Stephen C L Gough

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi request reprint CTLA4 gene polymorphism and autoimmunity
    Stephen C L Gough
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham B9 5SS, UK
    Immunol Rev 204:102-15. 2005
  2. ncbi request reprint A review of human and analogue insulin trials
    Stephen C L Gough
    Institute of Biomedical Research, The Medical School, University of Birmingham, Birmingham, UK
    Diabetes Res Clin Pract 77:1-15. 2007
  3. pmc Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
    John A Todd
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0XY, UK
    Nat Genet 39:857-64. 2007
  4. pmc Impact of obesity and type 2 diabetes on health-related quality of life in the general population in England
    Stephen Cl Gough
    University of Birmingham and University Hospital Birmingham NHS Foundation Trust, Birmingham, UK
    Diabetes Metab Syndr Obes 2:179-84. 2009
  5. pmc The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency
    Alice M Wood
    Division of Medical Sciences, The Medical School, University of Birmingham, Birmingham, B15 2TT, UK
    Respir Res 9:52. 2008
  6. ncbi request reprint The genetics of Graves' disease
    S C Gough
    Division of Medical Sciences, University of Birmingham, United Kingdom
    Endocrinol Metab Clin North Am 29:255-66. 2000
  7. ncbi request reprint Clustering of metabolic comorbidity in schizophrenia: a genetic contribution?
    Stephen C L Gough
    Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    J Psychopharmacol 19:47-55. 2005
  8. ncbi request reprint Post-marketing surveillance: a UK/European perspective
    Stephen Gough
    Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Curr Med Res Opin 21:565-70. 2005
  9. ncbi request reprint The thyroglobulin gene: the third locus for autoimmune thyroid disease or a false dawn?
    Stephen Gough
    Division of Medical Sciences, University of Birmingham, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, B9 5SS, UK
    Trends Mol Med 10:302-5. 2004
  10. ncbi request reprint Diabetes and its prevention: pragmatic solutions for people with schizophrenia
    Stephen Gough
    Division of Medical Sciences, University of Birmingham and Birmingham Heartlands Hospital, Birmingham, UK
    Br J Psychiatry Suppl 47:S106-11. 2004

Detail Information

Publications39

  1. ncbi request reprint CTLA4 gene polymorphism and autoimmunity
    Stephen C L Gough
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham B9 5SS, UK
    Immunol Rev 204:102-15. 2005
    ..In this review, we discuss recent progress in relating CTLA4 polymorphisms to disease susceptibility and consider the putative mechanisms by which CTLA4 may act to inhibit autoimmunity...
  2. ncbi request reprint A review of human and analogue insulin trials
    Stephen C L Gough
    Institute of Biomedical Research, The Medical School, University of Birmingham, Birmingham, UK
    Diabetes Res Clin Pract 77:1-15. 2007
    ..Significant benefits, including PPG lowering with the rapid-acting analogues and the potential for reduction in cardiovascular risk, should be investigated further...
  3. pmc Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
    John A Todd
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0XY, UK
    Nat Genet 39:857-64. 2007
    ..Several regions, including 18q22 and 18p11, showed association with autoimmune thyroid disease. This study increases the number of T1D loci with compelling evidence from six to at least ten...
  4. pmc Impact of obesity and type 2 diabetes on health-related quality of life in the general population in England
    Stephen Cl Gough
    University of Birmingham and University Hospital Birmingham NHS Foundation Trust, Birmingham, UK
    Diabetes Metab Syndr Obes 2:179-84. 2009
    ..The aim of this study was to determine whether having T2D and also being obese had a greater or lesser impact on health-related quality of life (HRQoL) than having either of the two conditions alone...
  5. pmc The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency
    Alice M Wood
    Division of Medical Sciences, The Medical School, University of Birmingham, Birmingham, B15 2TT, UK
    Respir Res 9:52. 2008
    ..This study investigated subjects with AATD to determine the relationship between specific phenotypes and TNFalpha polymorphisms...
