- Amyotrophic lateral sclerosis (motor neuron disease): proposed mechanisms and pathways to treatmentEmily F Goodall
Division of Neurosciences, University of Birmingham, Edgbaston, Birmingham, B152TT, UK
Expert Rev Mol Med 8:1-22. 2006..In addition to finding effective therapies, research also needs to identify early disease markers because therapy is likely to be of most benefit when given early in the course of disease...
- Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosisShangxi Xiao
Centre for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, University of Toronto, 6 Queen s Park Crescent West, Toronto, Ontario, Canada M5S 3H2
Neurobiol Aging 29:1279-82. 2008..The results revealed that the common variations in IFT74 and GRN neither constitute strong ALS risk factors nor modify the age-at-onset. However, the possibility of a modest risk effect remains to be assessed in large datasets...
- Large-scale pathways-based association study in amyotrophic lateral sclerosisDalia Kasperaviciute
Department of Neurodegenerative Disease, Institute of Neurology, University College London, London, UK
Brain 130:2292-301. 2007..It is reliable for large scale genotyping studies of diseases such as ALS, where DNA sample collections are limited because of low disease prevalence and short survival time...