S Gordon

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi Pattern recognition receptors: doubling up for the innate immune response
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, England
    Cell 111:927-30. 2002
  2. ncbi Macrophage-restricted molecules: role in differentiation and activation
    S Gordon
    Sir William Dunn School of Pathology, University of Oxford, UK
    Immunol Lett 65:5-8. 1999
  3. ncbi Positive about HIV--an immunological education project in South Africa
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Immunol 3:1115-7. 2002
  4. ncbi Alternative activation of macrophages
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Immunol 3:23-35. 2003
  5. ncbi Pathogen recognition or homeostasis? APC receptor functions in innate immunity
    Siamon Gordon
    Sir William Dunn School of Pathology, South Parks Road, Oxford OXI 3RE, UK
    C R Biol 327:603-7. 2004
  6. ncbi Monocyte and macrophage heterogeneity
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Immunol 5:953-64. 2005
  7. ncbi Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils
    M Stacey
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Biol Chem 276:18863-70. 2001
  8. ncbi Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97
    H H Lin
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom
    Genomics 67:188-200. 2000
  9. ncbi Analysis of macrophage scavenger receptor (SR-A) expression in human aortic atherosclerotic lesions
    P J Gough
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Arterioscler Thromb Vasc Biol 19:461-71. 1999
  10. ncbi Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex
    H H Lin
    Sir William Dunn School of Pathology, South Parks Road, Oxford, United Kingdom
    J Biol Chem 276:24160-9. 2001

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. ncbi Pattern recognition receptors: doubling up for the innate immune response
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, England
    Cell 111:927-30. 2002
    ..Several of these recognize endogenous as well as exogenous ligands, suggesting that they play a dual role in normal tissue function and host defense...
  2. ncbi Macrophage-restricted molecules: role in differentiation and activation
    S Gordon
    Sir William Dunn School of Pathology, University of Oxford, UK
    Immunol Lett 65:5-8. 1999
    ....
  3. ncbi Positive about HIV--an immunological education project in South Africa
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Immunol 3:1115-7. 2002
  4. ncbi Alternative activation of macrophages
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Immunol 3:23-35. 2003
    ..In this review, I assess the evidence in favour of alternative macrophage activation in the light of macrophage heterogeneity, and define its limits and relevance to a range of immune and inflammatory conditions...
  5. ncbi Pathogen recognition or homeostasis? APC receptor functions in innate immunity
    Siamon Gordon
    Sir William Dunn School of Pathology, South Parks Road, Oxford OXI 3RE, UK
    C R Biol 327:603-7. 2004
    ..This article will evaluate one of the paradigms that underlie innate immunity...
  6. ncbi Monocyte and macrophage heterogeneity
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Immunol 5:953-64. 2005
    ..These advances in our understanding have implications for the development of therapeutic strategies that are targeted to modify particular subpopulations of monocytes...
  7. ncbi Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils
    M Stacey
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Biol Chem 276:18863-70. 2001
    ..These interactions suggest a potential role for EMR3 in myeloid-myeloid interactions during immune and inflammatory responses...
  8. ncbi Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97
    H H Lin
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom
    Genomics 67:188-200. 2000
    ..EMR2 fails to interact with CD55, the cellular ligand for CD97, suggesting the possibility of a different cellular ligand(s). EMR2 may therefore have a unique function in cells of monocyte/Mφ and granulocyte lineages...
  9. ncbi Analysis of macrophage scavenger receptor (SR-A) expression in human aortic atherosclerotic lesions
    P J Gough
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Arterioscler Thromb Vasc Biol 19:461-71. 1999
    ....
  10. ncbi Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex
    H H Lin
    Sir William Dunn School of Pathology, South Parks Road, Oxford, United Kingdom
    J Biol Chem 276:24160-9. 2001
    ....
  11. pmc Macrophage class A scavenger receptor-mediated phagocytosis of Escherichia coli: role of cell heterogeneity, microbial strain, and culture conditions in vitro
    L Peiser
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Infect Immun 68:1953-63. 2000
    ....
