T D Griffiths

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Mapping pitch representation in neural ensembles with fMRI
    Timothy D Griffiths
    Institute of Neuroscience, Newcastle University Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom
    J Neurosci 32:13343-7. 2012
  2. ncbi request reprint Evidence for a sound movement area in the human cerebral cortex
    T D Griffiths
    Department of Physiological Sciences, Newcastle University Medical School, Newcastle upon Tyne, UK
    Nature 383:425-7. 1996
  3. ncbi request reprint What is an auditory object?
    Timothy D Griffiths
    Auditory Group, University of Newcastle Medical School, Newcastle upon Tyne NE2 4HH, UK
    Nat Rev Neurosci 5:887-92. 2004
  4. ncbi request reprint Functional imaging of pitch analysis
    Timothy D Griffiths
    Auditory Group, Newcastle University, Newcastle upon Tyne, UK
    Ann N Y Acad Sci 999:40-9. 2003
  5. ncbi request reprint Approaches to the cortical analysis of auditory objects
    Timothy D Griffiths
    Auditory Group, Medical School, Framlington Place, University of Newcastle, Newcastle upon Tyne, UK
    Hear Res 229:46-53. 2007
  6. ncbi request reprint The planum temporale as a computational hub
    Timothy D Griffiths
    Newcastle University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Trends Neurosci 25:348-53. 2002
  7. ncbi request reprint Central auditory processing disorders
    Timothy D Griffiths
    Department of Neurology, Newcastle University Medical School, Newcastle upon Tyne, UK
    Curr Opin Neurol 15:31-3. 2002
  8. ncbi request reprint Tone deafness: a model complex cortical phenotype
    Timothy D Griffiths
    Newcastle University
    Clin Med 8:592-5. 2008
  9. ncbi request reprint The neural processing of complex sounds
    T D Griffiths
    Departments of Neurology and Physiological Sciences, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Ann N Y Acad Sci 930:133-42. 2001
  10. ncbi request reprint Cortical processing of complex sound: a way forward?
    Timothy D Griffiths
    Department of Psychology, University College London, London WC1H 0AP, UK
    Trends Neurosci 27:181-5. 2004

Detail Information

Publications51

  1. ncbi request reprint Mapping pitch representation in neural ensembles with fMRI
    Timothy D Griffiths
    Institute of Neuroscience, Newcastle University Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom
    J Neurosci 32:13343-7. 2012
    ..The BOLD data provide support for the pitch-center concept, with ongoing debate about its location...
  2. ncbi request reprint Evidence for a sound movement area in the human cerebral cortex
    T D Griffiths
    Department of Physiological Sciences, Newcastle University Medical School, Newcastle upon Tyne, UK
    Nature 383:425-7. 1996
    ..The deficit is analagous to cerebral akinotopsia (motion blindness) in the visual system, and so the auditory system may, like the visual system, show localization of specialized functions to different cortical regions...
  3. ncbi request reprint What is an auditory object?
    Timothy D Griffiths
    Auditory Group, University of Newcastle Medical School, Newcastle upon Tyne NE2 4HH, UK
    Nat Rev Neurosci 5:887-92. 2004
    ..The concept of an auditory object challenges our understanding of object perception. Here, we offer a critical perspective on the concept and its basis in the brain...
  4. ncbi request reprint Functional imaging of pitch analysis
    Timothy D Griffiths
    Auditory Group, Newcastle University, Newcastle upon Tyne, UK
    Ann N Y Acad Sci 999:40-9. 2003
    ..Involvement of the frontal lobe in pitch pattern analysis may in part reflect whether subjects analyze the pitch patterns in order to carry out an output task...
  5. ncbi request reprint Approaches to the cortical analysis of auditory objects
    Timothy D Griffiths
    Auditory Group, Medical School, Framlington Place, University of Newcastle, Newcastle upon Tyne, UK
    Hear Res 229:46-53. 2007
    ..The subjects have lesions of the normal network described above with normal perception of pitch strength but abnormal perception of the analysis of spectral envelope change...
  6. ncbi request reprint The planum temporale as a computational hub
    Timothy D Griffiths
    Newcastle University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Trends Neurosci 25:348-53. 2002
    ..We review the evidence for the model and specific predictions that follow from it...
  7. ncbi request reprint Central auditory processing disorders
    Timothy D Griffiths
    Department of Neurology, Newcastle University Medical School, Newcastle upon Tyne, UK
    Curr Opin Neurol 15:31-3. 2002
    ..Recent work has investigated sound processing by the unconscious brain; such investigations may provide a 'window' into residual brain function and prognosis...
