I M Gould

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. ncbi request reprint Community-acquired MRSA: can we control it?
    Ian M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    Lancet 368:824-6. 2006
  2. ncbi request reprint MRSA bacteraemia
    Ian M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
    Int J Antimicrob Agents 30:S66-70. 2007
  3. doi request reprint Management of serious meticillin-resistant Staphylococcus aureus infections: what are the limits?
    Ian M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB252ZN, UK
    Int J Antimicrob Agents 37:202-9. 2011
  4. doi request reprint Daptomycin: the role of high-dose and combination therapy for Gram-positive infections
    Ian M Gould
    Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    Int J Antimicrob Agents 42:202-10. 2013
  5. doi request reprint Treatment of bacteraemia: meticillin-resistant Staphylococcus aureus (MRSA) to vancomycin-resistant S. aureus (VRSA)
    I M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    Int J Antimicrob Agents 42:S17-21. 2013
  6. pmc New antibiotic agents in the pipeline and how they can help overcome microbial resistance
    Ian M Gould
    Royal Infirmary, Aberdeen, Scotland
    Virulence 4:185-91. 2013
  7. doi request reprint New insights into meticillin-resistant Staphylococcus aureus (MRSA) pathogenesis, treatment and resistance
    Ian M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    Int J Antimicrob Agents 39:96-104. 2012
  8. doi request reprint Antibiotic resistance: the perfect storm
    I M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    Int J Antimicrob Agents 34:S2-5. 2009
  9. doi request reprint Antibiotics, skin and soft tissue infection and meticillin-resistant Staphylococcus aureus: cause and effect
    Ian M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB252ZN, UK
    Int J Antimicrob Agents 34:S8-11. 2009
  10. doi request reprint Report of a hospital neonatal unit outbreak of community-associated methicillin-resistant Staphylococcus aureus
    I M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
    Epidemiol Infect 137:1242-8. 2009

Detail Information

Publications65

  1. ncbi request reprint Community-acquired MRSA: can we control it?
    Ian M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    Lancet 368:824-6. 2006
  2. ncbi request reprint MRSA bacteraemia
    Ian M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
    Int J Antimicrob Agents 30:S66-70. 2007
    ....
  3. doi request reprint Management of serious meticillin-resistant Staphylococcus aureus infections: what are the limits?
    Ian M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB252ZN, UK
    Int J Antimicrob Agents 37:202-9. 2011
    ..Daptomycin is generally preferred for bacteraemia/endocarditis and linezolid for pneumonia. Better outcome data for vancomycin, based on achievable PK/PD targets and using robust MIC tests, are urgently required...
  4. doi request reprint Daptomycin: the role of high-dose and combination therapy for Gram-positive infections
    Ian M Gould
    Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    Int J Antimicrob Agents 42:202-10. 2013
    ..The use of high-dose daptomycin, alone or in combination, may be useful for difficult-to-treat Gram-positive infections and further evaluation of these strategies is warranted...
  5. doi request reprint Treatment of bacteraemia: meticillin-resistant Staphylococcus aureus (MRSA) to vancomycin-resistant S. aureus (VRSA)
    I M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    Int J Antimicrob Agents 42:S17-21. 2013
    ..5mg/L). If not, daptomycin (8-10mg/L) can be used as monotherapy but the MIC should be measured as soon as possible...
  6. pmc New antibiotic agents in the pipeline and how they can help overcome microbial resistance
    Ian M Gould
    Royal Infirmary, Aberdeen, Scotland
    Virulence 4:185-91. 2013
    ..We also briefly mention the new compounds on the horizon and some newly approved compounds that might help us tide over this crisis...
  7. doi request reprint New insights into meticillin-resistant Staphylococcus aureus (MRSA) pathogenesis, treatment and resistance
    Ian M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    Int J Antimicrob Agents 39:96-104. 2012
    ..Novel antimicrobial targets must be identified with some regularity or we will face the risk of untreatable S. aureus infections...