  6. ncbi request reprint The genetics of Graves' disease
    S C Gough
    Division of Medical Sciences, University of Birmingham, United Kingdom
    Endocrinol Metab Clin North Am 29:255-66. 2000
    ..Additional loci are likely to be identified via a combination of genome-wide linkage analysis and allelic association analysis of candidate genes...
  7. ncbi request reprint Clustering of metabolic comorbidity in schizophrenia: a genetic contribution?
    Stephen C L Gough
    Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    J Psychopharmacol 19:47-55. 2005
    ..This article reviews the genetic basis to schizophrenia and type 2 diabetes and discusses the potential for shared loci between both conditions...
  8. ncbi request reprint Post-marketing surveillance: a UK/European perspective
    Stephen Gough
    Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Curr Med Res Opin 21:565-70. 2005
    ..This article discusses post-marketing pharmacovigilance and the role of PMS studies in the context of current UK and European legislation...
  9. ncbi request reprint The thyroglobulin gene: the third locus for autoimmune thyroid disease or a false dawn?
    Stephen Gough
    Division of Medical Sciences, University of Birmingham, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, B9 5SS, UK
    Trends Mol Med 10:302-5. 2004
    ..Although these preliminary data are potentially exciting, caution needs to be exercised, and replication of the data sought before Tg can be designated as the third locus for AITD...
  10. ncbi request reprint Diabetes and its prevention: pragmatic solutions for people with schizophrenia
    Stephen Gough
    Division of Medical Sciences, University of Birmingham and Birmingham Heartlands Hospital, Birmingham, UK
    Br J Psychiatry Suppl 47:S106-11. 2004
    ..Patients with schizophrenia have an increased risk of developing diabetes. However, no pragmatic pathway of care has ever been proposed in order to identify individuals at risk and manage that risk effectively...
  11. ncbi request reprint Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs
    Oliver J Brand
    Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Clin Endocrinol (Oxf) 66:508-12. 2007
    ..Because certain autoimmune diseases, such as autoimmune thyroid disease (AITD) and T1D cluster together in certain families, we sought to determine if the TID-associated CD25 region was also associated with Graves' disease (GD)...
  12. ncbi request reprint Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression
    Kadija Yesmin
    Centre for Endocrinology, Diabetes and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, UK
    Clin Endocrinol (Oxf) 73:119-25. 2010
    ..This study aimed to determine whether FcGRIIa is associated with Graves' disease (GD) in the UK Caucasian population by Tag SNP screening common polymorphisms within the FcGRIIa region...
  13. ncbi request reprint A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect
    Matthew J Simmonds
    Division of Medical Sciences, University of Birmingham, UK
    Hum Mol Genet 16:2149-53. 2007
    ..Our results point to a primary role for class I-mediated responses in GD, a condition classically assumed to be a straightforward HLA-class II-restricted autoantibody response to the thyroid stimulating hormone receptor...
  14. doi request reprint Confirmation of association of chromosome 5q31-33 with United Kingdom Caucasian Graves' disease
    Matthew J Simmonds
    Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, UK
    Thyroid 20:413-7. 2010
    ..We sought to confirm this association in a large Caucasian U.K. GD cohort...
  15. doi request reprint CT60 and +49 polymorphisms of CTLA 4 are associated with ANCA-positive small vessel vasculitis
    Lavanya Kamesh
    Renal Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
    Rheumatology (Oxford) 48:1502-5. 2009
    ..To investigate whether single nucleotide polymorphisms (SNPs) within cytotoxic T-lymphocyte antigen-4 (CTLA-4) are associated with ANCA-associated small vessel vasculitis (SVV)...
  16. pmc Regression mapping of association between the human leukocyte antigen region and Graves disease
    Matthew J Simmonds
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, and Birmingham Heartlands Hospital, Birmingham B9 5SS, United Kingdom
    Am J Hum Genet 76:157-63. 2005
    ..However, we cannot yet exclude a primary role for DQA1 or for other polymorphisms that affect DRB1 function or expression...
