D Goldblatt

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Natural and vaccine-induced immunity and immunologic memory to Neisseria meningitidis serogroup C in young adults
    David Goldblatt
    Immunobiology Unit, Institute of Child Health, Public Health Laboratory Service, Communicable Disease Surveillance Centre, London, United Kingdom
    J Infect Dis 185:397-400. 2002
  2. ncbi request reprint Current treatment options for chronic granulomatous disease
    David Goldblatt
    Immunology Department, Great Ormond Street Children s Hospital NHS Trust, Great Ormond Street, London, WC1N 3JH, UK
    Expert Opin Pharmacother 3:857-63. 2002
  3. ncbi request reprint Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: a longitudinal household study
    David Goldblatt
    Immunobiology Unit, Institute of Child Health, University College London, UK
    J Infect Dis 192:387-93. 2005
  4. ncbi request reprint Pneumococcal vaccination in developing countries
    Orin S Levine
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Lancet 367:1880-2. 2006
  5. pmc A prospective study of urinary pneumococcal antigen detection in healthy Karen mothers with high rates of pneumococcal nasopharyngeal carriage
    Paul Turner
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    BMC Infect Dis 11:108. 2011
  6. ncbi request reprint Immunogenicity and boosting after a reduced number of doses of a pneumococcal conjugate vaccine in infants and toddlers
    David Goldblatt
    Institute of Child Health, University College London, UK
    Pediatr Infect Dis J 25:312-9. 2006
  7. doi request reprint Bacteria, polysaccharides, vaccines and boosting: measuring and maintaining population immunity
    David Goldblatt
    Immunobiology Unit, UCL Institute of Child Health, 30 Guilford Street, London, UK
    Arch Dis Child 93:646-7. 2008
  8. doi request reprint Immunogenicity of a reduced schedule of pneumococcal conjugate vaccine in healthy infants and correlates of protection for serotype 6B in the United Kingdom
    David Goldblatt
    Immunobiology Unit, UCL Institute of Child Health, London, United Kingdom
    Pediatr Infect Dis J 29:401-5. 2010
  9. pmc Establishment of a new human pneumococcal standard reference serum, 007sp
    D Goldblatt
    University College London, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Clin Vaccine Immunol 18:1728-36. 2011
  10. pmc Comparison of a new multiplex binding assay versus the enzyme-linked immunosorbent assay for measurement of serotype-specific pneumococcal capsular polysaccharide IgG
    David Goldblatt
    Immunobiology Unit, University College London, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Clin Vaccine Immunol 18:1744-51. 2011

