Ian Grierson

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. ncbi Modification of the surface properties of a lens material to influence posterior capsular opacification
    Conrad Yuen
    Ophthalmology, University Clinical Department, School of Clinical Sciences, University of Liverpool, Liverpool, UK
    Clin Experiment Ophthalmol 34:568-74. 2006
  2. ncbi Basement membranes and artificial substrates in cell transplantation
    Carl Sheridan
    Unit of Ophthalmology, Department of Medicine, University Clinical Departments, University of Liverpool, UK
    Graefes Arch Clin Exp Ophthalmol 242:68-75. 2004
  3. ncbi Jon R. Polansky (1948-2005)
    Ian Grierson
    Liverpool University, Liverpool, UK
    Exp Eye Res 82:925-6. 2006
  4. ncbi Morphometric effects of long-term exposure to latanoprost
    Kathryn P B Cracknell
    St Paul s Unit of Ophthalmology, Department of Medicine, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Ophthalmology 114:938-48. 2007
  5. ncbi Melanin in the trabecular meshwork is associated with age, POAG but not Latanoprost treatment. A masked morphometric study
    Kathryn P B Cracknell
    St Paul's Unit of Ophthalmology, Department of Medicine, Royal Liverpool University Hospital, Liverpool L69 3GA, UK
    Exp Eye Res 82:986-93. 2006
  6. ncbi Suppression of thrombospondin 1 and 2 production by herpes simplex virus 1 infection in cultured keratocytes
    Anshoo Choudhary
    Unit of Ophthalmology, Department of Medicine, UCD, University of Liverpool, Liverpool, United Kingdom
    Mol Vis 11:163-8. 2005
  7. ncbi Latanoprost and pigmentation
    Ian Grierson
    Unit of Ophthalmology, Department of Medicine, University of Liverpool L693G, UK
    Jpn J Ophthalmol 48:602-12. 2004
  8. ncbi Unexpected intracellular localization of the AMD-associated cystatin C variant
    Luminita Paraoan
    Unit of Ophthalmology, Department of Medicine, Centre for Cell Imaging, School of Biological Sciences, University of Liverpool, UK
    Traffic 5:884-95. 2004
  9. ncbi A dual Golgi- and mitochondria-localised Ala25Ser precursor cystatin C: an additional tool for characterising intracellular mis-localisation leading to increased AMD susceptibility
    Arjuna Ratnayaka
    Exp Eye Res 84:1135-9. 2007
  10. ncbi Latanoprost-induced iris darkening: a morphometric study of human peripheral iridectomies
    Kathryn P B Cracknell
    St Paul's Unit of Ophthalmology, Department of Medicine, Royal Liverpool University Hospital, Liverpool L69 3GA, UK
    Exp Eye Res 77:721-30. 2003

