Helen E Grote
Affiliation: University of Oxford
- Cognitive disorders and neurogenesis deficits in Huntington's disease mice are rescued by fluoxetineHelen E Grote
Howard Florey Institute, University of Melbourne, Parkville, VIC 3010, Australia
Eur J Neurosci 22:2081-8. 2005..Furthermore, fluoxetine was found to rescue deficits of neurogenesis and volume loss in the dentate gyrus of HD mice...
- Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanismTara L Spires
University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom
J Neurosci 24:2270-6. 2004..These results suggest that environmental enrichment benefits animals at early stages of the disease by rescuing protein deficits, possibly through rescuing transcription or protein transport problems...
- Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic miceTara L Spires
University Laboratory of Physiology, University of Oxford, Parks Road, Oxford, OX1 3PT, UK
Eur J Neurosci 19:2799-807. 2004..Furthermore, we demonstrate that Huntington's disease pathology interferes with the normal plastic response of dendritic spines to environmental enrichment...
- Gene-environment interactions, neuronal dysfunction and pathological plasticity in Huntington's diseaseAnton van Dellen
University Laboratory of Physiology, University of Oxford, Oxford, UK
Clin Exp Pharmacol Physiol 32:1007-19. 2005..The effects of specific environmental manipulations are discussed in the context of gene-environment interactions and experience-dependent plasticity in the healthy and diseased brain, particularly the cerebral cortex...
- Neurogenesis in the R6/1 transgenic mouse model of Huntington's disease: effects of environmental enrichmentStanley E Lazic
Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK
Eur J Neurosci 23:1829-38. 2006....
- Olfactory abnormalities in Huntington's disease: decreased plasticity in the primary olfactory cortex of R6/1 transgenic mice and reduced olfactory discrimination in patientsStanley E Lazic
Centre for Brain Repair, University of Cambridge, CB2 2PY, UK
Brain Res 1151:219-26. 2007..These results suggest that olfactory impairments observed in HD patients may be the result of reduced plasticity in the primary olfactory cortex...
- Regulators of adult neurogenesis in the healthy and diseased brainHelen E Grote
University Laboratory of Physiology, University of Oxford, Oxford, United Kingdom
Clin Exp Pharmacol Physiol 34:533-45. 2007..Recent evidence supports this idea and, furthermore, also indicates that factors promoting neurogenesis can modify the onset and progression of specific brain disorders, including Huntington's disease and depression...