Andrea L Graham

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Ecological rules governing helminth-microparasite coinfection
    Andrea L Graham
    Institute of Evolution, School of Biological Sciences, University of Edinburgh, King s Buildings, Ashworth Laboratories, Edinburgh EH9 3JT, Scotland
    Proc Natl Acad Sci U S A 105:566-70. 2008
  2. ncbi request reprint When T-helper cells don't help: immunopathology during concomitant infection
    Andrea L Graham
    Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, New York 14853, USA
    Q Rev Biol 77:409-34. 2002
  3. ncbi request reprint Effects of snail size and age on the prevalence and intensity of avian schistosome infection: relating laboratory to field studies
    Andrea L Graham
    Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, New York 14853, USA
    J Parasitol 89:458-63. 2003
  4. ncbi request reprint Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency
    Andrea L Graham
    Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland
    J Infect Dis 191:410-21. 2005
  5. ncbi request reprint Transmission consequences of coinfection: cytokines writ large?
    Andrea L Graham
    Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Trends Parasitol 23:284-91. 2007
  6. pmc Plasmodium chabaudi limits early Nippostrongylus brasiliensis-induced pulmonary immune activation and Th2 polarization in co-infected mice
    Marieke A Hoeve
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK
    BMC Immunol 10:60. 2009
  7. pmc Experimental manipulation of immune-mediated disease and its fitness costs for rodent malaria parasites
    Gráinne H Long
    Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh, EH9 3JT, UK
    BMC Evol Biol 8:128. 2008
  8. ncbi request reprint Quantitative appraisal of murine filariasis confirms host strain differences but reveals that BALB/c females are more susceptible than males to Litomosoides sigmodontis
    Andrea L Graham
    Institute of Evolution, School of Biological Sciences, University of Edinburgh, King s Buildings, Ashworth Laboratories, Edinburgh EH9 3JT, UK
    Microbes Infect 7:612-8. 2005
  9. ncbi request reprint IL-4 is required to prevent filarial nematode development in resistant but not susceptible strains of mice
    Laetitia Le Goff
    Institute of Cell, Animal and Population Biology, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh, UK
    Int J Parasitol 32:1277-84. 2002
  10. pmc Quantifying variation in the potential for antibody-mediated apparent competition among nine genotypes of the rodent malaria parasite Plasmodium chabaudi
    Karen J Fairlie-Clarke
    Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, King s Buildings, University of Edinburgh, Edinburgh, UK Electronic address
    Infect Genet Evol 20:270-5. 2013

