Research Topics
Species | D GoldblattSummaryAffiliation: University College London Country: UK Publications
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Publications
Natural and vaccine-induced immunity and immunologic memory to Neisseria meningitidis serogroup C in young adultsDavid Goldblatt
Immunobiology Unit, Institute of Child Health, Public Health Laboratory Service, Communicable Disease Surveillance Centre, London, United Kingdom
J Infect Dis 185:397-400. 2002....- Current treatment options for chronic granulomatous diseaseDavid Goldblatt
Immunology Department, Great Ormond Street Children s Hospital NHS Trust, Great Ormond Street, London, WC1N 3JH, UK
Expert Opin Pharmacother 3:857-63. 2002..New antifungal agents provide the promise of improved cure rates for invasive Aspergillus, while bone marrow transplants and gene therapy may offer the promise of complete cure... - Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: a longitudinal household studyDavid Goldblatt
Immunobiology Unit, Institute of Child Health, University College London, UK
J Infect Dis 192:387-93. 2005..pneumoniae or cross-reactive antigens. No longitudinal studies of carriage of and immune responses to S. pneumoniae have been conducted using sophisticated immunological laboratory techniques... - Pneumococcal vaccination in developing countriesOrin S Levine
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Lancet 367:1880-2. 2006 
A prospective study of urinary pneumococcal antigen detection in healthy Karen mothers with high rates of pneumococcal nasopharyngeal carriagePaul Turner
Shoklo Malaria Research Unit, Mae Sot, Thailand
BMC Infect Dis 11:108. 2011..The relationship between pneumococcal carriage and urinary antigen detection in adults from developing countries with high pneumococcal carriage prevalence has not been well established...- Immunogenicity and boosting after a reduced number of doses of a pneumococcal conjugate vaccine in infants and toddlersDavid Goldblatt
Institute of Child Health, University College London, UK
Pediatr Infect Dis J 25:312-9. 2006..The minimum number of doses of pneumococcal conjugate vaccine required for protection is not known. We studied the immunogenicity of a reduced schedule in infants and toddlers... - Bacteria, polysaccharides, vaccines and boosting: measuring and maintaining population immunityDavid Goldblatt
Immunobiology Unit, UCL Institute of Child Health, 30 Guilford Street, London, UK
Arch Dis Child 93:646-7. 2008 
Immunogenicity of a reduced schedule of pneumococcal conjugate vaccine in healthy infants and correlates of protection for serotype 6B in the United KingdomDavid Goldblatt
Immunobiology Unit, UCL Institute of Child Health, London, United Kingdom
Pediatr Infect Dis J 29:401-5. 2010..This study was conducted to establish the immunogenicity of licensed PCV (Prevenar) at a reduced, 2 priming dose schedule (2+1) and to evaluate functional responses in the context of vaccine effectiveness...- Establishment of a new human pneumococcal standard reference serum, 007spD Goldblatt
University College London, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Clin Vaccine Immunol 18:1728-36. 2011..The 007sp preparation has replaced 89SF as the pneumococcal reference standard. Sufficient quantity of this new preparation is available such that, with judicious use, it should be available for at least 25 years... - Comparison of a new multiplex binding assay versus the enzyme-linked immunosorbent assay for measurement of serotype-specific pneumococcal capsular polysaccharide IgGDavid Goldblatt
Immunobiology Unit, University College London, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Clin Vaccine Immunol 18:1744-51. 2011..We conclude that the Meso Scale Discovery (MSD) platform provides a promising new technique for the simultaneous measurement of antipneumococcal antibodies... - Antibody avidity as a surrogate marker of successful priming by Haemophilus influenzae type b conjugate vaccines following infant immunizationD Goldblatt
Institute of Child Health, and Immunisation Division, Communicable Disease Surveillance Centre, London, United Kingdom
J Infect Dis 177:1112-5. 1998..Antibody avidity may help distinguish, in persons with low antibody titers, between those who are primed for memory and those who are not... - The induction of immunologic memory after vaccination with Haemophilus influenzae type b conjugate and acellular pertussis-containing diphtheria, tetanus, and pertussis vaccine combinationD Goldblatt
