Mark Gurnell

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. doi request reprint What should be done when thyroid function tests do not make sense?
    Mark Gurnell
    Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Clin Endocrinol (Oxf) 74:673-8. 2011
  2. doi request reprint An adult female with resistance to thyroid hormone mediated by defective thyroid hormone receptor α
    Carla Moran
    University of Cambridge, Metabolic Research Laboratories, Institute of Metabolic Science, Level 4, Box 289, Addenbrooke s Hospital, Cambridge, CB2 0QQ, United Kingdom
    J Clin Endocrinol Metab 98:4254-61. 2013
  3. doi request reprint A comprehensive study of clinical, biochemical, radiological, vascular, cardiac, and sleep parameters in an unselected cohort of patients with acromegaly undergoing presurgical somatostatin receptor ligand therapy
    Anand K Annamalai
    Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Box 289, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom
    J Clin Endocrinol Metab 98:1040-50. 2013
  4. pmc Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans
    Erik Schoenmakers
    Institute of Metabolic Science, University of Cambridge, Cambridge, UK
    J Clin Invest 120:4220-35. 2010
  5. pmc From molecule to market: steroid hormones and financial risk-taking
    John M Coates
    Judge Business School, University of Cambridge, Cambridge CB2 1AG, UK
    Philos Trans R Soc Lond B Biol Sci 365:331-43. 2010
  6. pmc Second-to-fourth digit ratio predicts success among high-frequency financial traders
    John M Coates
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    Proc Natl Acad Sci U S A 106:623-8. 2009
  7. ncbi request reprint Digenic inheritance of severe insulin resistance in a human pedigree
    David B Savage
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Nat Genet 31:379-84. 2002
  8. ncbi request reprint Peroxisome proliferator-activated receptor gamma and the regulation of adipocyte function: lessons from human genetic studies
    Mark Gurnell
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Hills Road, UK
    Best Pract Res Clin Endocrinol Metab 19:501-23. 2005
  9. ncbi request reprint PPARgamma and metabolism: insights from the study of human genetic variants
    Mark Gurnell
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Clin Endocrinol (Oxf) 59:267-77. 2003
  10. ncbi request reprint The metabolic syndrome: peroxisome proliferator-activated receptor gamma and its therapeutic modulation
    Mark Gurnell
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    J Clin Endocrinol Metab 88:2412-21. 2003

