F K Habib

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi The loss of 5alpha-reductase type I and type II mRNA expression in metastatic prostate cancer to bone and lymph node metastasis
    Fouad K Habib
    Prostate Research Group, University Department of Oncology, Western General Hospital, Edinburgh, Scotland EH4 2XU, United Kingdom
    Clin Cancer Res 9:1815-9. 2003
  2. ncbi Not all brands are created equal: a comparison of selected components of different brands of Serenoa repens extract
    F K Habib
    Prostate Research Group, University Department of Oncology, Western General Hospital, Edinburgh, UK
    Prostate Cancer Prostatic Dis 7:195-200. 2004
  3. ncbi Measurement of tissue mechanical characteristics to distinguish between benign and malignant prostatic disease
    S Phipps
    Prostate Research Group, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    Urology 66:447-50. 2005
  4. ncbi In-vitro dynamic micro-probing and the mechanical properties of human prostate tissues
    T H J Yang
    Heriot Watt University, School of Engineering and Physical Sciences, Edinburgh, UK
    Technol Health Care 14:281-96. 2006
  5. ncbi Micro-engineered remote palpation device for assessing tissue compliance
    M Hien
    Heriot Watt University, School of Engineering and Physical Sciences, Edinburgh, UK
    Stud Health Technol Inform 133:123-31. 2008
  6. ncbi Development of a new in vitro model for the study of benign prostatic hyperplasia
    F K Habib
    Prostate Research Group, University Department of Oncology, Western General Hospital, Edinburgh, Scotland, UK
    Prostate Suppl 9:15-20. 2000
  7. ncbi Factors controlling the expression of 5alpha-reductase in human prostate: A possible new approach for the treatment of prostate cancer
    F K Habib
    Prostate Research Group, Department of Oncology, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Eur Urol 35:439-42. 1999
  8. pmc Epidermal growth factor and transforming growth factor alpha concentrations in BPH and cancer of the prostate: their relationships with tissue androgen levels
    Y Yang
    University Department of Surgery WGH, Western General Hospital, Edinburgh, Scotland, UK
    Br J Cancer 67:152-5. 1993
  9. pmc Divergent responses to epidermal growth factor in hormone sensitive and insensitive human prostate cancer cell lines
    A MacDonald
    University Department of Surgery, Western General Hospital, Edinburgh, UK
    Br J Cancer 65:177-82. 1992
  10. pmc Production and response of a human prostatic cancer line to transforming growth factor-like molecules
    A MacDonald
    University Department of Surgery WGH, Western General Hospital, Edinburgh, UK
    Br J Cancer 62:579-84. 1990

