Research Topics
| T D GriffithsSummaryAffiliation: University of Newcastle Country: UK Publications
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Detail Information
Publications
Mapping pitch representation in neural ensembles with fMRITimothy D Griffiths
Institute of Neuroscience, Newcastle University Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom
J Neurosci 32:13343-7. 2012..The BOLD data provide support for the pitch-center concept, with ongoing debate about its location...- Evidence for a sound movement area in the human cerebral cortexT D Griffiths
Department of Physiological Sciences, Newcastle University Medical School, Newcastle upon Tyne, UK
Nature 383:425-7. 1996..The deficit is analagous to cerebral akinotopsia (motion blindness) in the visual system, and so the auditory system may, like the visual system, show localization of specialized functions to different cortical regions... - What is an auditory object?Timothy D Griffiths
Auditory Group, University of Newcastle Medical School, Newcastle upon Tyne NE2 4HH, UK
Nat Rev Neurosci 5:887-92. 2004..The concept of an auditory object challenges our understanding of object perception. Here, we offer a critical perspective on the concept and its basis in the brain... - Functional imaging of pitch analysisTimothy D Griffiths
Auditory Group, Newcastle University, Newcastle upon Tyne, UK
Ann N Y Acad Sci 999:40-9. 2003..Involvement of the frontal lobe in pitch pattern analysis may in part reflect whether subjects analyze the pitch patterns in order to carry out an output task... - Approaches to the cortical analysis of auditory objectsTimothy D Griffiths
Auditory Group, Medical School, Framlington Place, University of Newcastle, Newcastle upon Tyne, UK
Hear Res 229:46-53. 2007..The subjects have lesions of the normal network described above with normal perception of pitch strength but abnormal perception of the analysis of spectral envelope change... - The planum temporale as a computational hubTimothy D Griffiths
Newcastle University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
Trends Neurosci 25:348-53. 2002..We review the evidence for the model and specific predictions that follow from it... - Central auditory processing disordersTimothy D Griffiths
Department of Neurology, Newcastle University Medical School, Newcastle upon Tyne, UK
Curr Opin Neurol 15:31-3. 2002..Recent work has investigated sound processing by the unconscious brain; such investigations may provide a 'window' into residual brain function and prognosis... - Tone deafness: a model complex cortical phenotypeTimothy D Griffiths
Newcastle University
Clin Med 8:592-5. 2008..Although tone deafness is not pernicious, the underlying abnormality may prove to be a disorder of cortical connectivity that provides a model for disorders that are more so, such as schizophrenia... - The neural processing of complex soundsT D Griffiths
Departments of Neurology and Physiological Sciences, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
Ann N Y Acad Sci 930:133-42. 2001.... - Cortical processing of complex sound: a way forward?Timothy D Griffiths
Department of Psychology, University College London, London WC1H 0AP, UK
Trends Neurosci 27:181-5. 2004..There is a crucial need for better understanding of the anatomy of the auditory cortex in different species and for comparative studies that will underpin both approaches... - Musical hallucinosis in acquired deafness. Phenomenology and brain substrateT D Griffiths
Department of Neurology, Newcastle University, Newcastle upon Tyne, UK
Brain 123:2065-76. 2000..This network is similar to that previously demonstrated during the normal perception and imagery of patterned-segmented sound, and is consistent with the proposed neuropsychological and neural mechanism... - Encoding of the temporal regularity of sound in the human brainstemT D Griffiths
Centre for the Neural Basis of Hearing, Physiology Department, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK
Nat Neurosci 4:633-7. 2001..This work shows that the process of recoding temporal patterns into a more stable form begins as early as the cochlear nucleus and continues up to auditory cortex... - The Newcastle Auditory Battery (NAB). A temporal and spatial test battery for use on adult naïve subjectsT D Griffiths
Department of Physiological Sciences, Newcastle University Medical School, Newcastle upon Tyne, UK
Hear Res 154:165-9. 2001..Normal values are given for the threshold data for 30 naïve control subjects aged from 20 to 60 years. Future modifications of the battery are allowed by modular software architecture... - The spectrum of hearing loss due to mitochondrial DNA defectsP F Chinnery
Department of Neurology, The University of Newcastle upon Tyne, Newcastle upon Tyne, UK
Brain 123:82-92. 2000..These findings are consistent with a predominantly cochlear origin for the hearing deficit, which is determined by the precise genetic defect and the percentage mutation load... - Analysis of temporal structure in sound by the human brainT D Griffiths
Physiology Department, University of Cambridge, UK
Nat Neurosci 1:422-7. 1998..These results suggest a hierarchical analysis of time structure in the human brain... - Processing the acoustic effect of size in speech soundsK Von Kriegstein
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Neuroimage 32:368-75. 2006.... - The processing of temporal pitch and melody information in auditory cortexRoy D Patterson
Centre for the Neural Basis of Hearing, Physiology Department, University of Cambridge, Downing Street, Cambridge, United Kingdom
Neuron 36:767-76. 2002..The results support the view that there is hierarchy of pitch processing in which the center of activity moves anterolaterally away from primary auditory cortex as the processing of melodic sounds proceeds... - Human brain mechanisms for the early analysis of voicesJ D Warren
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, Queen Square, London WC1N3BG, UK
Neuroimage 31:1389-97. 2006.... 
