Christopher E M Griffiths

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. pmc Impaired Langerhans cell migration in psoriasis
    Marie Cumberbatch
    Syngenta Central Toxicology Laboratory, Macclesfield, Cheshire, SK10 4TJ, England, UK
    J Exp Med 203:953-60. 2006
  2. pmc Chemical consequences of cutaneous photoageing
    Sarah A Thurstan
    Developmental Biomedicine Research Groups, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    Chem Cent J 6:34. 2012
  3. doi request reprint Does p40-targeted therapy represent a significant evolution in the management of plaque psoriasis?
    Christopher E M Griffiths
    Dermatology Centre, Salford Royal Hospital, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    J Eur Acad Dermatol Venereol 26:2-8. 2012
  4. doi request reprint Comparing biological therapies in psoriasis: implications for clinical practice
    C E M Griffiths
    Dermatological Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    J Eur Acad Dermatol Venereol 24:10-4. 2010
  5. ncbi request reprint A classification of psoriasis vulgaris according to phenotype
    C E M Griffiths
    Dermatology Centre, The University of Manchester, Hope Hospital, Salford, Manchester, UK
    Br J Dermatol 156:258-62. 2007
  6. doi request reprint Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis
    Christopher E M Griffiths
    University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
    N Engl J Med 362:118-28. 2010
  7. ncbi request reprint Update on the use of ciclosporin in immune-mediated dermatoses
    C E M Griffiths
    Dermatology Centre, University of Manchester, Hope Hospital, Manchester, UK
    Br J Dermatol 155:1-16. 2006
  8. ncbi request reprint Pathogenesis and clinical features of psoriasis
    Christopher E M Griffiths
    Dermatology Centre, Hope Hospital, University of Manchester, Manchester M6 8HD, UK
    Lancet 370:263-71. 2007
  9. ncbi request reprint The impact of psoriasis guidelines on appropriateness of referral from primary to secondary care: a randomized controlled trial
    C E M Griffiths
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Br J Dermatol 155:393-400. 2006
  10. ncbi request reprint Evidence for common genetic control in pathways of inflammation for Crohn's disease and psoriatic arthritis
    Pauline Ho
    University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Arthritis Rheum 52:3596-602. 2005

Detail Information

Publications138 found, 100 shown here

  1. pmc Impaired Langerhans cell migration in psoriasis
    Marie Cumberbatch
    Syngenta Central Toxicology Laboratory, Macclesfield, Cheshire, SK10 4TJ, England, UK
    J Exp Med 203:953-60. 2006
    ..Although a role for altered dynamics of LC migration/turnover has not been formally excluded, these data reveal a very consistent decrement of LC function in psoriasis that may play a decisive role in disease pathogenesis...
  2. pmc Chemical consequences of cutaneous photoageing
    Sarah A Thurstan
    Developmental Biomedicine Research Groups, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    Chem Cent J 6:34. 2012
    ....
  3. doi request reprint Does p40-targeted therapy represent a significant evolution in the management of plaque psoriasis?
    Christopher E M Griffiths
    Dermatology Centre, Salford Royal Hospital, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    J Eur Acad Dermatol Venereol 26:2-8. 2012
    ..Registries incorporating rigorous pharmacovigilance are now required to further understand the clinical profile of these drugs over long-term use...
  4. doi request reprint Comparing biological therapies in psoriasis: implications for clinical practice
    C E M Griffiths
    Dermatological Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    J Eur Acad Dermatol Venereol 24:10-4. 2010
    ..The level of response was consistent with previously published data for both drugs, and may have important implications for the management of psoriasis...
  5. ncbi request reprint A classification of psoriasis vulgaris according to phenotype
    C E M Griffiths
    Dermatology Centre, The University of Manchester, Hope Hospital, Salford, Manchester, UK
    Br J Dermatol 156:258-62. 2007
    ..A meeting of the International Psoriasis Council produced a consensus on clinical phenotypes of psoriasis equally relevant to clinical practitioners and psoriasis researchers...
  6. doi request reprint Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis
    Christopher E M Griffiths
    University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
    N Engl J Med 362:118-28. 2010
    ..We compared two biologic agents, ustekinumab (an interleukin-12 and interleukin-23 blocker) and etanercept (an inhibitor of tumor necrosis factor alpha), for the treatment of psoriasis...
  7. ncbi request reprint Update on the use of ciclosporin in immune-mediated dermatoses
    C E M Griffiths
    Dermatology Centre, University of Manchester, Hope Hospital, Manchester, UK
    Br J Dermatol 155:1-16. 2006
    ..The risk of potential adverse events associated with ciclosporin is greatly reduced if current treatment and monitoring guidelines are followed...
  8. ncbi request reprint Pathogenesis and clinical features of psoriasis
    Christopher E M Griffiths
    Dermatology Centre, Hope Hospital, University of Manchester, Manchester M6 8HD, UK
    Lancet 370:263-71. 2007
    ..A more complete understanding of underlying pathomechanisms is leading to new treatments, which will be discussed in the second part of this Series...
  9. ncbi request reprint The impact of psoriasis guidelines on appropriateness of referral from primary to secondary care: a randomized controlled trial
    C E M Griffiths
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Br J Dermatol 155:393-400. 2006
    ..There is a marked variation in the frequency of referrals between practices reflecting, in part, inadequate training of general practitioners (GPs) in the management of psoriasis...