Collaborators

Detail Information

Publications18

  1. doi request reprint What should be done when thyroid function tests do not make sense?
    Mark Gurnell
    Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Clin Endocrinol (Oxf) 74:673-8. 2011
    ..Here, focusing particularly on the combination of hyperthyroxinaemia with nonsuppressed thyrotropin, we show how a structured approach to investigation can help make sense of atypical TFTs...
  2. doi request reprint An adult female with resistance to thyroid hormone mediated by defective thyroid hormone receptor α
    Carla Moran
    University of Cambridge, Metabolic Research Laboratories, Institute of Metabolic Science, Level 4, Box 289, Addenbrooke s Hospital, Cambridge, CB2 0QQ, United Kingdom
    J Clin Endocrinol Metab 98:4254-61. 2013
    ..The first human cases (female, age 6 y; father and daughter, ages 47 and 11 y, respectively) with growth retardation/short stature, skeletal dysplasia, constipation, and defective thyroid receptor α (TRα) have been recently described...
  3. doi request reprint A comprehensive study of clinical, biochemical, radiological, vascular, cardiac, and sleep parameters in an unselected cohort of patients with acromegaly undergoing presurgical somatostatin receptor ligand therapy
    Anand K Annamalai
    Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Box 289, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom
    J Clin Endocrinol Metab 98:1040-50. 2013
    ..However, responses vary considerably between individuals, and attainment of biochemical control cannot be assumed to equate to universal complication control...
  4. pmc Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans
    Erik Schoenmakers
    Institute of Metabolic Science, University of Cambridge, Cambridge, UK
    J Clin Invest 120:4220-35. 2010
    ..Thus, mutation of SECISBP2 is associated with a multisystem disorder with defective biosynthesis of many selenoproteins, highlighting their role in diverse biological processes...
  5. pmc From molecule to market: steroid hormones and financial risk-taking
    John M Coates
    Judge Business School, University of Cambridge, Cambridge CB2 1AG, UK
    Philos Trans R Soc Lond B Biol Sci 365:331-43. 2010
    ..If hormones can exaggerate market moves, then perhaps the age and sex composition among traders and asset managers may affect the level of instability witnessed in the financial markets...
  6. pmc Second-to-fourth digit ratio predicts success among high-frequency financial traders
    John M Coates
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    Proc Natl Acad Sci U S A 106:623-8. 2009
    ..The success and longevity of traders exposed to high levels of prenatal androgens further suggests that financial markets may select for biological traits rather than rational expectations...
  7. ncbi request reprint Digenic inheritance of severe insulin resistance in a human pedigree
    David B Savage
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Nat Genet 31:379-84. 2002
    ....
  8. ncbi request reprint Peroxisome proliferator-activated receptor gamma and the regulation of adipocyte function: lessons from human genetic studies
    Mark Gurnell
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Hills Road, UK
    Best Pract Res Clin Endocrinol Metab 19:501-23. 2005
    ....
  9. ncbi request reprint PPARgamma and metabolism: insights from the study of human genetic variants
    Mark Gurnell
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Clin Endocrinol (Oxf) 59:267-77. 2003
    ..This review highlights recent studies which have advanced our understanding of the pivotal role that this receptor plays in metabolism, with particular reference to the consequences of inherited variation in the human receptor gene...
  10. ncbi request reprint The metabolic syndrome: peroxisome proliferator-activated receptor gamma and its therapeutic modulation
    Mark Gurnell
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    J Clin Endocrinol Metab 88:2412-21. 2003
    ..These studies provide further support for the future development of more selective receptor modulators, targeting specific pathways to ameliorate facets of the metabolic syndrome...
  11. doi request reprint Resistance to thyroid hormone mediated by defective thyroid hormone receptor alpha
    Nadia Schoenmakers
    Institute of Metabolic Science, University of Cambridge, UK
    Biochim Biophys Acta 1830:4004-8. 2013
    ..THRB mutations cause a disorder with central (hypothalamic-pituitary) resistance to thyroid hormone action with markedly elevated thyroid hormone and normal TSH levels...
  12. ncbi request reprint Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma
    David B Savage
    Department of Medicine, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 52:910-7. 2003
    ..Although the condition is rare, the study of humans with dominant-negative mutations in PPAR-gamma can provide important insight into the roles of this nuclear receptor in human metabolism...
  13. pmc Pitfalls in the measurement and interpretation of thyroid function tests
    Olympia Koulouri
    Metabolic Research Laboratories, Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Best Pract Res Clin Endocrinol Metab 27:745-62. 2013
    ..Here, we discuss the main pitfalls in the measurement and interpretation of TFTs, and propose a structured algorithm for the investigation and management of patients with anomalous/discordant TFTs...
  14. doi request reprint Maternal isodisomy for chromosome 9 causing homozygosity for a novel FOXE1 mutation in syndromic congenital hypothyroidism
    Mireille Castanet
    University of Cambridge, Metabolic Research Laboratories, Institute of Metabolic Science, Department of Medicine, Level 4, Box 289, Addenbrooke s Hospital, Cambridge CB2 0QQ, United Kingdom
    J Clin Endocrinol Metab 95:4031-6. 2010
    ..We have elucidated the molecular basis of the disorder in a female with a similar clinical phenotype, born to nonconsanguineous parents...
  15. ncbi request reprint Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma
    Maura Agostini
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, United Kingdom
    Endocrinology 145:1527-38. 2004
    ..Having shown that rosiglitazone is of variable and limited efficacy in these subjects, we suggest that TAs may represent a more rational therapeutic approach...
  16. pmc Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance
    Maura Agostini
    Department of Medicine, University of Cambridge, United Kingdom
    Cell Metab 4:303-11. 2006
    ..Our observations suggest that these mutants restrict wild-type PPARgamma action via a non-DNA binding, transcriptional interference mechanism, which may involve sequestration of functionally limiting coactivators...
  17. doi request reprint Increased prevalence of gallbladder polyps in acromegaly
    Anand K Annamalai
    Institute of Metabolic ScienceAddenbrooke s Hospital, Cambridge University Hospitals National Health Service Foundation Trust, University of Cambridge, Addenbrooke s Hospital, CB2 0QQ Cambridge, United Kingdom
    J Clin Endocrinol Metab 96:E1120-5. 2011
    ..The gallbladder's epithelial similarity to the colon raises the possibility that gallbladder polyps (GBP) may occur more frequently in acromegaly...
  18. doi request reprint A mutation in the thyroid hormone receptor alpha gene
    Elena Bochukova
    University of Cambridge Metabolic Research Laboratories and National Institute for Health Research Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 366:243-9. 2012
    ..Our observations are consistent with defective human TRα-mediated thyroid hormone resistance and substantiate the concept of hormone action through distinct receptor subtypes in different target tissues...