K Gull

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi request reprint The cytoskeleton of trypanosomatid parasites
    K Gull
    School of Biological Sciences, University of Manchester, United Kingdom
    Annu Rev Microbiol 53:629-55. 1999
  2. ncbi request reprint Genomics and post-genomics in parasitology: genome babble or a real opportunity?
    K Gull
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Biochem Soc Trans 28:541-4. 2000
  3. ncbi request reprint Segregation of minichromosomes in trypanosomes: implications for mitotic mechanisms
    K Gull
    School of Biological Sciences, University of Manchester, UK
    Trends Microbiol 6:319-23. 1998
  4. ncbi request reprint The cell biology of parasitism in Trypanosoma brucei: insights and drug targets from genomic approaches?
    K Gull
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Curr Pharm Des 8:241-56. 2002
  5. pmc The bloodstream differentiation-division of Trypanosoma brucei studied using mitochondrial markers
    K M Tyler
    School of Biological Sciences, University of Manchester, UK
    Proc Biol Sci 264:1481-90. 1997
  6. ncbi request reprint The biology of kinetoplastid parasites: insights and challenges from genomics and post-genomics
    K Gull
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, M13 9PT, Manchester, UK
    Int J Parasitol 31:443-52. 2001
  7. ncbi request reprint Protist tubulins: new arrivals, evolutionary relationships and insights to cytoskeletal function
    K Gull
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Curr Opin Microbiol 4:427-32. 2001
  8. ncbi request reprint Partitioning of large and minichromosomes in Trypanosoma brucei
    K Ersfeld
    University of Manchester, School of Biological Sciences, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Science 276:611-4. 1997
  9. ncbi request reprint Assembly of the paraflagellar rod and the flagellum attachment zone complex during the Trypanosoma brucei cell cycle
    L Kohl
    School of Biological Sciences, University of Manchester, United Kingdom
    J Eukaryot Microbiol 46:105-9. 1999
  10. ncbi request reprint Identification of stage-regulated and differentiation-enriched transcripts during transformation of the African trypanosome from its bloodstream to procyclic form
    K R Matthews
    University of Manchester, UK
    Mol Biochem Parasitol 95:81-95. 1998