  12. ncbi Cloning and characterization of CPVL, a novel serine carboxypeptidase, from human macrophages
    J A Mahoney
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom
    Genomics 72:243-51. 2001
    ..Possible functions for CPVL in macrophages include digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation...
  13. ncbi A functional soluble form of the murine mannose receptor is produced by macrophages in vitro and is present in mouse serum
    L Martinez-Pomares
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom
    J Biol Chem 273:23376-80. 1998
    ..A role for sMR in the immune response is proposed based on its binding properties, regulation by cytokines, and the previous discovery of putative ligands for the cysteine-rich domain of the mannose receptor in lymph nodes and spleen...
  14. ncbi Cloning of a novel C-type lectin expressed by murine macrophages
    S G Balch
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Biol Chem 273:18656-64. 1998
    ..The mcl gene locus has been mapped between the genes for the interleukin-17 receptor and CD4 on mouse chromosome 6, the same chromosome as the mouse natural killer cell gene complex...
  15. ncbi Cell-specific glycoforms of sialoadhesin and CD45 are counter-receptors for the cysteine-rich domain of the mannose receptor
    L Martinez-Pomares
    Sir William Dunn School of Pathology, Oxford University, Oxford OX1 3RE, Scotland
    J Biol Chem 274:35211-8. 1999
    ..We also demonstrate that the same glycoprotein expressed in different cells of the same organ can display distinct sugar epitopes that determine its binding properties...
  16. ncbi Linked chromosome 16q13 chemokines, macrophage-derived chemokine, fractalkine, and thymus- and activation-regulated chemokine, are expressed in human atherosclerotic lesions
    D R Greaves
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Arterioscler Thromb Vasc Biol 21:923-9. 2001
    ..Macrophage-expressed chemokines upregulated by interleukin-4 may be useful surrogate markers for the presence of Th2-type immune responses in human atherosclerotic lesions...
  17. ncbi Apoptotic thymocyte clearance in scavenger receptor class A-deficient mice is apparently normal
    N Platt
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Immunol 164:4861-7. 2000
    ..This provides the first direct evidence of redundancy in apoptotic cell clearance mechanisms in vivo...
  18. ncbi Organization of the mouse macrophage C-type lectin (Mcl) gene and identification of a subgroup of related lectin molecules
    S G Balch
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Eur J Immunogenet 29:61-4. 2002
    ..The genomic organization of the MCL gene and the sequence of the promoter region, with putative regulatory elements, were determined from a mouse MCL genomic DNA clone and are described here in detail...
  19. ncbi The human eukaryotic initiation factor 4AI gene (EIF4A1) contains multiple regulatory elements that direct high-level reporter gene expression in mammalian cell lines
    C M Quinn
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom
    Genomics 62:468-76. 1999
    ..Sequences of the human EIF4AI gene may find application in the development of new vectors for gene therapy and genetic vaccination...
  20. ncbi A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake
    P J Gough
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Lipid Res 39:531-43. 1998
    ..The demonstration that a naturally occurring splice variant of SR-A mRNA can act as a dominant negative isoform suggests a novel mechanism for regulation of scavenger receptor activity in macrophages...
  21. ncbi Macrophage receptors and immune recognition
    P R Taylor
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom, USA
    Annu Rev Immunol 23:901-44. 2005
    ....
  22. ncbi Functional comparison of the murine macrosialin and human CD68 promoters in macrophage and nonmacrophage cell lines
    D R Greaves
    Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, United Kingdom
    Genomics 54:165-8. 1998
    ..We conclude that the genetic elements that are responsible for macrophage-specific gene expression are organized differently in the murine and human CD68 genes...
  23. pmc The use of human CD68 transcriptional regulatory sequences to direct high-level expression of class A scavenger receptor in macrophages in vitro and in vivo
    P J Gough
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Immunology 103:351-61. 2001
    ..These data show that CD68 transcriptional regulatory sequences can be used to direct high-level transgene expression in Mphi in vitro and in vivo...
