Paul D Griffiths

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Cytomegalovirus replication kinetics in solid organ transplant recipients managed by preemptive therapy
    S F Atabani
    Division of Infection and Immunity, Centre for Virology, Royal Free NHS Trust and UCL Medical School, London, UK
    Am J Transplant 12:2457-64. 2012
  2. ncbi request reprint Desirability and feasibility of a vaccine against cytomegalovirus
    Paul Griffiths
    University College London, UK
    Vaccine 31:B197-203. 2013
  3. doi request reprint Burden of disease associated with human cytomegalovirus and prospects for elimination by universal immunisation
    Paul D Griffiths
    Centre for Virology, UCL Medical School, London NW3 2PF, UK
    Lancet Infect Dis 12:790-8. 2012
  4. ncbi request reprint Importance of cytomegalovirus viraemia in risk of disease progression and death in HIV-infected patients receiving highly active antiretroviral therapy
    Jane R Deayton
    Department of Virology, Royal Free and University College Medical School of University College London, Royal Free Campus, London, UK
    Lancet 363:2116-21. 2004
  5. ncbi request reprint The prevalence of chromosomally integrated human herpesvirus 6 genomes in the blood of UK blood donors
    Hoe Nam Leong
    Division of Infection and Immunity, Centre for Virology, Hampstead Campus, Royal Free and University College Medical School, London, UK
    J Med Virol 79:45-51. 2007
  6. pmc Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: a phase 2 randomised placebo-controlled trial
    Paul D Griffiths
    Centre for Virology, UCL Medical School, London, UK
    Lancet 377:1256-63. 2011
  7. pmc Human herpesvirus 6 chromosomal integration in immunocompetent patients results in high levels of viral DNA in blood, sera, and hair follicles
    Katherine N Ward
    Centre for Virology, Division of Infection and Immunity, Royal Free and University College Medical School UCL Campus, Windeyer Institute of Medical Sciences, 46 Cleveland St, London W1T 4JF, United Kingdom
    J Clin Microbiol 44:1571-4. 2006
  8. ncbi request reprint Susceptibility of porcine cytomegalovirus to antiviral drugs
    Jacqueline F L Fryer
    Centre for Virology, Department of Infection, Royal Free and University College Medical School of UCL, Hampstead Site, Rowland Hill Street, London NW3 2PF, UK
    J Antimicrob Chemother 53:975-80. 2004
  9. ncbi request reprint Porcine cytomegalovirus in pigs being bred for xenograft organs: progress towards control
    Duncan A Clark
    Department of Virology, Royal Free and University College Medical School of UCL, Royal Free Campus, London, UK
    Xenotransplantation 10:142-8. 2003
  10. ncbi request reprint Rapid reconstitution of humoral immunity against cytomegalovirus but not HIV following highly active antiretroviral therapy
    Jane R Deayton
    Department of Virology, Royal Free Hampstead NHS Trust and Royal Free and University College School of Medicine, London, UK
    AIDS 16:2129-35. 2002