  10. ncbi request reprint Evidence for common genetic control in pathways of inflammation for Crohn's disease and psoriatic arthritis
    Pauline Ho
    University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Arthritis Rheum 52:3596-602. 2005
    ..The SLC22A4 gene has also been associated with rheumatoid arthritis. This study was undertaken to further elucidate associations of PsA with Crohn's disease susceptibility genes...
  11. ncbi request reprint Measurement of cytokine expression and Langerhans cell migration in human skin following suction blister formation
    Rebecca J Dearman
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Exp Dermatol 13:452-60. 2004
    ..In conclusion, the suction blister technique appears to be a powerful tool for measurement of induced changes in cutaneous cytokines...
  12. doi request reprint Genetic variation in efflux transporters influences outcome to methotrexate therapy in patients with psoriasis
    Richard B Warren
    Dermatological Sciences, The University of Manchester, Salford Royal Hospital, Manchester, UK
    J Invest Dermatol 128:1925-9. 2008
    ..2 (95% confidence interval: 1.3-3.6; P=0.001) for developing toxicity to methotrexate. These data indicate that knowledge of SNPs in genes relevant to methotrexate efflux may be important in selecting patients suitable for this therapy...
  13. ncbi request reprint Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene
    Anne Hinks
    University of Manchester, Manchester, UK
    Arthritis Rheum 52:1694-9. 2005
    ....
  14. ncbi request reprint The effects of acute social stress on epidermal Langerhans' cell frequency and expression of cutaneous neuropeptides
    C Elise Kleyn
    Dermatological Sciences, The University of Manchester, Manchester, UK
    J Invest Dermatol 128:1273-9. 2008
    ..These data suggest that acute social stress reduces epidermal LC frequency and modulates cutaneous neuropeptide expression thereby supporting the concept of a "brain-skin" axis...
  15. ncbi request reprint Diminished neural and cognitive responses to facial expressions of disgust in patients with psoriasis: a functional magnetic resonance imaging study
    C Elise Kleyn
    Dermatological Sciences, The University of Manchester, Manchester, UK
    J Invest Dermatol 129:2613-9. 2009
    ..We hypothesize that patients with psoriasis, in this case male patients, develop a coping mechanism to protect them from stressful emotional responses by blocking the processing of disgusted facial expressions...
  16. ncbi request reprint Biological therapy for psoriasis
    Suzanne E Clements
    The Dermatology Centre, The University of Manchester, Hope Hospital, Salford
    Br J Hosp Med (Lond) 67:184-7. 2006
  17. ncbi request reprint Targeting cognitive-behaviour therapy to patients' implicit model of psoriasis: results from a patient preference controlled trial
    Donal G Fortune
    Department of Behavioural Medicine, Hope Hospital, Salford, Manchester, UK
    Br J Clin Psychol 43:65-82. 2004
    ....
  18. ncbi request reprint Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis
    Helen S Young
    The Dermatology Centre, The University of Manchester School of Medicine, Hope Hospital, Manchester, UK
    J Invest Dermatol 126:453-9. 2006
    ..01). In future, determination of VEGF gene polymorphisms and thus individual patient VEGF "signatures" may be used as a prognostic factor for psoriasis susceptibility/severity and as a means for optimizing treatment response...
  19. ncbi request reprint The CX3CL1-CX3CR1 system and psoriasis
    Darren Plant
    ARC Epidemiology Unit, The University of Manchester, Manchester, UK
    Exp Dermatol 15:900-3. 2006
    ..These results support a role for the CX3CL1-CX3CR1 system in the pathogenesis of psoriasis and identify SNPs within the chemokine receptors that are associated with the disease...
  20. doi request reprint Responsiveness to change and interpretability of the simplified psoriasis index
    Leena Chularojanamontri
    1 Dermatology Centre, Salford Royal Hospital, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK 2 Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Invest Dermatol 134:351-8. 2014
    ..86-0.96). These studies further support the validity of SPI for use in routine clinical practice. ..
  21. ncbi request reprint Epidermal Langerhans cell migration and sensitisation to chemical allergens
    Marie Cumberbatch
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire and The Dermatology Centre, University of Manchester, Hope Hospital, Salford, Manchester, UK
    APMIS 111:797-804. 2003
    ..The second is examination of the ways in which LC may influence the polarity of induced T lymphocytes, and thereby the quality of immune responses...
  22. doi request reprint Cross-linking of structural proteins in ageing skin: an in situ assay for the detection of amine oxidase activity
    Abigail K Langton
    Dermatology Research Centre, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, 1 523 Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    Biogerontology 14:89-97. 2013
    ..The development of a technique to localise specific amine oxidase activity in tissue sections may provide crucial additional information on the exact role played by this class of enzymes in mediating age-related tissue stiffening...
  23. doi request reprint Systemic therapies for psoriasis: methotrexate, retinoids, and cyclosporine
    Richard B Warren
    Dermatologic Sciences, Hope Hospital, The University of Manchester, Manchester, M6 8HD UK
    Clin Dermatol 26:438-47. 2008
    ..Ideally, cyclosporine should be used for short courses of 3 to 4 months duration, within which it provides excellent disease control. Close assessment of renal function and blood pressure is essential...
