Guy M Goodwin

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint A single dose of citalopram increases fear recognition in healthy subjects
    M Browning
    Department of Psychiatry, Oxford University, Warneford Hospital, Oxford, UK
    J Psychopharmacol 21:684-90. 2007
  2. doi request reprint Is it time to shift to better characterization of patients in trials assessing novel antidepressants? An example of two relapse prevention studies with agomelatine
    Guy M Goodwin
    Department of Psychiatry, Warneford Hospital, University of Oxford, UK
    Int Clin Psychopharmacol 28:20-8. 2013
  3. doi request reprint Aripiprazole in patients with bipolar mania and beyond: an update of practical guidance
    Guy M Goodwin
    Warneford Hospital, Oxford University, UK
    Curr Med Res Opin 27:2285-99. 2011
  4. doi request reprint Advantages and disadvantages of combination treatment with antipsychotics ECNP Consensus Meeting, March 2008, Nice
    Guy Goodwin
    University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Eur Neuropsychopharmacol 19:520-32. 2009
  5. ncbi request reprint A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder
    Guy M Goodwin
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, England, UK
    J Clin Psychiatry 65:432-41. 2004
  6. doi request reprint Agomelatine prevents relapse in patients with major depressive disorder without evidence of a discontinuation syndrome: a 24-week randomized, double-blind, placebo-controlled trial
    Guy M Goodwin
    Department of Psychiatry, University of Oxford, Warneford Hospital, Headington, Oxford, United Kingdom OX3 7JX, UK
    J Clin Psychiatry 70:1128-37. 2009
  7. ncbi request reprint Introduction to systematic reviews
    Guy M Goodwin
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    J Psychopharmacol 18:249-50. 2004
  8. ncbi request reprint Innovation translates into antidepressant effectiveness
    G M Goodwin
    University Department of Psychiatry, Warneford Hospital, Headington, Oxford, UK
    J Psychopharmacol 22:9-12. 2008
  9. ncbi request reprint Clinical studies on the efficacy of agomelatine on depressive symptoms
    Guy M Goodwin
    Oxford University Department of Psychiatry, Warneford Hospital, Oxford, UK
    CNS Drugs 23:35-9. 2009
  10. ncbi request reprint Aromatase inhibitors and bipolar mood disorder: a case report
    Guy M Goodwin
    University Department of Psychiatry, Warneford Hospital, Headington, Oxford, UK
    Bipolar Disord 8:516-8. 2006

Detail Information

Publications117 found, 100 shown here

  1. ncbi request reprint A single dose of citalopram increases fear recognition in healthy subjects
    M Browning
    Department of Psychiatry, Oxford University, Warneford Hospital, Oxford, UK
    J Psychopharmacol 21:684-90. 2007
    ..Our data also suggests that some of the positive biases in emotional processing produced by SSRI treatment might be detectable at the beginning of treatment...
  2. doi request reprint Is it time to shift to better characterization of patients in trials assessing novel antidepressants? An example of two relapse prevention studies with agomelatine
    Guy M Goodwin
    Department of Psychiatry, Warneford Hospital, University of Oxford, UK
    Int Clin Psychopharmacol 28:20-8. 2013
    ..Adopting these innovations could contribute towards lower failure rates for future placebo-controlled clinical trials in the field...
  3. doi request reprint Aripiprazole in patients with bipolar mania and beyond: an update of practical guidance
    Guy M Goodwin
    Warneford Hospital, Oxford University, UK
    Curr Med Res Opin 27:2285-99. 2011
    ..Aripiprazole is an atypical antipsychotic with a pharmacological and clinical profile distinct from other atypical antipsychotics...
  4. doi request reprint Advantages and disadvantages of combination treatment with antipsychotics ECNP Consensus Meeting, March 2008, Nice
    Guy Goodwin
    University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Eur Neuropsychopharmacol 19:520-32. 2009
    ....
  5. ncbi request reprint A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder
    Guy M Goodwin
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, England, UK
    J Clin Psychiatry 65:432-41. 2004
    ..Two clinical trials, prospectively designed for combined analysis, compared placebo, lithium, and lamotrigine for treatment of bipolar I disorder in recently depressed or manic patients...
  6. doi request reprint Agomelatine prevents relapse in patients with major depressive disorder without evidence of a discontinuation syndrome: a 24-week randomized, double-blind, placebo-controlled trial
    Guy M Goodwin
    Department of Psychiatry, University of Oxford, Warneford Hospital, Headington, Oxford, United Kingdom OX3 7JX, UK
    J Clin Psychiatry 70:1128-37. 2009
    ..This study evaluates the efficacy of agomelatine, the first antidepressant that is an agonist at MT(1)/MT(2) receptors and an antagonist at 5-HT(2C) receptor, in the prevention of relapse of depression following successful response...
