Research Topics
Species | D GrammatopoulosSummaryAffiliation: University of Warwick Country: UK Publications
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Detail Information
Publications
The role of CRH receptors and their agonists in myometrial contractility and quiescence during pregnancy and labourDimitris K Grammatopoulos
Endocrinology and Metabolism, Division of Clinical Sciences, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, United Kingdom
Front Biosci 12:561-71. 2007..This review will provide the current concepts about the role of CRH and UCNs and their myometrial receptors during pregnancy, labor and delivery...- Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonistsDimitris K Grammatopoulos
Sir Quinton Hazell Molecular Medicine Research Centre, Dept of Biological Sciences, The University of Warwick, Coventry, UK CV4 7AL
Trends Endocrinol Metab 13:436-44. 2002..Because of the complex network of multiple CRH receptor subtypes and their tissue- and agonist-specific signaling diversity, antagonists need to be developed that can target specific CRH receptor isoform-driven signaling pathways... 
Measurement of thyroglobulin mRNA in peripheral blood as an adjunctive test for monitoring thyroid cancerD Grammatopoulos
Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK
Mol Pathol 56:162-6. 2003..This study investigated whether the detection of Tg mRNA in peripheral blood, using reverse transcriptase polymerase chain reaction (RT-PCR), is of value in the biochemical surveillance of patients with thyroid cancer...- Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasisH S Randeva
Sir Quinton Hazel Molecular Medicine Research Center, Department of Biological Sciences, University of Warwick, Coventry, United Kingdom CV4 7AL
J Clin Endocrinol Metab 86:4808-13. 2001..The concept that the peptide acting via these receptors in the adult adrenal is responsible for steroidogenesis and energy balance is attractive... - Corticotropin-releasing hormone receptorsE W Hillhouse
Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK
Biochem Soc Trans 30:428-32. 2002..In this review we focus on the diverse structural and functional characteristics of the family of CRH-like peptides and their receptors... - Human corticotropin-releasing hormone receptor: differences in subtype expression between pregnant and nonpregnant myometriaD Grammatopoulos
Sir Quinton Hazell Molecular Medicine Research Center, Department of Biological Sciences, University of Warwick, Coventry, United Kingdom
J Clin Endocrinol Metab 83:2539-44. 1998..These findings suggest that CRH receptor expression plays an important modulatory role in myometrial and possibly in cervical function... - The onset of labor alters corticotropin-releasing hormone type 1 receptor variant expression in human myometrium: putative role of interleukin-1betaDanijela Markovic
Endocrinology and Metabolism, Warwick Medical School, The University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
Endocrinology 148:3205-13. 2007.... - Identification of signaling molecules mediating corticotropin-releasing hormone-R1alpha-mitogen-activated protein kinase (MAPK) interactions: the critical role of phosphatidylinositol 3-kinase in regulating ERK1/2 but not p38 MAPK activationAnu Punn
Endocrinology and Metabolism, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
Mol Endocrinol 20:3179-95. 2006..In conclusion, a complex signaling network appears to mediate CRH-R1alpha-MAPK interactions; PI3-K might play a critical role in the regulation of CRH-R1alpha signaling selectivity and cellular responses... - Preeclampsia is associated with impaired regulation of the placental nitric oxide-cyclic guanosine monophosphate pathway by corticotropin-releasing hormone (CRH) and CRH-related peptidesEmmanouil Karteris
Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
J Clin Endocrinol Metab 90:3680-7. 2005..This pathway appears to be impaired in PE and may contribute toward dysregulation of the balance controlling vascular resistance... - Protein kinase A-induced negative regulation of the corticotropin-releasing hormone R1alpha receptor-extracellularly regulated kinase signal transduction pathway: the critical role of Ser301 for signaling switch and selectivityNikolleta Papadopoulou
Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, The University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
Mol Endocrinol 18:624-39. 2004..Phosphorylation by PKA prevents maximal coupling of the CRH-R1alpha to Gq-protein, and thereby reduces activation of ERK 1/2... - Corticotropin-releasing factor receptors couple to multiple G-proteins to activate diverse intracellular signaling pathways in mouse hippocampus: role in neuronal excitability and associative learningThomas Blank
Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, D 37075 Goettingen, Germany
J Neurosci 23:700-7. 2003..These results indicate that the CRF system activates different intracellular signaling pathways in mouse hippocampus and may have distinct effects on associative learning depending on the mouse strain investigated... - Role of stress peptides during human pregnancy and labourEdward W Hillhouse
The Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK
Reproduction 124:323-9. 2002..These peptides and receptors are phylogenetically ancient and well preserved across species. They may have evolved as a mechanism to protect against the 'stress' of premature birth... - Up-regulation of nitric oxide synthase and modulation of the guanylate cyclase activity by corticotropin-releasing hormone but not urocortin II or urocortin III in cultured human pregnant myometrial cellsEleni Aggelidou
Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
Proc Natl Acad Sci U S A 99:3300-5. 2002.... - Intracellular mechanisms regulating corticotropin-releasing hormone receptor-2beta endocytosis and interaction with extracellularly regulated kinase 1/2 and p38 mitogen-activated protein kinase signaling cascadesDanijela Markovic
Endocrinology and Metabolism, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
Mol Endocrinol 22:689-706. 2008..These findings provide new insights about the signaling mechanisms regulating CRH-R2beta functional activity and determining its biological responses... - Regulation of corticotropin-releasing hormone receptor type 1alpha signaling: structural determinants for G protein-coupled receptor kinase-mediated phosphorylation and agonist-mediated desensitizationThalia Teli
Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, The University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
Mol Endocrinol 19:474-90. 2005..Based on our identification of key amino acid(s) for GRK-dependent phosphorylation, we demonstrate the importance of the CRH-R1alpha carboxyl tail for regulation of receptor activity... - The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiologyEdward W Hillhouse
The Leeds Institute of Genetics, Health and Therapeutics, The University of Leeds, Leeds LS2 9NL, UK
Endocr Rev 27:260-86. 2006..The type of activating agonist, receptor, and target cell appears to play a major role in determining the overall signaling and biological responses in health and disease... - Differential responses of corticotropin-releasing hormone receptor type 1 variants to protein kinase C phosphorylationDanijela Markovic
Endocrinology and Metabolism, Division of Clinical Sciences, Warwick Medical School, University of Warwick, Coventry, UK
J Pharmacol Exp Ther 319:1032-42. 2006..Our findings indicate that CRH-R1alpha and -R1beta exhibit differential responses to PKC-induced phosphorylation, and this might represent an important mechanism for functional regulation of CRH signaling in target cells... - Potential signalling pathways underlying corticotrophin-releasing hormone-mediated neuroprotection from excitotoxicity in rat hippocampusCaroline R Elliott-Hunt
Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Coventry, UK
J Neurochem 80:416-25. 2002.... - Structural domains determining signalling characteristics of the CRH-receptor type 1 variant R1beta and response to PKC phosphorylationThalia Teli
Endocrinology and Metabolism, Division of Clinical Sciences, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK
Cell Signal 20:40-9. 2008..These findings provide new insights about the structural determinants of CRH-R1 coupling to Gs proteins and response to protein kinase phosphorylation...