  24. pmc Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris
    John Bowes
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK
    Ann Rheum Dis 70:1016-9. 2011
    ..Given this intriguing evidence, association to this gene was investigated in large collections of PsA and PsV patients and healthy controls...
  25. ncbi request reprint Illness perception in individuals with atopic dermatitis
    Anja Wittkowski
    Academic Division of Clinical Psychology, The University of Manchester, UK
    Psychol Health Med 12:433-44. 2007
    ..This study suggests that participants' beliefs and emotional response are more strongly associated with the meaning they ascribe to their condition rather than its severity...
  26. ncbi request reprint Alexithymia in patients with psoriasis: clinical correlates and psychometric properties of the Toronto Alexithymia Scale-20
    Helen L Richards
    Department of Behavioural Medicine, Hope Hospital, Salford Royal Hospitals NHS Trust, Manchester, UK
    J Psychosom Res 58:89-96. 2005
    ..The objective of this study was to examine the psychometric properties and clinical correlates of the 20-item Toronto Alexithymia Scale (TAS-20) in patients with psoriasis...
  27. pmc The role of DMARDs in reducing the immunogenicity of TNF inhibitors in chronic inflammatory diseases
    Meghna Jani
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Rheumatology (Oxford) 53:213-22. 2014
    ..We also discuss whether such a strategy should be employed in SpA and psoriasis, and if optimization of the MTX dose could improve biologic drug survival and thereby benefit disease management...
  28. pmc Tumour necrosis factor alpha, interferon gamma and substance P are novel modulators of extrapituitary prolactin expression in human skin
    Ewan A Langan
    Dermatology Research Centre, Manchester Academic Health Science Centre, and Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom
    PLoS ONE 8:e60819. 2013
    ....
  29. ncbi request reprint Psychological distress impairs clearance of psoriasis in patients treated with photochemotherapy
    Donal G Fortune
    Dermatology Centre, University of Manchester School of Medicine, and the Department of Behavioural Medicine, Hope Hospital, Salford, Manchester, England
    Arch Dermatol 139:752-6. 2003
    ..To assess whether psychological distress affects treatment outcome in psoriasis...
  30. ncbi request reprint Macrophage migration inhibitory factor gene polymorphism is associated with psoriasis
    Rachelle P Donn
    Arthritis Research Campaign Epidemiology Unit, Stopford Building, University of Manchester, Manchester, UK
    J Invest Dermatol 123:484-7. 2004
    ..69 95% CI 1.2-2.5 (p=0.008). The results provide evidence for polymorphisms in the MIF gene, and in particular the CATT(7)-MIF-173(*)C haplotype, being of importance in susceptibility to psoriasis...
  31. ncbi request reprint The impact of psychological and clinical factors on quality of life in individuals with atopic dermatitis
    Anja Wittkowski
    Academic Division of Clinical Psychology, School of Psychiatry and Behavioural Sciences, University of Manchester, 2nd Floor Education and Research Centre, Wythenshawe Hospital, Manchester M23 9LT, UK
    J Psychosom Res 57:195-200. 2004
    ..The aim of the study was to assess the influence of general and dermatitis-specific psychological and clinical factors on quality of life in adults with atopic dermatitis (AD)...
  32. ncbi request reprint Divergent beliefs about psoriasis are associated with increased psychological distress
    Helen L Richards
    Department of Behavioral Medicine, University of Manchester School of Medicine, Hope Hospital, Manchester, UK
    J Invest Dermatol 123:49-56. 2004
    ....
  33. ncbi request reprint Modern management of psoriasis
    Sharizan Abdul Ghaffar
    The Dermatology Centre, University of Manchester, Hope Hospital, Salford
    Clin Med 5:564-8. 2005
  34. ncbi request reprint A European perspective on the challenges of managing psoriasis
    Rosita Saraceno
    Dermatology Centre, The University of Manchester, Hope Hospital, Manchester, United Kingdom
    J Am Acad Dermatol 54:S81-4. 2006
  35. doi request reprint Severely photosensitive psoriasis: a phenotypically defined patient subset
    Kirsty J Rutter
    Department of Dermatological Sciences, School of Translational Medicine, University of Manchester, Manchester M6 8HD, UK
    J Invest Dermatol 129:2861-7. 2009
    ..Thus, a phenotypically distinct subset of psoriasis has been characterized. In contrast with earlier assumptions, UV can provoke psoriasiform features rapidly de novo; a role for memory effector T cells is supported in the early phase...
  36. ncbi request reprint Treatment of photoaged skin with a cream containing 0.05% isotretinoin and sunscreens
    C E M Griffiths
    Dermatology Centre, Hope Hospital, University of Manchester, Manchester, UK
    J Dermatolog Treat 16:79-86. 2005
    ..To determine the safety and efficacy of a cream formulation of 0.05% isotretinoin with sunscreens (SPF 15) (I+S) in the treatment of photoaged skin...
  37. ncbi request reprint Infliximab for the treatment of psoriasis
    C Elise Kleyn
    The Dermatology Centre, Hope Hospital, The University of Manchester, Salford, Manchester, M6 8HD, UK
    Expert Opin Biol Ther 6:797-805. 2006
    ..Regular 8-weekly infusions of infliximab maintain significant clinical improvement in the majority of patients for at least 1 year. Infliximab is generally well tolerated, but patients may be susceptible to infection and malignancy...