Hierarchical processing of auditory objects in humansSukhbinder Kumar
Auditory Group, Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
PLoS Comput Biol 3:e100. 2007..The work supports a computational model of auditory object processing, based on the abstraction of spectro-temporal "templates" in the PT before further analysis of the abstracted form in anterior temporal lobe areas...
Mapping unpleasantness of sounds to their auditory representationSukhbinder Kumar
Auditory Group, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne, United Kingdom
J Acoust Soc Am 124:3810-7. 2008..It was observed that the existence region corresponded to spectral frequencies between 2500 and 5500 Hz, and temporal modulations in the range 1-16 Hz...
Task-dependent modulation of medial geniculate body is behaviorally relevant for speech recognitionKatharina von Kriegstein
Wellcome Trust Centre for Neuroimaging, University College London, Queen Square, London WC1N 3BG, UK
Curr Biol 18:1855-9. 2008..Together with studies in nonhuman mammals, our findings imply a mechanism in which the first-order auditory thalamus, possibly by corticothalamic modulation, reacts adaptively to features of sensory input...- Analysis of the spectral envelope of sounds by the human brainJ D Warren
Auditory Group, Medical School, University of Newcastle, Newcastle-upon-Tyne, NE2 4HH, UK
Neuroimage 24:1052-7. 2005..These distinct levels of spectral analysis may represent early computational stages in a putative anteriorly directed stream for the categorization of sound... - Characterization of deficits in pitch perception underlying 'tone deafness'Jessica M Foxton
Auditory Group, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, UK
Brain 127:801-10. 2004..In contrast, no abnormalities were identified in the perceptual organization of pitch. The pitch deficits identified are able to account for the music perception difficulties in this disorder, and implicate deficient cortical processing... - Representation of interaural time delay in the human auditory midbrainSarah K Thompson
Department of Physiology and UCL Ear Institute, University College London, 332 Gray's Inn Road, London WC1X 8EE, UK
Nat Neurosci 9:1096-8. 2006..The data require a new model for human ITD processing... - Characterisation of the BOLD response time course at different levels of the auditory pathway in non-human primatesSimon Baumann
Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK
Neuroimage 50:1099-108. 2010..Furthermore, the data will aid optimal design of future auditory fMRI studies in non-human primates... - Dissociation of duration-based and beat-based auditory timing in cerebellar degenerationManon Grube
Newcastle Auditory Group, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
Proc Natl Acad Sci U S A 107:11597-601. 2010..The findings support the existence of a stopwatch-like cerebellar timing mechanism for absolute intervals that is distinct from mechanisms for entrainment with a regular beat... - Metricality-enhanced temporal encoding and the subjective perception of rhythmic sequencesManon Grube
Newcastle Auditory Group, Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, UK
Cortex 45:72-9. 2009..The data support an increase in the precision of temporal pattern encoding for sequences with a higher-order metrical time framework... - The contribution of the cerebellum to cognition in Spinocerebellar Ataxia Type 6Freya E Cooper
Institute of Neuroscience, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne, UK
Behav Neurol 23:3-15. 2010.... - Training improves acoustic pattern perceptionJessica M Foxton
Auditory Group, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
Curr Biol 14:322-5. 2004..Further studies are required to determine whether pitch-contour training is effective in improving speech and melody perception... - Reading skills are related to global, but not local, acoustic pattern perceptionJessica M Foxton
Auditory Group, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Framlington Place, Newcastle NE2 4HH, UK
Nat Neurosci 6:343-4. 2003 - Absence of auditory 'global interference' in autismJessica M Foxton
School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
Brain 126:2703-9. 2003..This was attributed to the absence of interference from an auditory coherent whole. The results are consistent with the presence of abnormal interactions between local and global auditory perception in ASD... - Orthogonal representation of sound dimensions in the primate midbrainSimon Baumann
Institute of Neuroscience, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
Nat Neurosci 14:423-5. 2011..These representations are organized as a map with two approximately perpendicular axes: one representing increasing temporal rate and the other increasing spectral frequency... - Limbic encephalitis: Not a picture to forgetPatrick F Chinnery
Newcastle upon Tyne, United Kingdom
Neurology 62:1019. 2004 - Psychophysical evaluation of cochlear hair cell damage due to the A3243G mitochondrial DNA mutationT D Griffiths
Newcastle Auditory Group, Department of Physiological Sciences, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, United Kingdom
J Assoc Res Otolaryngol 2:172-9. 2001..The common occurrence of dead regions in the basal cochlea has treatment implication for this form of deafness; such people may not be helped by amplification of high frequencies... - Neural representation of auditory size in the human voice and in sounds from other resonant sourcesKatharina von Kriegstein
