Ian Grainge

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. doi request reprint Sporulation: SpoIIIE is the key to cell differentiation
    Ian Grainge
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
    Curr Biol 18:R871-2. 2008
  2. doi request reprint The Escherichia coli DNA translocase FtsK
    David J Sherratt
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
    Biochem Soc Trans 38:395-8. 2010
  3. pmc Separating speed and ability to displace roadblocks during DNA translocation by FtsK
    Estelle Crozat
    Department of Biochemistry, University of Oxford, Oxford, UK
    EMBO J 29:1423-33. 2010
  4. doi request reprint FtsK DNA translocase: the fast motor that knows where it's going
    Estelle Crozat
    Department of Biochemistry, University of Oxford, Oxford, UK
    Chembiochem 11:2232-43. 2010
  5. pmc Unlinking chromosome catenanes in vivo by site-specific recombination
    Ian Grainge
    Department of Biochemistry, University of Oxford, Oxford, UK
    EMBO J 26:4228-38. 2007
  6. pmc Activation of XerCD-dif recombination by the FtsK DNA translocase
    Ian Grainge
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Nucleic Acids Res 39:5140-8. 2011
  7. pmc Tracking of controlled Escherichia coli replication fork stalling and restart at repressor-bound DNA in vivo
    Christophe Possoz
    Division of Molecular Genetics, Department of Biochemistry, University of Oxford, Oxford, UK
    EMBO J 25:2596-604. 2006
  8. pmc Biochemical analysis of components of the pre-replication complex of Archaeoglobus fulgidus
    Ian Grainge
    Cancer Research UK, Clare Hall Laboratories, The London Research Institute, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3LD, UK
    Nucleic Acids Res 31:4888-98. 2003
  9. pmc Molecular mechanism of sequence-directed DNA loading and translocation by FtsK
    Jan Lowe
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB20QH, UK
    Mol Cell 31:498-509. 2008

Detail Information

Publications9

  1. doi request reprint Sporulation: SpoIIIE is the key to cell differentiation
    Ian Grainge
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
    Curr Biol 18:R871-2. 2008
    ..Several recent studies highlight the key roles of the SpoIIIE motor in this process...
  2. doi request reprint The Escherichia coli DNA translocase FtsK
    David J Sherratt
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
    Biochem Soc Trans 38:395-8. 2010
    ..In the present paper, the properties in vivo and in vitro of FtsK and its relatives are discussed in relation to the biological functions of these remarkable enzymes...
  3. pmc Separating speed and ability to displace roadblocks during DNA translocation by FtsK
    Estelle Crozat
    Department of Biochemistry, University of Oxford, Oxford, UK
    EMBO J 29:1423-33. 2010
    ..This separation of translocation velocity and ability to displace roadblocks is more consistent with a sequential escort mechanism than stochastic, hand-off, or concerted mechanisms...
  4. doi request reprint FtsK DNA translocase: the fast motor that knows where it's going
    Estelle Crozat
    Department of Biochemistry, University of Oxford, Oxford, UK
    Chembiochem 11:2232-43. 2010
    ..Once the FtsK translocase has located the dif site it then interacts with the XerCD site-specific recombinases to activate recombination...
  5. pmc Unlinking chromosome catenanes in vivo by site-specific recombination
    Ian Grainge
    Department of Biochemistry, University of Oxford, Oxford, UK
    EMBO J 26:4228-38. 2007
    ..We conclude that FtsK acts in vivo to simplify chromosomal topology as Xer recombination interconverts monomeric and dimeric chromosomes...
  6. pmc Activation of XerCD-dif recombination by the FtsK DNA translocase
    Ian Grainge
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Nucleic Acids Res 39:5140-8. 2011
    ....
  7. pmc Tracking of controlled Escherichia coli replication fork stalling and restart at repressor-bound DNA in vivo
    Christophe Possoz
    Division of Molecular Genetics, Department of Biochemistry, University of Oxford, Oxford, UK
    EMBO J 25:2596-604. 2006
    ..Roadblocks positioned near oriC or the dif site did not prevent replication and segregation of the rest of the chromosome...
  8. pmc Biochemical analysis of components of the pre-replication complex of Archaeoglobus fulgidus
    Ian Grainge
    Cancer Research UK, Clare Hall Laboratories, The London Research Institute, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3LD, UK
    Nucleic Acids Res 31:4888-98. 2003
    ..Nuclease protection showed that the binding sites for Mcm and Orc/Cdc6 overlap. The Orc/Cdc6 protein bound more tightly to these substrates and was able to displace pre-bound Mcm hexamer...
  9. pmc Molecular mechanism of sequence-directed DNA loading and translocation by FtsK
    Jan Lowe
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB20QH, UK
    Mol Cell 31:498-509. 2008
    ..During translocation, FtsK fails to recognize an inverted KOPS sequence. Therefore, we propose that KOPS act solely as a loading site for FtsK, resulting in a unidirectionally oriented hexameric motor upon DNA...