  7. ncbi request reprint Introduction to systematic reviews
    Guy M Goodwin
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    J Psychopharmacol 18:249-50. 2004
  8. ncbi request reprint Innovation translates into antidepressant effectiveness
    G M Goodwin
    University Department of Psychiatry, Warneford Hospital, Headington, Oxford, UK
    J Psychopharmacol 22:9-12. 2008
    ..Agomelatine is well tolerated in other respects; only occasional dizziness emerges at significant rates higher than with placebo in the controlled data...
  9. ncbi request reprint Clinical studies on the efficacy of agomelatine on depressive symptoms
    Guy M Goodwin
    Oxford University Department of Psychiatry, Warneford Hospital, Oxford, UK
    CNS Drugs 23:35-9. 2009
    ..The efficacy of agomelatine in major depression has thus been demonstrated at doses of 25-50 mg against the full range of symptoms that make up the depressive syndrome in patients with moderate to severe major depression...
  10. ncbi request reprint Aromatase inhibitors and bipolar mood disorder: a case report
    Guy M Goodwin
    University Department of Psychiatry, Warneford Hospital, Headington, Oxford, UK
    Bipolar Disord 8:516-8. 2006
    ..To report a case in which the aromatase inhibitor letrozole produced irritable mood elevation followed by depression in a woman with a history of postpartum depression...
  11. ncbi request reprint Using guidelines in real clinical situations: clozapine and breast feeding in bipolar disorder
    Guy Goodwin
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    J Psychopharmacol 19:317-8. 2005
  12. ncbi request reprint ECNP consensus meeting. Bipolar depression. Nice, March 2007
    Guy M Goodwin
    University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Eur Neuropsychopharmacol 18:535-49. 2008
    ..Assay sensitivity and patient acceptability are enhanced if the outcome in long-term studies is 'time to intervention for a new episode' for discontinuation designs...
  13. doi request reprint Symptom relief and facilitation of emotional processing
    G M Goodwin
    Oxford University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Eur Neuropsychopharmacol 21:S710-5. 2011
    ....
  14. ncbi request reprint Effective maintenance treatment--breaking the cycle of bipolar disorder
    Guy Goodwin
    Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK
    Eur Psychiatry 20:365-71. 2005
    ..A new collaborative approach based on simple clinical trials is required to change current medical practice...
  15. ncbi request reprint Prophylaxis of bipolar disorder: how and who should we treat in the long term?
    G M Goodwin
    Department of Psychiatry, Warneford Hospital, Oxford, UK
    Eur Neuropsychopharmacol 9:S125-9. 1999
    ..These can only develop out of genuine clinician and patient uncertainty and the creation of a trial culture in everyday practice...
  16. ncbi request reprint Differential effects of erythropoietin on neural and cognitive measures of executive function 3 and 7 days post-administration
    Kamilla Miskowiak
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK
    Exp Brain Res 184:313-21. 2008
    ..The present study supports the notion that Epo may have clinical applications in the treatment of psychiatric disorder characterized by cognitive dysfunction...
  17. ncbi request reprint Effect of acute antidepressant administration on negative affective bias in depressed patients
    Catherine J Harmer
    University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Am J Psychiatry 166:1178-84. 2009
    ..The authors investigated whether this effect is apparent in depressed patients early in treatment, prior to changes in mood and symptoms...
  18. ncbi request reprint Highly neurotic never-depressed students have negative biases in information processing
    Stella W Y Chan
    Department of Experimental Psychology, University of Oxford, UK
    Psychol Med 37:1281-91. 2007
    ..Although negatively biased cognitions are well documented in depressed patients and to some extent in recovered patients, it remains unclear whether these abnormalities are present before the first depressive episode...
  19. ncbi request reprint Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition
    Catherine J Harmer
    University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Am J Psychiatry 161:1256-63. 2004
    ..The present study therefore assessed the actions of repeated antidepressant administration on perception and memory for positive and negative emotional information in healthy volunteers...
  20. ncbi request reprint Induction of depressed mood disrupts emotion regulation neurocircuitry and enhances pain unpleasantness
    Chantal Berna
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom
    Biol Psychiatry 67:1083-90. 2010
    ..We hypothesized that dysregulation of the neural circuitry underlying emotion regulation is the mechanism whereby pain processing is affected during depressed mood...
  21. ncbi request reprint Low-dose tryptophan depletion in recovered depressed patients induces changes in cognitive processing without depressive symptoms
    Gail Hayward
    University Department of Psychiatry, Warneford Hospital, Oxford OX1 3UD, UK
    Biol Psychiatry 57:517-24. 2005
    ..The neurochemical mechanism is thought to be impairment of brain serotonin neurotransmission, but the neuropsychologic mechanisms underlying the effect are unclear...