Collaborators

Detail Information

Publications26

  1. ncbi The loss of 5alpha-reductase type I and type II mRNA expression in metastatic prostate cancer to bone and lymph node metastasis
    Fouad K Habib
    Prostate Research Group, University Department of Oncology, Western General Hospital, Edinburgh, Scotland EH4 2XU, United Kingdom
    Clin Cancer Res 9:1815-9. 2003
    ..The present report addresses this issue in the hope that this might help to identify the steps leading to the development of prostate cancer metastasis...
  2. ncbi Not all brands are created equal: a comparison of selected components of different brands of Serenoa repens extract
    F K Habib
    Prostate Research Group, University Department of Oncology, Western General Hospital, Edinburgh, UK
    Prostate Cancer Prostatic Dis 7:195-200. 2004
    ..Only extracts with demonstrated pharmacological activities and proven clinical efficacy should be considered for the treatment of patients with BPH...
  3. ncbi Measurement of tissue mechanical characteristics to distinguish between benign and malignant prostatic disease
    S Phipps
    Prostate Research Group, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    Urology 66:447-50. 2005
    ..To investigate the relationship between the morphology and mechanical properties of benign and malignant prostatic tissues measured in vitro...
  4. ncbi In-vitro dynamic micro-probing and the mechanical properties of human prostate tissues
    T H J Yang
    Heriot Watt University, School of Engineering and Physical Sciences, Edinburgh, UK
    Technol Health Care 14:281-96. 2006
    ..However, no significant difference was found between phase lags for epithelial and stromal tissues...
  5. ncbi Micro-engineered remote palpation device for assessing tissue compliance
    M Hien
    Heriot Watt University, School of Engineering and Physical Sciences, Edinburgh, UK
    Stud Health Technol Inform 133:123-31. 2008
    ..The purpose of the present work is to assess the functionality of the actuator assembly...
  6. ncbi Development of a new in vitro model for the study of benign prostatic hyperplasia
    F K Habib
    Prostate Research Group, University Department of Oncology, Western General Hospital, Edinburgh, Scotland, UK
    Prostate Suppl 9:15-20. 2000
    ..Unfortunately, in vitro and animal models have been of limited value...
  7. ncbi Factors controlling the expression of 5alpha-reductase in human prostate: A possible new approach for the treatment of prostate cancer
    F K Habib
    Prostate Research Group, Department of Oncology, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Eur Urol 35:439-42. 1999
    ..This finding presents a totally new concept to the control of 5alpha-reductase in the human prostate and offers a possibility for an interesting and alternative approach to the management of prostate cancer...
  8. pmc Epidermal growth factor and transforming growth factor alpha concentrations in BPH and cancer of the prostate: their relationships with tissue androgen levels
    Y Yang
    University Department of Surgery WGH, Western General Hospital, Edinburgh, Scotland, UK
    Br J Cancer 67:152-5. 1993
    ..61, P < 0.05) in CaP. The absence of any similar correlation in BPH where DHT becomes the predominant hormone may suggest an indirect role for testosterone in the regulation of growth factor production...
  9. pmc Divergent responses to epidermal growth factor in hormone sensitive and insensitive human prostate cancer cell lines
    A MacDonald
    University Department of Surgery, Western General Hospital, Edinburgh, UK
    Br J Cancer 65:177-82. 1992
    ..Western blot analysis, using monoclonal antibodies directed against the EGF receptor revealed a band of approximately 170 kD with DU145 cell lysates but the LNCaP EGF receptor was not detected using this technique...
  10. pmc Production and response of a human prostatic cancer line to transforming growth factor-like molecules
    A MacDonald
    University Department of Surgery WGH, Western General Hospital, Edinburgh, UK
    Br J Cancer 62:579-84. 1990
    ..d. = 1.0 +/- 0.5 nmol l-1). Although DU145 cells express high levels of EGF receptors, DNA synthesis was only minimally affected by exogenous EGF and TGF alpha...
  11. ncbi The insulin-like growth factor type I receptor stimulates growth and suppresses apoptosis in prostatic stromal cells
    E S Grant
    University Department of Surgery, University of Edinburgh, Western General Hospital, Scotland
    J Clin Endocrinol Metab 83:3252-7. 1998
    ..The data suggest that IGF-IR is a pivotal molecule in prostatic stromal cell maintenance, and that specific antagonism may offer a novel means of controlling the fibromuscular expansion characteristic of benign prostatic hyperplasia...
  12. pmc Variation in dermcidin expression in a range of primary human tumours and in hypoxic/oxidatively stressed human cell lines
    G D Stewart
    Tissue Injury and Repair Group, Clinical and Surgical Sciences Surgery, University of Edinburgh, Edinburgh EH16 4SB, UK
    Br J Cancer 99:126-32. 2008
    ..The relationship of these findings to dermcidin protein levels and cell survival remains to be determined...
  13. ncbi Identification and isolation of human prostate epithelial stem cells based on alpha(2)beta(1)-integrin expression
    A T Collins
    Prostate Research Group, Department of Surgery, The Medical School, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK
    J Cell Sci 114:3865-72. 2001
    ..These properties are consistent with a stem cell origin. Furthermore, the presence of surface integrins on prostate stem cells suggests that these cells share common pathways with stem cells in other tissues...