Detail Information

Publications22

  1. pmc Ecological rules governing helminth-microparasite coinfection
    Andrea L Graham
    Institute of Evolution, School of Biological Sciences, University of Edinburgh, King s Buildings, Ashworth Laboratories, Edinburgh EH9 3JT, Scotland
    Proc Natl Acad Sci U S A 105:566-70. 2008
    ..Surprisingly simple rules and an ecological framework within which to analyze biomedical data thus emerge from analysis of this dataset. Through such an interdisciplinary lens, predicting the outcome of coinfection may become tractable...
  2. ncbi request reprint When T-helper cells don't help: immunopathology during concomitant infection
    Andrea L Graham
    Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, New York 14853, USA
    Q Rev Biol 77:409-34. 2002
    ..The synthesis of evolutionary ecology and immunology could therefore be of mutual benefit to the two disciplines...
  3. ncbi request reprint Effects of snail size and age on the prevalence and intensity of avian schistosome infection: relating laboratory to field studies
    Andrea L Graham
    Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, New York 14853, USA
    J Parasitol 89:458-63. 2003
    ..In addition, under these experimental conditions, infected snails were no larger than uninfected snails, so the patterns observed in the field might not be attributable to gigantism...
  4. ncbi request reprint Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency
    Andrea L Graham
    Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland
    J Infect Dis 191:410-21. 2005
    ..Thus, in Mf(-) mice, filariasis upset a delicate immunological balance in malaria infection and exacerbated malaria-induced immunopathology...
  5. ncbi request reprint Transmission consequences of coinfection: cytokines writ large?
    Andrea L Graham
    Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Trends Parasitol 23:284-91. 2007
    ..Testable predictions about the epidemiological consequences of coinfection are generated by this conceptual framework...
  6. pmc Plasmodium chabaudi limits early Nippostrongylus brasiliensis-induced pulmonary immune activation and Th2 polarization in co-infected mice
    Marieke A Hoeve
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK
    BMC Immunol 10:60. 2009
    ..Co-infected animals received both infections on the same day, and disease was assessed daily before immunological measurements were taken at 3, 5, 7 or 20 days post-infection...
  7. pmc Experimental manipulation of immune-mediated disease and its fitness costs for rodent malaria parasites
    Gráinne H Long
    Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh, EH9 3JT, UK
    BMC Evol Biol 8:128. 2008
    ..Here we studied the effects of immunopathology on infection-induced host mortality rate and lifetime transmission potential - key components of parasite fitness - using the rodent malaria model, Plasmodium chabaudi chabaudi...
  8. ncbi request reprint Quantitative appraisal of murine filariasis confirms host strain differences but reveals that BALB/c females are more susceptible than males to Litomosoides sigmodontis
    Andrea L Graham
    Institute of Evolution, School of Biological Sciences, University of Edinburgh, King s Buildings, Ashworth Laboratories, Edinburgh EH9 3JT, UK
    Microbes Infect 7:612-8. 2005
    ..In summary, this study has significantly refined our understanding of the host-L. sigmodontis relationship and, critically, has challenged the dogma that males are more susceptible to filarial infection...
  9. ncbi request reprint IL-4 is required to prevent filarial nematode development in resistant but not susceptible strains of mice
    Laetitia Le Goff
    Institute of Cell, Animal and Population Biology, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh, UK
    Int J Parasitol 32:1277-84. 2002
    ..Our data suggest that the mechanisms that determine parasite clearance in a resistant/non-permissive host are Th2 dependent but that in a susceptible/permissive host, the parasite can develop in the face of a Th2 dominated response...
  10. pmc Quantifying variation in the potential for antibody-mediated apparent competition among nine genotypes of the rodent malaria parasite Plasmodium chabaudi
    Karen J Fairlie-Clarke
    Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, King s Buildings, University of Edinburgh, Edinburgh, UK Electronic address
    Infect Genet Evol 20:270-5. 2013
    ..Our results help explain the outcome of chronic-phase mixed infections and generate testable predictions about the pairwise competitive ability of P. chabaudi clones...
  11. ncbi request reprint Early recruitment of natural CD4+ Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection
    Matthew D Taylor
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 39:192-206. 2009
    ..These CD4(+)Foxp3(+) Treg cells are predominantly recruited from the 'natural' regulatory pool and act to inhibit protective immunity over the full course of infection...
  12. pmc Antibody isotype analysis of malaria-nematode co-infection: problems and solutions associated with cross-reactivity
    Karen J Fairlie-Clarke
    Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, King s Buildings, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    BMC Immunol 11:6. 2010
    ..The potential for cross-reactive antibodies to influence disease outcome is also discussed...
  13. ncbi request reprint Blockade of TNF receptor 1 reduces disease severity but increases parasite transmission during Plasmodium chabaudi chabaudi infection
    Gráinne H Long
    Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    Int J Parasitol 38:1073-81. 2008
    ..These results suggest that the effects of candidate malaria interventions on infectivity should be examined alongside effects on disease severity so that the epidemiological consequences of such interventions can be evaluated...
  14. pmc Multivariate immune defences and fitness in the wild: complex but ecologically important associations among plasma antibodies, health and survival
    Daniel H Nussey
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK, Institute of Infection and Immunity Research, University of Edinburgh, Edinburgh, UK, Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, UK, Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA, Moredun Research Institute, Pentlands Science Park, Bush Loan, Midlothian, UK
    Proc Biol Sci 281:20132931. 2014
    ..Our results highlight both the evolutionary and ecological importance and the complex nature of the immune phenotype in the wild. ..
  15. doi request reprint Optimality analysis of Th1/Th2 immune responses during microparasite-macroparasite co-infection, with epidemiological feedbacks
    Andy Fenton
    School of Biological Sciences, University of Liverpool, Biosciences Building, Crown Street, Liverpool, L69 7ZB, UK
    Parasitology 135:841-53. 2008
    ....
  16. pmc Cross-reactive immune responses as primary drivers of malaria chronicity
    Eili Y Klein
    Princeton University, Department of Ecology and Evolutionary Biology, Princeton, New Jersey, USA
    Infect Immun 82:140-51. 2014
    ..Importantly, we also find that it is the primary response to the initially expressed PfEMP1, or small subset thereof, that structures the cascading cross-immune dynamics and allows for elongation of the infection. ..
  17. doi request reprint Patterns and processes in parasite co-infection
    Mark E Viney
    School of Biological Sciences, University of Bristol, Woodland Road, UK
    Adv Parasitol 82:321-69. 2013
    ..The challenge for us all is to become scholars of co-infections...
  18. doi request reprint Fitness correlates of heritable variation in antibody responsiveness in a wild mammal
    Andrea L Graham
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Science 330:662-5. 2010
    ..Our results highlight the complex effects of natural selection on immune responsiveness and suggest that fitness trade-offs may maintain immunoheterogeneity, including genetic variation in autoimmune susceptibility...
  19. doi request reprint Wild immunology: converging on the real world
    Simon A Babayan
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, Kings Buildings, Edinburgh, United Kingdom
    Ann N Y Acad Sci 1236:17-29. 2011
    ..The meeting on wild immunology, organized by Amy Pedersen, Simon Babayan, and Rick Maizels, was held at the University of Edinburgh on 30 June 2011...
  20. pmc The coevolution of virulence: tolerance in perspective
    Tom J Little
    Institute of Evolutionary Biology, Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Pathog 6:e1001006. 2010
    ....
  21. pmc Evolution of parasite virulence when host responses cause disease
    Troy Day
    Department of Mathematics and Statistics, Jeffery Hall, Queen s University, Kingston, Canada K7L 3N6
    Proc Biol Sci 274:2685-92. 2007
    ..Immunopathology complicates our understanding of disease evolution, but can nevertheless be readily accounted for within the framework of the trade-off hypothesis...
  22. doi request reprint T testing the immune system
    Tracey J Lamb
    Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Immunity 28:288-92. 2008
    ..Amid the flurry of grant writing and experimentation, statistical analysis sometimes gets less attention than it requires. Here, we describe fully the considerations that should go into the employment of the statistical two-sample t test...