  8. ncbi request reprint Tone deafness: a model complex cortical phenotype
    Timothy D Griffiths
    Newcastle University
    Clin Med 8:592-5. 2008
    ..Although tone deafness is not pernicious, the underlying abnormality may prove to be a disorder of cortical connectivity that provides a model for disorders that are more so, such as schizophrenia...
  9. ncbi request reprint The neural processing of complex sounds
    T D Griffiths
    Departments of Neurology and Physiological Sciences, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Ann N Y Acad Sci 930:133-42. 2001
    ....
  10. ncbi request reprint Cortical processing of complex sound: a way forward?
    Timothy D Griffiths
    Department of Psychology, University College London, London WC1H 0AP, UK
    Trends Neurosci 27:181-5. 2004
    ..There is a crucial need for better understanding of the anatomy of the auditory cortex in different species and for comparative studies that will underpin both approaches...
  11. ncbi request reprint Musical hallucinosis in acquired deafness. Phenomenology and brain substrate
    T D Griffiths
    Department of Neurology, Newcastle University, Newcastle upon Tyne, UK
    Brain 123:2065-76. 2000
    ..This network is similar to that previously demonstrated during the normal perception and imagery of patterned-segmented sound, and is consistent with the proposed neuropsychological and neural mechanism...
  12. ncbi request reprint Encoding of the temporal regularity of sound in the human brainstem
    T D Griffiths
    Centre for the Neural Basis of Hearing, Physiology Department, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK
    Nat Neurosci 4:633-7. 2001
    ..This work shows that the process of recoding temporal patterns into a more stable form begins as early as the cochlear nucleus and continues up to auditory cortex...
  13. ncbi request reprint The Newcastle Auditory Battery (NAB). A temporal and spatial test battery for use on adult naïve subjects
    T D Griffiths
    Department of Physiological Sciences, Newcastle University Medical School, Newcastle upon Tyne, UK
    Hear Res 154:165-9. 2001
    ..Normal values are given for the threshold data for 30 naïve control subjects aged from 20 to 60 years. Future modifications of the battery are allowed by modular software architecture...
  14. ncbi request reprint The spectrum of hearing loss due to mitochondrial DNA defects
    P F Chinnery
    Department of Neurology, The University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Brain 123:82-92. 2000
    ..These findings are consistent with a predominantly cochlear origin for the hearing deficit, which is determined by the precise genetic defect and the percentage mutation load...
  15. ncbi request reprint Analysis of temporal structure in sound by the human brain
    T D Griffiths
    Physiology Department, University of Cambridge, UK
    Nat Neurosci 1:422-7. 1998
    ..These results suggest a hierarchical analysis of time structure in the human brain...
  16. ncbi request reprint Processing the acoustic effect of size in speech sounds
    K Von Kriegstein
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 32:368-75. 2006
    ....
  17. ncbi request reprint The processing of temporal pitch and melody information in auditory cortex
    Roy D Patterson
    Centre for the Neural Basis of Hearing, Physiology Department, University of Cambridge, Downing Street, Cambridge, United Kingdom
    Neuron 36:767-76. 2002
    ..The results support the view that there is hierarchy of pitch processing in which the center of activity moves anterolaterally away from primary auditory cortex as the processing of melodic sounds proceeds...
  18. ncbi request reprint Human brain mechanisms for the early analysis of voices
    J D Warren
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, Queen Square, London WC1N3BG, UK
    Neuroimage 31:1389-97. 2006
    ....
  19. pmc Hierarchical processing of auditory objects in humans
    Sukhbinder Kumar
    Auditory Group, Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
    PLoS Comput Biol 3:e100. 2007
    ..The work supports a computational model of auditory object processing, based on the abstraction of spectro-temporal "templates" in the PT before further analysis of the abstracted form in anterior temporal lobe areas...
  20. doi request reprint Mapping unpleasantness of sounds to their auditory representation
    Sukhbinder Kumar
    Auditory Group, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne, United Kingdom
    J Acoust Soc Am 124:3810-7. 2008
    ..It was observed that the existence region corresponded to spectral frequencies between 2500 and 5500 Hz, and temporal modulations in the range 1-16 Hz...
  21. pmc Task-dependent modulation of medial geniculate body is behaviorally relevant for speech recognition
    Katharina von Kriegstein
    Wellcome Trust Centre for Neuroimaging, University College London, Queen Square, London WC1N 3BG, UK
    Curr Biol 18:1855-9. 2008
    ..Together with studies in nonhuman mammals, our findings imply a mechanism in which the first-order auditory thalamus, possibly by corticothalamic modulation, reacts adaptively to features of sensory input...
