Helen E Grote

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi Cognitive disorders and neurogenesis deficits in Huntington's disease mice are rescued by fluoxetine
    Helen E Grote
    Howard Florey Institute, University of Melbourne, Parkville, VIC 3010, Australia
    Eur J Neurosci 22:2081-8. 2005
  2. ncbi Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism
    Tara L Spires
    University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom
    J Neurosci 24:2270-6. 2004
  3. ncbi Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice
    Tara L Spires
    University Laboratory of Physiology, University of Oxford, Parks Road, Oxford, OX1 3PT, UK
    Eur J Neurosci 19:2799-807. 2004
  4. ncbi Gene-environment interactions, neuronal dysfunction and pathological plasticity in Huntington's disease
    Anton van Dellen
    University Laboratory of Physiology, University of Oxford, Oxford, UK
    Clin Exp Pharmacol Physiol 32:1007-19. 2005
  5. ncbi Neurogenesis in the R6/1 transgenic mouse model of Huntington's disease: effects of environmental enrichment
    Stanley E Lazic
    Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK
    Eur J Neurosci 23:1829-38. 2006
  6. ncbi Olfactory abnormalities in Huntington's disease: decreased plasticity in the primary olfactory cortex of R6/1 transgenic mice and reduced olfactory discrimination in patients
    Stanley E Lazic
    Centre for Brain Repair, University of Cambridge, CB2 2PY, UK
    Brain Res 1151:219-26. 2007
  7. ncbi Regulators of adult neurogenesis in the healthy and diseased brain
    Helen E Grote
    University Laboratory of Physiology, University of Oxford, Oxford, United Kingdom
    Clin Exp Pharmacol Physiol 34:533-45. 2007

Detail Information

Publications7

  1. ncbi Cognitive disorders and neurogenesis deficits in Huntington's disease mice are rescued by fluoxetine
    Helen E Grote
    Howard Florey Institute, University of Melbourne, Parkville, VIC 3010, Australia
    Eur J Neurosci 22:2081-8. 2005
    ..Furthermore, fluoxetine was found to rescue deficits of neurogenesis and volume loss in the dentate gyrus of HD mice...
  2. ncbi Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism
    Tara L Spires
    University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom
    J Neurosci 24:2270-6. 2004
    ..These results suggest that environmental enrichment benefits animals at early stages of the disease by rescuing protein deficits, possibly through rescuing transcription or protein transport problems...
  3. ncbi Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice
    Tara L Spires
    University Laboratory of Physiology, University of Oxford, Parks Road, Oxford, OX1 3PT, UK
    Eur J Neurosci 19:2799-807. 2004
    ..Furthermore, we demonstrate that Huntington's disease pathology interferes with the normal plastic response of dendritic spines to environmental enrichment...
  4. ncbi Gene-environment interactions, neuronal dysfunction and pathological plasticity in Huntington's disease
    Anton van Dellen
    University Laboratory of Physiology, University of Oxford, Oxford, UK
    Clin Exp Pharmacol Physiol 32:1007-19. 2005
    ..The effects of specific environmental manipulations are discussed in the context of gene-environment interactions and experience-dependent plasticity in the healthy and diseased brain, particularly the cerebral cortex...
  5. ncbi Neurogenesis in the R6/1 transgenic mouse model of Huntington's disease: effects of environmental enrichment
    Stanley E Lazic
    Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK
    Eur J Neurosci 23:1829-38. 2006
    ....
  6. ncbi Olfactory abnormalities in Huntington's disease: decreased plasticity in the primary olfactory cortex of R6/1 transgenic mice and reduced olfactory discrimination in patients
    Stanley E Lazic
    Centre for Brain Repair, University of Cambridge, CB2 2PY, UK
    Brain Res 1151:219-26. 2007
    ..These results suggest that olfactory impairments observed in HD patients may be the result of reduced plasticity in the primary olfactory cortex...
  7. ncbi Regulators of adult neurogenesis in the healthy and diseased brain
    Helen E Grote
    University Laboratory of Physiology, University of Oxford, Oxford, United Kingdom
    Clin Exp Pharmacol Physiol 34:533-45. 2007
    ..Recent evidence supports this idea and, furthermore, also indicates that factors promoting neurogenesis can modify the onset and progression of specific brain disorders, including Huntington's disease and depression...