  38. pmc Liver X receptor β: maintenance of epidermal expression in intrinsic and extrinsic skin aging
    Christopher T Ford
    Dermatological Sciences, The University of Manchester, 1 443 Stopford Building, Oxford Road, Manchester, UK
    Age (Dordr) 31:365-72. 2009
    ..75). Our data therefore suggest that, while not playing a major role in skin aging, robust cutaneous expression implies a fundamental role for LXRβ in epidermal biology...
  39. ncbi request reprint The use of retinoids in the treatment of photoaging
    Minal Singh
    Dermatopharmacology Unit, The Dermatology Center, University of Manchester, Hope Hospital, Manchester, UK
    Dermatol Ther 19:297-305. 2006
    ..There is in addition emerging evidence that topical retinoids could be beneficial in the treatment of intrinsically aged skin...
  40. doi request reprint Unmasking of axial spondyloarthritis and oligoarthritis following discontinuation of tumour necrosis factor inhibitor therapy for psoriasis
    Amy C Foulkes
    Dermatology Centre, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    J Dermatolog Treat 25:61-2. 2014
    ..We advocate the use of screening for psoriatic arthritis, including before and during treatment with biologic therapies. ..
  41. ncbi request reprint A pilot study of body image dissatisfaction and the psychological impact of systemic sclerosis-related telangiectases
    Holly Ennis
    Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Science Center, Manchester, UK
    Clin Exp Rheumatol 31:12-7. 2013
    ....
  42. ncbi request reprint Psychologic factors in psoriasis: consequences, mechanisms, and interventions
    Donal G Fortune
    Department of Behavioral Medicine, Clinical Sciences Building, Hope Hospital, Salford Royal Hospitals NHS Trust, Manchester, UK
    Dermatol Clin 23:681-94. 2005
    ..The implications of the findings are discussed with reference to future directions for research and practice...
  43. doi request reprint Topical treatments for scalp psoriasis
    Richard B Warren
    Dermatological Sciences, Hope Hospital, The University of Manchester, Manchester, UK
    Drugs 68:2293-302. 2008
    ..The aim of this review is to critically assess the relative effectiveness and tolerability of available topical therapies for this problematic condition and provide recommendations for selection of treatment...
  44. doi request reprint The future of biological therapies
    Richard B Warren
    Dermatology Centre, Salford Royal Hospital, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
    Semin Cutan Med Surg 29:63-6. 2010
    ..In this article, we discuss approaches that may be utilized to refine these existing therapies and examine future therapeutic targets for biological therapies...
  45. doi request reprint Low-dose ultraviolet radiation selectively degrades chromophore-rich extracellular matrix components
    Michael J Sherratt
    Regenerative Biomedicine, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    J Pathol 222:32-40. 2010
    ..As a consequence, this selective acellular photochemical pathway may play an important role in initiating and/or exacerbating cell-mediated ECM remodelling in UVR-exposed skin...
  46. ncbi request reprint Cytokine blocking agents in dermatology
    J D L Williams
    The Dermatology Centre, University of Manchester, Hope Hospital, Salford, Manchester, UK
    Clin Exp Dermatol 27:585-90. 2002
    ..We review the current and prospective roles of cytokine blocking agents in the treatment of skin disease...
  47. ncbi request reprint Balancing the benefits and risks of drug treatment: a stated-preference, discrete choice experiment with patients with psoriasis
    Elizabeth M Seston
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PT, England
    Arch Dermatol 143:1175-9. 2007
    ..To examine the extent to which the attributes of a treatment affect patients' choice of treatment for psoriasis and the magnitude and nature of trade-offs between risks and benefits of treatment...
  48. doi request reprint Can stress reduction interventions improve psoriasis? A review
    Bethany Fordham
    a Institute of Inflammation and Repair, University of Manchester, Manchester, UK
    Psychol Health Med 18:501-14. 2013
    ..001). Due to low quality evidence it is currently insufficient to judge stress reduction interventions as either effective or ineffective. We make nine recommendations for future research in this multidisciplinary field. ..
  49. doi request reprint The Simplified Psoriasis Index (SPI): a practical tool for assessing psoriasis
    Leena Chularojanamontri
    Dermatology Centre, Salford Royal Hospital, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    J Invest Dermatol 133:1956-62. 2013
    ..75). There were wide response distributions for all three components. We believe that both professional (proSPI) and self-assessed (saSPI) versions can readily be introduced into routine clinical practice...
  50. doi request reprint Differential expression of elastic fibre components in intrinsically aged skin
    Abigail K Langton
    Dermatological Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    Biogerontology 13:37-48. 2012
    ..Consequently, any age-related perturbations in the expression of these components may have important consequences on remodelling of the extracellular matrix and hence on the mechanical properties of intrinsically aged skin...
  51. pmc A review of tazarotene in the treatment of photodamaged skin
    Stephanie Ogden
    Dermatology Centre, University of Manchester, Hope Hospital, Salford Manchester, M6 8HD, UK
    Clin Interv Aging 3:71-6. 2008
    ..Over recent years a number of RCTs, have affirmed that topical tazarotene is an effective and safe treatment for photodamaged skin...
