Melita A Gordon

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. pmc Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa
    Nicholas A Feasey
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi
    Lancet 379:2489-99. 2012
  2. pmc High-resolution single nucleotide polymorphism analysis distinguishes recrudescence and reinfection in recurrent invasive nontyphoidal Salmonella typhimurium disease
    Chinyere K Okoro
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Clin Infect Dis 54:955-63. 2012
  3. pmc The human transcriptome during nontyphoid Salmonella and HIV coinfection reveals attenuated NFkappaB-mediated inflammation and persistent cell cycle disruption
    Fernanda Schreiber
    Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
    J Infect Dis 204:1237-45. 2011
  4. ncbi Invasive salmonellosis in Malawi
    Melita A Gordon
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, Blantyre, Malawi
    J Infect Dev Ctries 2:438-42. 2008
  5. doi Salmonella infections in immunocompromised adults
    Melita A Gordon
    Division of Gastroenterology, Henry Wellcome Laboratories, Nuffield Building, Crown Street, Liverpool University L69 3GE, UK
    J Infect 56:413-22. 2008
  6. doi Epidemics of invasive Salmonella enterica serovar enteritidis and S. enterica Serovar typhimurium infection associated with multidrug resistance among adults and children in Malawi
    Melita A Gordon
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    Clin Infect Dis 46:963-9. 2008
  7. doi Invasive non-typhoid salmonellae establish systemic intracellular infection in HIV-infected adults: an emerging disease pathogenesis
    Melita A Gordon
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Liverpool, UK
    Clin Infect Dis 50:953-62. 2010
  8. pmc Gamma interferon enhances internalization and early nonoxidative killing of Salmonella enterica serovar Typhimurium by human macrophages and modifies cytokine responses
    Melita A Gordon
    Wellcome Trust Tropical Centre, Block E, Royal Infirmary Complex, 70 Pembroke Place, Liverpool L69 3GF, UK
    Infect Immun 73:3445-52. 2005
  9. ncbi Non-typhoidal salmonella bacteraemia among HIV-infected Malawian adults: high mortality and frequent recrudescence
    Melita A Gordon
    Department of Medicine, University of Malawi College of Medicine, Blantyre, Malawi
    AIDS 16:1633-41. 2002
  10. ncbi Primary macrophages from HIV-infected adults show dysregulated cytokine responses to Salmonella, but normal internalization and killing
    Melita A Gordon
    Malawi Liverpool Wellcome Trust Clinical Research Programme, University of Liverpool, UK
    AIDS 21:2399-408. 2007