  14. ncbi MUC1 expression, splice variant and short form transcription (MUC1/Z, MUC1/Y) in prostate cell lines and tissue
    I C Schut
    Breast Cancer Research Group, Department of Oncology, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, Scotland, UK
    BJU Int 91:278-83. 2003
    ....
  15. pmc The expression and localisation of beta-nerve growth factor (beta-NGF) in benign and malignant human prostate tissue: relationship to neuroendocrine differentiation
    A B Paul
    University Department of Surgery Urology, Western General Hospital, Edinburgh, Scotland, UK
    Br J Cancer 74:1990-6. 1996
    ..Clearly, the present study demonstrates that beta-NGF is a product of the prostate and may be involved in the control of the sympathetic innervation of the human prostate...
  16. doi Analysis of prostate cancer association with four single-nucleotide polymorphisms from genome-wide studies and serum phyto-estrogen concentrations
    C K M Ho
    Prostate Research Group, Department of Oncology, University of Edinburgh, Edinburgh, UK
    Prostate Cancer Prostatic Dis 15:365-8. 2012
    ..Potential relationships between serum concentrations of phyto-estrogens and SNPs were also investigated...
  17. doi FGFR4 Gly388Arg polymorphism and prostate cancer risk in Scottish men
    C K M Ho
    Prostate Research Group, The Chancellors Building, University of Edinburgh, Edinburgh, UK
    Prostate Cancer Prostatic Dis 13:94-6. 2010
    ..The single nucleotide polymorphism Gly(388)Arg in FGFR4 is not associated with increased risk of prostate cancer in Scottish men. This observation is in contrast with results from two previous studies conducted in the USA and Japan...
  18. pmc Epidermal growth factor receptors in human prostate cancer: correlation with histological differentiation of the tumour
    S Q Maddy
    University Department of Surgery, Western General Hospital, Edinburgh, UK
    Br J Cancer 60:41-4. 1989
    ..01). Clearly the depletion in the expression of EGF receptors in CaP is a function of the histological grade of the cancer and as such EGF receptors could be used as a biochemical marker for tumour differentiation...
  19. ncbi Measurement of the mechanical characteristics of benign prostatic tissue: a novel method for assessing benign prostatic disease
    S Phipps
    Prostate Research Group, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    Urology 65:1024-8. 2005
    ..To investigate the relationship between the morphology and the mechanical properties of benign prostatic tissues measured in vitro...
  20. ncbi CYP7B generates a selective estrogen receptor beta agonist in human prostate
    Cecile Martin
    Endocrinology Unit, Department of Oncology, University of Edinburgh Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    J Clin Endocrinol Metab 89:2928-35. 2004
    ..By this reaction, an ERbeta-specific agonist, 7HD, is produced. Therefore, CYP7B may be a novel regulator of the androgens/estrogenic balance within the prostate...
  21. ncbi Serenoa repens (Permixon) inhibits the 5alpha-reductase activity of human prostate cancer cell lines without interfering with PSA expression
    Fouad K Habib
    Prostate Research Group, University of Edinburgh, School of Molecular and Clinical Medicine, 2nd Floor Main Outpatient Building, Western General Hospital, Edinburgh EH2 2XU, Scotland, UK
    Int J Cancer 114:190-4. 2005
    ....
  22. ncbi Polymorphic forms of prostate specific antigen and their interaction with androgen receptor trinucleotide repeats in prostate cancer
    Margaret C Binnie
    Prostate Research Group, Division of Oncology, School of Molecular and Clinical Medicine, Western General Hospital, Edinburgh, United Kingdom
    Prostate 63:309-15. 2005
    ..The effect on PC risks from PSA polymorphisms alone and synergistically with the AR gene was examined in this report...
  23. ncbi Androgen receptor protein expression in prostatic tissues in Black and Caucasian men
    E Oluwabunmi Olapade-Olaopa
    Department of Urology, Leicester General Hospital, Leicester, United Kingdom
    Prostate 59:460-8. 2004
    ..CaP has a higher incidence and mortality in Black men. We hypothesized that subpopulation differences in AR expression may contribute to this phenomenon...
  24. ncbi Dermcidin expression confers a survival advantage in prostate cancer cells subjected to oxidative stress or hypoxia
    Grant D Stewart
    Tissue Injury and Repair Group, University of Edinburgh, UK
    Prostate 67:1308-17. 2007
    ..The aim of this work was to: (i) establish if the DCD gene confers resistance of prostate cancer cells to hypoxia and oxidative stress; (ii) identify the component of the gene transcript responsible for this effect...
  25. ncbi Quantitative morphometric analysis of individual resected prostatic tissue specimens, using immunohistochemical staining and colour-image analysis
    Simon Phipps
    Prostate Research Group, University Department of Oncology, Western General Hospital, Edinburgh, UK
    BJU Int 94:919-21. 2004
    ..To develop a method for obtaining morphometric measurements representative of individual chips from transurethral resection of the prostate (TURP)...
  26. ncbi Nitric oxide donating nonsteroidal anti-inflammatory drugs induce apoptosis in human prostate cancer cell systems and human prostatic stroma via caspase-3
    Justine Sarah Royle
    Department of Urology, Western General Hospital, Prostate Research Group, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    J Urol 172:338-44. 2004
    ..NO is a powerful biological messenger with multiple cellular effects. We established the effects of 2 of these new drugs in prostate cell systems...