Siamon Gordon

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis
    Dawn M E Bowdish
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    PLoS Pathog 5:e1000474. 2009
  2. pmc Genetic variants of MARCO are associated with susceptibility to pulmonary tuberculosis in a Gambian population
    Dawn Me Bowdish
    McMaster Immunology Research Centre, McMaster University, Hamilton, ON, L8S 4K1, Canada
    BMC Med Genet 14:47. 2013
  3. doi request reprint Tissue macrophage heterogeneity: issues and prospects
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    Semin Immunopathol 35:533-40. 2013
  4. pmc Genetic deletion of dectin-1 does not affect the course of murine experimental colitis
    Sigrid Em Heinsbroek
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands
    BMC Gastroenterol 12:33. 2012
  5. doi request reprint Macrophage heterogeneity: a personal scientific journey
    Siamon Gordon
    University of Oxford, South Parks Road, Oxford, United Kingdom
    Arterioscler Thromb Vasc Biol 32:1339-42. 2012
  6. ncbi request reprint The macrophage: past, present and future
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Eur J Immunol 37:S9-17. 2007
  7. ncbi request reprint Alternative activation of macrophages: mechanism and functions
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Immunity 32:593-604. 2010
  8. ncbi request reprint Elie Metchnikoff: father of natural immunity
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Eur J Immunol 38:3257-64. 2008
  9. pmc Macrophage heterogeneity and tissue lipids
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Clin Invest 117:89-93. 2007
  10. doi request reprint F4/80 and the related adhesion-GPCRs
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Eur J Immunol 41:2472-6. 2011

Research Grants

  1. INNATE IMMUNITY
    Siamon Gordon; Fiscal Year: 2005

Detail Information

Publications107 found, 100 shown here

  1. pmc MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis
    Dawn M E Bowdish
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    PLoS Pathog 5:e1000474. 2009
    ....
  2. pmc Genetic variants of MARCO are associated with susceptibility to pulmonary tuberculosis in a Gambian population
    Dawn Me Bowdish
    McMaster Immunology Research Centre, McMaster University, Hamilton, ON, L8S 4K1, Canada
    BMC Med Genet 14:47. 2013
    ....
  3. doi request reprint Tissue macrophage heterogeneity: issues and prospects
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    Semin Immunopathol 35:533-40. 2013
    ....
  4. pmc Genetic deletion of dectin-1 does not affect the course of murine experimental colitis
    Sigrid Em Heinsbroek
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands
    BMC Gastroenterol 12:33. 2012
    ..Dectin-1 is a widely expressed pattern recognition receptor that recognizes fungi and upon recognition it mediates cytokine responses and skewing of the adaptive immune system. Hence, dectin-1 may be involved in the pathogenesis of IBD...
  5. doi request reprint Macrophage heterogeneity: a personal scientific journey
    Siamon Gordon
    University of Oxford, South Parks Road, Oxford, United Kingdom
    Arterioscler Thromb Vasc Biol 32:1339-42. 2012
    ..In this brief account, I outline the history of my personal involvement in this subject...
  6. ncbi request reprint The macrophage: past, present and future
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Eur J Immunol 37:S9-17. 2007
    ..Much remains to be discovered regarding both their specific functions and by study of their general cellular properties, in vitro and in vivo...
  7. ncbi request reprint Alternative activation of macrophages: mechanism and functions
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Immunity 32:593-604. 2010
    ..The stage is now set to gain deeper insights into the role of alternatively activated macrophages in immunobiology...
  8. ncbi request reprint Elie Metchnikoff: father of natural immunity
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Eur J Immunol 38:3257-64. 2008
    ..He had a complex personality, yet his creative genius, imagination and insights justify the title of "Father of natural immunity"...
  9. pmc Macrophage heterogeneity and tissue lipids
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Clin Invest 117:89-93. 2007
    ..These studies raise prospects for selective therapeutic targets to ameliorate macrophage hyperinflammatory responses, while sparing host defense and repair mechanisms...
