R D Griffiths

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. ncbi request reprint Glutamine: essential for immune nutrition in the critically ill
    Francis J Andrews
    Department of Medicine, University of Liverpool, UK
    Br J Nutr 87:S3-8. 2002
  2. pmc Nutrition support for patients in the intensive care unit
    R D Griffiths
    Division of Metabolic and Cellular Medicine, School of Clinical Sciences, University of Liverpool, Whiston Hospital, Merseyside, UK
    Postgrad Med J 81:629-36. 2005
  3. pmc Sedation, delirium and psychological distress: let's not be deluded
    Richard D Griffiths
    Musculoskeletal Biology, Institute of Ageing and Chronic Disease, Faculty of Health and Life Sciences, University of Liverpool, Liverpool L69 3GA, UK
    Crit Care 16:109. 2012
  4. pmc Intensive care diaries reduce new onset post traumatic stress disorder following critical illness: a randomised, controlled trial
    Christina Jones
    ICU, Whiston Hospital, Warrington Road, Prescot L35 5DR, UK
    Crit Care 14:R168. 2010
  5. doi request reprint Intensive care unit-acquired weakness
    Richard D Griffiths
    Pathophysiology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom
    Crit Care Med 38:779-87. 2010
  6. pmc Too much of a good thing: the curse of overfeeding
    Richard D Griffiths
    Division of Metabolic and Cellular Medicine, School of Clinical Sciences, University of Liverpool, Liverpool, L69 3GA, UK
    Crit Care 11:176. 2007
  7. ncbi request reprint Seven lessons from 20 years of follow-up of intensive care unit survivors
    Richard D Griffiths
    Division of Metabolic and Cellular Medicine, School of Clinical Science, University of Liverpool, Liverpool, UK
    Curr Opin Crit Care 13:508-13. 2007
  8. ncbi request reprint Delirium, cognitive dysfunction and posttraumatic stress disorder
    Richard D Griffiths
    Division of Metabolic and Cellular Medicine, School of Clinical Science, University of Liverpool, Liverpool, UK
    Curr Opin Anaesthesiol 20:124-9. 2007
  9. ncbi request reprint Is parenteral nutrition really that risky in the intensive care unit?
    Richard D Griffiths
    Intensive Care Research Group, Department of Medicine, Duncan Building, UCD, University of Liverpool, Daulby Street, Liverpool L69 3GA, UK
    Curr Opin Clin Nutr Metab Care 7:175-81. 2004
  10. ncbi request reprint Nutrition support in critically ill septic patients
    Richard D Griffiths
    Intensive Care Research Group, Department of Medicien, University of Liverpool, Marseyside, UK
    Curr Opin Clin Nutr Metab Care 6:203-10. 2003

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Glutamine: essential for immune nutrition in the critically ill
    Francis J Andrews
    Department of Medicine, University of Liverpool, UK
    Br J Nutr 87:S3-8. 2002
    ..A number of trials of patients fed by the enteral or parenteral route have shown improved infectious morbidity when supplemented with glutamine. However, the exact mechanism of glutamine action in these patients remains to be determined...
  2. pmc Nutrition support for patients in the intensive care unit
    R D Griffiths
    Division of Metabolic and Cellular Medicine, School of Clinical Sciences, University of Liverpool, Whiston Hospital, Merseyside, UK
    Postgrad Med J 81:629-36. 2005
    ..Real outcome benefits have been described with the new glutamine containing PN formulations. PN remains important in the presence of gastrointestinal feed intolerance or failure...
  3. pmc Sedation, delirium and psychological distress: let's not be deluded
    Richard D Griffiths
    Musculoskeletal Biology, Institute of Ageing and Chronic Disease, Faculty of Health and Life Sciences, University of Liverpool, Liverpool L69 3GA, UK
    Crit Care 16:109. 2012
    ..Long-term psychological problems are not insignificant and before we can assume benefit or harm of any new approach we must not delude ourselves by using sampling methods that can miss those patients most at risk...