Collaborators

Detail Information

Publications29

  1. ncbi request reprint The cytoskeleton of trypanosomatid parasites
    K Gull
    School of Biological Sciences, University of Manchester, United Kingdom
    Annu Rev Microbiol 53:629-55. 1999
    ....
  2. ncbi request reprint Genomics and post-genomics in parasitology: genome babble or a real opportunity?
    K Gull
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Biochem Soc Trans 28:541-4. 2000
    ..Only then will the activity associated with post-genomics be turned from what I have termed 'genome babble' to real opportunities in understanding these parasites...
  3. ncbi request reprint Segregation of minichromosomes in trypanosomes: implications for mitotic mechanisms
    K Gull
    School of Biological Sciences, University of Manchester, UK
    Trends Microbiol 6:319-23. 1998
    ..This minichromosomal population is segregated on the mitotic spindle. How this is achieved provides insight into potential segregation mechanisms for small DNA molecules in eukaryotic microorganisms...
  4. ncbi request reprint The cell biology of parasitism in Trypanosoma brucei: insights and drug targets from genomic approaches?
    K Gull
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Curr Pharm Des 8:241-56. 2002
    ....
  5. pmc The bloodstream differentiation-division of Trypanosoma brucei studied using mitochondrial markers
    K M Tyler
    School of Biological Sciences, University of Manchester, UK
    Proc Biol Sci 264:1481-90. 1997
    ..The results implicate a temporal order of events: commitment, division, phenotypic differentiation...
  6. ncbi request reprint The biology of kinetoplastid parasites: insights and challenges from genomics and post-genomics
    K Gull
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, M13 9PT, Manchester, UK
    Int J Parasitol 31:443-52. 2001
    ..The presentation slants therefore towards T. brucei biology, however, in each case the reader will, no doubt, see the generalities of application to other kinetoplastid parasites...
  7. ncbi request reprint Protist tubulins: new arrivals, evolutionary relationships and insights to cytoskeletal function
    K Gull
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Curr Opin Microbiol 4:427-32. 2001
    ..Tubulins and microtubules lie at the heart of this morphogenetic pattern...
  8. ncbi request reprint Partitioning of large and minichromosomes in Trypanosoma brucei
    K Ersfeld
    University of Manchester, School of Biological Sciences, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Science 276:611-4. 1997
    ..However, their positional dynamics differed from that of the large chromosomes, which were partitioned by kinetochore microtubules...
  9. ncbi request reprint Assembly of the paraflagellar rod and the flagellum attachment zone complex during the Trypanosoma brucei cell cycle
    L Kohl
    School of Biological Sciences, University of Manchester, United Kingdom
    J Eukaryot Microbiol 46:105-9. 1999
    ....
  10. ncbi request reprint Identification of stage-regulated and differentiation-enriched transcripts during transformation of the African trypanosome from its bloodstream to procyclic form
    K R Matthews
    University of Manchester, UK
    Mol Biochem Parasitol 95:81-95. 1998
    ....
  11. ncbi request reprint Diversity and dynamics of the minichromosomal karyotype in Trypanosoma brucei
    S Alsford
    School of Biological Sciences, University of Manchester, 2.205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Mol Biochem Parasitol 113:79-88. 2001
    ..This steady telomeric growth, counteracted by stochastic large losses of telomeric sequences is the most likely cause of minichromosome karyotype heterogeneity within a population...
  12. ncbi request reprint Targeting of cytoskeletal proteins to the flagellum of Trypanosoma brucei
    K Ersfeld
    School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    J Cell Sci 114:141-148. 2001
    ..We propose that this motif represents an essential part of a flagellar targeting machinery in trypanosomes and possibly in other flagellated organisms...
  13. ncbi request reprint A trypanosome structure involved in transmitting cytoplasmic information during cell division
    F F Moreira-Leite
    School of Biological Sciences, 2.205 Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Science 294:610-2. 2001
    ..This connector was present only during cell duplication and was found to be involved in the replication of the helical cell pattern and polarity. This finding implicates the concept of cytotaxis in cell morphogenesis in trypanosomes...
  14. ncbi request reprint CAP5.5, a life-cycle-regulated, cytoskeleton-associated protein is a member of a novel family of calpain-related proteins in Trypanosoma brucei
    C Hertz-Fowler
    School of Biological Sciences, University of Manchester, 2.205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Mol Biochem Parasitol 116:25-34. 2001
    ..5, but of varying length. We suggest a nomenclature for this new family of proteins in T. brucei...
  15. ncbi request reprint Flagellum ontogeny in trypanosomes studied via an inherited and regulated RNA interference system
    P Bastin
    University of Manchester, School of Biological Sciences, Oxford Road, Manchester M13 9PT, UK
    J Cell Sci 113:3321-8. 2000
