R F Grimble

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. doi request reprint The true cost of in-patient obesity: impact of obesity on inflammatory stress and morbidity
    Robert F Grimble
    Institute of Human Nutrition, DOHaD Division, School of Medicine, University of Southampton, Mailpoint 887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Proc Nutr Soc 69:511-7. 2010
  2. ncbi request reprint Immunonutrition
    Robert F Grimble
    Institute of Human Nutrition, School of Medicine, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, United Kingdom
    Curr Opin Gastroenterol 21:216-22. 2005
  3. ncbi request reprint The effects of sulfur amino acid intake on immune function in humans
    Robert F Grimble
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton SO16 7PX, UK
    J Nutr 136:1660S-1665S. 2006
  4. ncbi request reprint Inflammatory status and insulin resistance
    Robert F Grimble
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton SO16 7PX, UK
    Curr Opin Clin Nutr Metab Care 5:551-9. 2002
  5. ncbi request reprint The ability of fish oil to suppress tumor necrosis factor alpha production by peripheral blood mononuclear cells in healthy men is associated with polymorphisms in genes that influence tumor necrosis factor alpha production
    Robert F Grimble
    Institute of Human Nutrition, School of Medicine, and the Biochemistry and Molecular Biology Division, School of Biological Sciences, University of Southampton, Southampton, United Kingdom
    Am J Clin Nutr 76:454-9. 2002
  6. ncbi request reprint Nutritional modulation of immune function
    R F Grimble
    Institute of Human Nutrition, School of Medicine, University of Southampton, UK
    Proc Nutr Soc 60:389-97. 2001
  7. doi request reprint Polymorphisms in the CD36 gene modulate the ability of fish oil supplements to lower fasting plasma triacyl glycerol and raise HDL cholesterol concentrations in healthy middle-aged men
    Jacqueline Madden
    Institute of Human Nutrition, Department of Surgery, School of Medicine, University of Southampton, Southampton, UK
    Prostaglandins Leukot Essent Fatty Acids 78:327-35. 2008
  8. ncbi request reprint Role of single nucleotide polymorphisms of pro-inflammatory cytokine genes in the relationship between serum lipids and inflammatory parameters, and the lipid-lowering effect of fish oil in healthy males
    Olivera Markovic
    Institute of Human Nutrition, School of Medicine, University of Southampton, S016 7PX, UK
    Clin Nutr 23:1084-95. 2004
  9. ncbi request reprint Polyunsaturated fatty acids, inflammation and immunity
    P C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, UK
    Eur J Clin Nutr 56:S14-9. 2002
  10. ncbi request reprint C-reactive protein is elevated in symptomatic compared with asymptomatic patients with carotid artery disease
    K Rerkasem
    Department of Vascular Surgery, Southampton General Hospital, UK
    Eur J Vasc Endovasc Surg 23:505-9. 2002