  52. doi request reprint A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: the TARGET study
    William G Newman
    Genetic Medicine, Manchester Academic Health Science Centre MAHSC, University of Manchester and Central Manchester NHS Foundation Trust, UK
    Pharmacogenomics 12:815-26. 2011
    ..To conduct a pragmatic, randomized controlled trial to assess whether thiopurine methyltransferase (TPMT) genotyping prior to azathioprine reduces adverse drug reactions (ADRs)...
  53. doi request reprint Noninvasive imaging techniques in the assessment of scleroderma spectrum disorders
    Andrea K Murray
    School of Translational Medicine, University of Manchester, Salford Royal NHS Foundation Trust, Salford, UK
    Arthritis Rheum 61:1103-11. 2009
    ....
  54. ncbi request reprint Trade-offs between the benefits and risks of drug treatment for psoriasis: a discrete choice experiment with U.K. dermatologists
    D M Ashcroft
    School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, Oxford Road, Manchester, UK
    Br J Dermatol 155:1236-41. 2006
    ..The choice of drug treatment for an individual patient is a complex matter. In the case of psoriasis there is a range of treatments available, with varying degrees of efficacy and risk of adverse events...
  55. ncbi request reprint Randomized comparison of the type 4 phosphodiesterase inhibitor cipamfylline cream, cream vehicle and hydrocortisone 17-butyrate cream for the treatment of atopic dermatitis
    C E M Griffiths
    Dermatology Centre, University of Manchester, Hope Hospital, Eccles Old Road, Manchester M6 8HD, UK
    Br J Dermatol 147:299-307. 2002
    ..Cipamfylline is a new potent and selective inhibitor of PDE-4...
  56. pmc Outcomes of methotrexate therapy for psoriasis and relationship to genetic polymorphisms
    R B Warren
    Dermatological Sciences, Salford Royal Hospital, The University of Manchester, Manchester M6 8HD, UK
    Br J Dermatol 160:438-41. 2009
    ..Previous studies in patients with either rheumatoid arthritis or psoriasis suggest that genetic variation across the methotrexate metabolic pathway might enable prediction of both efficacy and toxicity of the drug...
  57. pmc Effects of a cosmetic 'anti-ageing' product improves photoaged skin [corrected]
    R E B Watson
    Dermatological Sciences Research Group, School of Translational Medicine, Faculty of Medical and Human Sciences, The University of Manchester, Oxford Road, Manchester, UK
    Br J Dermatol 161:419-26. 2009
    ..This observation infers potential to repair and perhaps clinically improve photoaged skin...
  58. ncbi request reprint Altered claudin expression is a feature of chronic plaque psoriasis
    R E B Watson
    Dermatological Sciences Research Group, Faculty of Medical and Human Sciences, University of Manchester, Manchester M13 9PT, UK
    J Pathol 212:450-8. 2007
    ..These data demonstrate that epidermal claudin expression is altered in chronic plaque psoriasis and that expression is in part modulated by interleukin-1beta...
  59. ncbi request reprint Dual wavelength (532 and 633 nm) laser Doppler imaging of plaque psoriasis
    A K Murray
    Laser Photonics Group, Department of Physics and Astronomy, University of Manchester, Manchester M13 9PL, UK
    Br J Dermatol 152:1182-6. 2005
    ..Increased blood flow occurs in plaques of psoriasis, and an increase in blood flow has been shown to occur in uninvolved skin adjacent to the active edge...
  60. ncbi request reprint Adherence to treatment in patients with psoriasis
    H L Richards
    Department of Behavioural Medicine, The University of Manchester, Hope Hospital, Salford, Manchester, UK
    J Eur Acad Dermatol Venereol 20:370-9. 2006
    ....
  61. doi request reprint What's new in psoriasis? Analysis of the clinical significance of new guidelines and systematic reviews on psoriasis published in 2008 and 2009
    R B Warren
    Dermatological Sciences, Salford Royal NHS Foundation Trust, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    Clin Exp Dermatol 35:688-91; quiz 692. 2010
    ..A similar and more detailed review to this appeared in the 2009 Annual Evidence Update on Psoriasis from NHS Evidence - Skin Disorders in November 2009...
  62. doi request reprint Biologic therapies for psoriasis: practical experience in a U.K. tertiary referral centre
    R B Warren
    Dermatological Sciences, Salford Royal Hospital, University of Manchester, Manchester M6 8HD, UK
    Br J Dermatol 160:162-9. 2009
    ..However, to date, there are few reports of the practical use of these therapies outside of the trial setting and, to our knowledge, none from a U.K. cohort of patients with psoriasis...
  63. pmc Polymorphisms in the PTPN22 region are associated with psoriasis of early onset
    Rh Ll Smith
    ARC Epidemiology Unit, The University of Manchester, and Dermatological Sciences, Hope Hospital, Manchester M6 8HD, UK
    Br J Dermatol 158:962-8. 2008
    ..Although the aetiology of psoriasis is poorly understood, patients with disease of early onset (Type I, age of onset<or=40 years) usually have a strong genetic component to the disease...
  64. doi request reprint Adalimumab for psoriasis: practical experience in a U.K. tertiary referral centre
    R B Warren
    Dermatology Centre, Salford Royal NHS Foundation Trust, University of Manchester, Manchester Academic Health Science Centre, Manchester M6 8HD, U K
    Br J Dermatol 163:859-62. 2010
    ..There are few reports of the practical use of adalimumab outside of a clinical trial setting and, to our knowledge, none from the U.K...