  8. doi request reprint Antibiotic resistance: the perfect storm
    I M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    Int J Antimicrob Agents 34:S2-5. 2009
    ..Another strategy is seriously to curtail the large amount of unnecessary antibiotic use in many areas of life, not only medical practice. The various aspects of this strategy are briefly reviewed...
  9. doi request reprint Antibiotics, skin and soft tissue infection and meticillin-resistant Staphylococcus aureus: cause and effect
    Ian M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB252ZN, UK
    Int J Antimicrob Agents 34:S8-11. 2009
    ..Future antibiotic policies should consider this, particularly in an era of widespread MRSA screening...
  10. doi request reprint Report of a hospital neonatal unit outbreak of community-associated methicillin-resistant Staphylococcus aureus
    I M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
    Epidemiol Infect 137:1242-8. 2009
    ..Region-wide surveillance of over 6000 MRSA isolates collected from 1998 to 2004 showed that 95 (1.6%) were closely related to the outbreak strain although only 60 carried the ETA gene. The strain has not been seen elsewhere in Scotland...
  11. doi request reprint Who's winning the war?
    I M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, Scotland, UK
    J Antimicrob Chemother 62:iii3-6. 2008
    ..Daptomycin has great promise in this regard as its rapid bactericidal activity makes it particularly suitable for the treatment of bacteraemia and endocarditis...
  12. doi request reprint The epidemiology of antibiotic resistance
    I M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    Int J Antimicrob Agents 32:S2-9. 2008
    ..Moreover, we urgently need better global early warning systems to detect new resistances and put mechanisms in place for their control...
  13. doi request reprint Antibiotic policies to control hospital-acquired infection
    I M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, Scotland, UK
    J Antimicrob Chemother 61:763-5. 2008
    ..Antibiotic stewardship should be given much more emphasis in the fight against HAI...
  14. ncbi request reprint Topical antimicrobials in combination with admission screening and barrier precautions to control endemic methicillin-resistant Staphylococcus aureus in an Intensive Care Unit
    Ian M Gould
    Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    Int J Antimicrob Agents 29:536-43. 2007
    ..001), as did the trend in glycopeptide use (P=0.014). An inexpensive and easy to implement intervention to control MRSA in the ICU was highly successful without compromising antimicrobial susceptibility...
  15. ncbi request reprint Can we control MRSA?
    I M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen
    Scott Med J 52:3-4. 2007
  16. ncbi request reprint Costs of hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) and its control
    I M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    Int J Antimicrob Agents 28:379-84. 2006
    ..In reality, there is a large body of consistent evidence that control is highly cost effective, particularly in the context of the huge societal costs of MRSA and the future ever-greater threats that it poses...
  17. ncbi request reprint Towards a European strategy for controlling antibiotic resistance Nijmegen, Holland August 29-31, 1999
    I M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Aberdeen, UK
    Clin Microbiol Infect 6:670-4. 2000
    ....
  18. doi request reprint Alexander Gordon, puerperal sepsis, and modern theories of infection control--Semmelweis in perspective
    Ian M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Aberdeen, UK
    Lancet Infect Dis 10:275-8. 2010
    ..Gordon's thesis was reprinted three times in Edinburgh, Philadelphia, and London over the next 55 years, suggesting that Semmelweis (1847) could well have known of his work. Like Semmelweis, Gordon was persecuted for his findings...
  19. ncbi request reprint Determinants of response to antibiotic therapy
    I M Gould
    Dept of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Scotland, UK
    J Chemother 10:347-53. 1998
    ..Understanding the interaction of antibiotics with the immune system and the consequences of the differing actions of the various antibiotic classes on the immune response is another door that is opening for the future...
  20. doi request reprint Clinical activity of anti-Gram-positive agents against methicillin-resistant Staphylococcus aureus
    Ian M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, Scotland
    J Antimicrob Chemother 66:iv17-iv21. 2011
    ..Its epidemiology and clinical presentation give cause for concern, but so far its impact has been strictly limited. While this may change, the loss of glycopeptides as a treatment option may not, in fact, be all bad news...