  22. ncbi request reprint Analysis of the spectral envelope of sounds by the human brain
    J D Warren
    Auditory Group, Medical School, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK
    Neuroimage 24:1052-7. 2005
    ..These distinct levels of spectral analysis may represent early computational stages in a putative anteriorly directed stream for the categorization of sound...
  23. ncbi request reprint Characterization of deficits in pitch perception underlying 'tone deafness'
    Jessica M Foxton
    Auditory Group, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, UK
    Brain 127:801-10. 2004
    ..In contrast, no abnormalities were identified in the perceptual organization of pitch. The pitch deficits identified are able to account for the music perception difficulties in this disorder, and implicate deficient cortical processing...
  24. ncbi request reprint Representation of interaural time delay in the human auditory midbrain
    Sarah K Thompson
    Department of Physiology and UCL Ear Institute, University College London, 332 Gray s Inn Road, London WC1X 8EE, UK
    Nat Neurosci 9:1096-8. 2006
    ..The data require a new model for human ITD processing...
  25. pmc Characterisation of the BOLD response time course at different levels of the auditory pathway in non-human primates
    Simon Baumann
    Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK
    Neuroimage 50:1099-108. 2010
    ..Furthermore, the data will aid optimal design of future auditory fMRI studies in non-human primates...
  26. pmc Dissociation of duration-based and beat-based auditory timing in cerebellar degeneration
    Manon Grube
    Newcastle Auditory Group, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
    Proc Natl Acad Sci U S A 107:11597-601. 2010
    ..The findings support the existence of a stopwatch-like cerebellar timing mechanism for absolute intervals that is distinct from mechanisms for entrainment with a regular beat...
  27. doi request reprint Metricality-enhanced temporal encoding and the subjective perception of rhythmic sequences
    Manon Grube
    Newcastle Auditory Group, Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, UK
    Cortex 45:72-9. 2009
    ..The data support an increase in the precision of temporal pattern encoding for sequences with a higher-order metrical time framework...
  28. doi request reprint The contribution of the cerebellum to cognition in Spinocerebellar Ataxia Type 6
    Freya E Cooper
    Institute of Neuroscience, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne, UK
    Behav Neurol 23:3-15. 2010
    ....
  29. ncbi request reprint Training improves acoustic pattern perception
    Jessica M Foxton
    Auditory Group, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    Curr Biol 14:322-5. 2004
    ..Further studies are required to determine whether pitch-contour training is effective in improving speech and melody perception...
  30. ncbi request reprint Reading skills are related to global, but not local, acoustic pattern perception
    Jessica M Foxton
    Auditory Group, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Framlington Place, Newcastle NE2 4HH, UK
    Nat Neurosci 6:343-4. 2003
  31. ncbi request reprint Absence of auditory 'global interference' in autism
    Jessica M Foxton
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Brain 126:2703-9. 2003
    ..This was attributed to the absence of interference from an auditory coherent whole. The results are consistent with the presence of abnormal interactions between local and global auditory perception in ASD...
  32. pmc Orthogonal representation of sound dimensions in the primate midbrain
    Simon Baumann
    Institute of Neuroscience, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
    Nat Neurosci 14:423-5. 2011
    ..These representations are organized as a map with two approximately perpendicular axes: one representing increasing temporal rate and the other increasing spectral frequency...
  33. ncbi request reprint Limbic encephalitis: Not a picture to forget
    Patrick F Chinnery
    Newcastle upon Tyne, United Kingdom
    Neurology 62:1019. 2004
  34. pmc Psychophysical evaluation of cochlear hair cell damage due to the A3243G mitochondrial DNA mutation
    T D Griffiths
    Newcastle Auditory Group, Department of Physiological Sciences, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, United Kingdom
    J Assoc Res Otolaryngol 2:172-9. 2001
    ..The common occurrence of dead regions in the basal cochlea has treatment implication for this form of deafness; such people may not be helped by amplification of high frequencies...
  35. pmc Neural representation of auditory size in the human voice and in sounds from other resonant sources
    Katharina von Kriegstein
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
    Curr Biol 17:1123-8. 2007
    ..The results imply that the human voice requires special processing of acoustic scale, whereas the anterior temporal lobe and intraparietal sulcus process auditory size information independent of source category...
  36. ncbi request reprint Rhythm deficits in 'tone deafness'
    Jessica M Foxton
    Auditory Group, University of Newcastle upon Tyne, Framlington Place, Newcastle NE2 4HH, UK
    Brain Cogn 62:24-9. 2006
    ..These results suggest that the rhythm deficits in congenital amusia result from the pitch-variations in music...