  65. ncbi request reprint Repair of photoaged dermal matrix by topical application of a cosmetic 'antiageing' product
    R E B Watson
    Dermatological Sciences Research Group, The University of Manchester, Manchester M13 9PT, UK
    Br J Dermatol 158:472-7. 2008
    ..To date, little is known regarding the ability of over-the-counter 'antiageing' products to repair photoaged skin...
  66. doi request reprint Methotrexate for psoriasis in the era of biological therapy
    R B Warren
    Department of Dermatological Sciences, Salford Royal Hospital, University of Manchester, Manchester, UK
    Clin Exp Dermatol 33:551-4. 2008
    ..Furthermore, the potential for personalized methotrexate use by application of modern pharmacogenetics and pharmacokinetics may ensure its place as a first-line agent for the treatment of psoriasis for the foreseeable future...
  67. doi request reprint An investigation into the blood-flow characteristics of telangiectatic skin lesions in systemic sclerosis using dual-wavelength laser Doppler imaging
    A K Murray
    Rheumatic Diseases Centre, Hope Hospital, University of Manchester, Manchester, UK
    Clin Exp Dermatol 34:618-20. 2009
    ..Dual-wavelength LDI may help predict treatment response...
  68. doi request reprint A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21
    R B Warren
    Dermatological Sciences, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, UK
    Br J Dermatol 164:660-4. 2011
    ..Many autoimmune diseases share common susceptibility loci suggesting similar underlying cellular mechanisms involved in disease expression...
  69. pmc 'On the surface': a qualitative study of GPs' and patients' perspectives on psoriasis
    Pauline A Nelson
    Dermatology Research Centre, Institute of Inflammation and Repair, The University of Manchester and Manchester Academic Health Science Centre, Suite 14, 5th Floor, Williamson Building, University of Manchester, Oxford Rd, Manchester M13 9PL, UK
    BMC Fam Pract 14:158. 2013
    ..This article reports an in-depth study which compares and contrasts the perspectives of people with psoriasis and of GPs on the challenges of managing psoriasis in primary care...
  70. ncbi request reprint Single-nucleotide polymorphisms of vascular endothelial growth factor in psoriasis of early onset
    Helen S Young
    The Dermatology Center, University of Manchester School of Medicine, Hope Hospital, Manchester, UK
    J Invest Dermatol 122:209-15. 2004
    ..These results suggest that alterations in the biology of VEGF may be involved in the pathogenesis of psoriasis. VEGF, flt-1, and KDR could provide attractive targets for future psoriasis therapy...
  71. doi request reprint Global epidemiology of psoriasis: a systematic review of incidence and prevalence
    Rosa Parisi
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK
    J Invest Dermatol 133:377-85. 2013
    ..However, further research is required to fill existing gaps in understanding the epidemiology of psoriasis and trends in incidence over time...
  72. doi request reprint Exploring the role of prolactin in psoriasis
    Ewan A Langan
    Dermatology Centre, Salford Royal NHS Foundation Trust, School of Translational Medicine, Manchester Academic Health Science Centre, The University of Manchester, UK
    Arch Dermatol Res 304:115-8. 2012
    ..We take the occasion of these reports to underscore the importance of dissecting the role(s) of PRL in the aetiopathology of psoriasis, not least since this may help to identify novel hormonal treatment strategies in its management...
  73. ncbi request reprint A randomized, investigator-masked clinical evaluation of the efficacy and safety of clobetasol propionate 0.05% shampoo and tar blend 1% shampoo in the treatment of moderate to severe scalp psoriasis
    Christopher E M Griffiths
    Dermatology Centre, Hope Hospital, University of Manchester, Manchester, UK
    J Dermatolog Treat 17:90-5. 2006
    ..Clobetasol propionate 0.05% shampoo is a good alternative to tar blend shampoo in the treatment of moderate to severe scalp psoriasis...
  74. ncbi request reprint Psoriasis: future research needs and goals for the twenty-first century
    Christopher E M Griffiths
    The Dermatology Centre, Hope Hospital, Irving Building, Salford, Manchester M6 8HD, UK
    Dermatol Clin 22:493-9, x. 2004
    ..A concerted effort between academia, industry, and patients will take forward the understanding of, and therapy for, psoriasis...
  75. ncbi request reprint Optimal management of severe plaque form of psoriasis
    David A Fairhurst
    Dermatology Centre, Hope Hospital, The University of Manchester, Manchester, UK
    Am J Clin Dermatol 6:283-94. 2005
    ..Importantly, treatment should be tailored to each individual patient depending on concurrent medical problems (which might preclude certain agents), patient choice and acceptance of the risk of adverse effects...
  76. ncbi request reprint Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor haplotype
    Adam Stevens
    Endocrine Sciences Research Group and Centre for Molecular Medicine, Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester M13 9PT, United Kingdom
    J Clin Endocrinol Metab 89:892-7. 2004
    ..This haplotype may help predetermine variation in clinical response to GC therapy and also assist the understanding of diseases related to GC production...
