Christopher D Gregory

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Persistence of apoptotic cells without autoimmune disease or inflammation in CD14-/- mice
    Andrew Devitt
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, Scotland, UK
    J Cell Biol 167:1161-70. 2004
  2. doi request reprint Inflammation and cancer revisited: an hypothesis on the oncogenic potential of the apoptotic tumor cell
    Christopher D Gregory
    MRC Centre for Inflammation Research, University of Edinburgh, Queens Medical Research Institute, Edinburgh, United Kingdom
    Autoimmunity 46:312-6. 2013
  3. doi request reprint Microenvironmental influences of apoptosis in vivo and in vitro
    Christopher D Gregory
    MRC University of Edinburgh Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, UK
    Apoptosis 15:1029-49. 2010
  4. doi request reprint Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissues
    Christopher D Gregory
    MRC Centre for Inflammation Research, University of Edinburgh, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    J Pathol 223:177-94. 2011
  5. pmc Leukocyte migratory responses to apoptosis: the attraction and the distraction
    Christopher D Gregory
    MRC Centre for Inflammation Research University of Edinburgh, Queens Medical Research Institute, Edinburgh, UK
    Cell Adh Migr 5:293-7. 2011
  6. pmc The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically?
    Christopher D Gregory
    University of Edinburgh MRC Centre for Inflammation Research, College of Medicine and Veterinary Medicine, UK
    Immunology 113:1-14. 2004
  7. ncbi request reprint Enhanced apoptotic cell clearance capacity and B cell survival factor production by IL-10-activated macrophages: implications for Burkitt's lymphoma
    Carol Anne Ogden
    Centre for Inflammation Research, University of Edinburgh College of Medicine and Veterinary Medicine, Edinburgh, United Kingdom
    J Immunol 174:3015-23. 2005
  8. doi request reprint Pure populations of murine macrophages from cultured embryonic stem cells. Application to studies of chemotaxis and apoptotic cell clearance
    Lihui Zhuang
    University of Edinburgh MRC Centre for Inflammation Research, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 2TJ, UK
    J Immunol Methods 385:1-14. 2012
  9. ncbi request reprint CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis
    Lucy A Truman
    Medical Research Council MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    Blood 112:5026-36. 2008
  10. pmc Trappin-2 promotes early clearance of Pseudomonas aeruginosa through CD14-dependent macrophage activation and neutrophil recruitment
    Thomas S Wilkinson
    MRC Centre for Inflammation Research, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Am J Pathol 174:1338-46. 2009