  4. pmc Intensive care diaries reduce new onset post traumatic stress disorder following critical illness: a randomised, controlled trial
    Christina Jones
    ICU, Whiston Hospital, Warrington Road, Prescot L35 5DR, UK
    Crit Care 14:R168. 2010
    ..This study was to evaluate whether a prospectively collected diary of a patient's intensive care unit (ICU) stay when used during convalescence following critical illness will reduce the development of new onset PTSD...
  5. doi request reprint Intensive care unit-acquired weakness
    Richard D Griffiths
    Pathophysiology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom
    Crit Care Med 38:779-87. 2010
    ..Despite the apparent importance of this problem, much remains to be understood about its incidence, causes, prevention, and treatment...
  6. pmc Too much of a good thing: the curse of overfeeding
    Richard D Griffiths
    Division of Metabolic and Cellular Medicine, School of Clinical Sciences, University of Liverpool, Liverpool, L69 3GA, UK
    Crit Care 11:176. 2007
    ..Over-feeding presents a significant metabolic stress but tight glycaemic control is now masking the traditional warning signs and does not on its own negate the need to give patients the right amount at the right time...
  7. ncbi request reprint Seven lessons from 20 years of follow-up of intensive care unit survivors
    Richard D Griffiths
    Division of Metabolic and Cellular Medicine, School of Clinical Science, University of Liverpool, Liverpool, UK
    Curr Opin Crit Care 13:508-13. 2007
    ..Through a personal narrative, the authors discuss the lessons they have learned from 20 years of intensive care follow-up and rehabilitation...
  8. ncbi request reprint Delirium, cognitive dysfunction and posttraumatic stress disorder
    Richard D Griffiths
    Division of Metabolic and Cellular Medicine, School of Clinical Science, University of Liverpool, Liverpool, UK
    Curr Opin Anaesthesiol 20:124-9. 2007
    ..Simple tools are now available to recognise such problems. This review highlights neuropsychiatric and cognitive observations that have direct relevance to patient care and outcome...
  9. ncbi request reprint Is parenteral nutrition really that risky in the intensive care unit?
    Richard D Griffiths
    Intensive Care Research Group, Department of Medicine, Duncan Building, UCD, University of Liverpool, Daulby Street, Liverpool L69 3GA, UK
    Curr Opin Clin Nutr Metab Care 7:175-81. 2004
    ..This review attempts to dispel these myths and compares and contrasts the risks of enteral nutrition with those of parenteral nutrition in the critically ill...
  10. ncbi request reprint Nutrition support in critically ill septic patients
    Richard D Griffiths
    Intensive Care Research Group, Department of Medicien, University of Liverpool, Marseyside, UK
    Curr Opin Clin Nutr Metab Care 6:203-10. 2003
    ..How nutritional therapy can effect real clinical outcomes is not easily apparent from the clinical data. Despite reducing infectious incidence, many studies show little difference in meaningful clinical outcomes...
  11. ncbi request reprint Glutamine: establishing clinical indications
    R D Griffiths
    Department of Medicine, University of Liverpool, UK
    Curr Opin Clin Nutr Metab Care 2:177-82. 1999
    ..A number of new clinical studies of glutamine supplementation have shown interesting outcomes that should be influencing clinical decision-making...
  12. ncbi request reprint Infection, multiple organ failure, and survival in the intensive care unit: influence of glutamine-supplemented parenteral nutrition on acquired infection
    Richard D Griffiths
    Intensive Care Research Group, Department of Medicine, University of Liverpool, Duncan Building, UCDF, Daulby Street, Liverpool L69 3GA, UK
    Nutrition 18:546-52. 2002
    ..We investigated the effect of a glutamine-supplemented parenteral nutrition on intensive-care-acquired infection (ICAI) and its relation to outcome...