Immunobiology Unit, Institute of Child Health, London WC1N 1EH, UK
J Infect Dis 180:538-41. 1999..Despite reduced immunogenicity, DTaP-Hib combination vaccines appear to prime for immunologic memory... - Immunogenetic analysis of the immune response to pneumococcal polysaccharideH E Baxendale
Immunobiology Unit, Institute of Child Health, University College London, London, GB
Eur J Immunol 30:1214-23. 2000.... - Safety and immunogenicity of a new Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in healthy adultsP Richmond
Immunobiology Unit, Institute of Child Health, 30 Guilford Street, London, UK
Vaccine 18:641-6. 1999..Conclusion: meningococcal C-tetanus toxoid conjugate vaccine is immunogenic and well tolerated in healthy adults... - Ability of 3 different meningococcal C conjugate vaccines to induce immunologic memory after a single dose in UK toddlersP Richmond
Immunisation Division, Communicable Disease Surveillance Centre, Public Health Laboratory Service, London, United Kingdom
J Infect Dis 183:160-3. 2001..This evidence justified the use of a single dose in a catch-up immunization program for children 1-18 years old... - Natural human antibodies to pneumococcus have distinctive molecular characteristics and protect against pneumococcal diseaseH E Baxendale
Infectious Diseases and Microbiology Unit, Institute of Child Health, University College London, London, UK
Clin Exp Immunol 151:51-60. 2008..4 (+/-4.2) and selective use of IGHD6 (P < 0.001) and IGHJ6 (P < 0.01) family genes. The clones expressing IGHV1-69 and IGHV 3-21 provided significant passive protection against invasive pneumococcal disease in vivo... - Correlation of molecular characteristics, isotype, and in vitro functional activity of human antipneumococcal monoclonal antibodiesH E Baxendale
Infectious Diseases and Microbiology Unit, Institute of Child Health, University of London Medical School, 30 Guilford St, London WC1N 1EH, United Kingdom
Infect Immun 74:1025-31. 2006..5). These data suggest that the use of canonical genes in the Pnc antibody response is associated with highly functional antibodies and that most somatic mutations seen in these genes are not antigen selected... - Persistence of antibody responses to Haemophilus influenzae type b polysaccharide conjugate vaccine in children with vertically acquired human immunodeficiency virus infectionD Gibb
Institute of Child Health, London, United Kingdom
Pediatr Infect Dis J 15:1097-101. 1996..Long term persistence of anti-Hib antibody and the need for, or timing of, a booster dose has not been adequately studied... - Dendritic cell anergy results from endotoxemia in severe malnutritionStephen Miles Hughes
Immunobiology Unit, Centre for International Health and Development, Institute of Child Health, London, United Kingdom
J Immunol 183:2818-26. 2009..Defects in DC number and the immunosuppressive phenotype of DCs from severely malnourished children with endotoxemia provide a rational basis for the anergy found in severe malnutrition... - Safety and immunogenicity of pneumococcal conjugate vaccine in combination with diphtheria, tetanus toxoid, pertussis and Haemophilus influenzae type b conjugate vaccineStephen K Obaro
Imperial College School of Medicine, London, United Kingdom
Pediatr Infect Dis J 21:940-7. 2002..77, 7.68 in the control group; 5.15 IU/ml, 95% CI 4.39, 6.03 in the combined group; P= 0.02). However, all vaccinees achieved protective antibody values. CONCLUSION: The combination of TETRAMUNE and PnCV is safe and immunogenic... - Human dendritic cells infected with an adenoviral vector suppress proliferation of autologous and allogeneic T cellsKaty R Newton
Rheumatology Unit, Institute of Child Health, UCL, London, UK
Immunology 125:469-79. 2008..Together our data suggest that infection of DCs by adenoviral vectors leads to suppression of the resulting immune response... - CD4 counts decline despite nutritional recovery in HIV-infected Zambian children with severe malnutritionStephen Miles Hughes
Immunobiology Unit, and Centre for International Health and Development, Institute of Child Health, 30 Guilford St, London, United Kingdom, WC1N 1EH
Pediatrics 123:e347-51. 2009..The objective of this study was to establish the contribution that severe malnutrition makes to CD4 lymphopenia in HIV-infected and uninfected children and to determine the changes in CD4 count during nutritional rehabilitation... - The early kinetics of circulating pneumococcal-specific memory B cells following pneumococcal conjugate and plain polysaccharide vaccines in the elderlyHelen E Baxendale
