Affiliation: University of Oxford
Hayward D, Alfonso Pérez T, Cundell M, Hopkins M, Holder J, Bancroft J, et al
. CDK1-CCNB1 creates a spindle checkpoint-permissive state by enabling MPS1 kinetochore localization. J Cell Biol. 2019;: pubmed publisher
..By acting together, CDK1-CCNB1 and PP2A-B55 thus create a spindle checkpoint-permissive state and ensure the fidelity of mitosis. ..
Alfonso Pérez T, Hayward D, Holder J, Gruneberg U, Barr F. MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling. J Cell Biol. 2019;: pubmed publisher
..CDK1-CCNB1 is therefore an integral component of the spindle checkpoint, ensuring the fidelity of mitosis. ..
Espert A, Uluocak P, Bastos R, Mangat D, Graab P, Gruneberg U. PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing. J Cell Biol. 2014;206:833-42 pubmed publisher
..Our findings extend the previously reported role for BubR1-associated PP2A-B56 in opposing Aurora B and suggest that BubR1-bound PP2A-B56 integrates kinetochore surveillance and silencing of the SAC. ..