D I Graham

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint Novel aspects of the neuropathology of the vegetative state after blunt head injury
    D I Graham
    Academic Unit of Neuropathology, Institute of Neurological Sciences, Southern General Hospital, University of Glasgow, Glasgow, G51 4TF, UK
    Prog Brain Res 150:445-55. 2005
  2. pmc The structural basis of moderate disability after traumatic brain damage
    J H Adams
    University Department of Neuropathology, Institute of Neurological Sciences, South Glasgow University Hospitals NHS Trust, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK
    J Neurol Neurosurg Psychiatry 71:521-4. 2001
  3. ncbi request reprint Trials and tribulations of using beta-amyloid precursor protein immunohistochemistry to evaluate traumatic brain injury in adults
    D I Graham
    Academic Unit of Neuropathology, Division of Clinical Neuroscience, Institute of Neurological Sciences, Southern General Hospital NHS Trust, Glasgow, Scotland, UK
    Forensic Sci Int 146:89-96. 2004
  4. ncbi request reprint Tissue tears in the white matter after lateral fluid percussion brain injury in the rat: relevance to human brain injury
    D I Graham
    Department of Neuropathology, Southern General Hospital NHS Trust, University of Glasgow, Scotland
    Acta Neuropathol 99:117-24. 2000
  5. ncbi request reprint Neuropathology of the vegetative state after head injury
    D I Graham
    University of Glasgow, UK
    Neuropsychol Rehabil 15:198-213. 2005
  6. ncbi request reprint No evidence for the presence of apolipoprotein epsilon4, interleukin-lalpha allele 2 and interleukin-1beta allele 2 cause an increase in programmed cell death following traumatic brain injury in humans
    V E Johnson
    Academic Unit of Neuropathology, University of Glasgow, Glasgow, Scotland, UK
    Clin Neuropathol 25:255-64. 2006
  7. ncbi request reprint In situ DNA fragmentation occurs in white matter up to 12 months after head injury in man
    S Williams
    University Department of Neuropathology, Institute of Neurological Sciences, South Glasgow University Hospitals, NHS Trust, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, UK
    Acta Neuropathol 102:581-90. 2001
  8. pmc The neuroinflammatory response in humans after traumatic brain injury
    C Smith
    Academic Dept of Neuropathology, University of Edinburgh, Edinburgh, UK University Academic Dept of Neuropathology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK
    Neuropathol Appl Neurobiol 39:654-66. 2013
  9. pmc Association of APOE e4 and cerebrovascular pathology in traumatic brain injury
    C Smith
    Department of Neuropathology, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, UK
    J Neurol Neurosurg Psychiatry 77:363-6. 2006
  10. ncbi request reprint Long-term intracerebral inflammatory response after traumatic brain injury
    S M Gentleman
    Department of Neuropathology, Division of Neuroscience and Psychological Medicine, Imperial College London, Charing Cross Campus, London, UK
    Forensic Sci Int 146:97-104. 2004

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Novel aspects of the neuropathology of the vegetative state after blunt head injury
    D I Graham
    Academic Unit of Neuropathology, Institute of Neurological Sciences, Southern General Hospital, University of Glasgow, Glasgow, G51 4TF, UK
    Prog Brain Res 150:445-55. 2005
    ..Although amyloid plaques and tau inclusions were identified in some, their contribution did not seem important in the ultimate clinical outcome...
  2. pmc The structural basis of moderate disability after traumatic brain damage
    J H Adams
    University Department of Neuropathology, Institute of Neurological Sciences, South Glasgow University Hospitals NHS Trust, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK
    J Neurol Neurosurg Psychiatry 71:521-4. 2001
    ..In conclusion, the dominant lesion was focal damage from an evacuated intracranial haematoma. Severe diffuse damage was not found, with diffuse axonal injury only mild and thalamic damage in only one patient...
  3. ncbi request reprint Trials and tribulations of using beta-amyloid precursor protein immunohistochemistry to evaluate traumatic brain injury in adults
    D I Graham
    Academic Unit of Neuropathology, Division of Clinical Neuroscience, Institute of Neurological Sciences, Southern General Hospital NHS Trust, Glasgow, Scotland, UK
    Forensic Sci Int 146:89-96. 2004
    ..betaAPP carried out on a small number of randomly taken blocks is likely to lead to misinterpretation of the clinico-pathological correlations and possibly to a miscarriage of justice...
