Alan J Gow

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. doi request reprint Occupational characteristics and cognitive aging in the Glostrup 1914 Cohort
    Alan J Gow
    Correspondence should be addressed to Alan J Gow, Ph D, Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK E mail
    J Gerontol B Psychol Sci Soc Sci 69:228-36. 2014
  2. doi request reprint Reverse causation in activity-cognitive ability associations: the Lothian Birth Cohort 1936
    Alan J Gow
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
    Psychol Aging 27:250-5. 2012
  3. doi request reprint Neuroprotective lifestyles and the aging brain: activity, atrophy, and white matter integrity
    Alan J Gow
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
    Neurology 79:1802-8. 2012
  4. doi request reprint Stability and change in intelligence from age 11 to ages 70, 79, and 87: the Lothian Birth Cohorts of 1921 and 1936
    Alan J Gow
    Department of Psychology, University of Edinburgh, Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh EH8 9JZ, Scotland
    Psychol Aging 26:232-40. 2011
  5. doi request reprint A stairway to heaven? Structure of the religious involvement inventory and spiritual well-being scale
    Alan J Gow
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
    J Relig Health 50:5-19. 2011
  6. doi request reprint Psychosocial factors and health as determinants of quality of life in community-dwelling older adults
    Caroline E Brett
    Department of Psychology, University of Edinburgh, 7 George Square, Scotland, Edinburgh, EH8 9JZ, UK
    Qual Life Res 21:505-16. 2012
  7. doi request reprint Apolipoprotein E is not related to memory abilities at 70 years of age
    Michelle Luciano
    Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK
    Behav Genet 39:6-14. 2009
  8. pmc Genetic copy number variation and general cognitive ability
    Andrew K MacLeod
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 7:e37385. 2012
  9. doi request reprint A general factor of brain white matter integrity predicts information processing speed in healthy older people
    Lars Penke
    Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom
    J Neurosci 30:7569-74. 2010
  10. doi request reprint Age-associated cognitive decline
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK
    Br Med Bull 92:135-52. 2009

Detail Information

Publications46

  1. doi request reprint Occupational characteristics and cognitive aging in the Glostrup 1914 Cohort
    Alan J Gow
    Correspondence should be addressed to Alan J Gow, Ph D, Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK E mail
    J Gerontol B Psychol Sci Soc Sci 69:228-36. 2014
    ..The effect of occupational characteristics on cognitive change over 20 years was examined...
  2. doi request reprint Reverse causation in activity-cognitive ability associations: the Lothian Birth Cohort 1936
    Alan J Gow
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
    Psychol Aging 27:250-5. 2012
    ..08 to .32, p ≤ .05). When age-11 IQ and adult social class were controlled, only physical activity remained significantly associated with general cognitive ability and processing speed...
  3. doi request reprint Neuroprotective lifestyles and the aging brain: activity, atrophy, and white matter integrity
    Alan J Gow
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
    Neurology 79:1802-8. 2012
    ..Whether activity might protect the integrity of the brain's white matter, or reduce atrophy and white matter lesion (WML) load, was examined in the Lothian Birth Cohort 1936 (n = 691), a longitudinal study of aging...
  4. doi request reprint Stability and change in intelligence from age 11 to ages 70, 79, and 87: the Lothian Birth Cohorts of 1921 and 1936
    Alan J Gow
    Department of Psychology, University of Edinburgh, Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh EH8 9JZ, Scotland
    Psychol Aging 26:232-40. 2011
    ..It did not. Higher intelligence from early life was apparently protective of intelligence in old age due to the stability of cognitive function across the lifespan, rather than because it slowed the decline experienced in later life...
  5. doi request reprint A stairway to heaven? Structure of the religious involvement inventory and spiritual well-being scale
    Alan J Gow
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
    J Relig Health 50:5-19. 2011
    ....
  6. doi request reprint Psychosocial factors and health as determinants of quality of life in community-dwelling older adults
    Caroline E Brett
    Department of Psychology, University of Edinburgh, 7 George Square, Scotland, Edinburgh, EH8 9JZ, UK
    Qual Life Res 21:505-16. 2012
    ..The present study investigated the determinants of quality of life in two groups of older adults for whom there was an unusually informative set of possible predictor variables...
  7. doi request reprint Apolipoprotein E is not related to memory abilities at 70 years of age
    Michelle Luciano
    Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK
    Behav Genet 39:6-14. 2009
    ..04) in the analysis not controlling for IQ. Neither of these tests was significant when a correction for multiple testing was applied. APOE e4 does not influence memory abilities in a normal population of 70-year-olds...
  8. pmc Genetic copy number variation and general cognitive ability
    Andrew K MacLeod
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 7:e37385. 2012
    ..This is the first study to examine the effects of rare CNVs as called by multiple algorithms on cognition in a large non-clinical sample, and finds no effects of such variants on general cognitive ability...