  10. doi request reprint F4/80 and the related adhesion-GPCRs
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Eur J Immunol 41:2472-6. 2011
    ..This Viewpoint summarises current knowledge of the expression, structure and functions of the EGF-TM7 family, as part of a larger family of tissue adhesion-GPCRs...
  11. ncbi request reprint The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Immunol 172:1157-62. 2004
    ..These studies have identified SIGNR1 as a major MR for fungal and other pathogens present on specific subsets of Mphi...
  12. ncbi request reprint Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes
    Andrew S J Marshall
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Biol Chem 279:14792-802. 2004
    ..These data suggest that MICL is a negative regulator of granulocyte and monocyte function...
  13. ncbi request reprint Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies
    Luisa Martinez-Pomares
    Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Leukoc Biol 73:604-13. 2003
    ..These data support a role for the MR in T helper cell type 2 cytokine-driven, immune responses and suggest a non-M(phi) contribution to sMR production in vivo...
  14. ncbi request reprint Glycosylation influences the lectin activities of the macrophage mannose receptor
    Yunpeng Su
    Glycobiology Institute and the Biochemistry Department, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Biol Chem 280:32811-20. 2005
    ..i) It is required for mannose recognition; and (ii) it modulates the tendency of MR to self-associate, effectively regulating the avidity of the CR domain for sulfated sugar ligands...
  15. ncbi request reprint Dectin-1 expression and function are enhanced on alternatively activated and GM-CSF-treated macrophages and are negatively regulated by IL-10, dexamethasone, and lipopolysaccharide
    Janet A Willment
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Immunol 171:4569-73. 2003
    ..These results correlate with the known effects of these cytokines and other agents on the ability of the immune system to recognize and respond to fungal pathogens...
  16. ncbi request reprint Immune inhibitory ligand CD200 induction by TLRs and NLRs limits macrophage activation to protect the host from meningococcal septicemia
    Subhankar Mukhopadhyay
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK
    Cell Host Microbe 8:236-47. 2010
    ..Thus CD200 is induced by TLR-, NOD2-, and NALP3-mediated pathways, limiting their function and protecting the host from excessive inflammation...
  17. ncbi request reprint Activation of murine macrophages by Neisseria meningitidis and IFN-gamma in vitro: distinct roles of class A scavenger and Toll-like pattern recognition receptors in selective modulation of surface phenotype
    Subhankar Mukhopadhyay
    Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK
    J Leukoc Biol 76:577-84. 2004
    ..These studies provide an experimental model and identify surface markers for analysis of innate and acquired immune activation of Mphi...
  18. ncbi request reprint The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, Oxford, United Kingdom
    J Immunol 169:3876-82. 2002
    ..These observations imply the existence of an additional mannan-dependent receptor involved in the recognition of zymosan by resident peritoneal Mphi...
  19. ncbi request reprint The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans
    Martin Stacey
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom
    Blood 102:2916-24. 2003
    ..EMR2-CS interaction is Ca2+- and sulphation-dependent and results in cell attachment. This is the first report of a GAG ligand for the TM7 receptors extending the already vast repertoire of stimuli of the GPCR superfamily...
  20. ncbi request reprint SR-A, MARCO and TLRs differentially recognise selected surface proteins from Neisseria meningitidis: an example of fine specificity in microbial ligand recognition by innate immune receptors
    Annette Plüddemann
    Sir William Dunn School of Pathology, University of Oxford, UK
    J Innate Immun 1:153-63. 2009
    ..SR ligation alone did not induce cytokine production; however, for proteins that were both SR and TLR ligands, the SRs were required for full activation of TLR pathways...
  21. ncbi request reprint The mannose receptor: linking homeostasis and immunity through sugar recognition
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX1 3RE, UK
    Trends Immunol 26:104-10. 2005
  22. ncbi request reprint The human beta-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells
    Janet A Willment
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Eur J Immunol 35:1539-47. 2005
    ....
  23. ncbi request reprint Mannose receptor expression and function define a new population of murine dendritic cells
    Emma J McKenzie
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Immunol 178:4975-83. 2007
    ..In accordance with these observations, ligands highly specific for the MR elicit enhanced humoral responses in vivo only when administered in combination with endotoxin...
