D Grammatopoulos

Summary

Affiliation: University of Warwick
Country: UK

Publications

  1. ncbi request reprint The role of CRH receptors and their agonists in myometrial contractility and quiescence during pregnancy and labour
    Dimitris K Grammatopoulos
    Endocrinology and Metabolism, Division of Clinical Sciences, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, United Kingdom
    Front Biosci 12:561-71. 2007
  2. ncbi request reprint Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists
    Dimitris K Grammatopoulos
    Sir Quinton Hazell Molecular Medicine Research Centre, Dept of Biological Sciences, The University of Warwick, Coventry, UK CV4 7AL
    Trends Endocrinol Metab 13:436-44. 2002
  3. pmc Measurement of thyroglobulin mRNA in peripheral blood as an adjunctive test for monitoring thyroid cancer
    D Grammatopoulos
    Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK
    Mol Pathol 56:162-6. 2003
  4. ncbi request reprint Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis
    H S Randeva
    Sir Quinton Hazel Molecular Medicine Research Center, Department of Biological Sciences, University of Warwick, Coventry, United Kingdom CV4 7AL
    J Clin Endocrinol Metab 86:4808-13. 2001
  5. ncbi request reprint Corticotropin-releasing hormone receptors
    E W Hillhouse
    Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK
    Biochem Soc Trans 30:428-32. 2002
  6. ncbi request reprint Human corticotropin-releasing hormone receptor: differences in subtype expression between pregnant and nonpregnant myometria
    D Grammatopoulos
    Sir Quinton Hazell Molecular Medicine Research Center, Department of Biological Sciences, University of Warwick, Coventry, United Kingdom
    J Clin Endocrinol Metab 83:2539-44. 1998
  7. ncbi request reprint The onset of labor alters corticotropin-releasing hormone type 1 receptor variant expression in human myometrium: putative role of interleukin-1beta
    Danijela Markovic
    Endocrinology and Metabolism, Warwick Medical School, The University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Endocrinology 148:3205-13. 2007
  8. ncbi request reprint Identification of signaling molecules mediating corticotropin-releasing hormone-R1alpha-mitogen-activated protein kinase (MAPK) interactions: the critical role of phosphatidylinositol 3-kinase in regulating ERK1/2 but not p38 MAPK activation
    Anu Punn
    Endocrinology and Metabolism, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Mol Endocrinol 20:3179-95. 2006
  9. ncbi request reprint Preeclampsia is associated with impaired regulation of the placental nitric oxide-cyclic guanosine monophosphate pathway by corticotropin-releasing hormone (CRH) and CRH-related peptides
    Emmanouil Karteris
    Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 90:3680-7. 2005
  10. ncbi request reprint Protein kinase A-induced negative regulation of the corticotropin-releasing hormone R1alpha receptor-extracellularly regulated kinase signal transduction pathway: the critical role of Ser301 for signaling switch and selectivity
    Nikolleta Papadopoulou
    Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, The University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Mol Endocrinol 18:624-39. 2004