Collaborators

Detail Information

Publications27

  1. ncbi Modification of the surface properties of a lens material to influence posterior capsular opacification
    Conrad Yuen
    Ophthalmology, University Clinical Department, School of Clinical Sciences, University of Liverpool, Liverpool, UK
    Clin Experiment Ophthalmol 34:568-74. 2006
    ..To study the effect of surface properties of materials on cellular behaviour and the formation of posterior capsular opacification (PCO)...
  2. ncbi Basement membranes and artificial substrates in cell transplantation
    Carl Sheridan
    Unit of Ophthalmology, Department of Medicine, University Clinical Departments, University of Liverpool, UK
    Graefes Arch Clin Exp Ophthalmol 242:68-75. 2004
  3. ncbi Jon R. Polansky (1948-2005)
    Ian Grierson
    Liverpool University, Liverpool, UK
    Exp Eye Res 82:925-6. 2006
  4. ncbi Morphometric effects of long-term exposure to latanoprost
    Kathryn P B Cracknell
    St Paul s Unit of Ophthalmology, Department of Medicine, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Ophthalmology 114:938-48. 2007
    ..To investigate the morphological and melanin granule changes in irides after variable-term exposure to latanoprost, where the latanoprost-induced iris darkening (LIID) side effect has been identified and photographically recorded...
  5. ncbi Melanin in the trabecular meshwork is associated with age, POAG but not Latanoprost treatment. A masked morphometric study
    Kathryn P B Cracknell
    St Paul's Unit of Ophthalmology, Department of Medicine, Royal Liverpool University Hospital, Liverpool L69 3GA, UK
    Exp Eye Res 82:986-93. 2006
    ..The melanin accumulation seems to be partly due to the disease process, partly as a consequence of chronic antiglaucoma medication but interestingly not due to latanoprost even in patients where there is iris darkening (four specimens)...
  6. ncbi Suppression of thrombospondin 1 and 2 production by herpes simplex virus 1 infection in cultured keratocytes
    Anshoo Choudhary
    Unit of Ophthalmology, Department of Medicine, UCD, University of Liverpool, Liverpool, United Kingdom
    Mol Vis 11:163-8. 2005
    ..We hypothesize that the synthesis of these anti-angiogenic proteins by keratocytes is inhibited by HSV1 and that such a mechanism may contribute to stromal vascularization in HSK...
  7. ncbi Latanoprost and pigmentation
    Ian Grierson
    Unit of Ophthalmology, Department of Medicine, University of Liverpool L693G, UK
    Jpn J Ophthalmol 48:602-12. 2004
    ..Additional studies are in progress to further elucidate the mechanism of latanoprost-induced increased iridial pigmentation...
  8. ncbi Unexpected intracellular localization of the AMD-associated cystatin C variant
    Luminita Paraoan
    Unit of Ophthalmology, Department of Medicine, Centre for Cell Imaging, School of Biological Sciences, University of Liverpool, UK
    Traffic 5:884-95. 2004
    ..Expression of the variant fusion protein did not appear to impair expression or secretion of endogenous cystatin C...
  9. ncbi A dual Golgi- and mitochondria-localised Ala25Ser precursor cystatin C: an additional tool for characterising intracellular mis-localisation leading to increased AMD susceptibility
    Arjuna Ratnayaka
    Exp Eye Res 84:1135-9. 2007
    ....
  10. ncbi Latanoprost-induced iris darkening: a morphometric study of human peripheral iridectomies
    Kathryn P B Cracknell
    St Paul's Unit of Ophthalmology, Department of Medicine, Royal Liverpool University Hospital, Liverpool L69 3GA, UK
    Exp Eye Res 77:721-30. 2003
    ....
  11. ncbi Edible mushroom (Agaricus bisporus) lectin inhibits human retinal pigment epithelial cell proliferation in vitro
    David Kent
    Unit of Ophthalmology, Department of Medicine, University of Liverpool, United Kingdom
    Wound Repair Regen 11:285-91. 2003
    ..It therefore merits consideration as a potential antiproliferative agent in the prevention and treatment of proliferative vitreoretinopathy and other nonocular anomalous wound healing processes...
  12. ncbi Fate of cystatin C lacking the leader sequence in RPE cells
    Luminita Paraoan
    Exp Eye Res 76:753-6. 2003
    ....
  13. ncbi The role of matricellular proteins thrombospondin-1 and osteonectin during RPE cell migration in proliferative vitreoretinopathy
    Carl M Sheridan
    Unit of Ophthalmology, Department of Medicine, University of Liverpool, UK
    Curr Eye Res 25:279-85. 2002
    ....
  14. ncbi Effects of the matricellular protein SPARC on human retinal pigment epithelial cell behavior
    Suzanne Hagan
    Unit of Ophthalmology, Department of Medicine, University of Liverpool, UK
    Mol Vis 9:87-92. 2003
    ....
  15. ncbi Fine structural evaluation of the iris after unilateral treatment with latanoprost in patients undergoing bilateral trabeculectomy (the Mainz II study)
    Norbert Pfeiffer
    Department of Ophthalmology, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55131 Mainz, Germany