  9. doi request reprint A general factor of brain white matter integrity predicts information processing speed in healthy older people
    Lars Penke
    Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom
    J Neurosci 30:7569-74. 2010
    ..Further studies should investigate whether these findings relate more to the role of tract integrity and information processing speed in nonpathological cognitive aging or in lifelong-stable processes...
  10. doi request reprint Age-associated cognitive decline
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK
    Br Med Bull 92:135-52. 2009
    ..The determinants of the differences in age-related cognitive decline are not fully understood. Progress in the field is taking place across many areas of biomedical and psychosocial sciences...
  11. doi request reprint Genetic associations between fibrinogen and cognitive performance in three Scottish cohorts
    Riccardo E Marioni
    Centre for Population Health Sciences, The University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Behav Genet 41:691-9. 2011
    ..These findings suggest a tentative role for fibrinogen as a determinant of late-life cognitive performance and justify further attempts at replication in older persons...
  12. doi request reprint Alcohol intake and cognitive abilities in old age: the Lothian Birth Cohort 1936 study
    Janie Corley
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, Scotland
    Neuropsychology 25:166-75. 2011
    ..Few studies have examined the potentially confounding roles of prior cognitive ability and social class in this relationship...
  13. doi request reprint Caffeine consumption and cognitive function at age 70: the Lothian Birth Cohort 1936 study
    Janie Corley
    Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, Scotland, UK
    Psychosom Med 72:206-14. 2010
    ..To investigate the association between caffeine consumption and cognitive outcomes in later life...
  14. doi request reprint Genetic variants associated with altered plasma levels of C-reactive protein are not associated with late-life cognitive ability in four Scottish samples
    Riccardo E Marioni
    Public Health Sciences Section, Division of Community Health Sciences, Centre for Population Health Sciences, University of Edinburgh, Medical School, Teviot Place, EH8 9AG Edinburgh, Scotland, UK
    Behav Genet 40:3-11. 2010
    ..038). After correction for multiple testing and adjustment for age and sex, no statistically significant associations were found between the SNPs and cognition. CRP is unlikely to be a causal determinant of late-life cognitive ability...
  15. doi request reprint Genetic contributions to stability and change in intelligence from childhood to old age
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Nature 482:212-5. 2012
    ..62. These estimates, derived from rarely available data on lifetime cognitive measures, warrant the search for genetic causes of cognitive stability and change...
  16. doi request reprint Association of existing and new candidate genes for anxiety, depression and personality traits in older people
    Michelle Luciano
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, Scotland, UK
    Behav Genet 40:518-32. 2010
    ..No SNPs withstood the correction to significance level for multiple testing. Nevertheless, the results will be of importance to future meta-analyses of these candidate genes in relation to psychological distress and personality...
  17. doi request reprint Variation in the uric acid transporter gene (SLC2A9) and memory performance
    Lorna M Houlihan
    Department of Psychology, The University of Edinburgh, Centre for Cognitive Ageing and Cognitive Epidemiology, 7 George Square, Edinburgh EH8 9JZ, UK
    Hum Mol Genet 19:2321-30. 2010
    ..These associations were not replicated in ET2DS (all P > 0.1). If the positive associations withstand, then this study could suggest that higher uric acid levels may be associated with increased performance on memory-related tasks...
  18. doi request reprint Circulating inflammatory markers are associated with magnetic resonance imaging-visible perivascular spaces but not directly with white matter hyperintensities
    Benjamin S Aribisala
    From Brain Research Imaging Centre B S A, S W, Z M, M C V H, N A R, S M M, M E B, J M W, Centre for Cognitive Ageing and Cognitive Epidemiology B S A, M C V H, N A R, S M M, A J G, M E B, J S, I J D, J M W, Department of Psychology J C, I J D, and Geriatric Medicine Unit J S, University of Edinburgh, Edinburgh, United Kingdom Scottish Imaging Network A Platform for Scientific Excellence SINAPSE, Edinburgh, United Kingdom B S A, M C V H, N A R, S M M, M E B, J M W Department of Computer Science, Lagos State University, Nigeria B S A and Department of Psychology, Heriot Watt University, Brazil
    Stroke 45:605-7. 2014
    ..Inflammation is a prominent pathological feature of small vessel disease. We examined the association between inflammation, PVS, and WMH in the Lothian Birth Cohort 1936 (N=634)...
  19. doi request reprint Cohort profile: the Lothian Birth Cohorts of 1921 and 1936
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK
    Int J Epidemiol 41:1576-84. 2012
    ..The LBC1936 participants also have a detailed structural magnetic resonance imaging (MRI) brain scan. A range of scientific findings is described, to illustrate the possible uses of the cohorts...
