Fedde Groot

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion
    Rogier W Sanders
    Laboratory of Experimental Virology, Dept, Medical Microbiology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 5:10. 2008
  2. doi Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses
    Fedde Groot
    Sir William Dunn School of Pathology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Blood 111:4660-3. 2008
  3. pmc Dendritic cell-mediated HIV-1 transmission to T cells of LAD-1 patients is impaired due to the defect in LFA-1
    Fedde Groot
    Department of Cell Biology and Histology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 3:75. 2006
  4. pmc Lactoferrin prevents dendritic cell-mediated human immunodeficiency virus type 1 transmission by blocking the DC-SIGN--gp120 interaction
    Fedde Groot
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Virol 79:3009-15. 2005
  5. pmc Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4+ T lymphocytes
    Marloes A Naarding
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Invest 115:3256-64. 2005
  6. ncbi Opposing roles of blood myeloid and plasmacytoid dendritic cells in HIV-1 infection of T cells: transmission facilitation versus replication inhibition
    Fedde Groot
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Blood 108:1957-64. 2006
  7. pmc Differential susceptibility of naïve, central memory and effector memory T cells to dendritic cell-mediated HIV-1 transmission
    Fedde Groot
    Dept, of Cell Biology and Histology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 3:52. 2006
  8. pmc Stimulated plasmacytoid dendritic cells impair human T-cell development
    Heike Schmidlin
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 108:3792-800. 2006
  9. pmc Histatin 5-derived peptide with improved fungicidal properties enhances human immunodeficiency virus type 1 replication by promoting viral entry
    Fedde Groot
    Department of Human Retrovirology, Academic Medical Center, Meibergdreef 15, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Virol 80:9236-43. 2006

Collaborators

  • B Berkhout
  • T W Kuijpers
  • T B Geijtenbeek
  • Hergen Spits
  • Jan G M Bolscher
  • Rogier W Sanders
  • William A Paxton
  • Heike Schmidlin
  • Marloes A Naarding
  • Ineke Braakman
  • Mark Melchers
  • Ilja Bontjer
  • Alexei A Nabatov
  • Martijn M Dankers
  • Els Busser
  • I Marije Liscaljet
  • Dirk Eggink
  • Eelco van Anken
  • Bianca Blom
  • Wendy Dontje
  • Arnaud D Colantonio
  • Suzanne J Ligthart
  • Esther J Schilder-Tol
  • Marcel Spaargaren
  • Monique E Oud
  • Christel H Uittenbogaart
  • Irene S Ludwig
  • Georgios Pollakis

Detail Information

Publications9

  1. pmc The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion
    Rogier W Sanders
    Laboratory of Experimental Virology, Dept, Medical Microbiology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 5:10. 2008
    ..Here we studied the role of the carbohydrate at position 386. We identified a virus variant that had lost the 386 glycan in an evolution study of a mutant virus lacking the disulfide bond at the base of the V4 domain...
  2. doi Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses
    Fedde Groot
    Sir William Dunn School of Pathology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Blood 111:4660-3. 2008
    ..Since HIV-1-infected macrophages can survive for many weeks, these results highlight the central role played by macrophages in HIV-1 infection and pathogenesis...
  3. pmc Dendritic cell-mediated HIV-1 transmission to T cells of LAD-1 patients is impaired due to the defect in LFA-1
    Fedde Groot
    Department of Cell Biology and Histology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 3:75. 2006
    ..To corroborate the importance of the ICAM-1- LFA-1 interaction, we performed transmission experiments to LFA-1 negative leukocytes from Leukocyte Adhesion Deficiency type 1 (LAD-1) patients...
  4. pmc Lactoferrin prevents dendritic cell-mediated human immunodeficiency virus type 1 transmission by blocking the DC-SIGN--gp120 interaction
    Fedde Groot
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Virol 79:3009-15. 2005
    ..DC-mediated capture of a bLF-resistant HIV-1 variant that was selected during long-term culturing in T cells could still be blocked by bLF. This underscores the usefulness of bLF as a microbicide drug to prevent HIV-1 transmission...
  5. pmc Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4+ T lymphocytes
    Marloes A Naarding
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Invest 115:3256-64. 2005
    ..The presence of such a DC-SIGN-binding molecule in human milk may both influence antigenic presentation and interfere with pathogen transfer in breastfed infants...
  6. ncbi Opposing roles of blood myeloid and plasmacytoid dendritic cells in HIV-1 infection of T cells: transmission facilitation versus replication inhibition
    Fedde Groot
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Blood 108:1957-64. 2006
    ..This study shows that the 2 main types of DCs have opposing roles in HIV-1 infection of T cells...
  7. pmc Differential susceptibility of naïve, central memory and effector memory T cells to dendritic cell-mediated HIV-1 transmission
    Fedde Groot
    Dept, of Cell Biology and Histology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 3:52. 2006
    ..The TEM cell subset, which can be further divided into effector Th1 and Th2 cells, has been shown to be the prime target for viral replication after HIV-1 infection, and is abundantly present in mucosal tissues...
  8. pmc Stimulated plasmacytoid dendritic cells impair human T-cell development
    Heike Schmidlin
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 108:3792-800. 2006
    ..It is evident from our data that IFN-alpha inhibits the IL-7R signal transduction pathway, although this could not be attributed to interference with either IL-7R proximal (STAT5, Akt/PKB, Erk1/2) or distal (p27(kip1), pRb) events...
  9. pmc Histatin 5-derived peptide with improved fungicidal properties enhances human immunodeficiency virus type 1 replication by promoting viral entry
    Fedde Groot
    Department of Human Retrovirology, Academic Medical Center, Meibergdreef 15, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Virol 80:9236-43. 2006
    ..This study shows that modification of antimicrobial peptides in order to improve their activity against a pathogen may have unpredictable and unwanted side effects on other pathogens...