    ..The inducible RNAi approach will have widespread applicability in studies of gene function and cellular processes in parasites...
  16. pmc Flagellar morphogenesis: protein targeting and assembly in the paraflagellar rod of trypanosomes
    P Bastin
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 19:8191-200. 1999
    ..This seven-amino-acid sequence is conserved in all PFRA and PFRC proteins and shows homology to a sequence in the flagellar dynein heavy chain of Chlamydomonas reinhardtii...
  17. ncbi request reprint Protein transport and flagellum assembly dynamics revealed by analysis of the paralysed trypanosome mutant snl-1
    P Bastin
    School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    J Cell Sci 112:3769-77. 1999
    ..Observation of PFR components indicate that these are likely to be regulated and modulated throughout the cell cycle...
  18. ncbi request reprint Direct visualisation of individual gene organisation in Trypanosoma brucei by high-resolution in situ hybridisation
    K Ersfeld
    School of Biological Sciences, 2 205 Stopford Building, University of Manchester, Manchester M13 9PT, UK
    Chromosoma 107:237-40. 1998
    ..We demonstrated the repetitive nature of the tubulin gene cluster, which consists of up to 19 alpha- and beta-tubulin genes arranged in tandem repeats...
  19. ncbi request reprint A fluorescence in situ hybridisation study of the regulation of histone mRNA levels during the cell cycle of Trypanosoma brucei
    K Ersfeld
    School of Biological Sciences, University of Manchester, UK
    Mol Biochem Parasitol 81:201-9. 1996
    ....
  20. ncbi request reprint Incorporation of tubulin from an evolutionarily diverse source, Physarum polycephalum, into the microtubules of a mammalian cell
    A R Prescott
    School of Biological Sciences, University of East Anglia, Norwich, UK
    J Cell Sci 92:595-605. 1989
    ..Use of this heterologous reporter tubulin system has also revealed features of variation in microtubule dynamics both within individual cells and between cells...
  21. ncbi request reprint Nuclear and genome organization of Trypanosoma brucei
    K Ersfeld
    University of Manchester, School of Biological Sciences, 2 205 Stopford Building, Oxford Road, Manchester, UK M13 9PT
    Parasitol Today 15:58-63. 1999
    ..However, recent work emphasizes the need for a more holistic approach to understanding these aspects of the biology of this parasite...
  22. ncbi request reprint The identification of circular extrachromosomal DNA in the nuclear genome of Trypanosoma brucei
    N S Alsford
    School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Mol Microbiol 47:277-89. 2003
    ..Therefore, we discuss a functional connection between the occurrence of this circular DNA and subtelomeric recombination events in T. brucei...
  23. ncbi request reprint Commitment to differentiation and cell cycle re-entry are coincident but separable events in the transformation of African trypanosomes from their bloodstream to their insect form
    K R Matthews
    School of Biological Sciences, University of Manchester, UK
    J Cell Sci 110:2609-18. 1997
    ....
  24. ncbi request reprint gamma-tubulin in trypanosomes: molecular characterisation and localisation to multiple and diverse microtubule organising centres
    V Scott
    School of Biological Sciences, University of Manchester, UK
    J Cell Sci 110:157-68. 1997
    ..Our results indicate that gamma-tubulin is associated with diverse microtubule organising centres and structures in trypanosomes...
  25. ncbi request reprint Inside and outside of the trypanosome flagellum:a multifunctional organelle
    P Bastin
    Department of Biochemistry, School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, M13 9PT, Manchester, UK
    Microbes Infect 2:1865-74. 2000
    ..This is the case of the flagellum, containing conventional and unique structures whose role in infectivity is still enigmatic...
  26. ncbi request reprint The extended tubulin superfamily
    P G McKean
    School of Biological Sciences, University of Manchester, UK
    J Cell Sci 114:2723-33. 2001
    ..On the basis of current evidence, we predict that delta-, epsilon-, zeta- and eta-tubulin all have functions associated with the centriole or basal body of eukaryotic cells and organisms...
  27. ncbi request reprint From fungi to flies: pattern and form in the cell cycle
    K Gull
    Department of Biochemistry and Molecular Biology, University of Manchester Medical School, UK
    Curr Opin Cell Biol 3:247-52. 1991
    ..This review shows how, in some lower eukaryotes, recent studies have made important connections between cell cycle control processes and complex events such as organelle positioning and the differentiation of cells and tissues...
  28. ncbi request reprint Microtubules, tubulin, and microtubule-associated proteins of trypanosomes
    D Robinson
    Methods Enzymol 196:285-99. 1991
  29. pmc Characterization and differential nuclear localization of Nopp140 and a novel Nopp140-like protein in trypanosomes
    S Kelly
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    Eukaryot Cell 5:876-9. 2006
    ..The restricted occurrence pattern of NoLP proteins reflects an intriguing convergence in evolution, suggestive of a function in nucleoplasmic small nucleolar ribonucleoprotein shuttling...