  4. ncbi request reprint Tissue tears in the white matter after lateral fluid percussion brain injury in the rat: relevance to human brain injury
    D I Graham
    Department of Neuropathology, Southern General Hospital NHS Trust, University of Glasgow, Scotland
    Acta Neuropathol 99:117-24. 2000
    ..This lesion is considered to be due to severe deformation of white matter and this is the first time that it has been identified reproducibly in a rodent model of head injury under controlled conditions...
  5. ncbi request reprint Neuropathology of the vegetative state after head injury
    D I Graham
    University of Glasgow, UK
    Neuropsychol Rehabil 15:198-213. 2005
    ..However, both ischaemic brain damage and the vascular complications of raised intracranial pressure contributed to the clinical signs and symptoms...
  6. ncbi request reprint No evidence for the presence of apolipoprotein epsilon4, interleukin-lalpha allele 2 and interleukin-1beta allele 2 cause an increase in programmed cell death following traumatic brain injury in humans
    V E Johnson
    Academic Unit of Neuropathology, University of Glasgow, Glasgow, Scotland, UK
    Clin Neuropathol 25:255-64. 2006
    ..The cellular and molecular responses after head injury are partly influenced by genetic polymorphisms of apolipoprotein E and the pro-inflammatory cytokine IL-I...
  7. ncbi request reprint In situ DNA fragmentation occurs in white matter up to 12 months after head injury in man
    S Williams
    University Department of Neuropathology, Institute of Neurological Sciences, South Glasgow University Hospitals, NHS Trust, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, UK
    Acta Neuropathol 102:581-90. 2001
    ..It was concluded that, as reflected by TUNEL histochemistry, long-term DNA fragmentation is present in white matter after traumatic brain injury in man...
  8. pmc The neuroinflammatory response in humans after traumatic brain injury
    C Smith
    Academic Dept of Neuropathology, University of Edinburgh, Edinburgh, UK University Academic Dept of Neuropathology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK
    Neuropathol Appl Neurobiol 39:654-66. 2013
    ....
  9. pmc Association of APOE e4 and cerebrovascular pathology in traumatic brain injury
    C Smith
    Department of Neuropathology, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, UK
    J Neurol Neurosurg Psychiatry 77:363-6. 2006
    ..Previous studies have found the e4 allele of the apolipoprotein E gene (APOE e4) is associated with an unfavourable outcome after head injury, but this has not been related to specific pathological features...
  10. ncbi request reprint Long-term intracerebral inflammatory response after traumatic brain injury
    S M Gentleman
    Department of Neuropathology, Division of Neuroscience and Psychological Medicine, Imperial College London, Charing Cross Campus, London, UK
    Forensic Sci Int 146:97-104. 2004
    ..In support of this hypothesis we present evidence of persistent elevated microglial activity in long-term survivors of head injury and the suggestion of an association between the extent of this activity and interleukin-1 genotype...
  11. ncbi request reprint The significance of beta-APP immunoreactivity in forensic practice
    R R Reichard
    Academic Unit of Neuropathology, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, UK
    Neuropathol Appl Neurobiol 31:304-13. 2005
    ....
  12. ncbi request reprint beta-amyloid (Abeta)42(43), abeta42, abeta40 and apoE immunostaining of plaques in fatal head injury
    K Horsburgh
    Wellcome Surgical Institute and Hugh Fraser Neuroscience Laboratories, University of Glasgow, Glasgow, UK
    Neuropathol Appl Neurobiol 26:124-32. 2000
    ..Further, the findings may be of relevance to the role of apoE genotype in influencing outcome after acute brain injury...
  13. ncbi request reprint Neuropathology in vegetative and severely disabled patients after head injury
    B Jennett
    University Department of Neurosurgery, Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK
    Neurology 56:486-90. 2001
    ..In the severely disabled patients with lesions similar to those of VS cases it is likely that a greater quantitative amount of damage occurred in the VS cases...
  14. ncbi request reprint Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia
    H Imai
    Wellcome Surgical Institute and Department of Neuropathology, University of Glasgow, Glasgow, Scotland
    Stroke 32:2149-54. 2001
    ..The reduction in tissue displaying evidence of oxidative stress suggests that the major mechanism of action is attenuation of free radical damage...
  15. ncbi request reprint Up-regulation of a growth arrest and DNA damage protein (GADD34) in the ischaemic human brain: implications for protein synthesis regulation and DNA repair
    F White
    Division of Clinical Neuroscience, University of Glasgow, UK
    Neuropathol Appl Neurobiol 30:683-91. 2004
    ..The up-regulation of GADD34 in response to global ischaemia in the human brain plus its influence on protein synthesis and DNA repair suggests that this protein may have the potential to influence cell survival...