  77. ncbi request reprint Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin
    E Campalani
    The Dermatology Centre, University of Manchester, Hope Hospital, Manchester, UK
    Br J Dermatol 154:345-52. 2006
    ..Apolipoprotein E (ApoE) variants have been linked to hypertriglyceridaemia and hypercholesterolaemia in normal individuals. Two coding single nucleotide polymorphisms at +3937 and +4075 define the three common ApoE alleles e2, e3 and e4...
  78. ncbi request reprint A cognitive-behavioural symptom management programme as an adjunct in psoriasis therapy
    D G Fortune
    Dermatology Centre, University of Manchester School of Medicine, Manchester M6 8HD, UK
    Br J Dermatol 146:458-65. 2002
    ..Stress or distress are proposed aggravators of the disease process in psoriasis. Preliminary studies to date have suggested that adjunctive psychological therapies may be effective in the clinical management of psoriasis...
  79. ncbi request reprint Environmental risk factors for the development of psoriatic arthritis: results from a case-control study
    E Pattison
    Epidemiology Unit, School of Translational Medicine, The University of Manchester, Manchester, UK
    Ann Rheum Dis 67:672-6. 2008
    ..To identify potential risk factors for the onset of inflammatory arthritis (IA) in a large cohort of patients with psoriatic arthritis (PsA) of recent onset...
  80. pmc Investigating the role of the HLA-Cw*06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: comparison with psoriasis and undifferentiated inflammatory arthritis
    P Y P C Ho
    Epidemiology Unit, Stopford Building, University of Manchester, Manchester, UK
    Ann Rheum Dis 67:677-82. 2008
    ..Our aim was to investigate the role of HLA-Cw*06 and HLA-DRB1 genes (including SE) with psoriatic arthritis (PsA) susceptibility...
  81. ncbi request reprint CARD15/NOD2 single nucleotide polymorphisms do not confer susceptibility to type I psoriasis
    D Plant
    Centre for Integrated Genetic Medical Research, University of Manchester, Manchester, UK
    Br J Dermatol 151:675-8. 2004
    ..1) confers susceptibility. In light of the overlap in linkage data, and the observation of comorbidity between Crohn's disease and psoriasis, it is plausible that both diseases share a common genetic factor...
  82. ncbi request reprint Anti-E-selectin is ineffective in the treatment of psoriasis: a randomized trial
    M Bhushan
    The Dermatology Centre, Irving Building, University of Manchester, Hope Hospital, Salford, Manchester M6 8HD, UK
    Br J Dermatol 146:824-31. 2002
    ..Thus an attractive option for targeted therapy of the disease would be blockade of skin-homing T cells with an antibody directed at E-selectin...
  83. ncbi request reprint The immunological basis of psoriasis
    C E M Griffiths
    The Dermatology Centre, University of Manchester School of Medicine, Hope Hospital, Salford, Manchester M6 8HD, UK
    J Eur Acad Dermatol Venereol 17:1-5. 2003
    ..New T-cell targeted approaches and cytokine modulation are advancing basic science in providing an understanding of the evidence for the importance of the immune process in the biology of psoriasis...
  84. ncbi request reprint Keloidal scleroderma
    T C Ling
    The Dermatology Centre, Hope Hospital, Manchester, UK
    Clin Exp Dermatol 28:171-3. 2003
    ..The nodules failed to respond to therapy with topical steroid, calcipotriol, or extended photochemotherapy. This is a rare, disfiguring variant of scleroderma, unresponsive to treatment, and poorly understood...
  85. ncbi request reprint Fumaric acid esters for severe psoriasis: a retrospective review of 58 cases
    M J Harries
    The Dermatology Centre, The University of Manchester, Hope Hospital, Stott Lane, Salford, Manchester, UK
    Br J Dermatol 153:549-51. 2005
    ..A recent systematic review has shown FAE to be an effective systemic treatment for severe psoriasis. However, FAE remain unlicensed in the U.K...
  86. ncbi request reprint Drug therapies in dermatology
    Arif Aslam
    Dermatology Centre, Salford Royal NHS Foundation Trust, University of Manchester, Manchester, UK
    Clin Med 14:47-53. 2014
    ..Better matching of patients with therapies is anticipated to have a major effect on both clinical practice and the development of new drugs and diagnostics. ..
  87. ncbi request reprint Photoageing: the darker side of the sun
    Evridiki Tsoureli-Nikita
    Dermatological Sciences Research Group, Faculty of Medical and Human Sciences, The University of Manchester, 1 443 Stopford Building, Oxford Road, Manchester, UK M13 9PT
    Photochem Photobiol Sci 5:160-4. 2006
  88. doi request reprint Evaluation of educational methods in dermatology and confidence levels: a national survey of UK medical students
    Yi Zhen Chiang
    Department of Medicine, Salford Royal National Health Service Foundation Trust, Manchester, UK
    Int J Dermatol 50:198-202. 2011
    ..The aim of this study was to assess the impact of different educational methods on confidence levels in dermatology among UK medical students...
  89. ncbi request reprint T-cell-targeted biologicals for psoriasis
    Christopher E M Griffiths
    The Dermatology Centre, Hope Hospital, University of Manchester, Manchester, UK
    Curr Drug Targets Inflamm Allergy 3:157-61. 2004
    ..This is a reflection of mode of action and relative safety for long-term administration...