Collaborators

Detail Information

Publications24

  1. pmc Cytomegalovirus replication kinetics in solid organ transplant recipients managed by preemptive therapy
    S F Atabani
    Division of Infection and Immunity, Centre for Virology, Royal Free NHS Trust and UCL Medical School, London, UK
    Am J Transplant 12:2457-64. 2012
    ..Overall, our findings provide quantitative biomarkers which can be used in pharmacodynamic assessments of the ability of novel CMV vaccines or antiviral drugs to reduce or even interrupt such transmission...
  2. ncbi request reprint Desirability and feasibility of a vaccine against cytomegalovirus
    Paul Griffiths
    University College London, UK
    Vaccine 31:B197-203. 2013
    ..In addition, prospective recipients of transplants and patients with AIDS would be expected to benefit...
  3. doi request reprint Burden of disease associated with human cytomegalovirus and prospects for elimination by universal immunisation
    Paul D Griffiths
    Centre for Virology, UCL Medical School, London NW3 2PF, UK
    Lancet Infect Dis 12:790-8. 2012
    ..This action should control disease in neonates and transplant recipients and could provide substantial additional benefits if other disease associations prove to be causal...
  4. ncbi request reprint Importance of cytomegalovirus viraemia in risk of disease progression and death in HIV-infected patients receiving highly active antiretroviral therapy
    Jane R Deayton
    Department of Virology, Royal Free and University College Medical School of University College London, Royal Free Campus, London, UK
    Lancet 363:2116-21. 2004
    ..We have investigated whether cytomegalovirus viraemia remains a significant risk factor for progression of HIV disease and death in the era of HAART...
  5. ncbi request reprint The prevalence of chromosomally integrated human herpesvirus 6 genomes in the blood of UK blood donors
    Hoe Nam Leong
    Division of Infection and Immunity, Centre for Virology, Hampstead Campus, Royal Free and University College Medical School, London, UK
    J Med Virol 79:45-51. 2007
    ..8% of UK blood donors. The presence of high HHV-6 viral loads in healthy normal individuals reiterates the need to consider the confounding effect of HHV-6 viral integration in any laboratory diagnosis of HHV-6 infection...
  6. pmc Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: a phase 2 randomised placebo-controlled trial
    Paul D Griffiths
    Centre for Virology, UCL Medical School, London, UK
    Lancet 377:1256-63. 2011
    ..Values of viral load correlate with development of end-organ disease and are moderated by pre-existing natural immunity. Our aim was to determine whether vaccine-induced immunity could do likewise...
  7. pmc Human herpesvirus 6 chromosomal integration in immunocompetent patients results in high levels of viral DNA in blood, sera, and hair follicles
    Katherine N Ward
    Centre for Virology, Division of Infection and Immunity, Royal Free and University College Medical School UCL Campus, Windeyer Institute of Medical Sciences, 46 Cleveland St, London W1T 4JF, United Kingdom
    J Clin Microbiol 44:1571-4. 2006
    ..The characteristically high HHV-6 DNA levels in chromosomal integration may confound laboratory diagnosis of HHV-6 infection and should be given due consideration...
  8. ncbi request reprint Susceptibility of porcine cytomegalovirus to antiviral drugs
    Jacqueline F L Fryer
    Centre for Virology, Department of Infection, Royal Free and University College Medical School of UCL, Hampstead Site, Rowland Hill Street, London NW3 2PF, UK
    J Antimicrob Chemother 53:975-80. 2004
    ..We therefore investigated the effect of selected antiviral agents, currently licensed for the treatment of human herpesvirus infections, on PCMV replication...
  9. ncbi request reprint Porcine cytomegalovirus in pigs being bred for xenograft organs: progress towards control
    Duncan A Clark
    Department of Virology, Royal Free and University College Medical School of UCL, Royal Free Campus, London, UK
    Xenotransplantation 10:142-8. 2003
    ..Our findings demonstrate that PCMV could be eradicated from pig herds being bred for xenotransplantation and argue that the spleen from donor animals should be examined as part of quality control procedures if clinical trials proceed...
  10. ncbi request reprint Rapid reconstitution of humoral immunity against cytomegalovirus but not HIV following highly active antiretroviral therapy
    Jane R Deayton
    Department of Virology, Royal Free Hampstead NHS Trust and Royal Free and University College School of Medicine, London, UK
    AIDS 16:2129-35. 2002
    ....
  11. doi request reprint Extensive human cytomegalovirus (HCMV) genomic DNA in the renal tubular epithelium early after renal transplantation: Relationship with HCMV DNAemia and long-term graft function
    Ying Ting Li
    Department of Infection, University College Medical School Campus, Rowland Hill Street, Hampstead, London, UK
    J Med Virol 82:85-93. 2010
