S G Grant

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Comparative study of human and mouse postsynaptic proteomes finds high compositional conservation and abundance differences for key synaptic proteins
    Alex Bayes
    Molecular Physiology of the Synapse Laboratory, Institut de Recerca de l Hospital de la Santa Creu i Sant Pau, UAB, Barcelona, Catalonia, Spain
    PLoS ONE 7:e46683. 2012
  2. pmc The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults
    Marc Andre Martel
    Centre for Integrative Physiology, University of Edinburgh School of Biomedical Sciences, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Neuron 74:543-56. 2012
  3. doi request reprint Synaptopathies: diseases of the synaptome
    Seth G N Grant
    Genes to Cognition Programme, Centre for Clinical Brain Sciences, The University of Edinburgh, Chancellors Building, 47 Little France Crescent, Edinburgh EH16 4SB, United Kingdom
    Curr Opin Neurobiol 22:522-9. 2012
  4. ncbi request reprint Proteomics of multiprotein complexes: answering fundamental questions in neuroscience
    S G Grant
    Dept of Neuroscience, University of Edinburgh, UK
    Trends Biotechnol 19:S49-54. 2001
  5. ncbi request reprint Proteomics in neuroscience: from protein to network
    S G Grant
    Department of Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom
    J Neurosci 21:8315-8. 2001
  6. ncbi request reprint Multiprotein complex signaling and the plasticity problem
    S G Grant
    Department of Neuroscience, University of Edinburgh, EH8 9JZ, Edinburgh, UK
    Curr Opin Neurobiol 11:363-8. 2001
  7. ncbi request reprint Systems biology in neuroscience: bridging genes to cognition
    Seth G N Grant
    Division of Neuroscience, 1 George Square, Edinburgh EH8 9JZ, UK
    Curr Opin Neurobiol 13:577-82. 2003
  8. ncbi request reprint Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein
    M Migaud
    Centre for Genome Research, University of Edinburgh, UK
    Nature 396:433-9. 1998
  9. ncbi request reprint Isolation of 2000-kDa complexes of N-methyl-D-aspartate receptor and postsynaptic density 95 from mouse brain
    H Husi
    Department of Neuroscience, University of Edinburgh, Edinburgh, UK
    J Neurochem 77:281-91. 2001
  10. ncbi request reprint SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor
    Noboru H Komiyama
    Division of Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom
    J Neurosci 22:9721-32. 2002

Collaborators

Detail Information

Publications38

  1. pmc Comparative study of human and mouse postsynaptic proteomes finds high compositional conservation and abundance differences for key synaptic proteins
    Alex Bayes
    Molecular Physiology of the Synapse Laboratory, Institut de Recerca de l Hospital de la Santa Creu i Sant Pau, UAB, Barcelona, Catalonia, Spain
    PLoS ONE 7:e46683. 2012
    ..Understanding synapse proteome diversity within and between species will be important to further our understanding of brain complexity and disease...
  2. pmc The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults
    Marc Andre Martel
    Centre for Integrative Physiology, University of Edinburgh School of Biomedical Sciences, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Neuron 74:543-56. 2012
    ..Dependence of NMDAR excitotoxicity on the GluN2 CTD subtype can be overcome by inducing high levels of NMDAR activity. Thus, the identity (2A versus 2B) of the GluN2 CTD controls the toxicity dose-response to episodes of NMDAR activity...
  3. doi request reprint Synaptopathies: diseases of the synaptome
    Seth G N Grant
    Genes to Cognition Programme, Centre for Clinical Brain Sciences, The University of Edinburgh, Chancellors Building, 47 Little France Crescent, Edinburgh EH16 4SB, United Kingdom
    Curr Opin Neurobiol 22:522-9. 2012
    ..Classifying synaptic disease phenotypes with genetic and proteome data provides a new brain disease classification system based on molecular etiology and pathogenesis...