Collaborators

Detail Information

Publications30

  1. doi request reprint The true cost of in-patient obesity: impact of obesity on inflammatory stress and morbidity
    Robert F Grimble
    Institute of Human Nutrition, DOHaD Division, School of Medicine, University of Southampton, Mailpoint 887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Proc Nutr Soc 69:511-7. 2010
    ..A better understanding of this aspect of nutrient-gene interactions and of the genomic factors that influence the intensity of inflammation during disease will help in the more effective targeting of nutritional therapy...
  2. ncbi request reprint Immunonutrition
    Robert F Grimble
    Institute of Human Nutrition, School of Medicine, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, United Kingdom
    Curr Opin Gastroenterol 21:216-22. 2005
    ..To outline recent findings on the efficacy of immunonutrients in patients undergoing inflammatory stress due to surgery, infection and cancer...
  3. ncbi request reprint The effects of sulfur amino acid intake on immune function in humans
    Robert F Grimble
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton SO16 7PX, UK
    J Nutr 136:1660S-1665S. 2006
    ..Studies directly linking methionine intake, genetics, plasma Hcy, Tau, and GSH and immune function are needed...
  4. ncbi request reprint Inflammatory status and insulin resistance
    Robert F Grimble
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton SO16 7PX, UK
    Curr Opin Clin Nutr Metab Care 5:551-9. 2002
    ..Insulin resistance and disordering of lipid metabolism occur in obesity, diabetes mellitus, atherosclerosis. This review examines recent research that links inflammation to insulin insensitivity...
  5. ncbi request reprint The ability of fish oil to suppress tumor necrosis factor alpha production by peripheral blood mononuclear cells in healthy men is associated with polymorphisms in genes that influence tumor necrosis factor alpha production
    Robert F Grimble
    Institute of Human Nutrition, School of Medicine, and the Biochemistry and Molecular Biology Division, School of Biological Sciences, University of Southampton, Southampton, United Kingdom
    Am J Clin Nutr 76:454-9. 2002
    ..Polymorphisms in the TNF-alpha and lymphotoxin alpha genes influence TNF-alpha production. Fish oil suppresses TNF-alpha production and has variable antiinflammatory effects on disease...
  6. ncbi request reprint Nutritional modulation of immune function
    R F Grimble
    Institute of Human Nutrition, School of Medicine, University of Southampton, UK
    Proc Nutr Soc 60:389-97. 2001
    ....
  7. doi request reprint Polymorphisms in the CD36 gene modulate the ability of fish oil supplements to lower fasting plasma triacyl glycerol and raise HDL cholesterol concentrations in healthy middle-aged men
    Jacqueline Madden
    Institute of Human Nutrition, Department of Surgery, School of Medicine, University of Southampton, Southampton, UK
    Prostaglandins Leukot Essent Fatty Acids 78:327-35. 2008
    ..The TAG-lowering effects may be via stimulation of CD36 activity in extrahepatic tissue in individuals with the GG variants of these SNPs...
  8. ncbi request reprint Role of single nucleotide polymorphisms of pro-inflammatory cytokine genes in the relationship between serum lipids and inflammatory parameters, and the lipid-lowering effect of fish oil in healthy males
    Olivera Markovic
    Institute of Human Nutrition, School of Medicine, University of Southampton, S016 7PX, UK
    Clin Nutr 23:1084-95. 2004
    ..Fish oil has lipid-lowering and anti-inflammatory properties. The influence of cytokine gene polymorphisms on the interaction between adiposity, inflammation and the properties of fish oil is unknown...
  9. ncbi request reprint Polyunsaturated fatty acids, inflammation and immunity
    P C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, UK
    Eur J Clin Nutr 56:S14-9. 2002
    ..Such n-3 fatty acid-induced effects may be of use as a therapy for acute and chronic inflammation, and for disorders which involve an inappropriately activated immune response...
  10. ncbi request reprint C-reactive protein is elevated in symptomatic compared with asymptomatic patients with carotid artery disease
    K Rerkasem
    Department of Vascular Surgery, Southampton General Hospital, UK
    Eur J Vasc Endovasc Surg 23:505-9. 2002
    ..to investigate the level of inflammatory markers between symptomatic and asymptomatic carotid stenosis patients...
  11. ncbi request reprint Fasting in healthy individuals and adaption to undernutrition during chronic disease
    R F Grimble
    Institute of Human Nutrition, University of Southampton, Hants, UK
    Curr Opin Clin Nutr Metab Care 1:369-74. 1998
    ..Repletion of tissue after undernutrition is energetically inefficient because of enhanced diet induced thermogenesis (following anorexia nervosa) and decreased fat, and increased protein, oxidation (in tuberculosis)...
  12. ncbi request reprint Long-chain n-3 fatty acid supplementation in men increases resistance to activated protein C
    Nicola A Englyst
    Endocrinology and Metabolism Unit, Developmental Origins of Health and Disease Division, Institute of Human Nutrition, University of Southampton, Southampton SO16 6YD, UK
    Metabolism 56:547-51. 2007
    ..These findings will need to be repeated in different disease states...
  13. ncbi request reprint Fish oil induced increase in walking distance, but not ankle brachial pressure index, in peripheral arterial disease is dependent on both body mass index and inflammatory genotype
    Jacqueline Madden
    Institute of Human Nutrition, School of Medicine, University of Southampton, and Department of Vascular Surgery, Southampton General Hospital, Southampton, UK
    Prostaglandins Leukot Essent Fatty Acids 76:331-40. 2007
    ..Neither BMI nor any of the genotypes examined affected the ability of fish oil to increase ABPI. The mechanisms by which fish oil affects walking distance and ABPI do not appear to be the same...
  14. ncbi request reprint Incorporation of cis-9, trans-11 conjugated linoleic acid and vaccenic acid (trans-11 18 : 1) into plasma and leucocyte lipids in healthy men consuming dairy products naturally enriched in these fatty acids
    Graham C Burdge
    Institute of Human Nutrition, Biomedical Sciences Building, University of Southhampton, Bassett Crescent East, Southhampton, S016 7PX, UK
    Br J Nutr 94:237-43. 2005
    ..001) and PBMC (84 %; P = 0.004). Overall, the present study shows that consumption of naturally enriched dairy products in amounts similar to habitual intakes of these foods increased the c9,t11 CLA content of plasma and cellular lipids...