  21. ncbi request reprint Attitudes to antibiotic prescribing, resistance and bacteriology investigations amongst practitioners and patients in the Grampian region of Scotland
    Ian M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Aberdeen, Scotland
    Eur J Gen Pract 13:35-6. 2007
  22. doi request reprint Controversies in infection: infection control or antibiotic stewardship to control healthcare-acquired infection?
    I M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    J Hosp Infect 73:386-91. 2009
    ..Arguably, traditional infection control is akin to fire-fighting and antibiotic stewardship to prevention...
  23. ncbi request reprint Antibiotic exposure as a risk factor for emergence of resistance: the influence of concentration
    I M Gould
    Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    J Appl Microbiol 92:78S-84S. 2002
    ..Lastly, the relevance of all this to the development of resistance in the normal bacterial flora will be discussed...
  24. ncbi request reprint Antibiotic policies and control of resistance
    Ian M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Aberdeen, Scotland, UK
    Curr Opin Infect Dis 15:395-400. 2002
    ....
  25. doi request reprint Costs of healthcare-associated methicillin-resistant Staphylococcus aureus and its control
    I M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
    Clin Microbiol Infect 16:1721-8. 2010
    ..Although the literature on the costs of MRSA and its control is suboptimal, it is clear that the control of MRSA is highly desirable and likely to be cost-effective. Any compromises in control are likely to be false economies...
  26. doi request reprint Is vancomycin redundant for serious staphylococcal infection?
    Ian M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
    Int J Antimicrob Agents 36:S55-7. 2010
    ..The same conclusions almost certainly apply to teicoplanin...
  27. doi request reprint Coping with antibiotic resistance: the impending crisis
    I M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, UK
    Int J Antimicrob Agents 36:S1-2. 2010
    ..When combined with the crisis in new drug development, antibiotic stewardship becomes ever more important in order to preserve the activity of these unique drugs...
  28. ncbi request reprint Temporal relationship between prevalence of meticillin-resistant Staphylococcus aureus (MRSA) in one hospital and prevalence of MRSA in the surrounding community: a time-series analysis
    F M MacKenzie
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Aberdeen, UK
    J Hosp Infect 67:225-31. 2007
    ..These results suggest that the reason for the increase in MRSA prevalence in the community was a hospital MRSA outbreak. Screening at patient discharge should be evaluated as a new measure to control spread of MRSA in the community...
  29. ncbi request reprint Antimicrobial drug use and infection control practices associated with the prevalence of methicillin-resistant Staphylococcus aureus in European hospitals
    F M MacKenzie
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Aberdeen, UK
    Clin Microbiol Infect 13:269-76. 2007
    ..Overall, this study highlighted significant associations between MRSA prevalence, antimicrobial use and various key infection control parameters, all of which showed significant individual variations according to geographical region...
  30. pmc Is vancomycin MIC "creep" method dependent? Analysis of methicillin-resistant Staphylococcus aureus susceptibility trends in blood isolates from North East Scotland from 2006 to 2010
    B Edwards
    Medical Microbiology Department, Aberdeen Royal Infirmary, Aberdeen, United Kingdom
    J Clin Microbiol 50:318-25. 2012
    ..There is a need to standardize and streamline susceptibility testing of vancomycin against MRSA...
  31. ncbi request reprint Control of methicillin-resistant Staphylococcus aureus in the UK
    I M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, AB25 2ZN, Aberdeen, UK
    Eur J Clin Microbiol Infect Dis 24:789-93. 2005
    ....
  32. ncbi request reprint Report of the Consensus Conference on Antibiotic Resistance; Prevention and Control (ARPAC)
    F M MacKenzie
    Medical Microbiology, Aberdeen Royal Infirmary, Aberdeen, UK
    Clin Microbiol Infect 11:938-54. 2005
    ..The conference delivered a set of high-priority recommendations likely to have a significant impact on antimicrobial resistance. This report summarises these recommendations...
  33. ncbi request reprint Antimicrobial susceptibility testing in European hospitals: report from the ARPAC study
    F M MacKenzie
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Aberdeen, UK
    Clin Microbiol Infect 12:1185-92. 2006
    ..The majority of respondents stated that they followed CLSI guidelines, but a high proportion had modified the CLSI methods for detecting MRSA and VRE, which may compromise clinical management and antimicrobial resistance surveillance...