  22. ncbi request reprint Risk for depression is associated with neural biases in emotional categorisation
    Stella W Y Chan
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, UK
    Neuropsychologia 46:2896-903. 2008
    ..These results highlight a role of the fronto-parietal circuitry in emotional processing and further suggest that negative biases in these neural processes may be involved in risk for depression...
  23. doi request reprint Agomelatine facilitates positive versus negative affective processing in healthy volunteer models
    Catherine J Harmer
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    J Psychopharmacol 25:1159-67. 2011
    ..The study highlights the potential value of volunteer models in drug development for screening and profiling of novel antidepressants...
  24. doi request reprint How psychological symptoms relate to different motivations for gambling: an online study of internet gamblers
    Joanne Lloyd
    Oxford University Department of Psychiatry, Oxford, United Kingdom
    Biol Psychiatry 68:733-40. 2010
    ..Thus, motivations constitute important mechanisms linking mood fluctuations and gambling. However, little is known about how different kinds of affective disturbance, such as mood elevation and dysphoria, motivate gambling behavior...
  25. ncbi request reprint Does depression influence symptom severity in irritable bowel syndrome? Case study of a patient with irritable bowel syndrome and bipolar disorder
    Catherine Crane
    Department of Experimental Psychology, University of Oxford, Warenford Hospital Oxford, UK
    Psychosom Med 65:919-23. 2003
    ....
  26. pmc Cognitions in bipolar affective disorder and unipolar depression: imagining suicide
    Susie A Hales
    Department of Psychiatry, University of Oxford, Oxford, UK
    Bipolar Disord 13:651-61. 2011
    ..Therefore the authors investigated and compared imagery and verbal thoughts related to past suicidality in individuals with bipolar disorder (n = 20) and unipolar depression (n = 20)...
  27. pmc Mood stability versus mood instability in bipolar disorder: a possible role for emotional mental imagery
    Emily A Holmes
    Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford OX3 7JX, UK
    Behav Res Ther 49:707-13. 2011
    ..The findings were consistent with predictions. Further investigation of imagery in bipolar disorder appears warranted as it may highlight processes that contribute to mood instability with relevance for cognitive behaviour therapy...
  28. ncbi request reprint Antidepressants for bipolar depression: a systematic review of randomized, controlled trials
    Harm J Gijsman
    Department of Psychiatry, Warneford Hospital, Oxford, UK
    Am J Psychiatry 161:1537-47. 2004
    ..This study reviewed the evidence from randomized, controlled trials on the efficacy and safety of antidepressants in the short-term treatment of bipolar depression...
  29. ncbi request reprint Single dose antidepressant administration modulates the neural processing of self-referent personality trait words
    Kamilla Miskowiak
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, UK
    Neuroimage 37:904-11. 2007
    ..These results support the hypothesis that antidepressants have early effects on the neural processing of emotional material which may be important in their therapeutic actions...
  30. ncbi request reprint Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant drug action
    Catherine J Harmer
    University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Br J Psychiatry 195:102-8. 2009
    ..The neuropharmacological actions of antidepressants are well characterised but our understanding of how these changes translate into improved mood are still emerging...
  31. ncbi request reprint Erythropoietin improves mood and modulates the cognitive and neural processing of emotion 3 days post administration
    Kamilla Miskowiak
    Department of Experimental Psychology, University of Oxford, Oxford, UK
    Neuropsychopharmacology 33:611-8. 2008
    ..Consistent with our previous finding, Epo improved self-reported mood for all 3 days post-administration. Together, these results suggest that characterization of the effects of Epo in a clinically depressed group is warranted...
  32. ncbi request reprint 5HT(3) antagonism abolishes the emotion potentiated startle effect in humans
    Catherine J Harmer
    Department of Experimental Psychology, University of Oxford, and University Department of Psychiatry, Warneford Hospital, Oxford, OX1 3UD, UK
    Psychopharmacology (Berl) 186:18-24. 2006
    ..The serotonergic system has been implicated in emotional processing in animals and humans. Although the contribution of different receptor subtypes has been hypothesised, there have been few direct tests of this in human subjects...
  33. doi request reprint Combined NK₁ antagonism and serotonin reuptake inhibition: effects on emotional processing in humans
    Catherine J Harmer
    Department of Psychiatry, University of Oxford, Oxford, UK
    J Psychopharmacol 27:435-43. 2013
    ..GSK424887 is a selective competitive antagonist of the human NK₁ receptor and inhibitor of the serotonin transporter. However, its actions in human models of depression have not been assessed...
  34. ncbi request reprint Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial
    John R Geddes
    Oxford Clinical Trials Unit for Mental Illness, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Lancet 375:385-95. 2010
    ..We aimed to establish whether lithium plus valproate was better than monotherapy with either drug alone for relapse prevention in bipolar I disorder...
