Sander Granneman

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc A cluster of ribosome synthesis factors regulate pre-rRNA folding and 5.8S rRNA maturation by the Rat1 exonuclease
    Sander Granneman
    Wellcome Trust Centre for Cell Biology and Centre for Systems Biology at Edinburgh, University of Edinburgh, Edinburgh, Scotland
    EMBO J 30:4006-19. 2011
  2. pmc Proofreading of pre-40S ribosome maturation by a translation initiation factor and 60S subunits
    Simon Lebaron
    Wellcome Trust Centre for Cell Biology, The University of Edinburgh, Edinburgh, Scotland, UK
    Nat Struct Mol Biol 19:744-53. 2012
  3. pmc Cracking pre-40S ribosomal subunit structure by systematic analyses of RNA-protein cross-linking
    Sander Granneman
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland, UK
    EMBO J 29:2026-36. 2010
  4. pmc Identification of protein binding sites on U3 snoRNA and pre-rRNA by UV cross-linking and high-throughput analysis of cDNAs
    Sander Granneman
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Kings Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland
    Proc Natl Acad Sci U S A 106:9613-8. 2009
  5. pmc The nuclear RNA polymerase II surveillance system targets polymerase III transcripts
    Wiebke Wlotzka
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK
    EMBO J 30:1790-803. 2011
  6. doi request reprint Rrp5 Binding at Multiple Sites Coordinates Pre-rRNA Processing and Assembly
    Simon Lebaron
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Kings Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland
    Mol Cell 52:707-19. 2013
  7. ncbi request reprint Building ribosomes: even more expensive than expected?
    Sander Granneman
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Mayfield Road, Kings Buildings, Michael Swann Building, Edinburgh EH9 3JR, Scotland, UK
    Curr Biol 17:R415-7. 2007

Collaborators

Detail Information

Publications7

  1. pmc A cluster of ribosome synthesis factors regulate pre-rRNA folding and 5.8S rRNA maturation by the Rat1 exonuclease
    Sander Granneman
    Wellcome Trust Centre for Cell Biology and Centre for Systems Biology at Edinburgh, University of Edinburgh, Edinburgh, Scotland
    EMBO J 30:4006-19. 2011
    ..We predict that Nop4 and the A(3) cluster establish long-range interactions between the 5.8S and 25S rRNAs, which are subsequently maintained by ribosomal protein binding...
  2. pmc Proofreading of pre-40S ribosome maturation by a translation initiation factor and 60S subunits
    Simon Lebaron
    Wellcome Trust Centre for Cell Biology, The University of Edinburgh, Edinburgh, Scotland, UK
    Nat Struct Mol Biol 19:744-53. 2012
    ..We propose that recruitment of 60S subunits promotes GTP hydrolysis by Fun12, leading to structural rearrangements within the pre-40S particle that bring Nob1 and the pre-rRNA cleavage site together...
  3. pmc Cracking pre-40S ribosomal subunit structure by systematic analyses of RNA-protein cross-linking
    Sander Granneman
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland, UK
    EMBO J 29:2026-36. 2010
    ..Nob1 binds before pre-rRNA cleavage, and we conclude that structural reorganization is needed to bring together the catalytic PIN domain and its target...
  4. pmc Identification of protein binding sites on U3 snoRNA and pre-rRNA by UV cross-linking and high-throughput analysis of cDNAs
    Sander Granneman
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Kings Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland
    Proc Natl Acad Sci U S A 106:9613-8. 2009
    ..This finding demonstrates that the snoRNP proteins directly contact the pre-rRNA substrate, suggesting roles in snoRNA recruitment. The techniques reported here should be widely applicable to analyses of RNA-protein interactions...
  5. pmc The nuclear RNA polymerase II surveillance system targets polymerase III transcripts
    Wiebke Wlotzka
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK
    EMBO J 30:1790-803. 2011
    ..Surveillance targets were enriched for non-encoded A-rich tails. These were generally very short (1–5 nt), potentially explaining why adenylation destabilizes these RNAs while stabilizing mRNAs with long poly(A) tails...
  6. doi request reprint Rrp5 Binding at Multiple Sites Coordinates Pre-rRNA Processing and Assembly
    Simon Lebaron
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Kings Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland
    Mol Cell 52:707-19. 2013
    ..A key role in coordinating preribosomal assembly and processing was confirmed by chromatin spreads. Following depletion of Rrp5, cotranscriptional cleavage was lost and preribosome compaction greatly reduced. ..
  7. ncbi request reprint Building ribosomes: even more expensive than expected?
    Sander Granneman
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Mayfield Road, Kings Buildings, Michael Swann Building, Edinburgh EH9 3JR, Scotland, UK
    Curr Biol 17:R415-7. 2007
    ..Recent quantitative analyses of ribosomal protein trafficking in HeLa cells have revealed a prominent and unexpected role for the proteasome in regulating the availability of ribosomal proteins for subunit assembly...