  4. ncbi request reprint Proteomics of multiprotein complexes: answering fundamental questions in neuroscience
    S G Grant
    Dept of Neuroscience, University of Edinburgh, UK
    Trends Biotechnol 19:S49-54. 2001
    ..Simultaneous analysis of multiple proteins enables the development of new concepts and approaches for neuroscience research...
  5. ncbi request reprint Proteomics in neuroscience: from protein to network
    S G Grant
    Department of Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom
    J Neurosci 21:8315-8. 2001
    ..Here we will discuss the technology of proteomics and its applications to the nervous system...
  6. ncbi request reprint Multiprotein complex signaling and the plasticity problem
    S G Grant
    Department of Neuroscience, University of Edinburgh, EH8 9JZ, Edinburgh, UK
    Curr Opin Neurobiol 11:363-8. 2001
    ....
  7. ncbi request reprint Systems biology in neuroscience: bridging genes to cognition
    Seth G N Grant
    Division of Neuroscience, 1 George Square, Edinburgh EH8 9JZ, UK
    Curr Opin Neurobiol 13:577-82. 2003
    ..A neuroscience systems biology programme, organized as a consortium, is proposed...
  8. ncbi request reprint Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein
    M Migaud
    Centre for Genome Research, University of Edinburgh, UK
    Nature 396:433-9. 1998
    ..PSD-95 thus appears to be important in coupling the NMDA receptor to pathways that control bidirectional synaptic plasticity and learning...
  9. ncbi request reprint Isolation of 2000-kDa complexes of N-methyl-D-aspartate receptor and postsynaptic density 95 from mouse brain
    H Husi
    Department of Neuroscience, University of Edinburgh, Edinburgh, UK
    J Neurochem 77:281-91. 2001
    ..These methods can be used to define the structure of the complexes at different synapses and in mice carrying gene mutations as well as new tools for drug discovery...
  10. ncbi request reprint SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor
    Noboru H Komiyama
    Division of Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom
    J Neurosci 22:9721-32. 2002
    ..A comparison of SynGAP and PSD-95 mutants suggests that PSD-95 couples NMDARs to multiple downstream signaling pathways with very different roles in LTP and learning...
  11. ncbi request reprint Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice
    S G Grant
    Center for Genome Research, University of Edinburgh, UK
    Genes Dev 9:1909-21. 1995
    ..Tyrosine phosphorylation is a critical regulator of FAK, and impairments in FAK signal transduction in fyn mutants may contribute to the mutant neural phenotype...
  12. ncbi request reprint Neurone specific regulation of dendritic spines in vivo by post synaptic density 95 protein (PSD-95)
    Catherine A Vickers
    Department of Pre Clinical Veterinary Sciences, RDSVS Summerhall, University of Edinburgh, Edinburgh EH9 1QH, UK
    Brain Res 1090:89-98. 2006
    ..Thus, PSD-95 is an important regulator of neuronal structure as well as plasticity in vivo...
  13. ncbi request reprint Proteomics of the nervous system
    H Husi
    Dept of Neuroscience, University of Edinburgh, 1 George Square, Edinburgh, UK, EH9 9JZ
    Trends Neurosci 24:259-66. 2001
    ..This article reviews the impact of and outlines the application of proteomic analysis in the field of neuroscience, illustrating this with the example of NMDA receptor complexes...
  14. ncbi request reprint Neuropathic sensitization of behavioral reflexes and spinal NMDA receptor/CaM kinase II interactions are disrupted in PSD-95 mutant mice
    Emer M Garry
    Division of Preclinical Veterinary Sciences, R D SVS, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
    Curr Biol 13:321-8. 2003
    ..Disruption of CaM kinase II docking to the NMDA receptor and activation may be responsible for the lack of neuropathic behavioral reflex sensitization in PSD-95 mutant mice...