  24. ncbi Endogenous ligands of carbohydrate recognition domains of the mannose receptor in murine macrophages, endothelial cells and secretory cells; potential relevance to inflammation and immunity
    S A Linehan
    Sir William Dunn School of Pathology, South Parks Road, Oxford, UK
    Eur J Immunol 31:1857-66. 2001
    ..Endocytosis of these ligands by MR may have implications for tissue homeostasis and immunity, including antigen presentation, in secretory organs...
  25. ncbi Characterization of the human beta -glucan receptor and its alternatively spliced isoforms
    J A Willment
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom
    J Biol Chem 276:43818-23. 2001
    ..The human receptor also binds T-lymphocytes at a site distinct from the beta-glucan binding site, indicating that this receptor can recognize both endogenous and exogenous ligands...
  26. ncbi Recent progress in defining the role of scavenger receptors in lipid transport, atherosclerosis and host defence
    D R Greaves
    Sir William Dunn School of Pathology, University of Oxford, UK
    Curr Opin Lipidol 9:425-32. 1998
    ..Recent progress in delineating the mechanisms by which oxidized LDL effects changes in gene expression will be reviewed...
  27. ncbi Chromosome mapping of the Emr1 gene
    A J McKnight
    Sir William Dunn School of Pathology, University of Oxford, England, UK
    Mamm Genome 8:946. 1997
  28. ncbi Binding properties of the mannose receptor
    L Martinez-Pomares
    Sir William Dunn School of Pathology, Oxford, UK
    Immunobiology 204:527-35. 2001
    ..It opens the possibility for a delivery pathway for MR carbohydrate recognition domains (CRDs) ligands that needs to be investigated further...
  29. ncbi Scavenger receptors: diverse activities and promiscuous binding of polyanionic ligands
    N Platt
    Sir William Dunn School of Pathology, University of Oxford, UK
    Chem Biol 5:R193-203. 1998
    ..Understanding the molecular interaction of receptor-ligand binding should provide insight into how scavenger receptors contribute to important biological processes...
  30. pmc The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo
    A D Lucas
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Am J Pathol 158:855-66. 2001
    ..Finally we discuss potential roles for fractalkine in constitutive leukocyte trafficking based on its observed pattern of expression in epithelia...
  31. pmc The macrophage scavenger receptor type A is expressed by activated macrophages and protects the host against lethal endotoxic shock
    R Haworth
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Exp Med 186:1431-9. 1997
    ..Modulation of SR-A may provide a novel therapeutic approach to control endotoxic shock...
  32. ncbi Divalent cation-independent macrophage adhesion inhibited by monoclonal antibody to murine scavenger receptor
    I Fraser
    Sir William Dunn School of Pathology, University of Oxford, UK
    Nature 364:343-6. 1993
    ..We propose a novel function for this molecule, previously described as an endocytic receptor, thus providing a mechanism for mononuclear phagocyte recruitment to and retention in ligand-rich tissues such as in atherosclerotic lesions...
  33. ncbi The function of scavenger receptors expressed by macrophages and their role in the regulation of inflammation
    L Peiser
    Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX1 3RE, UK
    Microbes Infect 3:149-59. 2001
    ....
  34. ncbi The EGF-TM7 family: unusual structures at the leukocyte surface
    A J McKnight
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Leukoc Biol 63:271-80. 1998
    ..The regulation of expression of the EGF-TM7 genes, the physiologic function(s) of these novel receptors and the further identification of their ligands is the subject of both intense study and this review...
  35. ncbi Antigen markers of macrophage differentiation in murine tissues
    S Gordon
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    Curr Top Microbiol Immunol 181:1-37. 1992
  36. pmc Phagocytosis stimulates alternative glycosylation of macrosialin (mouse CD68), a macrophage-specific endosomal protein
    R P da Silva
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Biochem J 338:687-94. 1999
    ..We also show that phagocytosis increases the complexity and length of O-linked chains. The data presented highlight the importance of differential glycosylation in the biology of macrosialin, phagosomes and macrophages in general...