  35. pmc Using an experimental medicine model to explore combination effects of pharmacological and cognitive interventions for depression and anxiety
    Michael Browning
    Department of Psychiatry, University of Oxford, Oxford, UK
    Neuropsychopharmacology 36:2689-97. 2011
    ..More generally, the findings suggest that pinpointing the cognitive actions of treatments may inform future development of combination strategies in mental health...
  36. ncbi request reprint Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials
    Matthew J Taylor
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    J Psychopharmacol 18:251-6. 2004
    ..It is currently unclear if this is the case both for people with normal folate levels, and for those with folate deficiency...
  37. ncbi request reprint Normalization of enhanced fear recognition by acute SSRI treatment in subjects with a previous history of depression
    Zubin Bhagwagar
    University Department of Psychiatry, Warneford Hospital, Oxford
    Am J Psychiatry 161:166-8. 2004
    ....
  38. ncbi request reprint Sustained attention-deficit confirmed in euthymic bipolar disorder but not in first-degree relatives of bipolar patients or euthymic unipolar depression
    Luke Clark
    University Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Biol Psychiatry 57:183-7. 2005
    ..This study aimed to replicate a deficit in sustained attention in euthymic bipolar patients and investigate sustained attention in first-degree relatives of bipolar probands and in remitted patients with major depressive disorder...
  39. ncbi request reprint Risk for depression and neural responses to fearful facial expressions of emotion
    Stella W Y Chan
    Department of Experimental Psychology, University of Oxford, Oxford, UK
    Br J Psychiatry 194:139-45. 2009
    ..Depression is associated with neural abnormalities in emotional processing...
  40. ncbi request reprint Antidepressant drug treatment modifies the neural processing of nonconscious threat cues
    Catherine J Harmer
    Department of Experimental Psychology, Warneford Hospital, Oxford, United Kingdom
    Biol Psychiatry 59:816-20. 2006
    ..Emotional disorders such as depression and anxiety have been associated with hyperactivity of the amygdala, but it is unknown whether antidepressant treatment directly affects amygdala responses to emotionally significant information...
  41. ncbi request reprint Bipolar disorder and violent crime: new evidence from population-based longitudinal studies and systematic review
    Seena Fazel
    Department of Psychiatry, University of Oxford, Warneford Hospital, England
    Arch Gen Psychiatry 67:931-8. 2010
    ..Although bipolar disorder is associated with various adverse health outcomes, the relationship with violent crime is uncertain...
  42. ncbi request reprint NK1 receptor antagonism and emotional processing in healthy volunteers
    P Chandra
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    J Psychopharmacol 24:481-7. 2010
    ..Human models of emotional processing may provide a useful means of assessing the likely therapeutic potential of new treatments for depression...
  43. ncbi request reprint Toward a neuropsychological theory of antidepressant drug action: increase in positive emotional bias after potentiation of norepinephrine activity
    Catherine J Harmer
    Department of Psychiatry, Oxford University, Warneford Hospital, Oxford OX3 7JX, USA
    Am J Psychiatry 160:990-2. 2003
    ..Cognitive theories suggest that biases in information processing lead depressed patients to make unrealistically negative judgments about themselves and the world...
  44. pmc Lateral prefrontal cortex mediates the cognitive modification of attentional bias
    Michael Browning
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Biol Psychiatry 67:919-25. 2010
    ..It has been hypothesized, but not proved, that psychological interventions may alter the function of prefrontal regions supervising the allocation of attentional resources...
  45. ncbi request reprint 5-HT(1A) receptor binding in euthymic bipolar patients using positron emission tomography with [carbonyl-(11)C]WAY-100635
    Peter A Sargent
    University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    J Affect Disord 123:77-80. 2010
    ..This study was undertaken to examine whether brain 5-HT(1A) receptor binding is reduced in euthymic bipolar patients...
  46. doi request reprint The common adolescent bipolar phenotype shows positive biases in emotional processing
    Philippa L Rock
    Department of Psychiatry, University of Oxford, Warneford Hospital, UK
    Bipolar Disord 12:606-15. 2010
    ..However, studies of euthymic bipolar disorder patients may be confounded by the experience of mood episodes and medication. We therefore assessed an adolescent group for vulnerability markers associated with the bipolar phenotype...
  47. ncbi request reprint Internet gamblers: a latent class analysis of their behaviours and health experiences
    Joanne Lloyd
    Department of Psychiatry, Warneford Hospital, Oxford University, UK
    J Gambl Stud 26:387-99. 2010
    ..Internet gamblers appear to be heterogeneous but composed of several subgroups, differing markedly on both demographic and clinical characteristics...
  48. pmc Presence of mental imagery associated with chronic pelvic pain: a pilot study
    Chantal Berna
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Pain Med 12:1086-93. 2011
    ..To ascertain whether a small sample of patients with chronic pelvic pain experienced any pain-related cognitions in the form of mental images...