Collaborators

Detail Information

Publications19

  1. ncbi request reprint The role of CRH receptors and their agonists in myometrial contractility and quiescence during pregnancy and labour
    Dimitris K Grammatopoulos
    Endocrinology and Metabolism, Division of Clinical Sciences, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, United Kingdom
    Front Biosci 12:561-71. 2007
    ..This review will provide the current concepts about the role of CRH and UCNs and their myometrial receptors during pregnancy, labor and delivery...
  2. ncbi request reprint Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists
    Dimitris K Grammatopoulos
    Sir Quinton Hazell Molecular Medicine Research Centre, Dept of Biological Sciences, The University of Warwick, Coventry, UK CV4 7AL
    Trends Endocrinol Metab 13:436-44. 2002
    ..Because of the complex network of multiple CRH receptor subtypes and their tissue- and agonist-specific signaling diversity, antagonists need to be developed that can target specific CRH receptor isoform-driven signaling pathways...
  3. pmc Measurement of thyroglobulin mRNA in peripheral blood as an adjunctive test for monitoring thyroid cancer
    D Grammatopoulos
    Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK
    Mol Pathol 56:162-6. 2003
    ..This study investigated whether the detection of Tg mRNA in peripheral blood, using reverse transcriptase polymerase chain reaction (RT-PCR), is of value in the biochemical surveillance of patients with thyroid cancer...
  4. ncbi request reprint Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis
    H S Randeva
    Sir Quinton Hazel Molecular Medicine Research Center, Department of Biological Sciences, University of Warwick, Coventry, United Kingdom CV4 7AL
    J Clin Endocrinol Metab 86:4808-13. 2001
    ..The concept that the peptide acting via these receptors in the adult adrenal is responsible for steroidogenesis and energy balance is attractive...
  5. ncbi request reprint Corticotropin-releasing hormone receptors
    E W Hillhouse
    Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK
    Biochem Soc Trans 30:428-32. 2002
    ..In this review we focus on the diverse structural and functional characteristics of the family of CRH-like peptides and their receptors...
  6. ncbi request reprint Human corticotropin-releasing hormone receptor: differences in subtype expression between pregnant and nonpregnant myometria
    D Grammatopoulos
    Sir Quinton Hazell Molecular Medicine Research Center, Department of Biological Sciences, University of Warwick, Coventry, United Kingdom
    J Clin Endocrinol Metab 83:2539-44. 1998
    ..These findings suggest that CRH receptor expression plays an important modulatory role in myometrial and possibly in cervical function...
  7. ncbi request reprint The onset of labor alters corticotropin-releasing hormone type 1 receptor variant expression in human myometrium: putative role of interleukin-1beta
    Danijela Markovic
    Endocrinology and Metabolism, Warwick Medical School, The University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Endocrinology 148:3205-13. 2007
    ....
  8. ncbi request reprint Identification of signaling molecules mediating corticotropin-releasing hormone-R1alpha-mitogen-activated protein kinase (MAPK) interactions: the critical role of phosphatidylinositol 3-kinase in regulating ERK1/2 but not p38 MAPK activation
    Anu Punn
    Endocrinology and Metabolism, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Mol Endocrinol 20:3179-95. 2006
    ..In conclusion, a complex signaling network appears to mediate CRH-R1alpha-MAPK interactions; PI3-K might play a critical role in the regulation of CRH-R1alpha signaling selectivity and cellular responses...
  9. ncbi request reprint Preeclampsia is associated with impaired regulation of the placental nitric oxide-cyclic guanosine monophosphate pathway by corticotropin-releasing hormone (CRH) and CRH-related peptides
    Emmanouil Karteris
    Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 90:3680-7. 2005
    ..This pathway appears to be impaired in PE and may contribute toward dysregulation of the balance controlling vascular resistance...
  10. ncbi request reprint Protein kinase A-induced negative regulation of the corticotropin-releasing hormone R1alpha receptor-extracellularly regulated kinase signal transduction pathway: the critical role of Ser301 for signaling switch and selectivity
    Nikolleta Papadopoulou
    Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, The University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Mol Endocrinol 18:624-39. 2004
    ..Phosphorylation by PKA prevents maximal coupling of the CRH-R1alpha to Gq-protein, and thereby reduces activation of ERK 1/2...
  11. ncbi request reprint Corticotropin-releasing factor receptors couple to multiple G-proteins to activate diverse intracellular signaling pathways in mouse hippocampus: role in neuronal excitability and associative learning
    Thomas Blank
    Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, D 37075 Goettingen, Germany
    J Neurosci 23:700-7. 2003
    ..These results indicate that the CRF system activates different intracellular signaling pathways in mouse hippocampus and may have distinct effects on associative learning depending on the mouse strain investigated...
  12. ncbi request reprint Role of stress peptides during human pregnancy and labour
    Edward W Hillhouse
    The Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK
    Reproduction 124:323-9. 2002
    ..These peptides and receptors are phylogenetically ancient and well preserved across species. They may have evolved as a mechanism to protect against the 'stress' of premature birth...
  13. pmc Up-regulation of nitric oxide synthase and modulation of the guanylate cyclase activity by corticotropin-releasing hormone but not urocortin II or urocortin III in cultured human pregnant myometrial cells
    Eleni Aggelidou
    Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Proc Natl Acad Sci U S A 99:3300-5. 2002
    ....
  14. ncbi request reprint Intracellular mechanisms regulating corticotropin-releasing hormone receptor-2beta endocytosis and interaction with extracellularly regulated kinase 1/2 and p38 mitogen-activated protein kinase signaling cascades
    Danijela Markovic
    Endocrinology and Metabolism, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom
    Mol Endocrinol 22:689-706. 2008
    ..These findings provide new insights about the signaling mechanisms regulating CRH-R2beta functional activity and determining its biological responses...
  15. ncbi request reprint Regulation of corticotropin-releasing hormone receptor type 1alpha signaling: structural determinants for G protein-coupled receptor kinase-mediated phosphorylation and agonist-mediated desensitization
    Thalia Teli
    Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, The University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Mol Endocrinol 19:474-90. 2005
    ..Based on our identification of key amino acid(s) for GRK-dependent phosphorylation, we demonstrate the importance of the CRH-R1alpha carboxyl tail for regulation of receptor activity...
  16. ncbi request reprint The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology
    Edward W Hillhouse
    The Leeds Institute of Genetics, Health and Therapeutics, The University of Leeds, Leeds LS2 9NL, UK
    Endocr Rev 27:260-86. 2006
    ..The type of activating agonist, receptor, and target cell appears to play a major role in determining the overall signaling and biological responses in health and disease...
  17. ncbi request reprint Differential responses of corticotropin-releasing hormone receptor type 1 variants to protein kinase C phosphorylation
    Danijela Markovic
    Endocrinology and Metabolism, Division of Clinical Sciences, Warwick Medical School, University of Warwick, Coventry, UK
    J Pharmacol Exp Ther 319:1032-42. 2006
    ..Our findings indicate that CRH-R1alpha and -R1beta exhibit differential responses to PKC-induced phosphorylation, and this might represent an important mechanism for functional regulation of CRH signaling in target cells...
  18. ncbi request reprint Potential signalling pathways underlying corticotrophin-releasing hormone-mediated neuroprotection from excitotoxicity in rat hippocampus
    Caroline R Elliott-Hunt
    Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Coventry, UK
    J Neurochem 80:416-25. 2002
    ....
  19. ncbi request reprint Structural domains determining signalling characteristics of the CRH-receptor type 1 variant R1beta and response to PKC phosphorylation
    Thalia Teli
    Endocrinology and Metabolism, Division of Clinical Sciences, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK
    Cell Signal 20:40-9. 2008
    ..These findings provide new insights about the structural determinants of CRH-R1 coupling to Gs proteins and response to protein kinase phosphorylation...