  37. ncbi Macrophage receptors implicated in the "adaptive" form of innate immunity
    D M E Bowdish
    Sir William Dunn School of Pathology, University of Oxford, 10 South Parks Road, Oxford OX1 3RE, UK
    Microbes Infect 9:1680-7. 2007
    ..This results in increased recognition of a broad spectrum of pathogens, enhancement of effector functions and altered regulation of the inflammatory response...
  38. ncbi Class A scavenger receptors and the phagocytosis of apoptotic cells
    N Platt
    Sir William Dunn School of Pathology, University of Oxford, UK
    Immunol Lett 65:15-9. 1999
    ..There is growing evidence that they contribute to several biological processes. We present data that suggest class A SRs are involved in the phagocytosis of apoptotic cells...
  39. pmc CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells
    D R Greaves
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Exp Med 186:837-44. 1997
    ..The cloning and characterization of a dendritic cell CC chemokine receptor suggests a role for chemokines in the control of the migration of dendritic cells and the regulation of dendritic cell function in immunity and infection...
  40. ncbi Characterization of the mouse sialoadhesin gene, Sn
    S Mucklow
    Imperial Cancer Research Fund Molecular Haemopoiesis Laboratory, Institute of Molecular Medicine, University of Oxford, John Radcliffe, UK
    Mamm Genome 8:934-7. 1997
  41. ncbi Macrophage phenotype in mice deficient in both macrophage-colony-stimulating factor (op) and apolipoprotein E
    W J de Villiers
    Sir William Dunn School of Pathology, University of Oxford, UK
    Arterioscler Thromb Vasc Biol 18:631-40. 1998
    ..This may explain preservation of SR-A activity in these animals. Our findings clearly illustrate the importance of both M-CSF and M-CSF-dependent monocytes/Mphis in maintaining cholesterol homeostasis and in atherogenesis...
  42. ncbi Immune recognition. A new receptor for beta-glucans
    G D Brown
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nature 413:36-7. 2001
    ..1), there is evidence that another beta-glucan receptor is present on macrophages. Here we identify this unknown receptor as dectin-1 (ref. 2), a finding that provides new insights into the innate immune recognition of beta-glucans...
  43. ncbi Homeostasis: a scavenger receptor for haemoglobin
    S Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK
    Curr Biol 11:R399-401. 2001
    ..Recent studies have identified a macrophage-specific receptor for the clearance of haemoglobin-haptoglobin complexes, which protects the host against the toxicity of free haemoglobin...
  44. ncbi Cloning of intestinal phospholipase A2 from intestinal epithelial RNA by differential display PCR
    S Keshav
    Sir William Dunn School of Pathology, University of Oxford, UK
    Cell Prolif 30:369-83. 1997
    ..The method we describe is well suited to the rapid identification of genes expressed exclusively or predominantly in Paneth cells...
  45. ncbi Molecular cloning of F4/80, a murine macrophage-restricted cell surface glycoprotein with homology to the G-protein-linked transmembrane 7 hormone receptor family
    A J McKnight
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Biol Chem 271:486-9. 1996
    ..The potential role of these distinct domains is discussed with respect to the possible function of the F4/80 molecule...
  46. ncbi EGF-TM7: a novel subfamily of seven-transmembrane-region leukocyte cell-surface molecules
    A J McKnight
    Sir William Dunn School of Pathology, University of Oxford, UK
    Immunol Today 17:283-7. 1996
  47. ncbi Expression and function of the type 3 complement receptor in tissues of the developing mouse
    D A Hughes
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Immunol 160:4543-52. 1998
    ....
  48. ncbi The linked human elongation initiation factor 4A1 (EIF4A1) and CD68 genes map to chromosome 17p13
    E Jones
    Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, United Kingdom
    Genomics 53:248-50. 1998
  49. ncbi HIV-macrophage interactions at the cellular and molecular level
    M Khati
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    Arch Immunol Ther Exp (Warsz) 49:367-78. 2001
    ..Efforts directed at understanding the cellular and molecular mechanisms underlying HIV-macrophage interactions remain the basis for devising novel and efficacious therapeutic strategies against HIV ant the AIDS epidemic...