Department of Immunology, University College London Medical School, Royal Free Hospital Campus, London NW3 2PF, UK
Vaccine 28:4763-70. 2010.... - Circulating pneumococcal specific plasma and memory B cells in the elderly two years after pneumococcal conjugate versus polysaccharide vaccinationHelen E Baxendale
Department of Immunology, University College London Medical School, Royal Free Hospital Campus, London NW3 2PF, UK
Vaccine 28:6915-22. 2010..Polysaccharide conjugate vaccines prime for lasting memory responses in children and young adults. The potential value of these vaccines in the elderly is unclear... - Effects of prior polysaccharide vaccination on magnitude, duration, and quality of immune responses to and safety profile of a meningococcal serogroup C tetanus toxoid conjugate vaccination in adultsJo Southern
Immunisation Department, Communicable Disease Surveillance Centre, Health Protection Agency, 61 Colindale Ave, Colindale, London, United Kingdom
Clin Diagn Lab Immunol 11:1100-4. 2004..The study shows that MCC-TT is safe and immunogenic in naive and previously MACP-vaccinated adults, though the magnitude and persistence of postvaccination SBA responses in the latter group were lower... - Diminished production of anti-inflammatory mediators during neutrophil apoptosis and macrophage phagocytosis in chronic granulomatous disease (CGD)Joanne R Brown
Immunobiology Unit, The Institute of Child Health, Great Ormond Street Hospital, University College London, United Kingdom
J Leukoc Biol 73:591-9. 2003.... - The immunogenicity of 7-valent pneumococcal conjugate vaccine versus 23-valent polysaccharide vaccine in adults aged 50-80 yearsDavid Goldblatt
Institute of Child Health, University College London, UK
Clin Infect Dis 49:1318-25. 2009..Although 23-valent pneumococcal polysaccharide vaccine (PPV) is recommended for elderly persons, the potential benefits of conjugate vaccine use in this age group remain unclear... - The nature of colitis in chronic granulomatous diseaseMichela G Schäppi
Departments of Gastroenterology, dagger Immunology, and double dagger Histopathology, Institute of Child Health and Great Ormond Street Hospital, London, UK
J Pediatr Gastroenterol Nutr 36:623-31. 2003..Patients with chronic granulomatous disease (CGD) may have gastrointestinal manifestations, commonly colitis. The etiology, prevalence, and inflammatory process of CGD colitis are unclear... - Pneumococcal polysaccharides interact with human dendritic cellsUlrike Meltzer
Immunobiology Unit, The Institute of Child Health, Great Ormond Street Hospital, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom
Infect Immun 74:1890-5. 2006..This effect was not seen using the control antigen tetanus toxoid. DC-pneumococcus interaction may affect subsequent immune responses to pneumococci, as an altered cytokine balance may have a profound effect on DC-driven T-cell priming... - Human constant regions influence the antibody binding characteristics of mouse-human chimeric IgG subclassesN McCloskey
Institute of Child Health, London, UK
Immunology 88:169-73. 1996..The exact mechanism for this phenomenon remains obscure but such differences should be taken into account when designing or choosing antibodies for therapeutic use... - Cutaneous and other lupus-like symptoms in carriers of X-linked chronic granulomatous disease: incidence and autoimmune serologyC M Cale
Immunology Department, Great Ormond Street Hospital for Children, London, UK
Clin Exp Immunol 148:79-84. 2007..as symptoms may respond well to appropriate treatment... - Lack of association between the nasopharyngeal carriage of Streptococcus pneumoniae and Staphylococcus aureus in HIV-1-infected South African childrenLisa M McNally
Centre for International Child Health, Institute of Child Health, University College, London, United Kingdom
J Infect Dis 194:385-90. 2006..3% vs. 36.0%; P=.11). We did not find a negative association between S. pneumoniae and S. aureus carriage in HIV-1-positive hospitalized children with severe pneumonia... - Effect of age, polymicrobial disease, and maternal HIV status on treatment response and cause of severe pneumonia in South African children: a prospective descriptive studyLisa M McNally