  16. ncbi request reprint There is no evidence of an association in children and teenagers between the apolipoprotein E epsilon4 allele and post-traumatic brain swelling
    T J Quinn
    University of Glasgow Academic Unit of Neuropathology, Southern General Hospital, Glasgow, UK
    Neuropathol Appl Neurobiol 30:569-75. 2004
    ..Thus, a significant relationship was not found between diffuse brain swelling and possession of APOEepsilon4, and in this cohort of patients there was an identifying cause of the brain swelling in all cases...
  17. ncbi request reprint TUNEL-positive staining in white and grey matter after fatal head injury in man
    K Shaw
    University Department of Neuropathology, South Glasgow University Hospitals NHS Trust, Southern General Hospital, UK
    Clin Neuropathol 20:106-12. 2001
    ..In the grey matter, most TUNEL+ cells had the morphology of necrosis. However, the histological appearances of some of the neurons (2-3%), and of oligodendroglia and macrophages in white matter (about 5%) were those of apoptosis...
  18. ncbi request reprint Increased tau immunoreactivity in oligodendrocytes following human stroke and head injury
    E A Irving
    Wellcome Surgical Institute, Glasgow, UK
    Neurosci Lett 213:189-92. 1996
    ....
  19. ncbi request reprint Non-traumatic forensic neuropathology
    W Stewart
    Academic Unit of Neuropathology, University of Glasgow, Glasgow, Scotland, UK
    Forensic Sci Int 146:125-47. 2004
    ....
  20. ncbi request reprint Amyloid precursor protein accumulates in white matter at the margin of a focal ischaemic lesion
    P S Yam
    Wellcome Surgical Institute and Hugh Fraser Neuroscience Laboratories, University of Glasgow, Garscube Estate, UK
    Brain Res 760:150-7. 1997
    ..Increased APP immunoreactivity in subcortical white matter and myelinated fibre tracts at the margin of the ischaemic zone may prove to be a valuable marker for assessing strategies to protect axons after an ischaemic insult...
  21. ncbi request reprint Age does not influence DNA fragmentation in the hippocampus after fatal traumatic brain injury in young and aged humans compared with controls
    J Fowler
    University Department of Neuropathology, South Glasgow University Hospitals NHS Trust, Southern General Hospital, UK
    Clin Neuropathol 21:156-62. 2002
    ....
  22. ncbi request reprint There is differential loss of pyramidal cells from the human hippocampus with survival after blunt head injury
    W L Maxwell
    Department of Anatomy, IBLS, University of Glasgow, Glasgow, United Kingdom
    J Neuropathol Exp Neurol 62:272-9. 2003
    ..Second, there is an ongoing loss of neurons in sub-field CA1 and, most notably, in sub-field CA4, in patients surviving for more than 6 months. However, in neither group of patients is there loss of neurons from sub-field CA2...
  23. ncbi request reprint Prevention by a purine analogue of kainate-induced neuropathology in rat hippocampus
    D G MacGregor
    Division of Neuroscience and Biomedical Systems, University of Glasgow, UK
    Brain Res 725:115-20. 1996
    ....
  24. ncbi request reprint Specific expression of the cell cycle regulation proteins, GADD34 and PCNA, in the peri-infarct zone after focal cerebral ischaemia in the rat
    H Imai
    Wellcome Surgical Institute, University of Glasgow, Glasgow, UK
    Eur J Neurosci 15:1929-36. 2002
    ....
  25. ncbi request reprint 4-Hydroxynonenal immunoreactivity is increased in human hippocampus after global ischemia
    E McKracken
    Wellcome Surgical Institute and Hugh Fraser Neuroscience Laboratories, University of Glasgow, United Kingdom
    Brain Pathol 11:414-21. 2001
    ..This substantiates a role for lipid peroxidation in the pathogenesis of cerebral ischemia. There was no indication that APOE genotype influenced the extent of 4-HNE immunoreactivity...
  26. ncbi request reprint Axonal cytoskeletal responses to nondisruptive axonal injury and the short-term effects of posttraumatic hypothermia
    W L Maxwell
    Laboratory of Human Anatomy, Institute of Biomedical and Life Sciences, University of Glasgow, United Kingdom
    J Neurotrauma 16:1225-34. 1999
    ....
  27. ncbi request reprint Characterization of the microglial response to cerebral ischemia in the stroke-prone spontaneously hypertensive rat
    L Marks
    Wellcome Surgical Institute, Southern General Hospital, University of Glasgow, Glasgow, Scotland
    Hypertension 38:116-22. 2001
    ..This study demonstrates a more pronounced microglial response to focal ischemia in SHRSP compared with WKY and provides evidence of a potential role for inflammatory processes in response to ischemic damage...