Collaborators

Detail Information

Publications22

  1. pmc Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa
    Nicholas A Feasey
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi
    Lancet 379:2489-99. 2012
    ..A good understanding of the epidemiology of this neglected disease will open new avenues for development and implementation of vaccine and public health strategies to prevent infections and interrupt transmission...
  2. pmc High-resolution single nucleotide polymorphism analysis distinguishes recrudescence and reinfection in recurrent invasive nontyphoidal Salmonella typhimurium disease
    Chinyere K Okoro
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Clin Infect Dis 54:955-63. 2012
    ..The epidemiology of iNTS is poorly understood. Survivors frequently experience multiply recurrent iNTS disease, despite appropriate antimicrobial therapy, but recrudescence and reinfection have previously been difficult to distinguish...
  3. pmc The human transcriptome during nontyphoid Salmonella and HIV coinfection reveals attenuated NFkappaB-mediated inflammation and persistent cell cycle disruption
    Fernanda Schreiber
    Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
    J Infect Dis 204:1237-45. 2011
    ..We previously observed that ex vivo macrophages from HIV-infected subjects challenged with Salmonella Typhimurium exhibit dysregulated proinflammatory cytokine responses...
  4. ncbi Invasive salmonellosis in Malawi
    Melita A Gordon
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, Blantyre, Malawi
    J Infect Dev Ctries 2:438-42. 2008
    ..The huge burden of invasive salmonellosis in Malawi, the high associated mortality, and the recent emergence of drug resistance emphasise the need for a better understanding of the epidemiology and the need for vaccine development...
  5. doi Salmonella infections in immunocompromised adults
    Melita A Gordon
    Division of Gastroenterology, Henry Wellcome Laboratories, Nuffield Building, Crown Street, Liverpool University L69 3GE, UK
    J Infect 56:413-22. 2008
    ..This review will describe the presentation and pathogenesis of NTS in different categories of immunocompromised adults, contrasted to typhoid fever...
  6. doi Epidemics of invasive Salmonella enterica serovar enteritidis and S. enterica Serovar typhimurium infection associated with multidrug resistance among adults and children in Malawi
    Melita A Gordon
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    Clin Infect Dis 46:963-9. 2008
    ..Nontyphoidal salmonellae (NTS) have become the most common cause of bacteremia in tropical Africa, particularly among susceptible children and HIV-infected adults...
  7. doi Invasive non-typhoid salmonellae establish systemic intracellular infection in HIV-infected adults: an emerging disease pathogenesis
    Melita A Gordon
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Liverpool, UK
    Clin Infect Dis 50:953-62. 2010
    ..The importance of intracellular NTS infection in HIV is unknown...
  8. pmc Gamma interferon enhances internalization and early nonoxidative killing of Salmonella enterica serovar Typhimurium by human macrophages and modifies cytokine responses
    Melita A Gordon
    Wellcome Trust Tropical Centre, Block E, Royal Infirmary Complex, 70 Pembroke Place, Liverpool L69 3GF, UK
    Infect Immun 73:3445-52. 2005
    ..We conclude that 72-h priming with rIFN-gamma increases the efficiency of internalization and nonoxidative early intracellular killing of S. enterica serovar Typhimurium by human macrophages and modifies subsequent cytokine release...
  9. ncbi Non-typhoidal salmonella bacteraemia among HIV-infected Malawian adults: high mortality and frequent recrudescence
    Melita A Gordon
    Department of Medicine, University of Malawi College of Medicine, Blantyre, Malawi
    AIDS 16:1633-41. 2002
    ..We aimed to describe the presentation and outcome of NTS bacteraemia, the pattern of recurrence, and to determine whether recurrence results from re-infection or recrudescence...
  10. ncbi Primary macrophages from HIV-infected adults show dysregulated cytokine responses to Salmonella, but normal internalization and killing
    Melita A Gordon
    Malawi Liverpool Wellcome Trust Clinical Research Programme, University of Liverpool, UK
    AIDS 21:2399-408. 2007
    ..Adults with advanced HIV are susceptible to invasive and recrudescent infections with nontyphoidal salmonellae...
  11. pmc Genotypic homogeneity of multidrug resistant S. Typhimurium infecting distinct adult and childhood susceptibility groups in Blantyre, Malawi
    Chisomo L Msefula
    Department of Microbiology, College of Medicine, University of Malawi, Blantyre, Malawi
    PLoS ONE 7:e42085. 2012
    ..These data suggest that the MDR bacterial population is not static, but is undergoing microevolution which might result in further epidemiology change...
  12. pmc Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa
    Chinyere K Okoro
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nat Genet 44:1215-21. 2012
    ....
  13. ncbi Schistosomiasis does not contribute to death or recurrence of nontyphoid Salmonella bacteremia in human immunodeficiency virus-infected Malawian adults
    Melita A Gordon
    Wellcome Trust Laboratories, Malawi Liverpool Wellcome Trust Clinical Research Programme, Chichiri, Malawi
    Clin Infect Dis 37:e177-9. 2003
    ..The results suggest that active schistosomiasis is not associated with adverse outcome of NTS bacteremia in this population, in contrast to other groups...
  14. pmc Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype
    Robert A Kingsley
    The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Cambridge, United Kingdom
    Genome Res 19:2279-87. 2009
    ..Typhi are either pseudogenes or are absent. Genome analysis of other epidemic ST313 isolates from Malawi and Kenya provided evidence for microevolution and clonal replacement in the field...
  15. pmc Typhoid fever and invasive nontyphoid salmonellosis, Malawi and South Africa
    Nicholas A Feasey
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi
    Emerg Infect Dis 16:1448-51. 2010
    ..Invasive nontyphoid salmonellosis showed a clear bimodal age distribution; the infection developed in women at a younger age than in men. Case frequency for typhoid fever was lower than for salmonellosis...
  16. ncbi Non-typhoidal salmonella bacteraemia--an under-recognized feature of AIDS in African adults
    Anstead M Kankwatira
    Malawi Liverpool Wellcome Trust Clinical Research Programme, PO Box 30096, Blantyre, Malawi
    Trop Doct 34:198-200. 2004
    ..Successful ARV treatment also prevents recurrence. There is inadequate knowledge about the epidemiology of carriage and transmission among at-risk populations...
  17. pmc Invasive nontyphoidal Salmonella disease: epidemiology, pathogenesis and diagnosis
    Melita A Gordon
    Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
    Curr Opin Infect Dis 24:484-9. 2011
    ..This review highlights and discusses important publications over the past 12 months providing new insights on invasive nontyphoidal Salmonella (iNTS) disease...
  18. ncbi Pneumococcal disease in HIV-infected Malawian adults: acute mortality and long-term survival
    Stephen B Gordon
    Malawi Liverpool Wellcome Trust Clinical Research Programme, University of Malawi
    AIDS 16:1409-17. 2002
    ..We set out to determine which factors influence in-hospital mortality and long-term survival of Malawians with invasive pneumococcal disease...
  19. pmc Invasive non-typhoidal Salmonella typhimurium ST313 are not host-restricted and have an invasive phenotype in experimentally infected chickens
    Bryony N Parsons
    ZIPPP Group, Institute of Infection and Global Health, University of Liverpool, Neston, Cheshire, United Kingdom Institute of Translational Medicine University of Liverpool, Liverpool, United Kingdom
    PLoS Negl Trop Dis 7:e2487. 2013
    ..Typhimurium that has evolved to become a systemic pathogen that can cause disease in several hosts. ..
  20. pmc Genomic characterisation of invasive non-typhoidal Salmonella enterica Subspecies enterica Serovar Bovismorbificans isolates from Malawi
    Christina Bronowski
    Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom
    PLoS Negl Trop Dis 7:e2557. 2013
    ..Salmonella enterica serovar Bovismorbificans was a common serovar in Malawi between 1997 and 2004...
  21. pmc A reduction in adult blood stream infection and case fatality at a large African hospital following antiretroviral therapy roll-out
    Nicholas A Feasey
    Malawi Liverpool Wellcome Trust Clinical Research Programme MLW, University of Malawi College of Medicine, Blantyre, Malawi Department of Medicine, University of Malawi College of Medicine, Blantyre, Malawi Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS ONE 9:e92226. 2014
    ..Over the last 10 years, there has been rapid roll-out of anti-retroviral therapy (ART) and cotrimoxazole prophylactic therapy (CPT) in many high HIV prevalence African countries...
  22. pmc Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut
    Manuela Raffatellu
    Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, California 95616 8645, USA
    Nat Med 14:421-8. 2008
    ..We conclude that SIV infection impairs the IL-17 axis, an arm of the mucosal immune response preventing systemic microbial dissemination from the gastrointestinal tract...