  13. ncbi request reprint The evidence for glutamine use in the critically-ill
    R D Griffiths
    Intensive Care Research Group, Department of Medicine, University of Liverpool, UK
    Proc Nutr Soc 60:403-10. 2001
    ..In the critically-ill it is associated with improvements in immune function, and improved survival from infection leading to an overall improved outcome...
  14. ncbi request reprint Contractile activity-induced oxidative stress: cellular origin and adaptive responses
    A McArdle
    Department of Medicine, University of Liverpool, Liverpool L69 3GA, United Kingdom
    Am J Physiol Cell Physiol 280:C621-7. 2001
    ..These changes occurred in the absence of overt damage to the muscle cells...
  15. ncbi request reprint Memory, delusions, and the development of acute posttraumatic stress disorder-related symptoms after intensive care
    C Jones
    Intensive Care Research Group, The Department of Medicine, University of Liverpool, UK
    Crit Care Med 29:573-80. 2001
    ..This study suggests that even relatively unpleasant memories for real events during critical illness may give some protection from anxiety and the later development of PTSD-related symptoms when memories of delusions are prominent...
  16. ncbi request reprint Smoking cessation through comprehensive critical care
    C Jones
    Intensive Care Research Group, Department of Medicine, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    Intensive Care Med 27:1547-9. 2001
    ..At the 6-month follow-up, previous smokers given the rehabilitation package had a relative risk reduction for smoking of 89% (CI 98%-36%). Smoking cessation after critical illness is aided by the provision of a rehabilitation programme...
  17. ncbi request reprint Use of a screening questionnaire for post-traumatic stress disorder (PTSD) on a sample of UK ICU patients
    E Twigg
    Psychological Services Paediatrics, Royal Liverpool Children s Hospital, Liverpool, UK
    Acta Anaesthesiol Scand 52:202-8. 2008
    ..The aim of the study was to conduct a preliminary validation of such a measure, the UK- Post-Traumatic Stress Syndrome 14-Questions Inventory (UK-PTSS-14)...
  18. ncbi request reprint Specialized nutrition support in the critically ill: for whom and when?
    Richard D Griffiths
    Department of Medicine, University of Liverpool, UK
    Nestle Nutr Workshop Ser Clin Perform Programme 7:199-214; discussion 214-7. 2002
  19. ncbi request reprint Exogenous glutamine: the clinical evidence
    Thomas Bongers
    Division of Metabolic and Cellular Medicine, School of Clinical Science, University of Liverpool, UK
    Crit Care Med 35:S545-52. 2007
    ..However, the benefit of exogenous glutamine on morbidity and mortality is not universally accepted. This review critically appraises the current clinical evidence regarding glutamine supplementation in critical illness...
  20. ncbi request reprint Are there any real differences between enteral feed formulations used in the critically ill?
    Thomas Bongers
    ICU Whiston Hospital and School of Clinical Science, University of Liverpool, Liverpool, UK
    Curr Opin Crit Care 12:131-5. 2006
    ..The purpose of this review is to highlight recent advances in enteral nutrition in the critically ill adult patient...
  21. ncbi request reprint Significant cognitive dysfunction in non-delirious patients identified during and persisting following critical illness
    Christina Jones
    Whiston Hospital, Intensive Care Unit, L35 5DR, Prescot, UK
    Intensive Care Med 32:923-6. 2006
    ..Recent studies have shown significant cognitive problems some months after critical illness. However there has been no research examining cognitive function within the intensive care unit (ICU) in non-delirious patients...
  22. ncbi request reprint Specialized nutrition support in critically ill patients
    Richard D Griffiths
    Department of Medicine, University of Liverpool, Whiston Hospital, Merseyside, UK
    Curr Opin Crit Care 9:249-59. 2003
    ..Encouraging new evidence is starting to show that outcome can be improved by implementing relatively simple therapies well that have an impact on nutrition and metabolic control...
