Allan Hackshaw

..CONCLUSIONS ; Birth defects that are positively associated with maternal smoking should now be included in public health educational materials to encourage more women to quit before or during pregnancy...

..Screening programmes for women aged >/=50 years should be part of organised public health programmes. The adverse effects of screening were addressed and performance indicators of programmes were specified...

..The main side effects - hot flashes and reduction in bone density - often recede once treatment stops. Ongoing research will provide information about LHRH agonists when used with modern chemotherapy regimens and aromatase inhibitors...

..Systematic reviews have found that luteinizing hormone-releasing hormone (LHRH) agonists are effective in treating premenopausal women with early breast cancer...

..The Cancer Research UK "Over 50s" trial compared 5 and 2 years of tamoxifen in women with early breast cancer. Results are reported after median follow-up of 10 years...

..To evaluate the specific components of setting up a simple multicentre clinical study four years after the new UK law on clinical trials was implemented in 2004...

..Although many centers administer an activity of 100 mCi, there is uncertainty over using a lower activity...

..We evaluated thalidomide, an anti-angiogenic agent, when combined with chemotherapy and as maintenance treatment...

..We aimed to determine whether giving chemotherapy concurrently with radiotherapy or as maintenance therapy, or both, affected clinical outcome. Here we report survival and recurrence after 10 years of follow-up...

..We investigated whether erlotinib improves clinical outcome in these patients...

..Inhibiting angiogenesis is one of the most promising avenues for new therapies for ovarian cancer. We investigated the efficacy and safety of a novel agent, BIBF 1120, a triple angiokinase inhibitor, after chemotherapy for relapsed disease...

..The other markers, tumour response and progressive disease, were less good...

..Alternatively, if the cost could be reduced then all patients may be able to obtain the benefits. However, the evidence that prophylactic HGFs are clinically worthwhile is clear...

..We hypothesized that thalidomide, an oral antiangiogenic agent, when combined with chemotherapy, and as maintenance treatment, would improve survival in patients with advanced non-small-cell lung cancer (NSCLC)...

..81; 95% CI 0.67, 0.99; P = 0.038). Goserelin was well tolerated. These data show that the addition of goserelin to standard adjuvant therapy is more effective than standard therapy alone in pre-menopausal women with early breast cancer...

..The role of chemotherapy for neuroendocrine tumours remains controversial and there is no standard regimen...

..To investigate the association between urinary hormone levels and migraine, with particular reference to rising and falling levels of estrogen across the menstrual cycle in women with menstrual and menstrually related migraine...

..We report the clinical outcome for a series of ten patients with fibrolamellar hepatocellular treated with resection followed by close surveillance and aggressive management of relapse...

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..Despite the high response rates achieved following standard chemotherapy for small-cell lung cancer (SCLC), the majority of patients will subsequently die from disease progression...