  15. doi request reprint Hsp70 expression in monocytes from patients with peripheral arterial disease and healthy controls: monocyte Hsp70 in PAD
    Jacqueline Madden
    Institute of Human Nutrition, School of Medicine, University of Southampton, IDS Building, MP887 Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Cell Biol Toxicol 26:215-23. 2010
    ..Therefore, we wished to examine monocyte Hsp70 expression and induction in patients with peripheral arterial disease (PAD) and in healthy controls...
  16. ncbi request reprint Incorporation of cis-9,trans-11 or trans-10,cis-12 conjugated linoleic acid into plasma and cellular lipids in healthy men
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton, Southampton, SO16 7PX UK
    J Lipid Res 45:736-41. 2004
    ..These data suggest that the level of intake is a major determinant of plasma and PBMC CLA content, although PBMCs appear to incorporate both CLA isomers less readily...
  17. ncbi request reprint Gene polymorphisms, inflammatory diseases and cancer
    W Martin Howell
    Histocompatibilizy and Immunogenetics Laboratory Human Genetics Division, Southampton University Hospitals, Southampton SO16 6YD, UK
    Proc Nutr Soc 61:447-56. 2002
    ..In addition, preliminary work suggests that dietary modulation of expression levels of certain cytokines in healthy human subjects may be genotype dependent...
  18. doi request reprint Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability
    Abbie L Cawood
    School of Medicine, University of Southampton, Southampton, United Kingdom
    Atherosclerosis 212:252-9. 2010
    ..To examine n-3 polyunsaturated fatty acid (PUFA) incorporation into atherosclerotic plaques and the association with plaque inflammation and stability...
  19. ncbi request reprint Inflammatory response in the elderly
    Robert F Grimble
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton SO16 7PX, UK
    Curr Opin Clin Nutr Metab Care 6:21-9. 2003
    ..During ageing there may be the onset of a chronic inflammatory state. This review examines the underlying causes of this phenomenon and the role that genotype plays in its intensity...
  20. ncbi request reprint The effect of graded levels of dietary casein, with or without methionine supplementation, on glutathione concentration in unstressed and endotoxin-treated rats
    Adel A Alhamdan
    Institute of Human Nutrition, University of Southampton, Southampton SO16 7PX, UK
    Int J Vitam Nutr Res 73:468-77. 2003
    ..45 g L-methionine/kg diet, in experiment 2, hepatic GSH concentration significantly increased in the latter group, in animals fed ad libitum and in the endotoxin-treated animals, but not in the pair-fed controls...
  21. doi request reprint Altered monocyte CD44 expression in peripheral arterial disease is corrected by fish oil supplementation
    J Madden
    Institute of Human Nutrition, University of Southampton, Tremona Road, Southampton, UK
    Nutr Metab Cardiovasc Dis 19:247-52. 2009
    ..We have examined CD44 and CD44v3 expression on peripheral blood monocytes from patients with peripheral arterial disease (PAD) and healthy controls. We have also examined the effect of fish oil supplementation on these markers...
  22. ncbi request reprint The relationship between altered membrane composition, eicosanoids and TNF-induced IL1 and IL6 production in macrophages of rats fed fats of different unsaturated fatty acid composition
    P S Tappia
    Department of Human Nutrition, University of Southampton, UK
    Mol Cell Biochem 165:135-43. 1996
    ..The data from the present study provides some insight into how dietary fats could provide therapy for conditions in which inflammatory cytokines are implicated...
  23. pmc Nutritional therapy for cancer cachexia
    R F Grimble
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, UK rfg
    Gut 52:1391-2. 2003
  24. ncbi request reprint Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial
    Frank Thies
    Institute of Human Nutrition, University of Southampton, Basset Crescent East, Southampton, UK
    Lancet 361:477-85. 2003
    ..We aimed to assess the hypothesis that incorporation of n-3 and n-6 PUFAs into advanced atherosclerotic plaques increases and decreases plaque stability, respectively...
  25. ncbi request reprint Effects of dairy products naturally enriched with cis-9,trans-11 conjugated linoleic acid on the blood lipid profile in healthy middle-aged men
    Sabine Tricon
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences and the School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading RG6 6AP, United Kingdom
    Am J Clin Nutr 83:744-53. 2006
    ..However, feeding regimens that enhance the CLA content of milk also increase concentrations of trans-18:1 fatty acids. The implications for human health are not yet known...
  26. ncbi request reprint Does nutrition have a role in peripheral vascular disease?
    Juan J Carrero
    Department of Biochemistry and Molecular Biology, University of Granada, Spain
    Br J Nutr 95:217-29. 2006
    ..No practical recommendations can be given at this stage, and further studies are clearly needed...
  27. ncbi request reprint Pulmonary cachexia, systemic inflammatory profile, and the interleukin 1beta -511 single nucleotide polymorphism
    Roelinka Broekhuizen
    Department of Respiratory Medicine, University Hospital Maastricht, The Netherlands
    Am J Clin Nutr 82:1059-64. 2005
    ..Cachexia is common in chronic obstructive pulmonary disease (COPD) and is thought to be linked to an enhanced systemic inflammatory response...
  28. ncbi request reprint Dietary supplementation with fish oil modifies the ability of human monocytes to induce an inflammatory response
    Nguyet Thin Luu
    Centre for Cardiovascular Sciences, Department of Physiology, The Medical School, University of Birmingham, Birmingham, B15 2TT, UK
    J Nutr 137:2769-74. 2007
    ..Benefits, however, may depend on existing medical status and on other treatments being received...
  29. ncbi request reprint Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans
    Sabine Tricon
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Whiteknights, Reading RG6 6AP, United Kingdom
    Am J Clin Nutr 80:614-20. 2004
    ..However, the effects of CLA on human health and, in particular, the effects of individual CLA isomers are unclear...
  30. ncbi request reprint Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on immune cell function in healthy humans
    Sabine Tricon
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Reading, United Kingdom
    Am J Clin Nutr 80:1626-33. 2004
    ..However, little information on the effects of CLA on immune function is available, especially in humans. Furthermore, the effects of individual isomers of CLA have not been adequately investigated...