  20. doi request reprint Brain iron deposits are associated with general cognitive ability and cognitive aging
    Lars Penke
    Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom
    Neurobiol Aging 33:510-517.e2. 2012
    ..The pattern of results suggests that iron deposits are not only a biomarker of general cognitive ability in old age and age-related cognitive decline, but that they are also related to the lifelong-stable trait of intelligence...
  21. pmc Evolutionary conserved longevity genes and human cognitive abilities in elderly cohorts
    Lorna M Lopez
    Department of Psychology, The University of Edinburgh, Edinburgh, UK
    Eur J Hum Genet 20:341-7. 2012
    ..A meta-analysis replicated the SYNJ2 association with cognitive abilities (lowest P=0.00077). SYNJ2 is a novel gene in which variation is potentially associated with cognitive abilities...
  22. doi request reprint Is body mass index in old age related to cognitive abilities? The Lothian Birth Cohort 1936 Study
    Janie Corley
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, Scotland
    Psychol Aging 25:867-75. 2010
    ....
  23. doi request reprint Reverse causation in the association between C-reactive protein and fibrinogen levels and cognitive abilities in an aging sample
    Michelle Luciano
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Psychosom Med 71:404-9. 2009
    ..Blood inflammatory markers have been shown to predict late-life cognition, although the mechanism through which this occurs is unknown...
  24. doi request reprint White matter integrity in the splenium of the corpus callosum is related to successful cognitive aging and partly mediates the protective effect of an ancestral polymorphism in ADRB2
    Lars Penke
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK
    Behav Genet 40:146-56. 2010
    ..While the effects of the SNP and splenium integrity on cognitive aging were largely independent, there was some evidence for a partial mediation effect of ADRB2 status via splenium integrity...
  25. doi request reprint Smoking, childhood IQ, and cognitive function in old age
    Janie Corley
    Department of Psychology, University of Edinburgh, UK
    J Psychosom Res 73:132-8. 2012
    ..To examine the association between smoking history and cognitive function in old age, and whether it remains after controlling for childhood cognitive ability (IQ) and adult socioeconomic status (SES)...
  26. doi request reprint Cognitive ability at age 11 and 70 years, information processing speed, and APOE variation: the Lothian Birth Cohort 1936 study
    Michelle Luciano
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, Scotland
    Psychol Aging 24:129-38. 2009
    ..05): The correlation between childhood ability and speed was lower in e4 allele carriers. APOE has an influence on nonverbal cognition in old age and interacts with childhood IQ to influence processing speed...
  27. doi request reprint Estimated maximal and current brain volume predict cognitive ability in old age
    Natalie A Royle
    Brain Research Imaging Centre, Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK Scottish Imaging Network, a Platform for Scientific Excellence SINAPSE Collaboration, Edinburgh, UK Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Electronic address
    Neurobiol Aging 34:2726-33. 2013
    ..As 1 of the largest studies of associations between brain volume and cognitive ability with normal aging, this work contributes to the wider understanding of how some early-life factors influence cognitive aging. ..
  28. doi request reprint Predicting mortality from human faces
    Dominika Dykiert
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
    Psychosom Med 74:560-6. 2012
    ..To investigate whether and to what extent mortality is predictable from facial photographs of older people...
  29. doi request reprint Mental ability in childhood and cognitive aging
    Alan J Gow
    Department of Psychology, University of Edinburgh, Edinburgh, UK
    Gerontology 54:177-86. 2008
    ..Identifying the determinants of cognitive aging is a research priority; however, few studies are able to examine the influence of pre-morbid cognitive ability on later changes in cognitive function...
  30. doi request reprint Losing one's grip: a bivariate growth curve model of grip strength and nonverbal reasoning from age 79 to 87 years in the Lothian Birth Cohort 1921
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    J Gerontol B Psychol Sci Soc Sci 66:699-707. 2011
    ..Grip strength and reasoning are associated in old age. This is one of the few longitudinal studies addressing whether aging of one causes decline in the other or whether they share causal influences...
  31. doi request reprint Symmetry of the face in old age reflects childhood social status
    David Hope
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
    Econ Hum Biol 11:236-44. 2013
    ..Future research should clarify which elements of the environment cause these perturbations...
  32. pmc Associations between level and change in physical function and brain volumes
    Benjamin S Aribisala
    Brain Research Imaging Centre, Division of Neuroimaging Sciences, School of Clinical Sciences, University of Edinburgh, Edinburgh, United Kingdom Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom SINAPSE Scottish Imaging Network, A Platform for Scientific Excellence collaboration, Edinburgh, United Kingdom Department of Computer Science, Faculty of Science, Lagos State University, Lagos, Nigeria
    PLoS ONE 8:e80386. 2013
    ..We examined associations between brain structure and physical function (contemporaneous and change over the previous three years) in community-dwelling older adults...