  50. pmc Cloning the human lysozyme cDNA: inverted Alu repeat in the mRNA and in situ hybridization for macrophages and Paneth cells
    L P Chung
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    Proc Natl Acad Sci U S A 85:6227-31. 1988
    ..This human lysozyme cDNA clone is therefore likely to be a useful molecular probe for studying macrophage distribution and gene expression...
  51. doi In vitro generation of mature human osteoclasts
    F Hemingway
    The Botnar Research Centre, Institute of Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, UK
    Calcif Tissue Int 89:389-95. 2011
    ..g., cytokines, growth factors, hormones) and therapeutic agents on osteoclast resorption activity...
  52. ncbi Interleukin-10 inhibits initial reverse transcription of human immunodeficiency virus type 1 and mediates a virostatic latent state in primary blood-derived human macrophages in vitro
    L J Montaner
    Sir William Dunn School of Pathology, University of Oxford, U K
    J Gen Virol 75:3393-400. 1994
    ..Therefore, IL-10 may be involved in the effective control of HIV-1-infected macrophages in vivo...
  53. ncbi Carbohydrate-independent recognition of collagens by the macrophage mannose receptor
    Luisa Martinez-Pomares
    Sir William Dunn School of Pathology, Oxford, UK
    Eur J Immunol 36:1074-82. 2006
    ..Furthermore our findings extend the range of endogenous ligands recognised by MR, a molecule firmly placed at the interface between homeostasis and immunity...
  54. ncbi Expression of functionally different dectin-1 isoforms by murine macrophages
    Sigrid E M Heinsbroek
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Immunol 176:5513-8. 2006
    ..These results are the first evidence that dectin-1 isoforms are functionally distinct and indicate that differential isoform usage may represent a mechanism of regulating cellular responses to beta-glucans...
  55. ncbi Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype
    Thorsten Hagemann
    Cancer Research United Kingdom Translational Oncology Laboratory, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London, United Kingdom
    J Immunol 176:5023-32. 2006
    ..Chemical communication between tumor cells and macrophages may be important in regulating the cancer cytokine microenvironment...
  56. pmc A vitellogenic-like carboxypeptidase expressed by human macrophages is localized in endoplasmic reticulum and membrane ruffles
    James Harris
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Int J Exp Pathol 87:29-39. 2006
    ..We propose that CPVL may be involved in antigen processing, the secretory pathway and/or in actin remodelling and lamellipodium formation...
  57. ncbi The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose
    Eamon P McGreal
    Sir William Dunn School of Pathology, Oxford University, Oxford OX1 3RE, UK
    Glycobiology 16:422-30. 2006
    ....
  58. ncbi Regulation of cytosolic phospholipase A2 activation and cyclooxygenase 2 expression in macrophages by the beta-glucan receptor
    Saritha Suram
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Biol Chem 281:5506-14. 2006
    ....
  59. ncbi Glycosylation influences the ligand binding activities of mannose receptor
    Yunpeng Roc Su
    Glycobiology Institute, Oxford University, OX1, 3QU Oxford, UK
    Adv Exp Med Biol 564:25-6. 2005
  60. ncbi Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge
    Peter J Rice
    Department of Pharmacology, East Tennessee State University, Johnson City, TN 37614, USA
    J Pharmacol Exp Ther 314:1079-86. 2005
    ..The glucans are bound by GI epithelial and GALT cells, and they modulate the expression of pattern recognition receptors in the GALT, increase IL-12 expression, and induce protection against infectious challenge...
  61. ncbi Dectin-1 escape by fungal dimorphism
    Sigrid E M Heinsbroek
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK OX1 3RE
    Trends Immunol 26:352-4. 2005
    ..Here, we discuss the insights these results provide in relation to macrophage interactions with C. albicans and pathogen entry...
  62. ncbi Expression of mannose receptor and ligands for its cysteine-rich domain in venous sinuses of human spleen
    Luisa Martinez-Pomares
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Lab Invest 85:1238-49. 2005
    ..Our results suggest an unexpected contribution of MR to splenic function through the recognition of sulphated ligands that could influence the filtering capability of this organ...