  24. pmc Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion
    Audrey Varin
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    Blood 115:353-62. 2010
    ..These findings are relevant to host defense in mixed infections within a Th2 microenvironment and shed light on immunologic functions associated with alternative priming and full activation of macrophages...
  25. pmc Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis
    Sigrid E M Heinsbroek
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 4:e1000218. 2008
    ..albicans uptake. Our data suggest that pattern recognition receptors sample the fungal phagosome in a sequential fashion...
  26. pmc Identification of Neisseria meningitidis nonlipopolysaccharide ligands for class A macrophage scavenger receptor by using a novel assay
    Leanne Peiser
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, United Kingdom
    Infect Immun 74:5191-9. 2006
    ..Thus, we have identified novel, unmodified protein ligands for SR-A that are able to inhibit meningococcal interactions with macrophages in vitro...
  27. ncbi request reprint Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, Oxford, GB
    Eur J Immunol 33:2090-7. 2003
    ....
  28. ncbi request reprint The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis
    Alessia Cotena
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    J Immunol 173:6427-32. 2004
    ....
  29. ncbi request reprint MARCO, an innate activation marker of macrophages, is a class A scavenger receptor for Neisseria meningitidis
    Subhankar Mukhopadhyay
    Sir William Dunn School of Pathology, Oxford, UK
    Eur J Immunol 36:940-9. 2006
    ..We propose that the TLR-dependent induction of MARCO by innate immune stimulation enhances recognition and uptake of pathogenic organisms such as NM, thus contributing to host defence against infection...
  30. ncbi request reprint Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivo
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, Oxford, UK
    Eur J Immunol 35:2163-74. 2005
    ..These observations show Dectin-2 expression to be characteristic of monocyte activation/maturation at an inflammatory lesion and provide a new perspective on the interpretation of Dectin-2 function in vivo...
  31. ncbi request reprint The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose
    Eamon P McGreal
    Sir William Dunn School of Pathology, Oxford University, Oxford OX1 3RE, UK
    Glycobiology 16:422-30. 2006
    ....
  32. ncbi request reprint Expression of functionally different dectin-1 isoforms by murine macrophages
    Sigrid E M Heinsbroek
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Immunol 176:5513-8. 2006
    ..These results are the first evidence that dectin-1 isoforms are functionally distinct and indicate that differential isoform usage may represent a mechanism of regulating cellular responses to beta-glucans...
  33. ncbi request reprint Enhanced expression of the mannose receptor by endothelial cells of the liver and spleen microvascular beds in the macrophage-deficient PU.1 null mouse
    Sheena A Linehan
    Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK
    Histochem Cell Biol 123:365-76. 2005
    ..1 null mouse. This study provides the first evidence of apparently compensatory alterations in the microvasculature of the Mphi-deficient PU.1 null mouse...
  34. ncbi request reprint Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation
    Andrew S J Marshall
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Eur J Immunol 36:2159-69. 2006
    ..This suggests that human MICL may be involved in the control of myeloid cell activation during inflammation...
  35. pmc The mannose receptor mediates dengue virus infection of macrophages
    Joanna L Miller
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 4:e17. 2008
    ..Our findings indicate a new functional role for the MR in DV infection...
  36. pmc Development of a specific system for targeting protein to metallophilic macrophages
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 101:1963-8. 2004
    ..This model will allow the dissection of the role of metallophilic M in an immune response in vivo...
  37. pmc The class A macrophage scavenger receptor is a major pattern recognition receptor for Neisseria meningitidis which is independent of lipopolysaccharide and not required for secretory responses
    Leanne Peiser
    Sir William Dunn School of Pathology, Oxford University, Oxford, United Kingdom
    Infect Immun 70:5346-54. 2002
    ....
  38. pmc A vitellogenic-like carboxypeptidase expressed by human macrophages is localized in endoplasmic reticulum and membrane ruffles
    James Harris
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Int J Exp Pathol 87:29-39. 2006
    ..We propose that CPVL may be involved in antigen processing, the secretory pathway and/or in actin remodelling and lamellipodium formation...
