Penelope R Haddrill

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. doi request reprint Determinants of synonymous and nonsynonymous variability in three species of Drosophila
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Mol Biol Evol 28:1731-43. 2011
  2. pmc Estimating the parameters of selection on nonsynonymous mutations in Drosophila pseudoobscura and D. miranda
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 185:1381-96. 2010
  3. pmc Elevated levels of expression associated with regions of the Drosophila genome that lack crossing over
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King s Buildings, Edinburgh EH9 3JT, UK
    Biol Lett 4:758-61. 2008
  4. doi request reprint Female multiple mating in wild and laboratory populations of the two-spot ladybird, Adalia bipunctata
    Penelope R Haddrill
    Department of Genetics, University of Cambridge, Downing Street, Cambridge, UK
    Mol Ecol 17:3189-97. 2008
  5. pmc Positive and negative selection on noncoding DNA in Drosophila simulans
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Mol Biol Evol 25:1825-34. 2008
  6. pmc Non-neutral processes drive the nucleotide composition of non-coding sequences in Drosophila
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King s Buildings, Edinburgh, UK
    Biol Lett 4:438-41. 2008
  7. pmc Reduced efficacy of selection in regions of the Drosophila genome that lack crossing over
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK
    Genome Biol 8:R18. 2007
  8. pmc Patterns of intron sequence evolution in Drosophila are dependent upon length and GC content
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Genome Biol 6:R67. 2005
  9. pmc Codon usage bias and effective population sizes on the X chromosome versus the autosomes in Drosophila melanogaster
    José L Campos
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Mol Biol Evol 30:811-23. 2013
  10. doi request reprint A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila
    Beatriz Vicoso
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Genet Res (Camb) 90:421-31. 2008

Detail Information

Publications16

  1. doi request reprint Determinants of synonymous and nonsynonymous variability in three species of Drosophila
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Mol Biol Evol 28:1731-43. 2011
    ..Our correlational analysis of this data set suggested that both selective constraints on protein sequences and recurrent selective sweeps affect the overall level of codon usage...
  2. pmc Estimating the parameters of selection on nonsynonymous mutations in Drosophila pseudoobscura and D. miranda
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 185:1381-96. 2010
    ..Overall, the results show that both purifying selection and positive selection on nonsynonymous mutations are pervasive...
  3. pmc Elevated levels of expression associated with regions of the Drosophila genome that lack crossing over
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King s Buildings, Edinburgh EH9 3JT, UK
    Biol Lett 4:758-61. 2008
    ..Alternatively, higher gene expression may be evolving to compensate for defective protein products or reduced translational efficiency...
  4. doi request reprint Female multiple mating in wild and laboratory populations of the two-spot ladybird, Adalia bipunctata
    Penelope R Haddrill
    Department of Genetics, University of Cambridge, Downing Street, Cambridge, UK
    Mol Ecol 17:3189-97. 2008
    ..Our results emphasize the importance of combining field and laboratory data to explore mating rates in the wild...
  5. pmc Positive and negative selection on noncoding DNA in Drosophila simulans
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Mol Biol Evol 25:1825-34. 2008
    ..simulans lineage difficult to reconcile with demographic explanations...
  6. pmc Non-neutral processes drive the nucleotide composition of non-coding sequences in Drosophila
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King s Buildings, Edinburgh, UK
    Biol Lett 4:438-41. 2008
    ..The proportion of GC-->AT versus AT-->GC polymorphic mutations in a locus is correlated with its GC content. This implies the action of forces that favour GC over AT base pairs, which are apparently strongest in GC-rich sequences...
  7. pmc Reduced efficacy of selection in regions of the Drosophila genome that lack crossing over
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK
    Genome Biol 8:R18. 2007
    ..In freely recombining regions of the genome, selection should more effectively incorporate new beneficial mutations, and eliminate deleterious ones, than in regions with low rates of genetic recombination...
  8. pmc Patterns of intron sequence evolution in Drosophila are dependent upon length and GC content
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Genome Biol 6:R67. 2005
    ..No consistent patterns have emerged from studies that have investigated general levels of evolutionary constraint in introns...
  9. pmc Codon usage bias and effective population sizes on the X chromosome versus the autosomes in Drosophila melanogaster
    José L Campos
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Mol Biol Evol 30:811-23. 2013
    ....
  10. doi request reprint A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila
    Beatriz Vicoso
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Genet Res (Camb) 90:421-31. 2008
    ..They also suggest that genes that have become X-linked have higher levels of codon bias and slower synonymous site evolution, consistent with more effective selection on codon usage at X-linked sites...
  11. pmc The age and evolution of an antiviral resistance mutation in Drosophila melanogaster
    Jenny Bangham
    School of Biological Sciences, Institute of Evolutionary Biology, The University of Edinburgh, Ashworth Laboratories, The King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Proc Biol Sci 274:2027-34. 2007
    ..We find that the ref(2)P resistance mutation is considerably older than the recent spread of this viral strain and suggest that--possibly because it is recessive--the initial spread of the resistance mutation was very slow...
  12. doi request reprint Ancestral polymorphisms in Drosophila pseudoobscura and Drosophila miranda
    Reuben W Nowell
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Genet Res (Camb) 93:255-63. 2011
    ....
  13. pmc Multilocus patterns of nucleotide variability and the demographic and selection history of Drosophila melanogaster populations
    Penelope R Haddrill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, United Kingdom
    Genome Res 15:790-9. 2005
    ..Demographic departures from equilibrium expectations in both ancestral and derived populations thus represent a serious challenge to detecting positive selection in genome-wide scans using current methodologies...
  14. pmc Molecular evolution in nonrecombining regions of the Drosophila melanogaster genome
    José L Campos
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, United Kingdom
    Genome Biol Evol 4:278-88. 2012
    ..However, signatures of selection on both nonsynonymous mutations and on codon usage persist in all heterochromatic regions...
  15. pmc Genetic diversity, population structure and Wolbachia infection status in a worldwide sample of Drosophila melanogaster and D. simulans populations
    Rudi L Verspoor
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e26318. 2011
    ..Populations from Sub-Saharan Africa also differ in the prevalence of Wolbachia infection, with very low levels of infection compared to populations from the rest of the world...
  16. pmc Estimation of the Spontaneous Mutation Rate per Nucleotide Site in a Drosophila melanogaster Full-Sib Family
    Peter D Keightley
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 196:313-20. 2014
    ..We also detected three short deletion mutations and no insertions, giving a deletion mutation rate of 1.2 × 10(-9) (95% confidence interval = 0.7 × 10(-9) - 11 × 10(-9)). ..