  37. ncbi request reprint Music and the brain: disorders of musical listening
    Lauren Stewart
    Auditory Group, Newcastle University, Newcastle upon Tyne, London, UK
    Brain 129:2533-53. 2006
    ..Both the bases for normal musical listening and the clinical assessment of disorders now have a solid grounding in systems neuroscience...
  38. ncbi request reprint Proton magnetic resonance spectroscopy in frontotemporal dementia
    E Coulthard
    Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    J Neurol 253:861-8. 2006
    ..This opens up the possibility of using MR spectroscopy as a clinical tool to identify earlier presentations of the condition...
  39. ncbi request reprint Perception of sound-source motion by the human brain
    Jason D Warren
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuron 34:139-48. 2002
    ..The results support the existence of a posteriorly directed temporo-parietal pathway for obligatory perceptual processing of sound-source motion...
  40. ncbi request reprint Sorting out sound
    Timothy D Griffiths
    Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    Neuron 56:580-1. 2007
    ....
  41. pmc Course and outcome of acute limbic encephalitis with negative voltage-gated potassium channel antibodies
    S R Samarasekera
    Royal Victoria Infirmary, Newcastle upon Tyne, UK
    J Neurol Neurosurg Psychiatry 78:391-4. 2007
    ..Recent work has highlighted absent serum VGKC-Ab and distinct immunology in patients with the paraneoplastic form of limbic encephalitis...
  42. ncbi request reprint Central auditory pathologies
    Timothy D Griffiths
    Newcastle University Medical School, Newcastle upon Tyne, UK
    Br Med Bull 63:107-20. 2002
    ..Recent work focuses on the assessment of auditory processing in disorders that are not specifically auditory. In this case, auditory measurement may provide a 'window' into the condition...
  43. doi request reprint Sensory systems: auditory action streams?
    Timothy D Griffiths
    Newcastle University Medical School, Framlington Place, Newcastle upon Tyne, UK
    Curr Biol 18:R387-8. 2008
    ..Two recent studies suggest the existence of a comparable mechanism in the auditory system...
  44. pmc Direct recordings of pitch responses from human auditory cortex
    Timothy D Griffiths
    Institute of Neuroscience, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Curr Biol 20:1128-32. 2010
    ..The research suggests that two types of pitch-related activity occur in humans in early auditory cortex: time-locked neural correlates of stimulus regularity and an oscillatory response related to the pitch percept...
  45. ncbi request reprint Analyzing pitch chroma and pitch height in the human brain
    Jason D Warren
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, Queen Square, London, United Kingdom
    Ann N Y Acad Sci 999:212-4. 2003
    ....
  46. ncbi request reprint Morphometry of the amusic brain: a two-site study
    Krista L Hyde
    Department of Psychology, University of Montreal, Montreal, Quebec, Canada
    Brain 129:2562-70. 2006
    ..Moreover, the data point to the integrity of white matter tracts in right frontal brain areas as being key in acquiring normal musical competence...
  47. ncbi request reprint A common cortical substrate activated by horizontal and vertical sound movement in the human brain
    Francesco Pavani
    Institute of Cognitive Neuroscience, University College London, London, United Kingdom
    Curr Biol 12:1584-90. 2002
    ..These results demonstrate that sound movement in vertical and horizontal dimensions engages a common processing network in the human cerebral cortex and show that multidimensional spatial properties of sounds are processed at this level...
  48. pmc An information theoretic characterisation of auditory encoding
    Tobias Overath
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, United Kingdom
    PLoS Biol 5:e288. 2007
    ..The results establish PT as an efficient neural engine that demands less computational resource to encode redundant signals than those with high information content...
  49. ncbi request reprint Musically tone-deaf individuals have difficulty discriminating intonation contours extracted from speech
    Aniruddh D Patel
    The Neurosciences Institute, San Diego, CA, USA
    Brain Cogn 59:310-3. 2005
    ..Thus it appears that the dissociation between spoken and musical pitch perception in tone-deaf individuals is due to a deficit at a higher level than simple pitch-change detection...
  50. ncbi request reprint A neural basis for the perception of voices in external auditory space
    Michael D Hunter
    Sheffield Cognition and Neuroimaging Laboratory, Academic Department of Psychiatry, University of Sheffield, Sheffield, UK
    Brain 126:161-9. 2003
    ..Based on this, we suggest a model for the false perception of externally located auditory verbal hallucinations...
  51. ncbi request reprint Cortical thickness in congenital amusia: when less is better than more
    Krista L Hyde
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 27:13028-32. 2007
    ..These cortical thickness differences suggest the presence of cortical malformations in the amusic brain, such as abnormal neuronal migration, that may have compromised the normal development of a right frontotemporal pathway...