Andrew B Goryachev

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes
    Andrew B Goryachev
    Systems Biology Group, Bioinformatics Institute, Singapore, Singapore
    PLoS Comput Biol 2:e172. 2006
  2. pmc A catalytic role for Mod5 in the formation of the Tea1 cell polarity landmark
    Claudia C Bicho
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
    Curr Biol 20:1752-7. 2010
  3. pmc Daughter cell identity emerges from the interplay of Cdc42, septins, and exocytosis
    Satoshi Okada
    Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 26:148-61. 2013
  4. doi Excitable behavior can explain the "ping-pong" mode of communication between cells using the same chemoattractant
    Andrew B Goryachev
    Centre for Systems Biology, University of Edinburgh, Edinburgh, UK
    Bioessays 34:259-66. 2012
  5. doi Design principles of the bacterial quorum sensing gene networks
    Andrew B Goryachev
    Centre for Systems Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Wiley Interdiscip Rev Syst Biol Med 1:45-60. 2009
  6. doi Dynamics of Cdc42 network embodies a Turing-type mechanism of yeast cell polarity
    Andrew B Goryachev
    Centre for Systems Biology at Edinburgh, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    FEBS Lett 582:1437-43. 2008
  7. ncbi CDC-42 and RAC-1 regulate opposite chemotropisms in Neurospora crassa
    Alexander Lichius
    Institute of Cell Biology, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK
    J Cell Sci 127:1953-65. 2014
  8. doi Self-signalling and self-fusion in filamentous fungi
    Nick D Read
    Institute of Cell Biology, University of Edinburgh, Edinburgh EH9 3JH, United Kingdom
    Curr Opin Microbiol 12:608-15. 2009
  9. doi Lateral dynamics of charged lipids and peripheral proteins in spatially heterogeneous membranes: comparison of continuous and Monte Carlo approaches
    Vladimir Yu Kiselev
    Centre for Systems Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    J Chem Phys 135:155103. 2011
  10. ncbi Cellular deformation and intracellular stress propagation during optical stretching
    Soo Kng Teo
    A STAR Institute of High Performance Computing, Singapore, Singapore
    Phys Rev E Stat Nonlin Soft Matter Phys 81:051924. 2010

Collaborators

  • Kenneth E Sawin
  • Nick D Read
  • K H Chiam
  • JEFFREY E SETTLEMAN
  • Baltazar D Aguda
  • Alexander Lichius
  • Satoshi Okada
  • Marcin Leda
  • Vladimir Yu Kiselev
  • Soo Kng Teo
  • Claudia C Bicho
  • Mark D Bass
  • Ernestina Castro-Longoria
  • Mark D Fricker
  • Boguslaw Obara
  • Natasha S Savage
  • Erfei Bi
  • Julia Hanna
  • Davide Marenduzzo
  • Alexey I Lobanov
  • David A Kelly
  • Hilary A Snaith
  • Kim H Parker
  • Martin J Humphries
  • Mark R Morgan
  • Kirsty A Roach

Detail Information

Publications12

  1. pmc Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes
    Andrew B Goryachev
    Systems Biology Group, Bioinformatics Institute, Singapore, Singapore
    PLoS Comput Biol 2:e172. 2006
    ..Interestingly, we find that the cycling regimes are only weakly dependent on the concentration of GTPase itself...
  2. pmc A catalytic role for Mod5 in the formation of the Tea1 cell polarity landmark
    Claudia C Bicho
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
    Curr Biol 20:1752-7. 2010
    ..The model also suggests an emergent self-focusing property of the Tea1-Mod5 cluster network, which can increase the fidelity of polarized growth...
  3. pmc Daughter cell identity emerges from the interplay of Cdc42, septins, and exocytosis
    Satoshi Okada
    Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 26:148-61. 2013
    ..Our findings define a fundamental mechanism underlying eukaryotic cell fate differentiation. ..
  4. doi Excitable behavior can explain the "ping-pong" mode of communication between cells using the same chemoattractant
    Andrew B Goryachev
    Centre for Systems Biology, University of Edinburgh, Edinburgh, UK
    Bioessays 34:259-66. 2012
    ..We show that these properties result directly from both the excitability threshold and refractory period characteristic of excitable systems. Our model suggests possible molecular mechanisms for the ping-pong communication...
  5. doi Design principles of the bacterial quorum sensing gene networks
    Andrew B Goryachev
    Centre for Systems Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Wiley Interdiscip Rev Syst Biol Med 1:45-60. 2009
    ....
  6. doi Dynamics of Cdc42 network embodies a Turing-type mechanism of yeast cell polarity
    Andrew B Goryachev
    Centre for Systems Biology at Edinburgh, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    FEBS Lett 582:1437-43. 2008
    ..This exchange explains why only one bud forms per cell cycle, because the winner-takes-all competition of candidate sites inevitably selects a single site...
  7. ncbi CDC-42 and RAC-1 regulate opposite chemotropisms in Neurospora crassa
    Alexander Lichius
    Institute of Cell Biology, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK
    J Cell Sci 127:1953-65. 2014
    ....
  8. doi Self-signalling and self-fusion in filamentous fungi
    Nick D Read
    Institute of Cell Biology, University of Edinburgh, Edinburgh EH9 3JH, United Kingdom
    Curr Opin Microbiol 12:608-15. 2009
    ..It is proposed that this mechanism has evolved to increase the efficiency of fusion between genetically identical cells that are non-motile...
  9. doi Lateral dynamics of charged lipids and peripheral proteins in spatially heterogeneous membranes: comparison of continuous and Monte Carlo approaches
    Vladimir Yu Kiselev
    Centre for Systems Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    J Chem Phys 135:155103. 2011
    ....
  10. ncbi Cellular deformation and intracellular stress propagation during optical stretching
    Soo Kng Teo
    A STAR Institute of High Performance Computing, Singapore, Singapore
    Phys Rev E Stat Nonlin Soft Matter Phys 81:051924. 2010
    ..Our model also shows that maximal stress propagates into the nuclear region for malignant fibroblasts whereas for normal fibroblasts, it does not. We discuss how this may impact the transduction of cancer signaling pathways...
  11. pmc p190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4
    Mark D Bass
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, England, UK
    J Cell Biol 181:1013-26. 2008
    ..This molecular mechanism explains the cooperation between extracellular matrix receptors during cell adhesion...
  12. pmc From pathways databases to network models of switching behavior
    Baltazar D Aguda
    Mathematical Biosciences Institute, Ohio State University, Columbus, Ohio, USA
    PLoS Comput Biol 3:1674-8. 2007