol Hepatol 16:1143-6. 2004..Push enteroscopy is used in the assessment of refractory coeliac disease. However, its value in making the diagnosis of coeliac disease is still not defined... - Antibody negative coeliac disease presenting in elderly people--an easily missed diagnosisDavid S Sanders
Royal Hallamshire Hospital, Sheffield S10 2JF
BMJ 330:775-6. 2005 - A primary care cross-sectional study of undiagnosed adult coeliac diseaseDavid S Sanders
Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, UK
Eur J Gastroenterol Hepatol 15:407-13. 2003..To establish the prevalence of coeliac disease in the general population and in specific conditions, such as irritable bowel syndrome, iron deficiency anaemia, fatigue and other coeliac-related conditions... - Should we be 'nervous' about coeliac disease? Brain abnormalities in patients with coeliac disease referred for neurological opinionStuart Currie
Academic Unit of Radiology, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
J Neurol Neurosurg Psychiatry 83:1216-21. 2012.... - Magnetic resonance imaging biomarkers in patients with progressive ataxia: current status and future directionStuart Currie
Academic Unit of Radiology, Floor C, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK
Cerebellum 12:245-66. 2013..Finally, discussion will turn to the feasibility of applying these biomarkers in routine clinical practice... - High prevalence of microvascular complications in adults with type 1 diabetes and newly diagnosed celiac diseaseJohn S Leeds
Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, UK
Diabetes Care 34:2158-63. 2011..We identified CD in adults with type 1 diabetes and investigated the effect of a GFD on diabetes-related complications... - Adult coeliac diseaseAndrew D Hopper
Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield S10 2JF
BMJ 335:558-62. 2007 - Are lower gastrointestinal investigations necessary in patients with coeliac disease?Andrew D Hopper
Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield, UK
Eur J Gastroenterol Hepatol 17:617-21. 2005..However, there are limited data to support this approach... - Transglutaminase 6 antibodies in the diagnosis of gluten ataxiaMarios Hadjivassiliou
From the Departments of Neurology M H, R A G, O B and Gastroenterology D S S, Royal Hallamshire Hospital, Sheffield Matrix Biology and Tissue Repair Research Unit P A, D P A, School of Dentistry, Cardiff University, Cardiff, UK Department of Paediatrics M M, K K, School of Medicine, University of Tampere, Finland and Department of Biological Sciences N W, G H, Sheffield Hallam University, Sheffield, UK
Neurology 80:1740-5. 2013..The previous finding of an immunologic response primarily directed against transglutaminase (TG)6 in patients with gluten ataxia (GA) led us to investigate the role of TG6 antibodies in diagnosing GA... - Understanding MRI: basic MR physics for physiciansStuart Currie
Academic Unit of Radiology, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
Postgrad Med J 89:209-23. 2013..Examples provided are primarily referenced to neuroradiology reflecting the subspecialty for which MR currently has the greatest clinical application... - Magnetic resonance spectroscopy of the brainStuart Currie
Academic Unit of Radiology, University of Sheffield, Floor C, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
Postgrad Med J 89:94-106. 2013..In this review we discuss the issues regarding MR spectroscopy in the brain with particular attention paid to its technique. Key examples of current clinical applications are provided and future directions are discussed... - Magnetic resonance spectroscopy of the normal cerebellum: what degree of variability can be expected?Stuart Currie
Academic Unit of Radiology, University of Sheffield, Floor C, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK
Cerebellum 12:205-11. 2013..The regional variations of Cho/Cr and NAA/Cho within the hemisphere and vermis should be considered when performing studies of diseases, which may preferentially target a particular cerebellar location... - A novel MPZ gene mutation in exon 2 causing late-onset demyelinating Charcot-Marie-Tooth diseaseGovindsinh Chavada
Department of Neurology, Royal Hallamshire Hospital, Sheffield, United Kingdom
J Clin Neuromuscul Dis 13:206-8. 2012..We subsequently identified another affected member of the same family with the same genotype leading to the correct diagnosis. Both the affected individuals had an 8-base pair deletion, c.160_167delTCCCGGGT in MPZ exon 2... - A novel amyloidogenic transthyretin variant, Gly53Ala, associated with intermittent headaches and ataxiaC Douglass
Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
J Neurol Neurosurg Psychiatry 78:193-5. 2007..Serum amyloid P component scintigraphy did not show visceral amyloid in extra-cardiac sites, but magnetic resonance imaging indicated diffuse leptomeningeal amyloidosis... - Coeliac disease, epilepsy, and cerebral calcifications: association with TG6 autoantibodiesAlexandra M Johnson
Department of Neurology, Sydney Children s Hospital, Sydney, NSW, Australia
Dev Med Child Neurol 55:90-3. 2013..The positive response to the diet, TG6 antibodies, and neuronal antibody binding suggest that CEC might be autoimmune in nature, as in other extra-intestinal manifestations of gluten-related diseases, such as gluten ataxia... - Changing face of adult coeliac disease: experience of a single university hospital in South YorkshireD S Sanders
Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, UK
Postgrad Med J 78:31-3. 2002..To determine the incidence and presenting features of adult coeliac disease in a single university hospital in South Yorkshire... - Choreic syndrome and coeliac disease: a hitherto unrecognised associationAnthony C Pereira
Sobell Dept of Motor Neuroscience and Movement Disorders, Institute of Neurology, United Kingdom
Mov Disord 19:478-82. 2004..Unexpectedly, most of these patients showed a notable improvement in their motor symptoms after the introduction of a gluten-free diet... - Multiple sclerosis and occult gluten sensitivityMarios Hadjivassiliou
Neurology 64:933-4; author reply 933-4. 2005 - Detection of anti-brain serum antibodies using a semi-quantitative immunohistological methodSabrina Boscolo
BRAIN Centre for Neuroscience, Department of Biology, University of Trieste, Via L. Giorgieri, 10, 34127 Trieste, Italy
J Immunol Methods 309:139-49. 2006..In conclusion, this standardised semi-quantitative procedure makes immunohistochemistry a reliable diagnostic test for autoimmune neuropathologies and represents an excellent exclusion test for anti-neural autoimmunity... - Gluten ataxia: passive transfer in a mouse modelSabrina Boscolo
BRAIN Centre for Neuroscience, Department of Biology, University of Trieste, Via Giorgieri 10, 34127 Trieste, Italy
Ann N Y Acad Sci 1107:319-28. 2007..The aim of the present article is to review the knowledge on animal models of gluten sensitivity, as well as reviewing the role of anti-neural antibodies in GA...