  34. pmc Methicillin-resistant Staphylococcus aureus in Northeastern Scotland in 2003 to 2007: evolving strain distribution and resistance patterns
    A C Hunt
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Clin Microbiol 49:1975-8. 2011
    ..Use of oral antibiotics to eradicate throat carriage may have contributed to trimethoprim resistance, which was observed to increase 10-fold...
  35. ncbi request reprint Audit of an antibiotic policy and microbiological investigations for treating bacteraemia in a large teaching hospital
    A R Mackenzie
    The Infection Unit, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    Int J Antimicrob Agents 22:618-21. 2003
    ..The results show poor utilisation of an up-to-date antibiotic policy but confirm its potential benefits and the ability of traditional culture methods to guide antibiotic therapy in a useful time-scale...
  36. ncbi request reprint Molecular epidemiology and antibiotic resistance of Enterobacter spp. from three distinct populations in Grampian, UK
    F M E Wagenlehner
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Aberdeen, UK
    Int J Antimicrob Agents 20:419-25. 2002
    ..Isolates (27%) were clonally related and typed in four clusters. Consecutive isolates were studied in selected patients showing minor genomic changes. One environmental isolate from a deep sink at ITU was related to a patient's isolate...
  37. ncbi request reprint Trends in hospital antimicrobial prescribing after 9 years of stewardship
    I M Gould
    Departments of Microbiology and Pharmacy, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, Scotland, UK
    J Antimicrob Chemother 45:913-7. 2000
    ..4 DDDs for antibacterials). These findings highlight the current difficulty in controlling prescribing budgets, the increasing use of antibiotics and the consequent increase of antimicrobial-resistant microorganisms...
  38. ncbi request reprint Optimizing antibiotic therapy-the Aberdeen experience
    Y Kumarasamy
    Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, Aberdeen, UK
    Clin Microbiol Infect 9:406-11. 2003
    ....
  39. doi request reprint Combination testing of multidrug-resistant cystic fibrosis isolates of Pseudomonas aeruginosa: use of a new parameter, the susceptible breakpoint index
    K E N Milne
    Medical Microbiology Department, Aberdeen Royal Infirmary, Foresterhill, UK
    J Antimicrob Chemother 65:82-90. 2010
    ....
  40. ncbi request reprint The clinical significance of methicillin-resistant Staphylococcus aureus
    I M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, UK
    J Hosp Infect 61:277-82. 2005
    ..Current treatments are suboptimal. Control measures are likely to be effective and cost saving if they have a broad enough base, and should be implemented without further delay...
  41. ncbi request reprint Duration of intravenous therapy and hospital stay according to choice of empirical antimicrobial treatment for community-acquired respiratory infection
    R B Laing
    The Infection Unit, Aberdeen Royal Infirmary, Fosterhill, Scotland, UK
    Int J Antimicrob Agents 13:53-6. 1999
    ....
  42. pmc Combination antimicrobial susceptibility testing of multidrug-resistant Stenotrophomonas maltophilia from cystic fibrosis patients
    K E N Milne
    Microbiology Department, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, United Kingdom
    Antimicrob Agents Chemother 56:4071-7. 2012
    ..Addressing these issues specifically for organisms recovered from the respiratory tracts of individuals with cystic fibrosis should lead to better therapeutic outcomes and improved wellbeing of individuals with cystic fibrosis...
  43. ncbi request reprint Reassessment of cefaclor breakpoints for Haemophilus influenzae
    F M MacKenzie
    Medical Microbiology Department, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, AB25 2ZN Scotland, UK
    J Chemother 16:329-33. 2004
    ..8 mg/L for cefuroxime. Cefaclor MICs by NCCLS methodology were overestimated due to chemical instability over 18-24 hours. The bacteriostatic MICs by kill curve were not significantly different from those of cefuroxime...
  44. ncbi request reprint Antibiograms of resistant Gram-negative bacteria from Scottish CF patients
    F M MacKenzie
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    J Cyst Fibros 3:151-7. 2004
    ..Over a 19-month pilot phase, 93 multiply resistant Gram-negative isolates from Scottish cystic fibrosis patients were sent to a referral laboratory for further investigation...
