R H Green

Summary

Affiliation: University Hospitals of Leicester
Country: UK

Publications

  1. ncbi request reprint Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
    Ruth H Green
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, LE3 9PQ, Leicester, UK
    Lancet 360:1715-21. 2002
  2. ncbi request reprint The reclassification of asthma based on subphenotypes
    Ruth H Green
    Department of Respiratory Medicine, Glenfield Hospital, Groby Road, Leicester, UK
    Curr Opin Allergy Clin Immunol 7:43-50. 2007
  3. ncbi request reprint Evidence of a role of tumor necrosis factor alpha in refractory asthma
    Mike A Berry
    Institute for Lung Health, University Hospital of Leicester National Health Service Trust, Glenfield Hospital, Leicester, United Kingdom
    N Engl J Med 354:697-708. 2006
  4. pmc Management of asthma in adults: current therapy and future directions
    R H Green
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester, UK
    Postgrad Med J 79:259-67. 2003
  5. ncbi request reprint Comparison of asthma treatment given in addition to inhaled corticosteroids on airway inflammation and responsiveness
    R H Green
    Institute for Lung Health, Dept of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Groby Road, Leicester LE3 9PQ, UK
    Eur Respir J 27:1144-51. 2006
  6. pmc New therapies and management strategies in the treatment of asthma: patient-focused developments
    Joshua Agbetile
    Department of Respiratory Medicine and Thoracic Surgery, Institute for Lung Health, Glenfield Hospital, Leicester, UK
    J Asthma Allergy 4:1-12. 2011
  7. ncbi request reprint Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial
    R Siva
    Institute for Lung Health, Glenfield Hospital, Groby Road, Leicester, LE3 9PQ, UK
    Eur Respir J 29:906-13. 2007
  8. ncbi request reprint Observational study of the natural history of eosinophilic bronchitis
    M A Berry
    Institute of Lung Health, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Clin Exp Allergy 35:598-601. 2005
  9. pmc Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
    R H Green
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Groby Road, Leicester LE3 9PQ, UK
    Thorax 57:875-9. 2002
  10. ncbi request reprint The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma
    M A Berry
    Institute for Lung Health, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Clin Exp Allergy 35:1175-9. 2005