Centre for International Child Health and Development, Institute of Child Health, University College London, London WC1N 1EH, UK
Lancet 369:1440-51. 2007..We aimed to measure predictors of treatment failure and the cause of non-responsive pneumonia in children admitted to hospital with severe pneumonia in Durban, South Africa... - Effect of month of vaccine administration on antibody responses in The Gambia and PakistanSophie E Moore
MRC International Nutrition Group, Nutrition and Public Health Intervention Research Unit, London School of Hygiene and Tropical Medicine, London, UK
Trop Med Int Health 11:1529-41. 2006..To explore the relationship between calendar month of administration and antibody (Ab) response to vaccination in subjects from The Gambia and Pakistan, two countries with distinct patterns of seasonality... - Risk of relapse after meningococcal C conjugate vaccine in nephrotic syndromeA S Abeyagunawardena
Nephrourology Unit, Institute of Child Health, London, UK
Lancet 362:449-50. 2003..009). The relapse rate of nephrotic syndrome increased significantly after administration of MCCV. Whether to vaccinate such children needs to be carefully considered... - Optimising the use of conjugate vaccines to prevent disease caused by Haemophilus influenzae type b, Neisseria meningitidis and Streptococcus pneumoniaeCaroline L Trotter
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, UK
Vaccine 26:4434-45. 2008..The aim of this paper is to review the state of the current evidence on conjugate vaccines and to identify important areas for further study, in order to inform the debate regarding the best use of these vaccines... - Conjugate Hib vaccinesMark Steinhoff
Johns Hopkins University School of Medicine, School of Hygiene, Baltimore, MD 21205, USA
Lancet 361:360-1. 2003 - Antibody persistence and immunological memory at age 4 years after meningococcal group C conjugate vaccination in children in the United kingdomRay Borrow
Public Health Laboratory Service Meningococcal Reference Unit, Withington Hospital, Manchester, United Kingdom
J Infect Dis 186:1353-7. 2002..6; 95% CI, 338.0-2568.1). This is the first demonstration of immunological memory at 4 years of age in children receiving MCC vaccine on the United Kingdom's 2/3/4-month immunization schedule... - Effect of vaccination with carrier protein on response to meningococcal C conjugate vaccines and value of different immunoassays as predictors of protectionMoya Burrage
Centre for Applied Microbiology and Research, Porton Down, Salisbury, Wiltshire, United Kingdom
Infect Immun 70:4946-54. 2002.... - Avidity maturation following vaccination with a meningococcal recombinant hexavalent PorA OMV vaccine in UK infantsEmma Longworth
Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Nell Lane, UK
Vaccine 20:2592-6. 2002..No increase in avidity was observed in the control group. Antibody avidity indices are useful laboratory markers for the priming of immunological memory following vaccination with meningococcal serogroup B OMV vaccines... - Serological criteria for evaluation and licensure of new pneumococcal conjugate vaccine formulations for use in infantsLuis Jodar
Department of Vaccines and Biologicals, World Health Organization, CH 1211 27, Geneva, Switzerland
Vaccine 21:3265-72. 2003..More detailed recommendations for production and control of pneumococcal conjugate vaccines, including criteria for evaluation for licensure, are currently being drafted... - Quality of the Haemophilus influenzae type b (Hib) antibody response induced by diphtheria-tetanus-acellular pertussis/Hib combination vaccinesPhilippe A Denoel
GlaxoSmithKline Biologicals, Rue de l Institut 89, 1330 Rixensart, Belgium
Clin Vaccine Immunol 14:1362-9. 2007..In conclusion, in vitro and in vivo data as well as postmarketing vaccine effectiveness data attest to the ability of DTPa-based/Hib combination vaccines to effectively prevent Hib-induced disease in children... - Reduction of antibody response to an 11-valent pneumococcal vaccine coadministered with a vaccine containing acellular pertussis componentsRon Dagan
Pediatric Infectious Disease Unit, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University, Beer Sheva 84101, Israel
Infect Immun 72:5383-91. 2004..With the increasing use of multiple aP-containing vaccines in infancy, novel approaches to adjuvants and carrier protein technology are likely to be required... - Chronic granulomatous disease: from genetic defect to clinical presentationJohan Bylund