  17. ncbi request reprint Polymorphisms of interleukin 4 receptor gene and interleukin 10 gene are not associated with Graves' disease in the UK
    Karen F Tait
    Division of Medical Sciences, University of Birmingham, Birmingham B15 2TH, UK
    Autoimmunity 37:189-94. 2004
    ..We conclude these polymorphisms of IL-10 and IL-4R previously associated with other immune mediated diseases, do not confer susceptibility to GD in white Caucasians in the United Kingdom...
  18. ncbi request reprint A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians
    Joanne M Heward
    Division of Medical Sciences, University of Birmingham, Institute of Biomedical Research, Edgbaston, Birmingham, UK, B15 2TT
    Clin Endocrinol (Oxf) 61:269-72. 2004
    ..The aim of this study was to determine whether this SNP of the CD40 gene confers susceptibility to GD in UK Caucasians...
  19. doi request reprint Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease
    Oliver J Brand
    Institute of Biomedical Research, University of Birmingham, Edgbaston, West Midlands, UK
    Hum Mol Genet 18:1704-13. 2009
    ..8 x 10(-4)). In addition, we provide preliminary evidence that the disease-associated genotypes of rs179247 (AA) and rs12101255 (TT) show reduced mRNA expression ratios of flTSHR relative to two alternate TSHR mRNA splice variants...
  20. doi request reprint Skewed X chromosome inactivation and female preponderance in autoimmune thyroid disease: an association study and meta-analysis
    Matthew J Simmonds
    Oxford Centre for Diabetes, Endocrinology, and Metabolism M J S, F K K, O J B, S C L G and Oxford National Institute for Health Research Biomedical Research Centre F K K, S C L G, Churchill Hospital, Headington, Oxford OX3 7LJ, United Kingdom and Centre for Endocrinology, Diabetes, and Metabolism P R N, L E J, C E H, J A F, School of Clinical and Experimental Medicine, College of Medical and Dental Science, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 99:E127-31. 2014
    ....
  21. pmc Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study
    Paul R Newby
    Centre for Endocrinology, Diabetes and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham, West Midlands, UK
    Eur J Hum Genet 18:1021-6. 2010
    ..Our study confirms the need for large data sets and stringent analysis criteria when searching for susceptibility loci in common diseases...
  22. ncbi request reprint Polymorphism of the CTLA-4 gene is associated with autoimmune hypothyroidism in the United Kingdom
    Ratnasingam Nithiyananthan
    Division of Medical Sciences, University of Birmingham, Birmingham Heartlands Hospital, United Kingdom
    Thyroid 12:3-6. 2002
    ..8.8% and 50% vs. 46% respectively; chi2 = 11.7, p = 0.003). These results suggest that the CTLA-4 gene region on chromosome 2q33 is a susceptibility locus for autoimmune hypothyroidism in the United Kingdom...
  23. ncbi request reprint Genetic developments in autoimmune thyroid disease: an evolutionary process
    Abigail A Zeitlin
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham, B15 2TT, UK
    Clin Endocrinol (Oxf) 68:671-82. 2008
    ..Finally, large scale, ongoing genome-wide association studies in multiple autoimmune diseases (AID) states, including AITD seem likely to lead to the identification of additional MHC and non-MHC susceptibility loci...
  24. doi request reprint Exubera inhaled insulin in patients with type 1 and type 2 diabetes: the first 12 months
    Victoria Alabraba
    Diabetes Centre, Selly Oak Hospital, University Hospital Birmingham NHS Foundation Trust, University of Birmingham, Birmingham, United Kingdom
    Diabetes Technol Ther 11:427-30. 2009
    ..Between January and October 2007, eight patients started Exubera: six because of needle phobia (DSM-IV criteria) and two with injection site problems...
  25. ncbi request reprint The genetics of autoimmune endocrine disease
    Karen F Tait
    Division of Medical Sciences, University of Birmingham, Edgbaston and Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, UK
    Clin Endocrinol (Oxf) 59:1-11. 2003
    ....
  26. ncbi request reprint Autoimmunity in thyroid disease
    Joanne Collins
    Department of Medicine, University of Birmingham, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK
    Eur J Nucl Med Mol Imaging 29:S417-24. 2002
    ..This review will focus on some of the studies designed to identify genes that confer susceptibility to the autoimmune disease process within the thyroid gland...