  39. ncbi request reprint Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages
    Jurgen Herre
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    Blood 104:4038-45. 2004
    ..Furthermore, intracellular trafficking of this receptor was influenced by the nature of the beta-glucan ligand, which has significance for the biologic activity of these immunomodulatory carbohydrates...
  40. ncbi request reprint EMR4, a novel epidermal growth factor (EGF)-TM7 molecule up-regulated in activated mouse macrophages, binds to a putative cellular ligand on B lymphoma cell line A20
    Martin Stacey
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom
    J Biol Chem 277:29283-93. 2002
    ..The mEMR4-ligand interaction is Ca2+-independent and is mediated predominantly by the second EGF-like module. mEMR4 is the first EGF-TM7 receptor known to mediate the cellular interaction between myeloid cells and B cells...
  41. ncbi request reprint Carbohydrate-independent recognition of collagens by the macrophage mannose receptor
    Luisa Martinez-Pomares
    Sir William Dunn School of Pathology, Oxford, UK
    Eur J Immunol 36:1074-82. 2006
    ..Furthermore our findings extend the range of endogenous ligands recognised by MR, a molecule firmly placed at the interface between homeostasis and immunity...
  42. ncbi request reprint Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif
    Hsi Hsien Lin
    Sir William Dunn School of Pathology, The University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Biol Chem 279:31823-32. 2004
    ....
  43. ncbi request reprint IL-4 receptor signaling is required for mannose receptor expression by macrophages recruited to granulomata but not resident cells in mice infected with Schistosoma mansoni
    Sheena A Linehan
    Sir William Dunn School of Pathology, South Parks Road, Oxford, London, United Kingdom
    Lab Invest 83:1223-31. 2003
    ..We also present evidence that components of schistosome eggs and a fraction of their secretions are ligands of MR, and suggest that MR activity may be of functional significance in the granulomatous response...
  44. ncbi request reprint Expression of mannose receptor and ligands for its cysteine-rich domain in venous sinuses of human spleen
    Luisa Martinez-Pomares
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Lab Invest 85:1238-49. 2005
    ..Our results suggest an unexpected contribution of MR to splenic function through the recognition of sulphated ligands that could influence the filtering capability of this organ...
  45. ncbi request reprint The role of Dectin-1 in antifungal immunity
    Jurgen Herre
    Sir William Dunn School of Pathology, University of Oxford, UK
    Crit Rev Immunol 24:193-203. 2004
    ..This review will highlight the current knowledge of Dectin-1 and its potential role in antifungal immunity, as well as deficiencies in our understanding...
  46. ncbi request reprint A sensitive solid-phase assay for identification of class A macrophage scavenger receptor ligands using cell lysate
    Annette Plüddemann
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    J Immunol Methods 329:167-75. 2008
    ..Infect. Immun. 74, 5191-5199]). In this paper we describe the method in detail and define the specific variables governing the assay...
  47. pmc The macrophage scavenger receptor A is host-protective in experimental meningococcal septicaemia
    Annette Plüddemann
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 5:e1000297. 2009
    ....
  48. pmc Macrophage scavenger receptor A mediates adhesion to apolipoproteins A-I and E
    Claudine Neyen
    Sir William Dunn School of Pathology, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX13RE, United Kingdom
    Biochemistry 48:11858-71. 2009
    ....
  49. pmc Dectin-1 mediates the biological effects of beta-glucans
    Gordon D Brown
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Exp Med 197:1119-24. 2003
    ..Furthermore, these studies implicate Dectin-1 in the production of TNF-alpha in response to fungi, a critical step required for the successful control of these pathogens...
  50. ncbi request reprint CD312, the human adhesion-GPCR EMR2, is differentially expressed during differentiation, maturation, and activation of myeloid cells
    Gin Wen Chang
    Sir William Dunn School of Pathology, The University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    Biochem Biophys Res Commun 353:133-8. 2007
    ..The results presented here further support the idea that EMR2 plays a role in the migration and adhesion of myeloid cells during cell differentiation, maturation, and activation...
  51. pmc Dectin-1 is a major beta-glucan receptor on macrophages
    Gordon D Brown
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Exp Med 196:407-12. 2002
    ..Furthermore, these results identify Dectin-1 as a new target for examining the immunomodulatory properties of beta-glucans for therapeutic drug design...