Department of Pediatrics, B C Research Institute for Children's and Women's Health, University of British Columbia, Vancouver, Canada
Adv Exp Med Biol 568:67-87. 2005 - Use of opsonophagocytosis for serological evaluation of pneumococcal vaccinesSandra Romero-Steiner
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Clin Vaccine Immunol 13:165-9. 2006 - Critical differences between pneumococcal polysaccharide enzyme-linked immunosorbent assays with and without 22F inhibition at low antibody concentrations in pediatric seraIsabelle Henckaerts
Research and Development, GlaxoSmithKline Biologicals, Rue de l Institut 89, 1330 Rixensart, Belgium
Clin Vaccine Immunol 13:356-60. 2006..35 mug/ml determined with the non-22F ELISA corresponded to a concentration of 0.20 mug/ml with the 22F inhibition ELISA. Pneumococcal antipolysaccharide ELISA including 22F inhibition can be recommended as a reference method... - Enzyme-linked immunosorbent assay for quantitation of human antibodies to pneumococcal polysaccharidesCatherine M Wernette
Department of Pathology and Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35249-7331, USA
Clin Diagn Lab Immunol 10:514-9. 2003 - Immunogenicity of, and immunologic memory to, a reduced primary schedule of meningococcal C-tetanus toxoid conjugate vaccine in infants in the United kingdomRay Borrow
PHLS Meningococcal Reference Unit, Withington Hospital, Manchester, United Kingdom
Infect Immun 71:5549-55. 2003..This study provides the first evidence that the number of doses of MCC-TT used in infant immunization schedules could be decreased... - Clinical and immunologic risk factors for meningococcal C conjugate vaccine failure in the United KingdomCressida Auckland
Immunisation Department, Centre for Infections, Health Protection Agency, Manchester Royal Infirmary, Manchester, United Kingdom
J Infect Dis 194:1745-52. 2006..Persistence of antibodies may be a more appropriate correlate of long-term protection for MCC vaccines than the ability to generate a booster response on exposure... - Avidity of the immunoglobulin G response to a Neisseria meningitidis group C polysaccharide conjugate vaccine as measured by inhibition and chaotropic enzyme-linked immunosorbent assaysShannon L Harris
Wyeth Vaccines Research, Pearl River, NY 10965, USA
Clin Vaccine Immunol 14:397-403. 2007.... - Immunogenicity of a fourth dose of Haemophilus influenzae type b (Hib) conjugate vaccine and antibody persistence in young children from the United Kingdom who were primed with acellular or whole-cell pertussis component-containing Hib combinations in infJo Southern
Immunisation Department, Centre for Infections, Health Protection Agency, London NW9 5EQ, United Kingdom
Clin Vaccine Immunol 14:1328-33. 2007..15 microg/ml in about 90% of individuals. A booster dose of Hib vaccine given after the first year of life should provide long-lasting protection... - Humoral immunity in children with biliary atresia splenic malformation syndromeRachel M Taylor
Eur J Pediatr 162:539-40. 2003 - Multilaboratory evaluation of a viability assay for measurement of opsonophagocytic antibodies specific to the capsular polysaccharides of Streptococcus pneumoniaeSandra Romero-Steiner
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Clin Diagn Lab Immunol 10:1019-24. 2003..75 to 0.85]). All OPA median titers reported for quality control sera were within one dilution of the expected titer. We conclude that this OPA can be done in multiple laboratories with a high degree of interlaboratory reproducibility... - Prenatal diagnosis in two families with autosomal, p47(phox)-deficient chronic granulomatous disease due to a novel point mutation in NCF1Martin de Boer
Central Laboratory of the Netherlands Blood Transfusion Service (CLB, and Laboratory for Experimental and Clinical Immunology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Prenat Diagn 22:235-40. 2002..Following termination of the pregnancy, the diagnosis of p47(phox)-deficient CGD was confirmed on DNA extracted from fetal blood. CONCLUSION: This is the first report of prenatal diagnosis in p47(phox)-deficient CGD... - Combined schedules of pneumococcal conjugate and polysaccharide vaccines: is hyporesponsiveness an issue?Katherine L O'Brien
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Lancet Infect Dis 7:597-606. 2007..In this Review, we describe the evidence for and against this hyporesponsiveness and explore the possible mechanisms for such an occurrence...