  28. ncbi request reprint Tau immunohistochemistry in acute brain injury
    C Smith
    Department of Neuropathology, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK
    Neuropathol Appl Neurobiol 29:496-502. 2003
    ..Although alterations in tau immunoreactivity may occur which warrant further study, neurofibrillary tangles were not more prevalent after a single fatal episode of TBI...
  29. pmc Sudden unexplained death in adults caused by intracranial pathology
    M Black
    Department of Forensic Medicine and Science, University of Glasgow, University Avenue, Glasgow G12 8QQ, Scotland, UK
    J Clin Pathol 55:44-50. 2002
    ....
  30. pmc Association of interleukin-1 gene polymorphisms with Alzheimer's disease
    J A Nicoll
    Department of Neuropathology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland
    Ann Neurol 47:365-8. 2000
    ..Homozygosity for both allele 2 of IL-1A and allele 2 of IL-1B conferred even greater risk (odds ratio, 10.8). IL-1 genotypes may confer risk for Alzheimer's disease through IL-1 overexpression and IL-1-driven neurodegenerative cascades...
  31. ncbi request reprint Mild traumatic brain injury induces apoptotic cell death in the cortex that is preceded by decreases in cellular Bcl-2 immunoreactivity
    R Raghupathi
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neuroscience 110:605-16. 2002
    ....
  32. ncbi request reprint Experimental models of traumatic brain injury: do we really need to build a better mousetrap?
    D M Morales
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, 3320 Smith Walk, 105C Hayden Hall, Philadelphia, PA 19104, USA
    Neuroscience 136:971-89. 2005
    ..This review provides an up-to-date and critical analysis of the existing models of traumatic brain injury with a view toward guiding and improving future research endeavors...
  33. ncbi request reprint Axonal injury is accentuated in the caudal corpus callosum of head-injured patients
    P D Leclercq
    Department of Neuroinflammation, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, London, UK
    J Neurotrauma 18:1-9. 2001
    ..This supports previous nonquantitative reports in the literature and has important implications in terms of choosing where tissue should be sampled to maximize the chance of detecting axonal injury post mortem...
  34. pmc Cerebral amyloid angiopathy in traumatic brain injury: association with apolipoprotein E genotype
    P D Leclercq
    Division of Neuroscience and Psychological Medicine, Imperial College London, London W6 8RP, UK
    J Neurol Neurosurg Psychiatry 76:229-33. 2005
    ....
  35. ncbi request reprint The interpretation of beta-APP immunoreactivity: a response to C. Neiss et al., Acta Neuropathol (2002) 104:79
    C Smith
    Acta Neuropathol 106:97-8. 2003
  36. ncbi request reprint A review and rationale for the use of genetically engineered animals in the study of traumatic brain injury
    L Longhi
    Department of Neurosurgery, University of Pennsylvania and Veterans Administration Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Cereb Blood Flow Metab 21:1241-58. 2001
    ....
  37. ncbi request reprint Evidence for neuronal localisation of enteroviral sequences in motor neurone disease/amyotrophic lateral sclerosis by in situ hybridization
    C J Woodall
    School of Life Sciences, GCU, Cowcaddens Road, Glasgow G4 0BA, UK
    Eur J Histochem 48:129-34. 2004
    ..These findings provide further evidence for the possible involvement of enteroviruses in motor neurone disease/amyotrophic lateral sclerosis...
  38. ncbi request reprint Association between interleukin-1A polymorphism and cerebral amyloid angiopathy-related hemorrhage
    M O McCarron
    Department of Neurology, Royal Victoria Hospital, Belfast, BT12 6BA, UK
    Stroke 34:e193-5. 2003
    ..It has been suggested that the interleukin-1A (IL-1A) allele 2 is a risk factor for Alzheimer's disease (AD). Because cerebral amyloid angiopathy-related hemorrhage (CAAH) often coexists with AD, we examined the IL-1A polymorphism in CAAH...
  39. pmc Anti-ischaemic efficacy of a nitric oxide synthase inhibitor and a N-methyl-D-aspartate receptor antagonist in models of transient and permanent focal cerebral ischaemia
    D A Dawson
    Wellcome Surgical Institute, University of Glasgow
    Br J Pharmacol 113:247-53. 1994
    ..Keywords: Transient focal ischaemia; glutamate; MK-801; nitric oxide; L-NAME; endothelin-1..