  63. ncbi Prolonged reduction of leukocyte membrane-associated Dectin-1 levels following beta-glucan administration
    Tammy R Ozment-Skelton
    Department of Surgery, P O Box 70575, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Pharmacol Exp Ther 318:540-6. 2006
    ..These data may have important implications for developing dosing regimens for immunomodulatory carbohydrates...
  64. pmc Impaired phagocytic mechanism in annexin 1 null macrophages
    Simon Yona
    Department of Biochemical Pharmacology, The William Harvey Research Institute, St Bartholomew s and The Royal London School of Medicine, University of London
    Br J Pharmacol 148:469-77. 2006
    ..The production of the cytokines TNFalpha and IL-6 was increased in Anx-A1(-/-) macrophages following phagocytosis of all types of particle...
  65. ncbi Innate immune response to human bone marrow fibroblastic cell implantation in CB17 scid/beige mice
    Zhidao Xia
    Botnar Research Centre, Institute of Musculoskeletal Science, Nuffield Department of Orthopaedic Surgery, The University of Oxford, Oxford, OX3 7LD, United Kingdom
    J Cell Biochem 98:966-80. 2006
    ..This study highlights the importance of the innate immune cells in the anti-xenograft response and suggests that strategies to block the activities of these cells may ameliorate the progressive long-term elimination of xenotransplants...
  66. ncbi Glycosylation influences the lectin activities of the macrophage mannose receptor
    Yunpeng Su
    Glycobiology Institute and the Biochemistry Department, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Biol Chem 280:32811-20. 2005
    ..i) It is required for mannose recognition; and (ii) it modulates the tendency of MR to self-associate, effectively regulating the avidity of the CR domain for sulfated sugar ligands...
  67. doi Putative alternative trans-splicing of leukocyte adhesion-GPCR pre-mRNAs generates functional chimeric receptors
    Pei Ling Chiu
    Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    FEBS Lett 582:792-8. 2008
    ..Our results suggest that human leukocytes employ trans-splicing as well as cis-splicing to increase the repertoire of functional adhesion-GPCRs...
  68. pmc The mannose receptor mediates dengue virus infection of macrophages
    Joanna L Miller
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 4:e17. 2008
    ..Our findings indicate a new functional role for the MR in DV infection...
  69. pmc Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors
    Kevin M Dennehy
    Institute of Infectious Disease and Molecular Medicine, Clinical Laboratory Sciences Division of Immunology, University of Cape Town, Cape Town, South Africa
    Eur J Immunol 38:500-6. 2008
    ..These findings establish the first example of Syk- and MyD88-coupled PRR collaboration, further supporting the concept that paired receptors collaborate to control infectious agents...
  70. ncbi The macrophage: past, present and future
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Eur J Immunol 37:S9-17. 2007
    ..Much remains to be discovered regarding both their specific functions and by study of their general cellular properties, in vitro and in vivo...
  71. ncbi EMR1, the human homolog of F4/80, is an eosinophil-specific receptor
    Jörg Hamann
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 37:2797-802. 2007
    ..Absence on other leukocytes, including basophils, implies that EMR1 is a highly specific marker for eosinophils in humans...
  72. ncbi Mannose receptor expression and function define a new population of murine dendritic cells
    Emma J McKenzie
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Immunol 178:4975-83. 2007
    ..In accordance with these observations, ligands highly specific for the MR elicit enhanced humoral responses in vivo only when administered in combination with endotoxin...
  73. ncbi Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses
    Shlomo Nedvetzki
    Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London, UK
    Blood 109:3776-85. 2007
    ....
  74. ncbi Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression
    Fernando O Martinez
    Istituto Clinico Humanitas, Rozzano, Italy
    J Immunol 177:7303-11. 2006
    ..Thus, transcriptome profiling reveals novel molecules and signatures associated with human monocyte-to-macrophage differentiation and polarized activation which may represent candidate targets in pathophysiology...
  75. pmc Identification of Neisseria meningitidis nonlipopolysaccharide ligands for class A macrophage scavenger receptor by using a novel assay
    Leanne Peiser
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, United Kingdom
    Infect Immun 74:5191-9. 2006
    ..Thus, we have identified novel, unmodified protein ligands for SR-A that are able to inhibit meningococcal interactions with macrophages in vitro...