  15. ncbi request reprint Dynamic distribution of endoplasmic reticulum in hippocampal neuron dendritic spines
    Hakan Toresson
    Division of Neuroscience, College of Medicine and Veterinary Medicine, University of Edinburgh, 1 George Square, Edinburgh, UK
    Eur J Neurosci 22:1793-8. 2005
    ....
  16. ncbi request reprint Synaptic Ras GTPase activating protein regulates pattern formation in the trigeminal system of mice
    Mark W Barnett
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 26:1355-65. 2006
    ....
  17. ncbi request reprint Analyses of murine postsynaptic density-95 identify novel isoforms and potential translational control elements
    Matthew Bence
    Division of Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, UK
    Brain Res Mol Brain Res 133:143-52. 2005
    ..The variety of mRNA isoforms and regulatory elements identified provides for a high degree of diversity in the structure and function of PSD-95 proteins...
  18. pmc The proteomes of neurotransmitter receptor complexes form modular networks with distributed functionality underlying plasticity and behaviour
    Andrew J Pocklington
    School of Informatics, Edinburgh University, Edinburgh, UK
    Mol Syst Biol 2:2006.0023. 2006
    ..These studies of synapse proteome organisation suggest that molecular networks with simple design principles underpin synaptic signalling properties with important roles in physiology, behaviour and disease...
  19. ncbi request reprint Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories
    Niels Plath
    Molecular Neurobiology, Department of Biology Chemistry Pharmacy, Freie Universitat Berlin, 14195 Berlin, Germany
    Neuron 52:437-44. 2006
    ..In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage...
  20. pmc Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies
    Peter C Cuthbert
    Wellcome Trust Sanger Institute, Cambridge CB10 1SA, United Kingdom
    J Neurosci 27:2673-82. 2007
    ..This provides a mechanism for discriminating patterns of synaptic activity that lead to long-lasting changes in synaptic strength as well as distinct aspects of cognition in the mammalian nervous system...
  21. pmc Inhibition of the dopamine D1 receptor signaling by PSD-95
    Jingping Zhang
    Department of Psychiatry, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA
    J Biol Chem 282:15778-89. 2007
    ..These studies demonstrate a role for a glutamatergic scaffold in dopamine receptor signaling and trafficking and identify a new potential target for the modulation of abnormal dopaminergic function...
  22. pmc A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability
    Francesca Zalfa
    Dipartimento di Biologia, Universita Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy
    Nat Neurosci 10:578-87. 2007
    ..Through our functional analysis of this FMRP target we provide evidence that dysregulation of mRNA stability may contribute to the cognitive impairments in individuals with FXS...
  23. pmc Clustered gene expression changes flank targeted gene loci in knockout mice
    Luis M Valor
    Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Cambridge, United Kingdom
    PLoS ONE 2:e1303. 2007
    ..Gene expression profiling using microarrays is a powerful technology widely used to study regulatory networks. Profiling of mRNA levels in mutant organisms has the potential to identify genes regulated by the mutated protein...
  24. pmc Clustering of neuronal potassium channels is independent of their interaction with PSD-95
    Matthew N Rasband
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    J Cell Biol 159:663-72. 2002
    ..These data suggest that the primary function of PSD-95 at juxtaparanodes lies outside of its accepted role in mediating the high density clustering of Kv1 potassium channels at these sites...
  25. pmc Recording long-term potentiation of synaptic transmission by three-dimensional multi-electrode arrays
    Maksym V Kopanitsa
    Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    BMC Neurosci 7:61. 2006
    ....
  26. ncbi request reprint Phosphatidylinositol 3-kinase regulates the induction of long-term potentiation through extracellular signal-related kinase-independent mechanisms
    Patricio Opazo
    Department of Physiology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 23:3679-88. 2003
    ..Together, our results indicate that the role of PI3-kinase in LTP is not limited to its role as an upstream regulator of MAPK signaling but also includes signaling through ERK-independent pathways that regulate LTP induction...