  49. pmc Correlates of depression in bipolar disorder
    Paul J Moore
    Oxford Centre for Industrial and Applied Mathematics OCIAM, Mathematical Institute, University of Oxford, Oxford, UK, Smith School of Enterprise and the Environment, University of Oxford, Oxford, UK, Department of Psychiatry, University of Oxford, Oxford, UK, MIT Media Lab, Aston University, Birmingham, UK
    Proc Biol Sci 281:20132320. 2014
    ..Using surrogate time series as a reference dataset, we find no evidence that depression is correlated between patients, though we note a possible loss of information from sparse sampling. ..
  50. ncbi request reprint Developing the BALANCE trail--the role of the pilot study and start-up phase
    Jennifer M Rendell
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Bipolar Disord 6:26-31. 2004
    ..This report describes the adaptations to the initial design and trial procedures following the initial phases of the study. The rationale for the trial and full protocol have been published elsewhere...
  51. ncbi request reprint The role of the anterior cingulate cortex in the counting Stroop task
    Gail Hayward
    Department of Psychiatry, Oxford University, Oxford, UK
    Exp Brain Res 154:355-8. 2004
    ..The Stroop interference effect was abolished by TMS over both anterior cingulate sites. These findings support functional neuroimaging research which suggests that cingulate cortex is central to the processes underlying the Stroop task...
  52. ncbi request reprint Short-term antidepressant treatment and facial processing. Functional magnetic resonance imaging study
    Ray Norbury
    University of Oxford Centre for Clinical Magnetic Resonance Research, MRS Unit, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Br J Psychiatry 190:531-2. 2007
    ..Our results show that reboxetine modulates the neural substrates of emotional processing, highlighting a mechanism by which drug treatment could normalise negative bias in depression and anxiety...
  53. doi request reprint Short-term quetiapine treatment alters the use of reinforcement signals during risky decision-making and promotes the choice of negative expected values in healthy adult males
    Philippa L Rock
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, United Kingdom, and School of Psychology, Bangor University, Adeilad Brigantia, Bangor, Gwynedd, LL57 2AS, United Kingdom
    J Neurosci 33:15588-95. 2013
    ..These effects may be beneficial by correcting decision-making biases that feature in mood disorders. ..
  54. ncbi request reprint Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials
    John R Geddes
    Department of Psychiatry, University of Oxford, Warneford Hospital, UK
    Am J Psychiatry 161:217-22. 2004
    ..The authors sought to determine the efficacy and acceptability of lithium for relapse prevention in bipolar disorder...
  55. ncbi request reprint Mental imagery as an emotional amplifier: application to bipolar disorder
    Emily A Holmes
    University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, United Kingdom
    Behav Res Ther 46:1251-8. 2008
    ..Introducing imagery has novel implications for bipolar treatment innovation--an area where CBT improvements are much-needed...
  56. ncbi request reprint Enhanced early morning salivary cortisol in neuroticism
    Maria J Portella
    Department of Psychiatry, Warneford Hospital, Neurosciences Bldg, Oxford OX3 7JX, UK
    Am J Psychiatry 162:807-9. 2005
    ..This study compared waking cortisol levels in healthy subjects with high and low levels of neuroticism without a previous history of depression...
  57. ncbi request reprint Sustained attention deficit in bipolar disorder
    Luke Clark
    University Department of Psychiatry, Warneford Hospital, Oxford
    Br J Psychiatry 180:313-9. 2002
    ..Previous work has suggested that neuropsychological impairment persists during the euthymic state but has been confounded partly by mild affective symptoms in remitted patients...
  58. ncbi request reprint Antidopaminergic effects of dietary tyrosine depletion in healthy subjects and patients with manic illness
    S F McTavish
    University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Br J Psychiatry 179:356-60. 2001
    ..In rats, amino acid mixtures lacking tyrosine and its precursor phenylalanine decrease the release of dopamine produced by the psychostimulant drug amphetamine. Amphetamine has been proposed as a model for clinical mania...
  59. pmc Reduced subjective response to acute ethanol administration among young men with a broad bipolar phenotype
    Sarah W Yip
    Department of Psychiatry, University of Oxford, Oxford, UK
    Neuropsychopharmacology 37:1808-15. 2012
    ..These observations suggest that the dampened intoxication may contribute to the increased rates of alcohol misuse in young people at-risk for BD, and suggest possible shared etiological factors in the development of AUDs and BD...
  60. ncbi request reprint Sustained attention deficit in bipolar disorder is not a working memory impairment in disguise
    Catherine J Harmer
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Neuropsychologia 40:1586-90. 2002
    ..Deficits in sustaining attention may help explain the difficulties in psychological and occupational functioning in bipolar disorder patients during remission...
  61. doi request reprint Efficacy markers in depression
    Catherine J Harmer
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    J Psychopharmacol 25:1148-58. 2011
    ..Greater validation is required to assess whether these effects are an obligatory component of effective treatment of depression and whether use of these models can improve the accuracy of go/no-go decisions in drug development...
