Michael F Greaney

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi Tandem indole C-H alkenylation/arylation for tetra-substituted alkene synthesis
    Laura Lopez Suarez
    School of Chemistry, University of Edinburgh, King s Buildings, West Mains Rd, Edinburgh, EH9 3JJ, UK
    Chem Commun (Camb) 47:7992-4. 2011
  2. ncbi Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles
    Scott P Webster
    Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Bioorg Med Chem Lett 20:3265-71. 2010
  3. ncbi Discovery of glutathione S-transferase inhibitors using dynamic combinatorial chemistry
    Baolu Shi
    School of Chemistry, University of Edinburgh, The King's Buildings, West Mains Road, Edinburgh EH9 3JJ, United Kingdom
    J Am Chem Soc 128:8459-67. 2006

Collaborators

Detail Information

Publications3

  1. ncbi Tandem indole C-H alkenylation/arylation for tetra-substituted alkene synthesis
    Laura Lopez Suarez
    School of Chemistry, University of Edinburgh, King s Buildings, West Mains Rd, Edinburgh, EH9 3JJ, UK
    Chem Commun (Camb) 47:7992-4. 2011
    ..An array of functionalised indole alkenes have been prepared in good to excellent yield, with the reaction being selective for the Z-alkene...
  2. ncbi Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles
    Scott P Webster
    Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Bioorg Med Chem Lett 20:3265-71. 2010
    ..Compounds are selective for 11beta-HSD1 over 11beta-HSD2 and possess good cellular potency in human and murine 11beta-HSD1 assays. A range of in vitro stabilities are observed in human liver microsome assays...
  3. ncbi Discovery of glutathione S-transferase inhibitors using dynamic combinatorial chemistry
    Baolu Shi
    School of Chemistry, University of Edinburgh, The King's Buildings, West Mains Road, Edinburgh EH9 3JJ, United Kingdom
    J Am Chem Soc 128:8459-67. 2006
    ..In both cases the strongest binding DCL components are identified due to molecular amplification by GST which, in the latter system, leads to the identification of two new inhibitors for the GST enzyme...