  27. pmc Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling
    Michela Fagiolini
    Neuronal Circuit Development, Institute of Physical and Chemical Research, RIKEN, Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 100:2854-9. 2003
    ..Taken together, our results demonstrate that the cellular basis generating individual sensory response properties is separable in the developing neocortex...
  28. ncbi request reprint Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity
    Wei Dong Yao
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 41:625-38. 2004
    ..Our findings uncover a previously unappreciated role of PSD-95 in psychostimulant action and identify a molecular and cellular mechanism shared between drug-related plasticity and learning...
  29. ncbi request reprint Differential expression of two NMDA receptor interacting proteins, PSD-95 and SynGAP during mouse development
    Karen Porter
    Centre for Neuroscience Research, University of Edinburgh, Edinburgh UK
    Eur J Neurosci 21:351-62. 2005
    ..These data support the model that synaptic signalling complexes are heterogeneous and individual components show temporal and spatial specificity during development...
  30. ncbi request reprint Identification of PSD-93 as a substrate for the Src family tyrosine kinase Fyn
    Shigeyuki Nada
    Department of Oncogene Research, Research Institute for Microbial Disease, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 278:47610-21. 2003
    ..These results suggest that PSD-93 serves as a membrane-anchored substrate of Fyn and plays a role in the regulation of Fyn-mediated modification of NMDA receptor function...
  31. ncbi request reprint Synapse signalling complexes and networks: machines underlying cognition
    Seth G N Grant
    Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB1D 1SA, UK
    Bioessays 25:1229-35. 2003
    ..Supplementary material for this article can be found on the BioEssays website http://www.interscience.wiley.com/jpages/0265-9247/suppmat/index.html...
  32. pmc NMDA receptor activation dephosphorylates AMPA receptor glutamate receptor 1 subunits at threonine 840
    Jary Y Delgado
    Interdepartmental PhD Program for Neuroscience, University of California, Los Angeles, 90095, USA
    J Neurosci 27:13210-21. 2007
    ..Together, our results show that GluR1 phosphorylation at T840 is regulated by NMDA receptor activation and suggest that decreases in GluR1 phosphorylation at T840 may have a role in LTD...
  33. ncbi request reprint Toward a molecular catalogue of synapses
    Seth G N Grant
    Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Hinxton, Cambridge, Cambridgeshire, UK
    Brain Res Rev 55:445-9. 2007
    ..A case will be made for developing approaches that can be used to generate a general catalogue of synapse types based on molecular markers, which should have wide application...
  34. ncbi request reprint Proteomics in postgenomic neuroscience: the end of the beginning
    Jyoti Choudhary
    Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK
    Nat Neurosci 7:440-5. 2004
    ..The combination of proteomics with other global functional genomic approaches at the levels of genome and transcriptome, together with network biology, will provide important bridges between genes, physiology and pathology...
  35. pmc Network activity-independent coordinated gene expression program for synapse assembly
    Luis M Valor
    Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
    Proc Natl Acad Sci U S A 104:4658-63. 2007
    ..Thus, two distinct sequentially active gene expression programs underlie the genomic programs of synapse function...
  36. pmc The role of neuronal complexes in human X-linked brain diseases
    Frederic Laumonnier
    Genes to Cognition Programme, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, UK
    Am J Hum Genet 80:205-20. 2007
    ..We propose that systematic studies of PSD and NRC/MASC genes in mice and humans will give a high yield of novel genes important for human disease and new mechanistic insights into higher cognitive functions...
  37. ncbi request reprint AMPA receptor trafficking and GluR1
    Seth G N Grant
    Science 310:234-5; author reply 234-5. 2005
  38. ncbi request reprint Synapse proteomics of multiprotein complexes: en route from genes to nervous system diseases
    Seth G N Grant
    Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK
    Hum Mol Genet 14:R225-34. 2005
    ..genes2cognition.org) that links human and mouse genetics with proteomic studies...