  23. ncbi request reprint Measurement of free radical production by in vivo microdialysis during ischemia/reperfusion injury to skeletal muscle
    D Pattwell
    Department of Medicine, University of Liverpool, Liverpool, UK
    Free Radic Biol Med 30:979-85. 2001
    ....
  24. ncbi request reprint Elevated core and muscle temperature to levels comparable to exercise do not increase heat shock protein content of skeletal muscle of physically active men
    J P Morton
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Acta Physiol (Oxf) 190:319-27. 2007
    ..The aim of the present study was to therefore investigate the role of increased muscle and core temperature in contributing to the exercise-induced production of the major HSP families in human skeletal muscle...
  25. doi request reprint Muscle in defense
    Adam Lightfoot
    School of Clinical Science, University of Liverpool, Liverpool, UK
    Crit Care Med 37:S384-90. 2009
    ..Skeletal muscle is a major contributor to whole-body glucose and protein metabolism, exemplified by its role in nutrient provision for the immune system and other rapidly dividing tissues through glutamine production...
  26. ncbi request reprint Rehabilitation after critical illness: a randomized, controlled trial
    Christina Jones
    Department of Medicine, University of Liverpool, and the Intensive Care Unit, Whiston Hospital, Prescot, UK
    Crit Care Med 31:2456-61. 2003
    ..To evaluate the effectiveness of a rehabilitation program following critical illness to aid physical and psychological recovery...
  27. ncbi request reprint Patient and caregiver counselling after the intensive care unit: what are the needs and how should they be met?
    Christina Jones
    Critical Care Unit, Whiston Hospital, Prescot, Liverpool, UK
    Curr Opin Crit Care 13:503-7. 2007
    ..To examine current research on the psychological needs of both patients and their families following critical illness, and discuss how these may be met in a cost-effective manner...
  28. ncbi request reprint Post-traumatic stress disorder-related symptoms in relatives of patients following intensive care
    Christina Jones
    Department of Medicine, Intensive Care Research Group, University of Liverpool, Liverpool, Merseyside L69 3GA, UK
    Intensive Care Med 30:456-60. 2004
    ..To evaluate the effectiveness of the provision of information in the form of a rehabilitation program following critical illness in reducing psychological distress in the patients' close family...
  29. ncbi request reprint Precipitants of post-traumatic stress disorder following intensive care: a hypothesis generating study of diversity in care
    C Jones
    University of Liverpool, Intensive Care Research Group, Division of Metabolic and Cellular Medicine, School of Clinical Sciences, Faculty of Medicine, L69 3GA Liverpool, UK
    Intensive Care Med 33:978-85. 2007
    ..This prospective observational study was designed to explore the relationships between post-traumatic stress disorder (PTSD), patients' memories of the intensive care unit (ICU) and sedation practices...
  30. pmc Effect of vitamin C supplements on antioxidant defence and stress proteins in human lymphocytes and skeletal muscle
    M Khassaf
    Department of Medicine, University of Liverpool, Liverpool L69 3GA, UK
    J Physiol 549:645-52. 2003
    ....
  31. ncbi request reprint The impact of current media events on hallucinatory content: the experience of the intensive care unit (ICU) patient
    Paul Skirrow
    Intensive Care Research Group, Department of Clinical Psychology, University of Liverpool, Daulby Street, Liverpool L69 3GA, UK
    Br J Clin Psychol 41:87-91. 2002
    ..To investigate the influence of current media events on hallucinatory content in ICU patients...
  32. ncbi request reprint The intensive care experience: what really matters?
    Richard D Griffiths
    Crit Care Med 36:2945-6. 2008
  33. ncbi request reprint Keeping up the defenses
    Richard D Griffiths
    Nutrition 20:587-9. 2004
  34. ncbi request reprint Parenteral nutrition in adults with a functional gastrointestinal tract
    Richard D Griffiths
    Lancet 368:1868. 2006
  35. ncbi request reprint Glutamine and tight glycemic control: chicken or egg?
    Richard D Griffiths
    Crit Care Med 36:1965-6. 2008