  62. ncbi request reprint The cognitive neuropsychology of depression in the elderly
    Lucie L Herrmann
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Psychol Med 37:1693-702. 2007
    ....
  63. ncbi request reprint Cognitive impairment in bipolar disorder: neurodevelopment or neurodegeneration? An ECNP expert meeting report
    Guy M Goodwin
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Eur Neuropsychopharmacol 18:787-93. 2008
    ....
  64. ncbi request reprint Long-term prophylaxis in bipolar disorder
    Matthew J Taylor
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    CNS Drugs 20:303-10. 2006
    ..Where available, a range of specific psychological interventions can be effective as an adjunct to medication. When discontinuation of prophylaxis is necessary, gradual tapering of dose over weeks or months is recommended...
  65. ncbi request reprint Emotional side-effects of selective serotonin reuptake inhibitors: qualitative study
    Jonathan Price
    University of Oxford Department of Psychiatry, The Warneford Hospital, Oxford OX3 7JX, UK
    Br J Psychiatry 195:211-7. 2009
    ..Some people who take selective serotonin reuptake inhibitor (SSRI) antidepressants report that their experience of emotions is 'blunted'. This phenomenon is poorly understood...
  66. ncbi request reprint What is a mood stabilizer?
    Guy M Goodwin
    University Department of Psychiatry, Warnford Hospital, Oxford, UK
    Psychol Med 37:609-14. 2007
    ..Most importantly, however, it is a term that is innately appealing because of what it promises: for this reason alone it should encompass only those agents that can deliver...
  67. ncbi request reprint Lamotrigine for treatment of bipolar depression: independent meta-analysis and meta-regression of individual patient data from five randomised trials
    John R Geddes
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Br J Psychiatry 194:4-9. 2009
    ..There is uncertainty about the efficacy of lamotrigine in bipolar depressive episodes...
  68. ncbi request reprint Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review
    John R Geddes
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Lancet 361:653-61. 2003
    ..Antidepressant drugs can promote remission from acute depressive episodes. Our aim was to establish how long such treatments should be continued to prevent relapse...
  69. doi request reprint Lithium toxicity profile: a systematic review and meta-analysis
    Rebecca F McKnight
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Lancet 379:721-8. 2012
    ..There has been concern about its safety but no adequate synthesis of the evidence for adverse effects. We aimed to undertake a clinically informative, systematic toxicity profile of lithium...
  70. ncbi request reprint Exploring the physiological effects of double-cone coil TMS over the medial frontal cortex on the anterior cingulate cortex: an H2(15)O PET study
    Gail Hayward
    University Department of Psychiatry, Warneford Hospital, Oxford, OX3 7JX, UK
    Eur J Neurosci 25:2224-33. 2007
    ..However, a number of more distal cortical areas were also affected in these experiments. These additional changes may reflect either 'downstream' effects of altered cingulate cortex activity or direct effects of the coil...
  71. ncbi request reprint Latest maintenance data on lithium in bipolar disorder
    Guy M Goodwin
    Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK
    Eur Neuropsychopharmacol 13:S51-5. 2003
    ..72; 95% CI 0.49, 1.07). Factors such as disease subtype, likelihood of adherence to treatment regimen, tolerability, and dose uncertainty should be considered in the selection of lithium maintenance therapy...
  72. doi request reprint Reduced limbic connections may contraindicate subgenual cingulate deep brain stimulation for intractable depression
    Jennifer A McNab
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, UK
    J Neurosurg 111:780-4. 2009
    ..Correspondence between preoperative and higher resolution ex vivo DT supports the validity of DT as a presurgical planning tool for DBS...
  73. ncbi request reprint Acute administration of citalopram facilitates memory consolidation in healthy volunteers
    Catherine J Harmer
    Neurosciences Building, University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Psychopharmacology (Berl) 163:106-10. 2002
    ..However, the improvement in cognitive function often found following successful pharmacological treatment in depression may be confounded by symptom improvement...
  74. ncbi request reprint Suicide trends in discharged patients with mood disorders: associations with selective serotonin uptake inhibitors and comorbid substance misuse
    Seena Fazel
    Department of Psychiatry, University of Oxford, Warneford Hospital, UK
    Int Clin Psychopharmacol 21:111-5. 2006
    ..We conclude that there is no evidence from this study of an increase in suicide rates following the introduction of SSRIs in the general population or in a high-risk inpatient sample...
  75. ncbi request reprint Enhanced recognition of disgust in bipolar illness
    Catherine J Harmer
    University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Biol Psychiatry 51:298-304. 2002
    ..Although impairments of cognitive function have been found to persist in bipolar patients during periods of euthymic mood, it is not known whether abnormalities in emotional processing also occur during these periods of recovery...
