A Hadfield

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi Structure of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli, a key enzyme in the aspartate family of amino acid biosynthesis
    A Hadfield
    Department of Biochemistry Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA, 02254 9110, USA
    J Mol Biol 289:991-1002. 1999
  2. ncbi Active site analysis of the potential antimicrobial target aspartate semialdehyde dehydrogenase
    A Hadfield
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, England
    Biochemistry 40:14475-83. 2001
  3. ncbi Critical determinants of host receptor targeting by Neisseria meningitidis and Neisseria gonorrhoeae: identification of Opa adhesiotopes on the N-domain of CD66 molecules
    M Virji
    Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Mol Microbiol 34:538-51. 1999
  4. ncbi Carcinoembryonic antigens are targeted by diverse strains of typable and non-typable Haemophilus influenzae
    M Virji
    Department of Pathology and Microbiology, and Biochemistry, University of Bristol, Bristol BS8 1TD, UK
    Mol Microbiol 36:784-95. 2000

Detail Information

Publications4

  1. ncbi Structure of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli, a key enzyme in the aspartate family of amino acid biosynthesis
    A Hadfield
    Department of Biochemistry Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA, 02254 9110, USA
    J Mol Biol 289:991-1002. 1999
    ..A histidine residue is identified as a likely acid/base catalyst in the enzymic reaction. Other amino acids implicated in the enzymic activity by mutagenesis are found in the active site region and define the substrate binding pocket...
  2. ncbi Active site analysis of the potential antimicrobial target aspartate semialdehyde dehydrogenase
    A Hadfield
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, England
    Biochemistry 40:14475-83. 2001
    ..These results provide a structural explanation for the preferred order of substrate binding that is observed kinetically...
  3. ncbi Critical determinants of host receptor targeting by Neisseria meningitidis and Neisseria gonorrhoeae: identification of Opa adhesiotopes on the N-domain of CD66 molecules
    M Virji
    Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Mol Microbiol 34:538-51. 1999
    ..These studies define the molecular basis that directs the Opa specificity for the CD66 family and the rationale for tropism of the Opa proteins for the CD66 subgroups...
  4. ncbi Carcinoembryonic antigens are targeted by diverse strains of typable and non-typable Haemophilus influenzae
    M Virji
    Department of Pathology and Microbiology, and Biochemistry, University of Bristol, Bristol BS8 1TD, UK
    Mol Microbiol 36:784-95. 2000
    ....