  76. ncbi Soluble Dectin-1 as a tool to detect beta-glucans
    Lisa M Graham
    Institute of Infectious Disease and Molecular Medicine, CLS, Faculty of Health Sciences, University of Cape Town, Observatory, 7925 Cape Town, South Africa
    J Immunol Methods 314:164-9. 2006
    ....
  77. ncbi Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation
    Andrew S J Marshall
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Eur J Immunol 36:2159-69. 2006
    ..This suggests that human MICL may be involved in the control of myeloid cell activation during inflammation...
  78. ncbi Costimulation via CD55 on human CD4+ T cells mediated by CD97
    Melania Capasso
    Academic Department of Clinical Oncology, Institute of Infection, Immunity and Inflammation, University of Nottingham, City Hospital, Nottingham NG5 1PB, United Kingdom
    J Immunol 177:1070-7. 2006
    ..Our results support a multifaceted role for CD55 in human T cell activation, constituting a further link between innate and adaptive immunity...
  79. ncbi Enhanced expression of the mannose receptor by endothelial cells of the liver and spleen microvascular beds in the macrophage-deficient PU.1 null mouse
    Sheena A Linehan
    Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK
    Histochem Cell Biol 123:365-76. 2005
    ..1 null mouse. This study provides the first evidence of apparently compensatory alterations in the microvasculature of the Mphi-deficient PU.1 null mouse...
  80. pmc The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance
    Hsi Hsien Lin
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England, UK
    J Exp Med 201:1615-25. 2005
    ..Peripheral tolerance was restored in F4/80(-/-) mice by adoptive transfer of F4/80(+) APCs in both peripheral tolerance models, indicating a central role for the F4/80 molecule in the generation of efferent CD8(+) T reg cells...
  81. ncbi Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes
    Andrew S J Marshall
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Biol Chem 279:14792-802. 2004
    ..These data suggest that MICL is a negative regulator of granulocyte and monocyte function...
  82. pmc Alveolar macrophage-mediated killing of Pneumocystis carinii f. sp. muris involves molecular recognition by the Dectin-1 beta-glucan receptor
    Chad Steele
    Department of Pediatrics, Division of Pulmonology, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Exp Med 198:1677-88. 2003
    ..Taken together, these results show that nonopsonic phagocytosis and subsequent killing of P. carinii by alveolar macrophages is dependent upon recognition by the Dectin-1 beta-glucan receptor...
  83. ncbi The EGF-TM7 family: a postgenomic view
    Mark J Kwakkenbos
    Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, G1 106, PO Box 22700, 1100 DE, Amsterdam, The Netherlands
    Immunogenetics 55:655-66. 2004
    ..Here we discuss the currently available information on this intriguing receptor family...
  84. ncbi Dectin-1 expression and function are enhanced on alternatively activated and GM-CSF-treated macrophages and are negatively regulated by IL-10, dexamethasone, and lipopolysaccharide
    Janet A Willment
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Immunol 171:4569-73. 2003
    ..These results correlate with the known effects of these cytokines and other agents on the ability of the immune system to recognize and respond to fungal pathogens...
  85. ncbi Fungal beta-glucans and mammalian immunity
    Gordon D Brown
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 RE, United Kingdom
    Immunity 19:311-5. 2003
    ..Recent studies, however, are starting to shed some light on the cellular receptors and molecular mechanisms involved, which also have direct relevance on the innate immune response to fungal pathogens...
  86. ncbi IL-4 receptor signaling is required for mannose receptor expression by macrophages recruited to granulomata but not resident cells in mice infected with Schistosoma mansoni
    Sheena A Linehan
    Sir William Dunn School of Pathology, South Parks Road, Oxford, London, United Kingdom
    Lab Invest 83:1223-31. 2003
    ..We also present evidence that components of schistosome eggs and a fraction of their secretions are ligands of MR, and suggest that MR activity may be of functional significance in the granulomatous response...