  76. ncbi request reprint Neuropsychological and neuroimaging evidence for the involvement of the frontal lobes in depression
    G M Goodwin
    Department of Psychiatry, University of Oxford, Warneford Hospital, UK
    J Psychopharmacol 11:115-22. 1997
    ..The more prominent impairments of memory are likely to be associated with the finding of impaired temporal function or with a more diffuse failure of neuromodulation...
  77. ncbi request reprint Tryptophan depletion decreases the recognition of fear in female volunteers
    C J Harmer
    University Department of Psychiatry, Warneford Hospital, Oxford, OX3 7JX, UK
    Psychopharmacology (Berl) 167:411-7. 2003
    ..The processing of other fear-relevant cues, such as facial expressions, has also been associated with amygdala function, but an effect of serotonin depletion on these processes has not been assessed...
  78. ncbi request reprint Effects of a branched-chain amino acid drink in mania
    A Scarna
    University of Oxford, Warneford Hospital, UK
    Br J Psychiatry 182:210-3. 2003
    ..Administration of a complex tyrosine-free amino acid drink acutely decreases manic symptoms. Although a nutrient-based approach to illness management is attractive, complex amino acid drinks are too unpalatable for repeated administration...
  79. ncbi request reprint Acute SSRI administration affects the processing of social cues in healthy volunteers
    C J Harmer
    University Department of Psychiatry, Warneord Hospital, Oxford, UK
    Neuropsychopharmacology 28:148-52. 2003
    ..This effect may represent an early acute effect of SSRIs on social and emotional processing that is relevant to their therapeutic actions...
  80. ncbi request reprint Dysfunctional beliefs in bipolar disorder: hypomanic vs. depressive attitudes
    Y Alatiq
    University of Oxford, Department of Psychiatry, Warneford Hospital, Warneford Lane, Headington, Oxford OX3 7JX, UK
    J Affect Disord 122:294-300. 2010
    ..The current study examines whether Mansell's hypomania-related dysfunctional belief scale specifically identifies bipolar disorder patients...
  81. ncbi request reprint Transcranial magnetic stimulation of medial-frontal cortex impairs the processing of angry facial expressions
    C J Harmer
    MRC Human Movement and Balance Unit, Institute of Neurology, 8 11 Queen Square, London WC1N 3BG, UK
    Nat Neurosci 4:17-8. 2001
    ..We found that TMS over the medial-frontal cortex impairs the processing of angry, but not happy, facial expressions of emotion...
  82. pmc Mindfulness-based Cognitive Therapy (MBCT) in bipolar disorder: preliminary evaluation of immediate effects on between-episode functioning
    J M G Williams
    University of Oxford, Department of Psychiatry, Warneford Hospital, Warneford Lane, Headington, Oxford, OX3 7JX, UK
    J Affect Disord 107:275-9. 2008
    ..This study aimed to explore the feasibility and potential benefits of a new psychological treatment (Mindfulness-based Cognitive Therapy: MBCT) for people with bipolar disorder focusing on between-episode anxiety and depressive symptoms...
  83. ncbi request reprint The effects of reboxetine on emotional processing in healthy volunteers: an fMRI study
    R Norbury
    Department of Psychiatry, University of Oxford, Warneford Hospital, Headington, Oxford, UK
    Mol Psychiatry 13:1011-20. 2008
    ..Such adaptations in the neural processing of emotional information support the hypothesis that antidepressants have early effects on emotional processing in a manner which would be expected to reverse negative biases in depression...
  84. ncbi request reprint Administration of the beta-adrenoceptor blocker propranolol impairs the processing of facial expressions of sadness
    C J Harmer
    University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Psychopharmacology (Berl) 154:383-9. 2001
    ..The amygdala has also been associated with the processing of facial expressions of emotion, particularly those of fear and sadness. However, the role of noradrenaline in the latter process is unknown...
  85. ncbi request reprint Tyrosine depletion attenuates dopamine function in healthy volunteers
    C J Harmer
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Psychopharmacology (Berl) 154:105-11. 2001
    ..Such information could establish tyrosine depletion as an effective probe of dopamine function in healthy volunteers and would also have relevance for future therapeutic applications of this manipulation...
  86. ncbi request reprint The effects of a branched chain amino acid mixture supplemented with tryptophan on biochemical indices of neurotransmitter function and decision-making
    A Scarna
    University Department of Psychiatry, Warneford Hospital, Oxford, OX37JX, UK
    Psychopharmacology (Berl) 179:761-8. 2005
    ..However, the BCAA mixture also lowers the ratio of tryptophan (TRP) to BCAA which could impair brain serotonin function...