    Arch Ophthalmol 121:23-31. 2003
    ..To investigate by masked electron microscopy whether 6 months of topical latanoprost caused pathological changes in the peripheral iris of patients with glaucoma...
  16. ncbi Histology and fine structure of the iris and outflow system following latanoprost therapy
    Ian Grierson
    Unit of Ophthalmology, Department of Medicine, University Clinical Departments, University of Liverpool, Liverpool L69 3GA, United Kingdom
    Surv Ophthalmol 47:S176-84. 2002
    ..Concerns about latanoprost producing meshwork hyperpigmentation and pigmentary glaucoma are discussed...
  17. ncbi Direct comparison of the migration of three cell types involved in epiretinal membrane formation
    Penny A Hogg
    St Paul s Unit of Ophthalmology, Department of Medicine, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Invest Ophthalmol Vis Sci 43:2749-57. 2002
    ....
  18. ncbi Polydimethylsiloxane as a substrate for retinal pigment epithelial cell growth
    Yamini Krishna
    Department of Ophthalmology, School of Clinical Sciences, The University of Liverpool, Liverpool L69 3GA, United Kingdom
    J Biomed Mater Res A 80:669-78. 2007
    ..Furthermore, RPE monolayers were able to demonstrate phagocytosis of POS in a time-dependent manner similar to control. PDMS can support an intact functional monolayer of healthy differentiated RPE cells...
  19. ncbi Deficits in the electroretinogram in neovascular age-related macular degeneration and changes during photodynamic therapy
    Alison M Mackay
    Department of Clinical Engineering, Royal Liverpool University Hospital, Prescot Street, Liverpool, UK
    Doc Ophthalmol 115:69-76. 2007
    ..To describe the changes in these parameters during a course of verteporfin photodynamic therapy (PDT)...
  20. ncbi Multifocal electroretinography as a predictor of maintenance of vision after photodynamic therapy for neovascular age-related macular degeneration
    Alison M Mackay
    Department of Clinical Engineering, Royal Liverpool University Hospital, Liverpool, UK
    Doc Ophthalmol 116:13-8. 2008
    ..To investigate the role of multifocal electroretinography (mfERG) in predicting the outcome of photodynamic therapy (PDT) for neovascular age-related macular degeneration (AMD)...
  21. ncbi An N-terminal truncated form of Orp150 is a cytoplasmic ligand for the anti-proliferative mushroom Agaricus bisporus lectin and is required for nuclear localization sequence-dependent nuclear protein import
    Lu-Gang Yu
    Department of Medicine, The Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, University of Liverpool, Liverpool L69, United Kingdom
    J Biol Chem 277:24538-45. 2002
    ..This cytoplasmic form of Orp150 expresses the lectin carbohydrate ligand (sialyl-2,3-galactosyl-beta1,3-N-acetylgalactosamine-alpha) and is shown to be essential for nuclear localization sequence-dependent nuclear protein import...
  22. ncbi Expression of p53-induced apoptosis effector PERP in primary uveal melanomas: downregulation is associated with aggressive type
    Luminita Paraoan
    Unit of Ophthalmology, School of Clinical Sciences, University of Liverpool, UCD Building, Daulby Street, Liverpool L69 3GA, UK
    Exp Eye Res 83:911-9. 2006
    ....
  23. ncbi Focus on molecules: cystatin C
    Luminita Paraoan
    School of Clinical Sciences, Unit of Ophthalmology, UCD Building, University of Liverpool, Daulby Street, Liverpool, L69 3GA, UK
    Exp Eye Res 84:1019-20. 2007
  24. ncbi Differential expression of angioregulatory matricellular proteins in posterior uveal melanoma
    Jose L Ordonez
    Unit of Ophthalmology, School of Clinical Sciences, University of Liverpool, UK
    Melanoma Res 15:495-502. 2005
    ..Interventions inducing TSP1 expression and/or inhibiting SPARC expression may be candidates for therapies directed towards the inhibition of angiogenesis in posterior uveal melanoma...
  25. ncbi Dexamethasone alters F-actin architecture and promotes cross-linked actin network formation in human trabecular meshwork tissue
    Abbot F Clark
    Glaucoma Research, Alcon Research, Ltd Fort Worth, Texas 76134, USA
    Cell Motil Cytoskeleton 60:83-95. 2005
    ..These cytoskeletal changes may be associated with increased aqueous humor outflow resistance after ocular glucocorticoid treatment...
  26. ncbi Key developments in ophthalmology
    Ian Grierson
    Department of Medicine, University of Liverpool
    Practitioner 248:8, 11, 14-6 passim. 2004
  27. ncbi Long-term results of viscocanalostomy in pseudoexfoliative and primary open angle glaucoma
    Peter K Wishart
    St Paul s Eye Unit, Royal Liverpool and Broadgreen University Hospital, Liverpool, UK
    Clin Experiment Ophthalmol 36:148-55. 2008
    ..To document the outcome of viscocanalostomy (VC) alone or combined with phacoemulsification (phaco-VC) in eyes with pseudoexfoliation glaucoma (PEXG) and primary open angle glaucoma (POAG)...