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
    Ruth H Green
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, LE3 9PQ, Leicester, UK
    Lancet 360:1715-21. 2002
    ..We aimed to assess whether a management strategy that minimises eosinophilic inflammation reduces asthma exacerbations compared with a standard management strategy...
  2. ncbi request reprint The reclassification of asthma based on subphenotypes
    Ruth H Green
    Department of Respiratory Medicine, Glenfield Hospital, Groby Road, Leicester, UK
    Curr Opin Allergy Clin Immunol 7:43-50. 2007
    ..The present review discusses the important literature in this field, placing current work in its historical context...
  3. ncbi request reprint Evidence of a role of tumor necrosis factor alpha in refractory asthma
    Mike A Berry
    Institute for Lung Health, University Hospital of Leicester National Health Service Trust, Glenfield Hospital, Leicester, United Kingdom
    N Engl J Med 354:697-708. 2006
    ..The development of tumor necrosis factor alpha (TNF-alpha) antagonists has made it feasible to investigate the role of this cytokine in refractory asthma...
  4. pmc Management of asthma in adults: current therapy and future directions
    R H Green
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester, UK
    Postgrad Med J 79:259-67. 2003
    ....
  5. ncbi request reprint Comparison of asthma treatment given in addition to inhaled corticosteroids on airway inflammation and responsiveness
    R H Green
    Institute for Lung Health, Dept of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Groby Road, Leicester LE3 9PQ, UK
    Eur Respir J 27:1144-51. 2006
    ..In conclusion, treatment given in addition to low-dose inhaled corticosteroids results in modest benefits. Formoterol and high-dose budesonide have contrasting effects on eosinophilic airway inflammation...
  6. pmc New therapies and management strategies in the treatment of asthma: patient-focused developments
    Joshua Agbetile
    Department of Respiratory Medicine and Thoracic Surgery, Institute for Lung Health, Glenfield Hospital, Leicester, UK
    J Asthma Allergy 4:1-12. 2011
    ..Finally, we will review the novel therapies that are becoming available, both pharmacological and interventional, and discuss their likely place in the management of this complex disease...
  7. ncbi request reprint Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial
    R Siva
    Institute for Lung Health, Glenfield Hospital, Groby Road, Leicester, LE3 9PQ, UK
    Eur Respir J 29:906-13. 2007
    ..A management strategy that aims to minimise eosinophilic airway inflammation, as well as symptoms, is associated with a reduction in severe exacerbations of chronic obstructive pulmonary disease...
  8. ncbi request reprint Observational study of the natural history of eosinophilic bronchitis
    M A Berry
    Institute of Lung Health, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Clin Exp Allergy 35:598-601. 2005
    ..Eosinophilic bronchitis is an important cause of chronic cough. Treatment with inhaled corticosteroids is associated with a short-term improvement in cough and reduced sputum eosinophil count but the long-term outcome is uncertain...
  9. pmc Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
    R H Green
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Groby Road, Leicester LE3 9PQ, UK
    Thorax 57:875-9. 2002
    ....
  10. ncbi request reprint The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma
    M A Berry
    Institute for Lung Health, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Clin Exp Allergy 35:1175-9. 2005
    ..Nitric oxide (NO) has potential advantages as a tool to monitor airway inflammation although little is known about the relationship between NO and eosinophilic airway inflammation and the factors which influence it...
  11. ncbi request reprint Induced sputum and other outcome measures in chronic obstructive pulmonary disease: safety and repeatability
    C E Brightling
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK
    Respir Med 95:999-1002. 2001
    ..96. In conclusion, sputum induction is safe and the cell and fluid phase mediators repeatable in the investigation of airway inflammation in patients with COPD. VAS symptom scores and the CRQ are reproducible outcome measures in COPD...
  12. ncbi request reprint Alveolar nitric oxide in adults with asthma: evidence of distal lung inflammation in refractory asthma
    M Berry
    Dept of Respiratory Medicine and Thoracic Surgery, Institute for Lung Health, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Eur Respir J 25:986-91. 2005
    ..In conclusion, these findings support the hypothesis that alveolar nitric oxide is a measure of distal airway inflammation and suggest that distal lung inflammation is present in refractory asthma...
  13. ncbi request reprint Multiple inflammatory hits and the pathogenesis of severe airway disease
    I D Pavord
    Institute for Lung Health, Dept of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester, LE3 9QP, UK
    Eur Respir J 27:884-8. 2006
    ....
  14. pmc Isolation of filamentous fungi from sputum in asthma is associated with reduced post-bronchodilator FEV1
    J Agbetile
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK
    Clin Exp Allergy 42:782-91. 2012
    ..Fungal sensitization is common in severe asthma, but the clinical relevance of this and the relationship with airway colonization by fungi remain unclear. The range of fungi that may colonize the airways in asthma is unknown...
  15. pmc British Thoracic Society Winter Meeting 2001
    C M Richardson
    Department of Respiratory Medicine, Glenfield Hospital, Leicester LE3 9QP, UK
    Thorax 57:286-8. 2002
  16. ncbi request reprint Cluster analysis and clinical asthma phenotypes
    Pranab Haldar
    Institute for Lung Health, Glenfield Hospital, Leicester LE39QP, UK
    Am J Respir Crit Care Med 178:218-24. 2008
    ..Heterogeneity in asthma expression is multidimensional, including variability in clinical, physiologic, and pathologic parameters. Classification requires consideration of these disparate domains in a unified model...
  17. ncbi request reprint The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial
    Dominick E Shaw
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester, United Kingdom
    Am J Respir Crit Care Med 176:231-7. 2007
    ..Current asthma guidelines recommend adjusting antiinflammatory treatment on the basis of the results of lung function tests and symptom assessment, neither of which are closely associated with airway inflammation...
  18. ncbi request reprint Biomarkers predicting response to corticosteroid therapy in asthma
    Christopher E Brightling
    Institute for Lung Health, University of Leicester and University Hospitals of Leicester, Leicester, UK
    Treat Respir Med 4:309-16. 2005
    ....
  19. ncbi request reprint Association between neutrophilic airway inflammation and airflow limitation in adults with asthma
    Dominick E Shaw
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester LE3 9QP, UK
    Chest 132:1871-5. 2007
    ..Chronic inflammation is assumed to be important, although there is limited and contradictory information about the relationship between airway inflammation and postbronchodilator FEV1...
  20. ncbi request reprint The influence of age on induced sputum differential cell counts in normal subjects
    Rebecca A Thomas
    Department of Respiratory Medicine, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Chest 126:1811-4. 2004
    ..This study was undertaken to assess whether there are age-related differences in sputum cell differential cell counts in a population of normal, healthy volunteers...