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
Curr Biol 17:1123-8. 2007..The results imply that the human voice requires special processing of acoustic scale, whereas the anterior temporal lobe and intraparietal sulcus process auditory size information independent of source category... - Rhythm deficits in 'tone deafness'Jessica M Foxton
Auditory Group, University of Newcastle upon Tyne, Framlington Place, Newcastle NE2 4HH, UK
Brain Cogn 62:24-9. 2006..These results suggest that the rhythm deficits in congenital amusia result from the pitch-variations in music... - Music and the brain: disorders of musical listeningLauren Stewart
Auditory Group, Newcastle University, Newcastle upon Tyne, London, UK
Brain 129:2533-53. 2006..Both the bases for normal musical listening and the clinical assessment of disorders now have a solid grounding in systems neuroscience... - Proton magnetic resonance spectroscopy in frontotemporal dementiaE Coulthard
Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
J Neurol 253:861-8. 2006..This opens up the possibility of using MR spectroscopy as a clinical tool to identify earlier presentations of the condition... - Perception of sound-source motion by the human brainJason D Warren
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Neuron 34:139-48. 2002..The results support the existence of a posteriorly directed temporo-parietal pathway for obligatory perceptual processing of sound-source motion... - Sorting out soundTimothy D Griffiths
Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
Neuron 56:580-1. 2007.... - Course and outcome of acute limbic encephalitis with negative voltage-gated potassium channel antibodiesS R Samarasekera
Royal Victoria Infirmary, Newcastle upon Tyne, UK
J Neurol Neurosurg Psychiatry 78:391-4. 2007..Recent work has highlighted absent serum VGKC-Ab and distinct immunology in patients with the paraneoplastic form of limbic encephalitis... - Central auditory pathologiesTimothy D Griffiths
Newcastle University Medical School, Newcastle-upon-Tyne, UK
Br Med Bull 63:107-20. 2002..Recent work focuses on the assessment of auditory processing in disorders that are not specifically auditory. In this case, auditory measurement may provide a 'window' into the condition... - Sensory systems: auditory action streams?Timothy D Griffiths
Newcastle University Medical School, Framlington Place, Newcastle upon Tyne, UK
Curr Biol 18:R387-8. 2008..Two recent studies suggest the existence of a comparable mechanism in the auditory system... - Direct recordings of pitch responses from human auditory cortexTimothy D Griffiths
Institute of Neuroscience, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
Curr Biol 20:1128-32. 2010..The research suggests that two types of pitch-related activity occur in humans in early auditory cortex: time-locked neural correlates of stimulus regularity and an oscillatory response related to the pitch percept... - Analyzing pitch chroma and pitch height in the human brainJason D Warren
Wellcome Department of Imaging Neuroscience, Institute of Neurology, Queen Square, London, United Kingdom
Ann N Y Acad Sci 999:212-4. 2003.... - Morphometry of the amusic brain: a two-site studyKrista L Hyde
Department of Psychology, University of Montreal, Montreal, Quebec, Canada
Brain 129:2562-70. 2006..Moreover, the data point to the integrity of white matter tracts in right frontal brain areas as being key in acquiring normal musical competence... - A common cortical substrate activated by horizontal and vertical sound movement in the human brainFrancesco Pavani
Institute of Cognitive Neuroscience, University College London, London, United Kingdom
Curr Biol 12:1584-90. 2002..These results demonstrate that sound movement in vertical and horizontal dimensions engages a common processing network in the human cerebral cortex and show that multidimensional spatial properties of sounds are processed at this level... - An information theoretic characterisation of auditory encodingTobias Overath
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, United Kingdom
PLoS Biol 5:e288. 2007..The results establish PT as an efficient neural engine that demands less computational resource to encode redundant signals than those with high information content... - Musically tone-deaf individuals have difficulty discriminating intonation contours extracted from speechAniruddh D Patel
The Neurosciences Institute, San Diego, CA, USA
Brain Cogn 59:310-3. 2005..Thus it appears that the dissociation between spoken and musical pitch perception in tone-deaf individuals is due to a deficit at a higher level than simple pitch-change detection... - A neural basis for the perception of voices in external auditory spaceMichael D Hunter
Sheffield Cognition and Neuroimaging Laboratory, Academic Department of Psychiatry, University of Sheffield, Sheffield, UK
Brain 126:161-9. 2003..Based on this, we suggest a model for the false perception of externally located auditory verbal hallucinations... - Cortical thickness in congenital amusia: when less is better than moreKrista L Hyde
Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
J Neurosci 27:13028-32. 2007..These cortical thickness differences suggest the presence of cortical malformations in the amusic brain, such as abnormal neuronal migration, that may have compromised the normal development of a right frontotemporal pathway...