Collaborators

Detail Information

Publications21

  1. pmc Persistence of apoptotic cells without autoimmune disease or inflammation in CD14-/- mice
    Andrew Devitt
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, Scotland, UK
    J Cell Biol 167:1161-70. 2004
    ..We conclude that CD14 plays a broad tethering role in apoptotic cell clearance in vivo and that apoptotic cells can persist in the absence of proinflammatory consequences...
  2. doi request reprint Inflammation and cancer revisited: an hypothesis on the oncogenic potential of the apoptotic tumor cell
    Christopher D Gregory
    MRC Centre for Inflammation Research, University of Edinburgh, Queens Medical Research Institute, Edinburgh, United Kingdom
    Autoimmunity 46:312-6. 2013
    ..Those properties of apoptotic cells that influence their immediate microenvironment are reviewed here in the context of cancer progression and treatment. ..
  3. doi request reprint Microenvironmental influences of apoptosis in vivo and in vitro
    Christopher D Gregory
    MRC University of Edinburgh Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, UK
    Apoptosis 15:1029-49. 2010
    ....
  4. doi request reprint Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissues
    Christopher D Gregory
    MRC Centre for Inflammation Research, University of Edinburgh, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    J Pathol 223:177-94. 2011
    ....
  5. pmc Leukocyte migratory responses to apoptosis: the attraction and the distraction
    Christopher D Gregory
    MRC Centre for Inflammation Research University of Edinburgh, Queens Medical Research Institute, Edinburgh, UK
    Cell Adh Migr 5:293-7. 2011
    ..Finally, we speculate upon new therapeutic opportunities these mechanisms offer for a range of pathological conditions, including inflammatory disorders and cancer...
  6. pmc The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically?
    Christopher D Gregory
    University of Edinburgh MRC Centre for Inflammation Research, College of Medicine and Veterinary Medicine, UK
    Immunology 113:1-14. 2004
    ....
  7. ncbi request reprint Enhanced apoptotic cell clearance capacity and B cell survival factor production by IL-10-activated macrophages: implications for Burkitt's lymphoma
    Carol Anne Ogden
    Centre for Inflammation Research, University of Edinburgh College of Medicine and Veterinary Medicine, Edinburgh, United Kingdom
    J Immunol 174:3015-23. 2005
    ....
  8. doi request reprint Pure populations of murine macrophages from cultured embryonic stem cells. Application to studies of chemotaxis and apoptotic cell clearance
    Lihui Zhuang
    University of Edinburgh MRC Centre for Inflammation Research, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 2TJ, UK
    J Immunol Methods 385:1-14. 2012
    ....
  9. ncbi request reprint CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis
    Lucy A Truman
    Medical Research Council MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    Blood 112:5026-36. 2008
    ....
  10. pmc Trappin-2 promotes early clearance of Pseudomonas aeruginosa through CD14-dependent macrophage activation and neutrophil recruitment
    Thomas S Wilkinson
    MRC Centre for Inflammation Research, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Am J Pathol 174:1338-46. 2009
    ..Trappin-2 may therefore play an important role in innate recognition and clearance of pathogens during the very earliest stages of pulmonary infection...
  11. pmc Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin
    Irini Bournazou
    The University of Edinburgh Medical Research Council MRC Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, UK
    J Clin Invest 119:20-32. 2009
    ....
  12. doi request reprint Inhibition of eosinophil migration by lactoferrin
    Irini Bournazou
    Medical Research Council MRC Centre for Inflammation Research, Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
    Immunol Cell Biol 88:220-3. 2010
    ..Thus, through its ability to inhibit eosinophil migration, LTF has potential as an effective therapeutic in the control of eosinophil infiltration in atopic inflammatory conditions...
  13. ncbi request reprint Macrophage chemotaxis to apoptotic Burkitt's lymphoma cells in vitro: role of CD14 and CD36
    Lucy A Truman
    lnnate Immunity Group, MRC Centre for Inflammation Research, University of Edinburgh, 2nd Floor, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Immunobiology 209:21-30. 2004
    ....
  14. pmc Inhibitory effects of persistent apoptotic cells on monoclonal antibody production in vitro: simple removal of non-viable cells improves antibody productivity by hybridoma cells in culture
    Christopher D Gregory
    Immunosolv Limited, Edinburgh, EH16 4SB, UK
    MAbs 1:370-6. 2009
    ....
  15. ncbi request reprint Human dendritic cells produce TGF-beta 1 under the influence of lung carcinoma cells and prime the differentiation of CD4+CD25+Foxp3+ regulatory T cells
    Ingrid E Dumitriu
    Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 182:2795-807. 2009
    ..These results identify a novel mechanism by which the function of human DCs is altered by tumor cells and contributes to the evasion of the immune response...
  16. ncbi request reprint CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist
    Sana Sarvi
    Authors Affiliations MRC Centre for Inflammation Research, The Queen s Medical Research Institute MRC Centre for Regenerative Medicine School of Chemistry, Joseph Black Building, University of Edinburgh, Edinburgh Department of Thoracic Oncology, Papworth Hospital NHS Foundation Trust, Cambridge and Department of Respiratory Medicine and Allergy, Kings College Denmark Hill Campus, London, United Kingdom
    Cancer Res 74:1554-65. 2014
    ..Our results offer evidence that this agent can preferentially target chemoresistant CD133(+) cells with CSC character in SCLC, emphasizing its potential utility for improving therapy in this setting...
  17. ncbi request reprint "Dirty little secrets"--endotoxin contamination of recombinant proteins
    Sonia J Wakelin
    MRC Centre for Inflammation Research, University of Edinburgh, UK
    Immunol Lett 106:1-7. 2006
    ..We propose that considerable caution is needed in the investigation of TLR4 agonists, particularly when using proteins produced in a bacterium that also houses the most ideal TLR4 agonist, LPS...
  18. pmc Coexpression analysis of large cancer datasets provides insight into the cellular phenotypes of the tumour microenvironment
    Tamasin N Doig
    Centre for Inflammation Research, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh, UK
    BMC Genomics 14:469. 2013
    ....
  19. ncbi request reprint Apoptosis: eating sensibly
    Christopher D Gregory
    Nat Cell Biol 7:1161-3. 2005
  20. ncbi request reprint Measurement of apoptotic cell clearance in vitro
    Andrew Devitt
    Centre for Inflammation Research, The University of Edinburgh Medical School, UK
    Methods Mol Biol 282:207-21. 2004
    ..Such methods have been used successfully to identify phagocyte-associated or apoptotic cell-associated molecular players in the recognition process...
  21. ncbi request reprint Population depletion activates autonomous CD154-dependent survival in biopsylike Burkitt lymphoma cells
    Anita Challa
    MRC Centre for Immune Regulation and the Institute for Cancer Studies, The University of Birmingham, Birmingham, United Kingdom
    Blood 99:3411-8. 2002
    ..This process could be activated as cells discern depletions in their community or when deprived of signals otherwise furnished within an appropriate environmental niche...