  45. ncbi request reprint Use of the Malthus Microbial Growth Analyser to study the post antibiotic effect of antibiotics
    I M Gould
    Regional Laboratory, City Hospital, Aberdeen, UK
    J Antimicrob Chemother 24:523-31. 1989
    ..5 h) against Escherichia coli. The new method allows for the rapid and labour saving evaluation of PAE. We believe that further studies on PAE of antibiotic combinations are desirable...
  46. ncbi request reprint Antibiotic policies in European hospitals
    I M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Aberdeen, Scotland
    Med Mal Infect 35:S123-4. 2005
  47. ncbi request reprint Identification and characterization of teicoplanin-intermediate Staphylococcus aureus blood culture isolates in NE Scotland
    Fiona M MacKenzie
    Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    J Antimicrob Chemother 50:689-97. 2002
    ..Both MRSA and MSSA with reduced teicoplanin susceptibility may remain vancomycin sensitive by NCCLS and BSAC criteria and it is important to screen clinical isolates of MRSA and MSSA for reduced susceptibility to both agents...
  48. ncbi request reprint Calculation of composite recovery time: a new pharmacodynamic parameter
    Fiona M MacKenzie
    Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    J Antimicrob Chemother 50:281-4. 2002
    ..influenzae isolate, 1 mg/L for staphylococci and 0.5 mg/L for Enterobacteriaceae. Calculated pharmacodynamic breakpoints were very similar to traditional published MIC breakpoints...
  49. ncbi request reprint Empirical antimicrobial treatment for chemotherapy-induced febrile neutropenia
    Abhijit M Bal
    Department of Medical Microbiology, Royal Infirmary, Aberdeen, UK
    Int J Antimicrob Agents 29:501-9. 2007
    ..aureus, vancomycin-resistant S. aureus, vancomycin-resistant enterococci, Gram-negative bacilli that produce extended-spectrum beta-lactamases, Stenotrophomonas maltophilia, and multi-resistant Acinetobacter baumanii...
  50. doi request reprint Antibiotic stewardship and consumption: findings from a pan-European hospital study
    Julie Bruce
    Section of Population Health, University of Aberdeen, Medical School, Aberdeen AB25 2ZD, UK
    J Antimicrob Chemother 64:853-60. 2009
    ....
  51. ncbi request reprint Reassessment of the cefaclor breakpoint for Streptococcus pneumoniae
    Fiona M MacKenzie
    Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, Scotland, UK
    Int J Antimicrob Agents 23:337-42. 2004
    ..00058) there was no statistical differences between the bacteriostatic MICs (P = 0.259). Bacteriostatic MIC determination established that cefaclor and cefuroxime are equally active against pneumococci...
  52. ncbi request reprint The role of microbiology and pharmacy departments in the stewardship of antibiotic prescribing in European hospitals
    Fiona M MacKenzie
    Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
    J Hosp Infect 65:73-81. 2007
    ..There was also no evidence that pharmacy services reduced the amount of antibiotics prescribed...
  53. ncbi request reprint Relationship between the number of different antibiotics used and the total use of antibiotics in European hospitals
    Fiona M MacKenzie
    Medical Microbiology, Aberdeen Royal Infirmary Aberdeen, Scotland, UK
    J Antimicrob Chemother 58:657-60. 2006
    ..The aim of this study was to establish whether there was a relationship between the number of antibacterial agents used and total antibiotic use in European hospitals...
  54. ncbi request reprint Antibiotic resistance in Staphylococcus aureus and its relevance in therapy
    Abhijit M Bal
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, Scotland
    Expert Opin Pharmacother 6:2257-69. 2005
    ..This review summarises the therapeutic options for MRSA, glycopeptide-intermediate S. aureus and vancomycin-resistant S. aureus. Novel therapeutic strategies such as immunotherapy and vaccines are also discussed...