  87. ncbi The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans
    Martin Stacey
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom
    Blood 102:2916-24. 2003
    ..EMR2-CS interaction is Ca2+- and sulphation-dependent and results in cell attachment. This is the first report of a GAG ligand for the TM7 receptors extending the already vast repertoire of stimuli of the GPCR superfamily...
  88. ncbi Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner
    Dawn O'Reilly
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Biol Chem 278:21909-19. 2003
    ..We propose that expression of CD68 in myeloid cells requires the Ets transcription factors Elf-1 and PU.1 and CD68 expression is down-regulated in lymphoid cells by combinatorial interactions between PU.1 and IRF-4...
  89. ncbi The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, Oxford, United Kingdom
    J Immunol 169:3876-82. 2002
    ..These observations imply the existence of an additional mannan-dependent receptor involved in the recognition of zymosan by resident peritoneal Mphi...
  90. pmc The class A macrophage scavenger receptor is a major pattern recognition receptor for Neisseria meningitidis which is independent of lipopolysaccharide and not required for secretory responses
    Leanne Peiser
    Sir William Dunn School of Pathology, Oxford University, Oxford, United Kingdom
    Infect Immun 70:5346-54. 2002
    ....
  91. pmc Dectin-1 is a major beta-glucan receptor on macrophages
    Gordon D Brown
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Exp Med 196:407-12. 2002
    ..Furthermore, these results identify Dectin-1 as a new target for examining the immunomodulatory properties of beta-glucans for therapeutic drug design...
  92. ncbi EMR4, a novel epidermal growth factor (EGF)-TM7 molecule up-regulated in activated mouse macrophages, binds to a putative cellular ligand on B lymphoma cell line A20
    Martin Stacey
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom
    J Biol Chem 277:29283-93. 2002
    ..The mEMR4-ligand interaction is Ca2+-independent and is mediated predominantly by the second EGF-like module. mEMR4 is the first EGF-TM7 receptor known to mediate the cellular interaction between myeloid cells and B cells...
  93. ncbi The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells
    Mark J Kwakkenbos
    Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Leukoc Biol 71:854-62. 2002
    ..Different expression patterns and the inability of EMR2 to interact with the CD97 ligand CD55 indicate that the molecular twins EMR2 and CD97 likely have nonredundant functions...
  94. pmc Development of a specific system for targeting protein to metallophilic macrophages
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 101:1963-8. 2004
    ..This model will allow the dissection of the role of metallophilic M in an immune response in vivo...
  95. ncbi Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions
    Delyth M Reid
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, RG20 7NN, UK
    J Leukoc Biol 76:86-94. 2004
    ..Tissue localization thus revealed potential roles of Dectin-1 in leukocyte interactions during innate immune responses and T cell development...
  96. ncbi Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins
    Neil C Rogers
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Immunity 22:507-17. 2005
    ..These results identify a novel signaling pathway involved in pattern recognition by C type lectins and suggest a potential role for Syk kinase in regulation of innate immunity...
  97. ncbi The human beta-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells
    Janet A Willment
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Eur J Immunol 35:1539-47. 2005
    ....
  98. pmc A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice
    Hiroyuki Yoshitomi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    J Exp Med 201:949-60. 2005
    ....
  99. ncbi The mannose receptor: linking homeostasis and immunity through sugar recognition
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX1 3RE, UK
    Trends Immunol 26:104-10. 2005
  100. ncbi Ligand recognition by antigen-presenting cell C-type lectin receptors
    Eamon P McGreal
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Curr Opin Immunol 17:18-24. 2005
    ..New studies have also demonstrated that different ligand binding and/or sensing receptors collaborate for full and effective immune responses...
  101. ncbi Functional analysis of the murine Emr1 promoter identifies a novel purine-rich regulatory motif required for high-level gene expression in macrophages
    Dawn O'Reilly
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Genomics 84:1030-40. 2004
    ..Our results provide evidence that extended purine-rich sequence elements may constitute a new transcription regulatory motif and that PU.1 association is a prerequisite for macrophage-specific expression...