    ..HCMV DNA is frequently detected in renal tubular epithelial cells early after renal transplantation, precedes DNAemia and is associated with poor long-term graft function...
  12. ncbi request reprint CMV as a cofactor enhancing progression of AIDS
    Paul D Griffiths
    Centre for Virology, The Royal Free and University College Medical School, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK
    J Clin Virol 35:489-92. 2006
    ..Potential mechanisms which CMV could use as a cofactor have been described in vitro and potential criteria for assessing cofactor activity in vivo have been proposed...
  13. ncbi request reprint Cytomegalovirus
    Paul D Griffiths
    Centre for Virology, Royal Free and University College Medical School, London, UK
    Curr Opin Infect Dis 18:241-5. 2005
    ..To identify recent developments in the management of congenital cytomegalovirus infection which continues to exact a heavy toll on the developing central nervous system...
  14. doi request reprint A perspective on antiviral resistance
    Paul D Griffiths
    Centre for Virology, UCL Medical School, Rowland Hill Street, London NW3 2PF, United Kingdom
    J Clin Virol 46:3-8. 2009
    ....
  15. doi request reprint Microarray-based determination of the lytic cascade of human herpesvirus 6B
    Edward H Tsao
    Department of Infection, Division of Infection and Immunity, Royal Free and University College Medical School of UCL, London, UK
    J Gen Virol 90:2581-91. 2009
    ..Clustering of genes with similar expression profiles implied a shared function, thus revealing possible roles of previously uncharacterized HHV-6B genes...
  16. ncbi request reprint Transmission of integrated human herpesvirus 6 through stem cell transplantation: implications for laboratory diagnosis
    Duncan A Clark
    Centre for Virology, Division of Infection and Immunity, Royal Free and University College Medical School, London, United Kingdom
    J Infect Dis 193:912-6. 2006
    ..We suggest that the confounding influence of integration be considered in laboratory investigations associating HHV-6 with disease...
  17. ncbi request reprint Cytomegalovirus, human herpesvirus-6, and human herpesvirus-7 in hematological patients
    Duncan A Clark
    Department of Virology, Royal Free and University College Medical School of UCL, London, UK
    Semin Hematol 40:154-62. 2003
    ..Both of these newer herpesviruses are potentially susceptible to existing and licensed antiherpesvirus drugs...
  18. ncbi request reprint Antivirals in the transplant setting
    Paul D Griffiths
    Centre for Virology, Department of Infection, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, United Kingdom
    Antiviral Res 71:192-200. 2006
    ..This article will briefly summaries which viruses are important following transplantation and outline the evidence-base from randomized controlled clinical trails for the deployment of antiviral drugs to prevent viral diseases...
  19. ncbi request reprint Human cytomegalovirus (HCMV) replication dynamics in HCMV-naive and -experienced immunocompromised hosts
    Vincent C Emery
    Royal Free and University College Medical School, Dept of Virology, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    J Infect Dis 185:1723-8. 2002
    ....
  20. ncbi request reprint Human herpesvirus 6: relevance of infection in the immunocompromised host
    Duncan A Clark
    Department of Virology, Royal Free and University College Medical School of UCL, Royal Free Campus, London, UK
    Br J Haematol 120:384-95. 2003
  21. ncbi request reprint Strategies to prevent CMV infection in the neonate
    Paul D Griffiths
    Department of Virology, Royal Free Campus, Royal Free and University College Medical School, London, UK
    Semin Neonatol 7:293-9. 2002
    ....
  22. ncbi request reprint Resistance in viruses other than HIV
    Paul D Griffiths
    Royal Free and University College Medical School of UCL, London, UK
    Int J Infect Dis 6:S32-7. 2002
    ..Specific examples will be chosen to emphasize basic principles of the development of resistance and readers are referred elsewhere to a summary of resistance in HIV that follows the same principles...
  23. doi request reprint Sequence flexibility of the immunodominant HLA A*0201 restricted ppUL83 CD8 T-cell epitope of human cytomegalovirus
    Jakub Kopycinski
    Department of Infection, Centre for Virology, University College London, Hampstead, London, UK
    J Med Virol 82:94-103. 2010
    ..We subsequently investigated whether mutations of the HLA A*0201 epitope were evident in immunocompromized patients experiencing either rapid exponential or persistent cytomegalovirus replication...
  24. ncbi request reprint The 2001 Garrod lecture. The treatment of cytomegalovirus infection
    Paul D Griffiths
    Department of Virology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    J Antimicrob Chemother 49:243-53. 2002
    ..The controlled clinical trials performed to date will be summarized, together with suggestions about pharmacodynamic evaluations in the future...