  52. ncbi request reprint Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif
    Gin Wen Chang
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK
    FEBS Lett 547:145-50. 2003
    ..Thus, an alternatively spliced EMR2 isoform with a truncated stalk fails to undergo proteolytic cleavage. Alternative splicing therefore provides a means to regulate GPS cleavage, producing receptors with two distinct structures...
  53. ncbi request reprint The role of receptor oligomerization in modulating the expression and function of leukocyte adhesion-G protein-coupled receptors
    John Q Davies
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, United Kingdom
    J Biol Chem 282:27343-53. 2007
    ..These findings suggest that receptor homo- and hetero-oligomerization play a regulatory role in modulating the expression and function of leukocyte adhesion-GPCRs...
  54. ncbi request reprint Functional analysis of the murine Emr1 promoter identifies a novel purine-rich regulatory motif required for high-level gene expression in macrophages
    Dawn O'Reilly
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Genomics 84:1030-40. 2004
    ..Our results provide evidence that extended purine-rich sequence elements may constitute a new transcription regulatory motif and that PU.1 association is a prerequisite for macrophage-specific expression...
  55. ncbi request reprint Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function
    Simon Yona
    Sir William Dunn School of Pathology, Oxford University, Oxford, OX1 3RE, UK
    FASEB J 22:741-51. 2008
    ..Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function...
  56. doi request reprint SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens
    Subhankar Mukhopadhyay
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, United Kingdom
    Blood 117:1319-28. 2011
    ..We conclude that SR-A/MARCO-mediated rapid ligand internalization prevented sensing by surface TLRs while increasing ligand availability in intracellular compartments, thus allowing sensing and robust responses by intracellular sensors...
  57. pmc Actin and phosphoinositide recruitment to fully formed Candida albicans phagosomes in mouse macrophages
    Sigrid E M Heinsbroek
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    J Innate Immun 1:244-53. 2009
    ..albicans phagosome was independent of PI3K. The ability of mature C. albicans phagosomes to stimulate actin polymerization could facilitate the escape of the growing yeast from the Mphi...
  58. pmc Dectin-1 is required for beta-glucan recognition and control of fungal infection
    Philip R Taylor
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX13RE, UK
    Nat Immunol 8:31-8. 2007
    ..Our results establish a fundamental function for beta-glucan recognition by dectin-1 in antifungal immunity and demonstrate a signaling non-Toll-like pattern-recognition receptor required for the induction of protective immune responses...
  59. ncbi request reprint Characterisation of myeloid receptor expression and interferon alpha/beta production in murine plasmacytoid dendritic cells by flow cytomtery
    Rosalind E Seeds
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    J Immunol Methods 350:106-17. 2009
    ..The comparable sensitivities of these assays are often a critical determinant of the choice of assay and are an important consideration in experimental design...
  60. ncbi request reprint Pattern recognition receptors: doubling up for the innate immune response
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, England
    Cell 111:927-30. 2002
    ..Several of these recognize endogenous as well as exogenous ligands, suggesting that they play a dual role in normal tissue function and host defense...
  61. pmc The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance
    Hsi Hsien Lin
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England, UK
    J Exp Med 201:1615-25. 2005
    ..Peripheral tolerance was restored in F4/80(-/-) mice by adoptive transfer of F4/80(+) APCs in both peripheral tolerance models, indicating a central role for the F4/80 molecule in the generation of efferent CD8(+) T reg cells...
  62. ncbi request reprint The molecular basis of macrophage fusion
    Laura Helming
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Immunobiology 212:785-93. 2007
    ..The function of MGCs during granulomatous diseases is currently unknown. However, a better understanding of the mechanistic basis of macrophage fusion may lead to a better understanding of the function of MGCs found in granulomas...
  63. pmc Essential role of DAP12 signaling in macrophage programming into a fusion-competent state
    Laura Helming
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Sci Signal 1:ra11. 2008
    ..Thus, DAP12 is involved in programming of macrophages through the regulation of gene and protein expression to induce a fusion-competent state...