  55. ncbi request reprint Antimicrobial stewardship: lessons from human healthcare
    B Edwards
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Aberdeen, AB25 2ZD, Scotland, UK
    Rev Sci Tech 31:135-44. 2012
    ..Considering the frequent use of antimicrobials in animals, it would seem sensible to apply a similarly critical approach to conserve the efficacy of the antimicrobials still available, now and in the future...
  56. ncbi request reprint The post-exposure response of Enterobacteriaceae to ceftibuten
    F M MacKenzie
    Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, UK
    J Antimicrob Chemother 43:71-7. 1999
    ..The results of the PA-SME studies, which may be the most clinically relevant pharmacodynamic parameter, confirm the appropriateness of the current once- or twice-daily dosing schedules despite the lack of PAE...
  57. ncbi request reprint The effect of system design on bacterial contamination of enteral tube feeds
    J McKinlay
    Department of Nutrition and Dietetics, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, AB25 2ZU, UK
    J Hosp Infect 47:138-42. 2001
    ....
  58. doi request reprint Clinical relevance of increasing glycopeptide MICs against Staphylococcus aureus
    Ian M Gould
    Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
    Int J Antimicrob Agents 31:1-9. 2008
    ..The accurate measurement and ongoing surveillance of glycopeptide MICs at individual sites is therefore recommended to assist clinicians in their choice of empiric therapy for suspected serious S. aureus infections...
  59. ncbi request reprint Comparison of screening methods for TEM- and SHV-derived extended-spectrum beta-lactamase detection
    F M MacKenzie
    Aberdeen Royal Infirmary, UK
    Clin Microbiol Infect 8:715-24. 2002
    ..To compare common extended-spectrum beta-lactamase (ESBL) screening methods and beta-lactams for their ability to detect TEM- and SHV-related ESBL enzymes...
  60. ncbi request reprint Comparison of the E test with broth microdilution for antifungal susceptibility testing of yeasts
    I M Gould
    Dept of Microbiology, Royal Infirmary, Foresterhill, Aberdeen, UK
    J Chemother 10:3-6. 1998
    ..The E test was quick and relatively simple to perform. Results using the E test compared favourably with those of the OD80 and it should be suitable for the routine susceptibility testing of yeasts to antifungal agents...
  61. ncbi request reprint Pharmacodynamics and the relationship between in vitro and in vivo activity of antimicrobial agents
    I M Gould
    Dept of Medical Microbiology, Aberdeen Royal Hospitals NHS Trust, UK
    J Chemother 9:74-83. 1997
    ..The dosing of beta-lactams is discussed in detail, particularly in relation to the method dependence of the various models of post antibiotic effect (PAE) and the different morphological forms that are produced by different beta-lactams...
  62. ncbi request reprint Optimization of antibiotic dosing schedules in the light of increasing antibiotic resistance
    Susan V Smith
    Aberdeen Royal Infirmary, Foresterhill, UK
    Expert Rev Anti Infect Ther 2:227-34. 2004
    ..Where possible, recommendations relating to clinical practice will be made, or failing that, an indication of where further research would be of benefit...
  63. pmc Geographic and temporal trends in isolation and antifungal susceptibility of Candida parapsilosis: a global assessment from the ARTEMIS DISK Antifungal Surveillance Program, 2001 to 2005
    M A Pfaller
    Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Microbiol 46:842-9. 2008
    ..parapsilosis to fluconazole and voriconazole may vary by geographic region and clinical service...
  64. pmc Antimicrobial drug use and methicillin-resistant Staphylococcus aureus, Aberdeen, 1996-2000
    Dominique L Monnet
    Statens Serum Institut, Copenhagen, Denmark
    Emerg Infect Dis 10:1432-41. 2004
    ..Although these results may not be generalized to other hospitals, they suggest new directions for control of MRSA, which has thus far proved difficult and expensive...
  65. ncbi request reprint Antimicrobial agents are societal drugs: how should this influence prescribing?
    Paul Sarkar
    Department of GU Medicine, The Sandyford Initiative, 2 6 Sandyford Place, Glasgow G3 7NB, Scotland
    Drugs 66:893-901. 2006
    ..Many developing countries need improved access to more antimicrobials, preferably in the controlled environment of appropriate medical advice...