Paul D Griffiths

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Desirability and feasibility of a vaccine against cytomegalovirus
    Paul Griffiths
    University College London, UK
    Vaccine 31:B197-203. 2013
  2. doi request reprint Burden of disease associated with human cytomegalovirus and prospects for elimination by universal immunisation
    Paul D Griffiths
    Centre for Virology, UCL Medical School, London NW3 2PF, UK
    Lancet Infect Dis 12:790-8. 2012
  3. pmc Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: a phase 2 randomised placebo-controlled trial
    Paul D Griffiths
    Centre for Virology, UCL Medical School, London, UK
    Lancet 377:1256-63. 2011
  4. ncbi request reprint Cytomegalovirus
    Paul D Griffiths
    Centre for Virology, Royal Free and University College Medical School, London, UK
    Curr Opin Infect Dis 18:241-5. 2005
  5. ncbi request reprint Susceptibility of porcine cytomegalovirus to antiviral drugs
    Jacqueline F L Fryer
    Centre for Virology, Department of Infection, Royal Free and University College Medical School of UCL, Hampstead Site, Rowland Hill Street, London NW3 2PF, UK
    J Antimicrob Chemother 53:975-80. 2004
  6. ncbi request reprint The prevalence of chromosomally integrated human herpesvirus 6 genomes in the blood of UK blood donors
    Hoe Nam Leong
    Division of Infection and Immunity, Centre for Virology, Hampstead Campus, Royal Free and University College Medical School, London, UK
    J Med Virol 79:45-51. 2007
  7. ncbi request reprint Antivirals in the transplant setting
    Paul D Griffiths
    Centre for Virology, Department of Infection, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, United Kingdom
    Antiviral Res 71:192-200. 2006
  8. ncbi request reprint CMV as a cofactor enhancing progression of AIDS
    Paul D Griffiths
    Centre for Virology, The Royal Free and University College Medical School, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK
    J Clin Virol 35:489-92. 2006
  9. ncbi request reprint Human cytomegalovirus (HCMV) replication dynamics in HCMV-naive and -experienced immunocompromised hosts
    Vincent C Emery
    Royal Free and University College Medical School, Dept of Virology, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    J Infect Dis 185:1723-8. 2002
  10. doi request reprint A perspective on antiviral resistance
    Paul D Griffiths
    Centre for Virology, UCL Medical School, Rowland Hill Street, London NW3 2PF, United Kingdom
    J Clin Virol 46:3-8. 2009

Detail Information

Publications12

  1. doi request reprint Desirability and feasibility of a vaccine against cytomegalovirus
    Paul Griffiths
    University College London, UK
    Vaccine 31:B197-203. 2013
    ..In addition, prospective recipients of transplants and patients with AIDS would be expected to benefit...
  2. doi request reprint Burden of disease associated with human cytomegalovirus and prospects for elimination by universal immunisation
    Paul D Griffiths
    Centre for Virology, UCL Medical School, London NW3 2PF, UK
    Lancet Infect Dis 12:790-8. 2012
    ..This action should control disease in neonates and transplant recipients and could provide substantial additional benefits if other disease associations prove to be causal...
  3. pmc Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: a phase 2 randomised placebo-controlled trial
    Paul D Griffiths
    Centre for Virology, UCL Medical School, London, UK
    Lancet 377:1256-63. 2011
    ..Values of viral load correlate with development of end-organ disease and are moderated by pre-existing natural immunity. Our aim was to determine whether vaccine-induced immunity could do likewise...
  4. ncbi request reprint Cytomegalovirus
    Paul D Griffiths
    Centre for Virology, Royal Free and University College Medical School, London, UK
    Curr Opin Infect Dis 18:241-5. 2005
    ..To identify recent developments in the management of congenital cytomegalovirus infection which continues to exact a heavy toll on the developing central nervous system...
  5. ncbi request reprint Susceptibility of porcine cytomegalovirus to antiviral drugs
    Jacqueline F L Fryer
    Centre for Virology, Department of Infection, Royal Free and University College Medical School of UCL, Hampstead Site, Rowland Hill Street, London NW3 2PF, UK
    J Antimicrob Chemother 53:975-80. 2004
    ..We therefore investigated the effect of selected antiviral agents, currently licensed for the treatment of human herpesvirus infections, on PCMV replication...
  6. ncbi request reprint The prevalence of chromosomally integrated human herpesvirus 6 genomes in the blood of UK blood donors
    Hoe Nam Leong
    Division of Infection and Immunity, Centre for Virology, Hampstead Campus, Royal Free and University College Medical School, London, UK
    J Med Virol 79:45-51. 2007
    ..8% of UK blood donors. The presence of high HHV-6 viral loads in healthy normal individuals reiterates the need to consider the confounding effect of HHV-6 viral integration in any laboratory diagnosis of HHV-6 infection...
  7. ncbi request reprint Antivirals in the transplant setting
    Paul D Griffiths
    Centre for Virology, Department of Infection, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, United Kingdom
    Antiviral Res 71:192-200. 2006
    ..This article will briefly summaries which viruses are important following transplantation and outline the evidence-base from randomized controlled clinical trails for the deployment of antiviral drugs to prevent viral diseases...
  8. ncbi request reprint CMV as a cofactor enhancing progression of AIDS
    Paul D Griffiths
    Centre for Virology, The Royal Free and University College Medical School, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK
    J Clin Virol 35:489-92. 2006
    ..Potential mechanisms which CMV could use as a cofactor have been described in vitro and potential criteria for assessing cofactor activity in vivo have been proposed...
  9. ncbi request reprint Human cytomegalovirus (HCMV) replication dynamics in HCMV-naive and -experienced immunocompromised hosts
    Vincent C Emery
    Royal Free and University College Medical School, Dept of Virology, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    J Infect Dis 185:1723-8. 2002
    ....
  10. doi request reprint A perspective on antiviral resistance
    Paul D Griffiths
    Centre for Virology, UCL Medical School, Rowland Hill Street, London NW3 2PF, United Kingdom
    J Clin Virol 46:3-8. 2009
    ....
  11. doi request reprint Sequence flexibility of the immunodominant HLA A*0201 restricted ppUL83 CD8 T-cell epitope of human cytomegalovirus
    Jakub Kopycinski
    Department of Infection, Centre for Virology, University College London, Hampstead, London, UK
    J Med Virol 82:94-103. 2010
    ..We subsequently investigated whether mutations of the HLA A*0201 epitope were evident in immunocompromized patients experiencing either rapid exponential or persistent cytomegalovirus replication...
  12. ncbi request reprint The 2001 Garrod lecture. The treatment of cytomegalovirus infection
    Paul D Griffiths
    Department of Virology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    J Antimicrob Chemother 49:243-53. 2002
    ..The controlled clinical trials performed to date will be summarized, together with suggestions about pharmacodynamic evaluations in the future...