  64. ncbi request reprint Adhesion-GPCRs: emerging roles for novel receptors
    Simon Yona
    Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK
    Trends Biochem Sci 33:491-500. 2008
    ..More recent studies have provided structural, evolutionary, developmental and immunological insights in relation to the adhesion-GPCR family...
  65. pmc Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function
    James Brown
    CR UK Receptor Structure Research Group, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom
    Protein Sci 16:1042-52. 2007
    ..These combined structural and biophysical data considerably extend the current knowledge of dectin-1 structure and function, and suggest potential mechanisms of defense against fungal pathogens...
  66. pmc Macrophage scavenger receptor a promotes tumor progression in murine models of ovarian and pancreatic cancer
    Claudine Neyen
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Immunol 190:3798-805. 2013
    ..Our observations suggest that SR-A may be a potential drug target in the prevention of metastatic cancer progression...
  67. pmc The scavenger receptor CD36 plays a role in cytokine-induced macrophage fusion
    Laura Helming
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    J Cell Sci 122:453-9. 2009
    ..Furthermore, our results suggest that lipid capture by cell surface receptors may be a general feature of cell fusion...
  68. doi request reprint Leukocyte adhesion-GPCR EMR2 is aberrantly expressed in human breast carcinomas and is associated with patient survival
    John Q Davies
    Sir William Dunn School of Pathology, University of Oxford, The Nuffield Department of Clinical Laboratory Sciences and Molecular Oncology, John Radcliffe Hospital, Oxford, UK
    Oncol Rep 25:619-27. 2011
    ..The association of improved patient survival with higher nuclear expression levels identifies EMR2 as a potential biomarker in patients with invasive breast cancer...
  69. ncbi request reprint Macrophage fusion induced by IL-4 alternative activation is a multistage process involving multiple target molecules
    Laura Helming
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Eur J Immunol 37:33-42. 2007
    ..The model we describe will allow analysis of the molecular basis of membrane fusion and possible insight into alternative activation of macrophages...
  70. ncbi request reprint Innate immune response to human bone marrow fibroblastic cell implantation in CB17 scid/beige mice
    Zhidao Xia
    Botnar Research Centre, Institute of Musculoskeletal Science, Nuffield Department of Orthopaedic Surgery, The University of Oxford, Oxford, OX3 7LD, United Kingdom
    J Cell Biochem 98:966-80. 2006
    ..This study highlights the importance of the innate immune cells in the anti-xenograft response and suggests that strategies to block the activities of these cells may ameliorate the progressive long-term elimination of xenotransplants...
  71. ncbi request reprint Ligand recognition by antigen-presenting cell C-type lectin receptors
    Eamon P McGreal
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Curr Opin Immunol 17:18-24. 2005
    ..New studies have also demonstrated that different ligand binding and/or sensing receptors collaborate for full and effective immune responses...
  72. doi request reprint Conserved domains of the class A scavenger receptors: evolution and function
    Dawn M E Bowdish
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Immunol Rev 227:19-31. 2009
    ....
  73. ncbi request reprint Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner
    Dawn O'Reilly
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Biol Chem 278:21909-19. 2003
    ..We propose that expression of CD68 in myeloid cells requires the Ets transcription factors Elf-1 and PU.1 and CD68 expression is down-regulated in lymphoid cells by combinatorial interactions between PU.1 and IRF-4...
  74. ncbi request reprint Dectin-1 escape by fungal dimorphism
    Sigrid E M Heinsbroek
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK OX1 3RE
    Trends Immunol 26:352-4. 2005
    ..Here, we discuss the insights these results provide in relation to macrophage interactions with C. albicans and pathogen entry...
  75. ncbi request reprint Scavenger receptors in innate immunity
    Leanne Peiser
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK
    Curr Opin Immunol 14:123-8. 2002
    ..SR can alter cell morphology and their expression is affected by various cytokines. SR are involved in lipid metabolism and bind modified low-density lipoproteins...
  76. ncbi request reprint The many roles of the class A macrophage scavenger receptor
    Nick Platt
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    Int Rev Cytol 212:1-40. 2002
    ..In this review, we attempt to summarize the evidence and argue that these kinds of activities underlie the biological versatility of Mphi...