  90. ncbi request reprint Immunotherapy for psoriasis: from serendipity to selectivity
    Christopher E M Griffiths
    Dermatology Centre, University of Manchester School of Medicine, Hope Hospital, Salford, Manchester M6 8HD, UK
    Lancet 359:279-80. 2002
  91. ncbi request reprint The macrolide immunosuppressants in dermatology: mechanisms of action
    Alexander M Marsland
    Dermatology Centre, University of Manchester School of Medicine, Hope Hospital, United Kingdom
    Eur J Dermatol 12:618-22. 2002
    ..Neither topical tacrolimus nor pimecrolimus are capable of producing skin atrophy. Sirolimus has anti-angiogenic properties that may be beneficial to the treatment of psoriasis and perhaps skin cancer...
  92. ncbi request reprint Retinoic acid receptor alpha expression and cutaneous ageing
    Rachel E B Watson
    Dermatopharmacology Unit, Dermatology Centre, University of Manchester, Irving Building, Hope Hospital, Salford, Manchester M6 8HD, UK
    Mech Ageing Dev 125:465-73. 2004
    ..These results demonstrate that intrinsic ageing of human skin is accompanied by significant elevation in the content of RAR alpha and that over-expression of RAR alpha influences expression of MMP-1, an important mediator of skin ageing...
  93. ncbi request reprint Striae gravidarum in primiparae
    G S S Atwal
    Department of Obstetrics and Gynaecology, Hope Hospital, Stott Lane, Salford, Manchester, M6 8HD, U K
    Br J Dermatol 155:965-9. 2006
    ..Various factors have been reported to be associated with the development of striae but the results are conflicting...
  94. ncbi request reprint Competency assessment of dermatology trainees in the UK
    C E M Griffiths
    The Dermatology Centre, Hope Hospital, University of Manchester, Manchester, UK
    Clin Exp Dermatol 29:571-5. 2004
    ..These components of assessment will direct much needed rigour into the training system and may be the first step on the road to a formal exit examination in dermatology...
  95. ncbi request reprint Systemic ciclosporin and tacrolimus in dermatology
    V Madan
    The Dermatology Center, University of Manchester, Hope Hospital, Salford, Manchester, UK
    Dermatol Ther 20:239-50. 2007
    ..However, there are several case studies and anecdotal reports of the successful use of oral tacrolimus in various dermatoses. In this article we discuss the utility of systemic ciclosporin and tacrolimus in dermatology...
  96. ncbi request reprint Oral mucosal keratinocytes express RANTES and ICAM-1, but not interleukin-8, in oral lichen planus and oral lichenoid reactions induced by amalgam fillings
    M C Little
    Dermatology Centre, University of Manchester, Hope Hospital, Salford, Manchester, UK
    Clin Exp Dermatol 28:64-9. 2003
    ..Interleukin-8 was not detected in any of the samples. The expression of ICAM-1 and RANTES by epithelial keratinocytes in the oral mucosa in OLP and OLR could be a key inflammatory mechanism in these diseases...
  97. ncbi request reprint Successful treatment of psoriasis improves psoriasis-specific but not more general aspects of patients' well-being
    D G Fortune
    Department of Behavioural Medicine, Hope Hospital, Salford, Manchester, M6 8HD, U K
    Br J Dermatol 151:1219-26. 2004
    ..Psoriasis has a detrimental effect on patients' quality of life. However, there is a relative dearth of information on which aspects of a patient's well-being are affected by successful treatment...
  98. ncbi request reprint Psoriasis and psoriatic arthritis: immunological aspects and therapeutic guidelines
    C E M Griffiths
    The Dermatology Centre, University of Manchester, Hope Hospital, Salford, Manchester, UK
    Clin Exp Rheumatol 24:S72-8. 2006
    ..In this review, in addition to pathogenetic aspects, some preliminary guidelines for the use of anti-TNFalpha therapy in patients with psoriasis and psoriatic arthritis will be discussed...
  99. ncbi request reprint Patients' strategies for coping with psoriasis
    D G Fortune
    Dermatology Centre, University of Manchester School of Medicine, Hope Hospital, Salford, UK
    Clin Exp Dermatol 27:177-84. 2002
    ..It appears that illness brings with it a generic form of coping that may require shaping to fit the individual demands of diseases such as psoriasis...
  100. doi request reprint Pilot study of dual-wavelength (532 and 633 nm) laser Doppler imaging and infrared thermography of morphoea
    T L Moore
    Rheumatic Diseases Centre, University of Manchester, Salford Royal NHS Foundation Trust, Salford, UK
    Br J Dermatol 160:864-7. 2009
    ..Little is known about the pathophysiology of localized scleroderma (skin fibrosis, also termed 'morphoea'), although it is likely that microvascular dysfunction is a contributing factor...
  101. doi request reprint Noninvasive measurement of skin autofluorescence is increased in patients with systemic sclerosis: an indicator of increased advanced glycation endproducts?
    Andrea K Murray
    Musculoskeletal Research Group, School of Translational Medicine, Salford Royal NHS Foundation, Manchester M6 8HD, UK
    J Rheumatol 39:1654-8. 2012
    ..We investigated whether autofluorescence was increased in patients with SSc, primary Raynaud's phenomenon (RP), and morphea as compared to healthy controls...