  33. doi request reprint Cytomegalovirus infection and cognitive abilities in old age
    Alan J Gow
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
    Neurobiol Aging 34:1846-52. 2013
    ..Within cytomegalovirus seropositive individuals, however, higher cytomegalovirus antibody levels were associated with lower general cognitive ability...
  34. doi request reprint Brain white matter damage in aging and cognitive ability in youth and older age
    Maria Del C Valdés Hernández
    Brain Research Imaging Centre, Department of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK
    Neurobiol Aging 34:2740-7. 2013
    ..Early-life IQ also influenced WMH in later life. Determining how lower IQ in youth leads to increasing brain damage with aging is important for future successful cognitive aging. ..
  35. pmc Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time
    Lorna M Houlihan
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Am J Hum Genet 86:626-31. 2010
    ..16 x 10(-30)), KNG1 (rs710446, combined p = 9.52 x 10(-22)), and HRG (rs9898, combined p = 1.34 x 10(-11)). These three SNPs explain approximately 18% of phenotypic variance in aPTT in the Lothian Birth Cohorts...
  36. pmc Brain white matter tract integrity and cognitive abilities in community-dwelling older people: the Lothian Birth Cohort, 1936
    Tom Booth
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
    Neuropsychology 27:595-607. 2013
    ....
  37. pmc Incidental findings on brain MR imaging in older community-dwelling subjects are common but serious medical consequences are rare: a cohort study
    Elaine M Sandeman
    Brain Research Imaging Centre, Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e71467. 2013
    ..We determined the prevalence and medical consequences of incidental findings found in community-dwelling older subjects on brain magnetic resonance imaging...
  38. doi request reprint Activity participation and cognitive aging from age 50 to 80 in the glostrup 1914 cohort
    Alan J Gow
    Section of Social Medicine, University of Copenhagen, Copenhagen, Denmark
    J Am Geriatr Soc 60:1831-8. 2012
    ..To examine the cognitively protective effect of leisure and physical activities while accounting for prior cognitive ability, a rarely considered confounder of the previously reported associations between activity and cognitive aging...
  39. pmc The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    BMC Geriatr 7:28. 2007
    ..A limitation of many studies is the lack of a sufficiently long period between cognitive assessments to examine determinants. Here, the aim is to examine influences on cognitive ageing between childhood and old age...
  40. doi request reprint Minor physical anomalies, intelligence, and cognitive decline
    David Hope
    Centre for Cognitive Ageing and Cognitive Epidemiology and Department of Psychology, University of Edinburgh, Edinburgh, UK
    Exp Aging Res 38:265-78. 2012
    ..Here the authors examine a finger curvature anomaly, and evaluate its potential as a marker of the causes of cognitive aging...
  41. pmc Lifetime intellectual function and satisfaction with life in old age: longitudinal cohort study
    Alan J Gow
    Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ
    BMJ 331:141-2. 2005
  42. pmc Differences in the haematological profile of healthy 70 year old men and women: normal ranges with confirmatory factor analysis
    Rowan McIlhagger
    Geriatric Medicine Unit, University of Edinburgh, Edinburgh, UK
    BMC Blood Disord 10:4. 2010
    ..Reference ranges are available for different blood cell counts. These ranges treat each cell type independently and do not consider possible correlations between cell types...
  43. doi request reprint The utility of functional interaction and cluster analysis in CNS proteomics
    Ruth F Deighton
    Division of Clinical Neuroscience, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, United Kingdom
    J Neurosci Methods 180:321-9. 2009
    ..A strategy which combines arithmetic analysis and bioinformatics of protein-protein interactions is both generally applicable and will facilitate the interpretation of proteomic data...
  44. doi request reprint Which social network or support factors are associated with cognitive abilities in old age?
    Alan J Gow
    Centre for Cognitive Ageing and Cognitive Epidemiology, School of Life Sciences, Heriot Watt University, Edinburgh, UK
    Gerontology 59:454-63. 2013
    ..Social networks and support have been proposed as cognitively protective in old age. As studies often consider these social factors in isolation the question of which characteristics of the social environment are beneficial remains...
  45. ncbi request reprint Is the PASAT past it? Testing attention and concentration without numbers
    Alan J Gow
    Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom
    J Clin Exp Neuropsychol 26:723-36. 2004
    ..Performing the PASOT was significantly less aversive; teh PASAT induced more negative feelings of Tense Arousal (t38 = -4.52, p < .001)...
  46. doi request reprint Processing speed and visuospatial executive function predict visual working memory ability in older adults
    Louise A Brown
    Department of Psychology, The University of Edinburgh, Edinburgh, UK
    Exp Aging Res 38:1-19. 2012
    ..Determining which measures share variance with this cognitive ability in older adults may help to elucidate the key factors underlying the effects of aging...