  77. ncbi request reprint Thematic review series: the immune system and atherogenesis. Recent insights into the biology of macrophage scavenger receptors
    David R Greaves
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Lipid Res 46:11-20. 2005
    ..We critically evaluate the potential of scavenger receptors and their ligands as targets for therapeutic intervention in human disease...
  78. ncbi request reprint The role of scavenger receptors in pathogen recognition and innate immunity
    Subhankar Mukhopadhyay
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    Immunobiology 209:39-49. 2004
    ..They also bind and internalise a variety of microbial pathogens, as well as modified or endogenous molecules derived from the host, and contribute to a range of physiological or pathological processes...
  79. ncbi request reprint Divergent roles for C-type lectins expressed by cells of the innate immune system
    Eamon P McGreal
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford 0X1 3RE, UK
    Mol Immunol 41:1109-21. 2004
    ..We also review more recent data on several members of this family...
  80. ncbi request reprint Pathogen recognition or homeostasis? APC receptor functions in innate immunity
    Siamon Gordon
    Sir William Dunn School of Pathology, South Parks Road, Oxford OXI 3RE, UK
    C R Biol 327:603-7. 2004
    ..This article will evaluate one of the paradigms that underlie innate immunity...
  81. ncbi request reprint Commentary: C-type lectins on the macrophage cell surface--recent findings
    Andrew S J Marshall
    The Sir William Dunn School of Pathology, South Parks Road, Oxford, GB
    Eur J Immunol 34:18-24. 2004
    ..We aim to highlight the considerable body of novel/uncharacterized members of this receptor family and to place in context the initial description of CLECSF8, which is reported in this issue of the journal...
  82. ncbi request reprint Fungal beta-glucans and mammalian immunity
    Gordon D Brown
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 RE, United Kingdom
    Immunity 19:311-5. 2003
    ..Recent studies, however, are starting to shed some light on the cellular receptors and molecular mechanisms involved, which also have direct relevance on the innate immune response to fungal pathogens...
  83. ncbi request reprint Alternative activation of macrophages
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Immunol 3:23-35. 2003
    ..In this review, I assess the evidence in favour of alternative macrophage activation in the light of macrophage heterogeneity, and define its limits and relevance to a range of immune and inflammatory conditions...
  84. ncbi request reprint Positive about HIV--an immunological education project in South Africa
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Immunol 3:1115-7. 2002
  85. ncbi request reprint Macrophage-specific gene expression: current paradigms and future challenges
    David R Greaves
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    Int J Hematol 76:6-15. 2002
    ..A better understanding of macrophage gene expression may find application in gene therapy, genetic vaccination, and the development of new antiinflammatory drugs...
  86. ncbi request reprint Alternative activation of macrophages: an immunologic functional perspective
    Fernando O Martinez
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Annu Rev Immunol 27:451-83. 2009
    ..The evidence for in vivo alternative activation of macrophages is also analyzed, with nematode infection as prototypic disease. Finally, we revisit the concept of macrophage activation in the context of the immune response...
  87. pmc The macrophage scavenger receptor at 30 years of age: current knowledge and future challenges
    David R Greaves
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    J Lipid Res 50:S282-6. 2009
    ..g., regulation of macrophage cytokine responses) and we speculate on potential approaches to target the activity of this diverse family of receptors for therapeutic benefit in cardiovascular disease...
  88. ncbi request reprint Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins
    Neil C Rogers
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Immunity 22:507-17. 2005
    ..These results identify a novel signaling pathway involved in pattern recognition by C type lectins and suggest a potential role for Syk kinase in regulation of innate immunity...
  89. pmc Alveolar macrophage-mediated killing of Pneumocystis carinii f. sp. muris involves molecular recognition by the Dectin-1 beta-glucan receptor
    Chad Steele
    Department of Pediatrics, Division of Pulmonology, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Exp Med 198:1677-88. 2003
    ..Taken together, these results show that nonopsonic phagocytosis and subsequent killing of P. carinii by alveolar macrophages is dependent upon recognition by the Dectin-1 beta-glucan receptor...