  27. ncbi request reprint HLA , CTLA-4 and PTPN22 : the shared genetic master-key to autoimmunity?
    Oliver Brand
    Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Wolfson Drive, Edgbaston, Birmingham, B15 2TT, UK
    Expert Rev Mol Med 7:1-15. 2005
    ....
  28. pmc Donor ABCB1 variant associates with increased risk for kidney allograft failure
    Jason Moore
    Department of Nephrology and Kidney Transplantation, Queen Elizabeth Hospital, Birmingham, B15 2WB, United Kingdom
    J Am Soc Nephrol 23:1891-9. 2012
    ..84; 95% CI, 1.08-3.13; P=0.006). In conclusion, these data suggest that an ABCB1 variant known to alter protein expression represents an attractive candidate for future study and risk stratification in kidney transplantation...
  29. doi request reprint Inhibition of islet immunoreactivity by adiponectin is attenuated in human type 1 diabetes
    Terence T L Pang
    Centre of Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, College of Dental and Medical Sciences, University of Birmingham, Edgbaston B15 2TT, United Kingdom
    J Clin Endocrinol Metab 98:E418-28. 2013
    ..Adiponectin is an adipocyte-derived cytokine with insulin-sensitizing and antiinflammatory properties. These dual actions have not previously been examined in the context of human disease...
  30. doi request reprint Early change in blood glucose concentration is an indicator of mortality in critically ill children
    Prabhakar P Nayak
    Department of Paediatric Intensive Care Medicine, Birmingham Children s Hospital Foundation NHS Trust, Steelhouse Lane, Birmingham, B4 6NH, UK
    Intensive Care Med 39:123-8. 2013
    ..By exploring the longitudinal BG profile of individual children over time, this study investigates the importance of intact homeostasis early after admission to the paediatric intensive care unit (PICU)...
  31. pmc Management of peripheral arterial disease in primary care
    Paul Burns
    Department of Vascular Surgery, University of Birmingham, Birmingham B9 5SS
    BMJ 326:584-8. 2003
  32. pmc FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity
    Manuela Fanciulli
    Physiological Genomics and Medicine Group, UK Medical Research Council MRC Clinical Sciences Centre, Imperial College, London W12 0NN, UK
    Nat Genet 39:721-3. 2007
    ..Our findings suggest that low FCGR3B copy number, and in particular complete FCGR3B deficiency, has a key role in the development of systemic autoimmunity...
  33. ncbi request reprint Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
    Hironori Ueda
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Cambridge, CB2 2XY, UK
    Nature 423:506-11. 2003
    ..Genetic mapping of variants conferring a small disease risk can identify pathways in complex disorders, as exemplified by our discovery of inherited, quantitative alterations of CTLA4 contributing to autoimmune tissue destruction...
  34. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  35. ncbi request reprint Parameters for reliable results in genetic association studies in common disease
    Ingrid Dahlman
    JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, UK
    Nat Genet 30:149-50. 2002
    ..These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable...
  36. ncbi request reprint A nonsense mutation in exon 2 of the DNase I gene is not present in UK subjects with systemic lupus erythematosus and Graves' disease: Comment on the article by Rood et al
    Matthew J Simmonds
    Arthritis Rheum 46:3109-10. 2002
  37. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  38. ncbi request reprint Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus
    Deborah Smyth
    Juvenile Diabetes Research Foundation JDRF Wellcome Trust WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research CIMR, University of Cambridge, Cambridge, UK
    Diabetes 53:3020-3. 2004
    ..24 x 10(-4); OR 1.43 [95% CI 1.17-1.76]). Taken together, these results indicate a more general association of the PTPN22 locus with autoimmune disease...
  39. ncbi request reprint The deleted in colorectal carcinoma (DCC) gene 201 R --> G polymorphism: no evidence for genetic association with autoimmune disease
    Richard J Hall
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Eur J Hum Genet 11:840-4. 2003
    ..Thus, the DCC 201 R --> G polymorphism does not appreciably influence risk of developing the autoimmune diseases tested...