  87. pmc Facilitated Integrated Mood Management for adults with bipolar disorder
    David J Miklowitz
    Department of Psychiatry, University of California at Los Angeles Semel Institute, UCLA School of Medicine, Los Angeles, CA 90024 1759, USA
    Bipolar Disord 14:185-97. 2012
    ..FIMM incorporated a novel mood monitoring program based on mobile phone technology...
  88. doi request reprint Safety of antipsychotics in people with intellectual disability
    Valeria Frighi
    Department of Psychiatry, University of Oxford and Ridgeway Partnership Oxfordshire Learning Disability NHS Trust, Oxford, UK
    Br J Psychiatry 199:289-95. 2011
    ..Despite frequent use, little is known about the metabolic and endocrine side-effects of antipsychotics in individuals with intellectual disability...
  89. pmc Perceptual switch rates with ambiguous structure-from-motion figures in bipolar disorder
    Kristine Krug
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK
    Proc Biol Sci 275:1839-48. 2008
    ..We suggest that there is no single brain location responsible for perceptual switching in all different ambiguous figures and that perceptual switching is generated by the actions of local cortical circuitry...
  90. ncbi request reprint Lamotrigine in the treatment of bipolar disorder
    Zubin Bhagwagar
    Department of Psychiatry Warneford Hospital, University of Oxford, Oxford OX3 7JK, UK
    Expert Opin Pharmacother 6:1401-8. 2005
    ..Although usually well tolerated, headache, insomnia and drowsiness are probably the most common side effects...
  91. ncbi request reprint A neuropsychological investigation of prefrontal cortex involvement in acute mania
    L Clark
    Department of Psychiatry, University of Oxford, UK
    Am J Psychiatry 158:1605-11. 2001
    ..The data do not implicate ventral prefrontal cortex disruption as a locus of pathology in acute mania. Verbal memory and sustained attention deficits may relate differentially to the state and trait characteristics of bipolar disorder...
  92. ncbi request reprint Evidence-based guidelines for treating bipolar disorder: revised second edition--recommendations from the British Association for Psychopharmacology
    G M Goodwin
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    J Psychopharmacol 23:346-88. 2009
    ..The strength of supporting evidence was rated. The guidelines cover the diagnosis of bipolar disorder, clinical management, and strategies for the use of medicines in treatment of episodes, relapse prevention and stopping treatment...
  93. ncbi request reprint Sleep-related functioning in euthymic patients with bipolar disorder, patients with insomnia, and subjects without sleep problems
    Allison G Harvey
    Department of Experimental Psychology, University of Oxford, UK
    Am J Psychiatry 162:50-7. 2005
    ..The authors investigated sleep-related functioning in euthymic patients with bipolar disorder...
  94. ncbi request reprint Altered risk-aversion and risk-seeking behavior in bipolar disorder
    Rebecca A Chandler
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    Biol Psychiatry 66:840-6. 2009
    ..In this study, we investigated the effects of highlighting rewards versus highlighting punishments in the risky decision-making of euthymic individuals with bipolar disorder...
  95. pmc Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele
    Nicola Filippini
    University Department of Psychiatry, University of Oxford, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 106:7209-14. 2009
    ..The APOE epsilon4 allele modulates brain function decades before any clinical or neurophysiological expression of neurodegenerative processes...
  96. ncbi request reprint Evidence-based guidelines for treating bipolar disorder: recommendations from the British Association for Psychopharmacology
    G M Goodwin
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    J Psychopharmacol 17:149-73; discussion 147. 2003
    ..The guidelines cover the diagnosis of bipolar disorder, clinical management and strategies for the use of medicines in short-term treatment of episodes, relapse prevention and stopping treatment...
  97. ncbi request reprint Chronic, treatment-resistant depression and right fronto-striatal atrophy
    P J Shah
    Department of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, Scotland, UK
    Br J Psychiatry 180:434-40. 2002
    ..Fronto-striatal structural brain changes have been reported in patients with depression but their association with treatment resistance and chronicity has not been established...
  98. ncbi request reprint The influence of positive and negative mood states on risk taking, verbal fluency, and salivary cortisol
    L Clark
    University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    J Affect Disord 63:179-87. 2001
    ..Performance on frontal lobe tests appears to be insensitive to normal mood fluctuations, which supports the argument that the deficits in mood disorder patient groups may instead reflect core disturbances of neurobiological processes...
  99. ncbi request reprint Cerebellar responses during anticipation of noxious stimuli in subjects recovered from depression. Functional magnetic resonance imaging study
    K A Smith
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Br J Psychiatry 181:411-5. 2002
    ..Subjects recovered from depression have a substantial risk for recurrence of depression, suggesting persistent abnormalities in brain activity...
  100. ncbi request reprint The burden on informal caregivers of people with bipolar disorder
    Alan D Ogilvie
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Bipolar Disord 7:25-32. 2005
    ..However, services cannot be enhanced on a rational basis without an improved understanding and capacity to measure and target caregiver burden the impact of any change in services be evaluated...