  90. ncbi request reprint The EGF-TM7 family: a postgenomic view
    Mark J Kwakkenbos
    Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, G1 106, PO Box 22700, 1100 DE, Amsterdam, The Netherlands
    Immunogenetics 55:655-66. 2004
    ..Here we discuss the currently available information on this intriguing receptor family...
  91. ncbi request reprint EMR1, the human homolog of F4/80, is an eosinophil-specific receptor
    Jörg Hamann
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 37:2797-802. 2007
    ..Absence on other leukocytes, including basophils, implies that EMR1 is a highly specific marker for eosinophils in humans...
  92. ncbi request reprint Costimulation via CD55 on human CD4+ T cells mediated by CD97
    Melania Capasso
    Academic Department of Clinical Oncology, Institute of Infection, Immunity and Inflammation, University of Nottingham, City Hospital, Nottingham NG5 1PB, United Kingdom
    J Immunol 177:1070-7. 2006
    ..Our results support a multifaceted role for CD55 in human T cell activation, constituting a further link between innate and adaptive immunity...
  93. ncbi request reprint Soluble Dectin-1 as a tool to detect beta-glucans
    Lisa M Graham
    Institute of Infectious Disease and Molecular Medicine, CLS, Faculty of Health Sciences, University of Cape Town, Observatory, 7925 Cape Town, South Africa
    J Immunol Methods 314:164-9. 2006
    ....
  94. ncbi request reprint Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses
    Shlomo Nedvetzki
    Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London, UK
    Blood 109:3776-85. 2007
    ....
  95. ncbi request reprint Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression
    Fernando O Martinez
    Istituto Clinico Humanitas, Rozzano, Italy
    J Immunol 177:7303-11. 2006
    ..Thus, transcriptome profiling reveals novel molecules and signatures associated with human monocyte-to-macrophage differentiation and polarized activation which may represent candidate targets in pathophysiology...
  96. ncbi request reprint The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells
    Mark J Kwakkenbos
    Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Leukoc Biol 71:854-62. 2002
    ..Different expression patterns and the inability of EMR2 to interact with the CD97 ligand CD55 indicate that the molecular twins EMR2 and CD97 likely have nonredundant functions...
  97. pmc Impaired phagocytic mechanism in annexin 1 null macrophages
    Simon Yona
    Department of Biochemical Pharmacology, The William Harvey Research Institute, St Bartholomew s and The Royal London School of Medicine, University of London
    Br J Pharmacol 148:469-77. 2006
    ..The production of the cytokines TNFalpha and IL-6 was increased in Anx-A1(-/-) macrophages following phagocytosis of all types of particle...
  98. ncbi request reprint Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions
    Delyth M Reid
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, RG20 7NN, UK
    J Leukoc Biol 76:86-94. 2004
    ..Tissue localization thus revealed potential roles of Dectin-1 in leukocyte interactions during innate immune responses and T cell development...
  99. ncbi request reprint Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge
    Peter J Rice
    Department of Pharmacology, East Tennessee State University, Johnson City, TN 37614, USA
    J Pharmacol Exp Ther 314:1079-86. 2005
    ..The glucans are bound by GI epithelial and GALT cells, and they modulate the expression of pattern recognition receptors in the GALT, increase IL-12 expression, and induce protection against infectious challenge...
  100. ncbi request reprint Glycosylation influences the ligand binding activities of mannose receptor
    Yunpeng Roc Su
    Glycobiology Institute, Oxford University, OX1, 3QU Oxford, UK
    Adv Exp Med Biol 564:25-6. 2005
  101. ncbi request reprint Putative alternative trans-splicing of leukocyte adhesion-GPCR pre-mRNAs generates functional chimeric receptors
    Pei Ling Chiu
    Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    FEBS Lett 582:792-8. 2008
    ..Our results suggest that human leukocytes employ trans-splicing as well as cis-splicing to increase the repertoire of functional adhesion-GPCRs...

Research Grants1

  1. INNATE IMMUNITY
    Siamon Gordon; Fiscal Year: 2005
    ..The meeting will conclude with examples of how disorders of innate immunity can give rise to important diseases. ..