Detail Information

Publications55

  1. ncbi request reprint Natural and vaccine-induced immunity and immunologic memory to Neisseria meningitidis serogroup C in young adults
    David Goldblatt
    Immunobiology Unit, Institute of Child Health, Public Health Laboratory Service, Communicable Disease Surveillance Centre, London, United Kingdom
    J Infect Dis 185:397-400. 2002
    ....
  2. ncbi request reprint Current treatment options for chronic granulomatous disease
    David Goldblatt
    Immunology Department, Great Ormond Street Children s Hospital NHS Trust, Great Ormond Street, London, WC1N 3JH, UK
    Expert Opin Pharmacother 3:857-63. 2002
    ..New antifungal agents provide the promise of improved cure rates for invasive Aspergillus, while bone marrow transplants and gene therapy may offer the promise of complete cure...
  3. ncbi request reprint Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: a longitudinal household study
    David Goldblatt
    Immunobiology Unit, Institute of Child Health, University College London, UK
    J Infect Dis 192:387-93. 2005
    ..pneumoniae or cross-reactive antigens. No longitudinal studies of carriage of and immune responses to S. pneumoniae have been conducted using sophisticated immunological laboratory techniques...
  4. ncbi request reprint Pneumococcal vaccination in developing countries
    Orin S Levine
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Lancet 367:1880-2. 2006
  5. pmc A prospective study of urinary pneumococcal antigen detection in healthy Karen mothers with high rates of pneumococcal nasopharyngeal carriage
    Paul Turner
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    BMC Infect Dis 11:108. 2011
    ..The relationship between pneumococcal carriage and urinary antigen detection in adults from developing countries with high pneumococcal carriage prevalence has not been well established...
  6. ncbi request reprint Immunogenicity and boosting after a reduced number of doses of a pneumococcal conjugate vaccine in infants and toddlers
    David Goldblatt
    Institute of Child Health, University College London, UK
    Pediatr Infect Dis J 25:312-9. 2006
    ..The minimum number of doses of pneumococcal conjugate vaccine required for protection is not known. We studied the immunogenicity of a reduced schedule in infants and toddlers...
  7. doi request reprint Bacteria, polysaccharides, vaccines and boosting: measuring and maintaining population immunity
    David Goldblatt
    Immunobiology Unit, UCL Institute of Child Health, 30 Guilford Street, London, UK
    Arch Dis Child 93:646-7. 2008
  8. doi request reprint Immunogenicity of a reduced schedule of pneumococcal conjugate vaccine in healthy infants and correlates of protection for serotype 6B in the United Kingdom
    David Goldblatt
    Immunobiology Unit, UCL Institute of Child Health, London, United Kingdom
    Pediatr Infect Dis J 29:401-5. 2010
    ..This study was conducted to establish the immunogenicity of licensed PCV (Prevenar) at a reduced, 2 priming dose schedule (2+1) and to evaluate functional responses in the context of vaccine effectiveness...
  9. pmc Establishment of a new human pneumococcal standard reference serum, 007sp
    D Goldblatt
    University College London, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Clin Vaccine Immunol 18:1728-36. 2011
    ..The 007sp preparation has replaced 89SF as the pneumococcal reference standard. Sufficient quantity of this new preparation is available such that, with judicious use, it should be available for at least 25 years...
  10. pmc Comparison of a new multiplex binding assay versus the enzyme-linked immunosorbent assay for measurement of serotype-specific pneumococcal capsular polysaccharide IgG
    David Goldblatt
    Immunobiology Unit, University College London, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Clin Vaccine Immunol 18:1744-51. 2011
    ..We conclude that the Meso Scale Discovery (MSD) platform provides a promising new technique for the simultaneous measurement of antipneumococcal antibodies...
  11. ncbi request reprint Antibody avidity as a surrogate marker of successful priming by Haemophilus influenzae type b conjugate vaccines following infant immunization
    D Goldblatt
    Institute of Child Health, and Immunisation Division, Communicable Disease Surveillance Centre, London, United Kingdom
    J Infect Dis 177:1112-5. 1998
    ..Antibody avidity may help distinguish, in persons with low antibody titers, between those who are primed for memory and those who are not...
  12. ncbi request reprint The induction of immunologic memory after vaccination with Haemophilus influenzae type b conjugate and acellular pertussis-containing diphtheria, tetanus, and pertussis vaccine combination
    D Goldblatt
    Immunobiology Unit, Institute of Child Health, London WC1N 1EH, UK
    J Infect Dis 180:538-41. 1999
    ..Despite reduced immunogenicity, DTaP-Hib combination vaccines appear to prime for immunologic memory...
  13. ncbi request reprint Immunogenetic analysis of the immune response to pneumococcal polysaccharide
    H E Baxendale
    Immunobiology Unit, Institute of Child Health, University College London, London, GB
    Eur J Immunol 30:1214-23. 2000
    ....
  14. ncbi request reprint Safety and immunogenicity of a new Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in healthy adults
    P Richmond
    Immunobiology Unit, Institute of Child Health, 30 Guilford Street, London, UK
    Vaccine 18:641-6. 1999
    ..Conclusion: meningococcal C-tetanus toxoid conjugate vaccine is immunogenic and well tolerated in healthy adults...
  15. ncbi request reprint Ability of 3 different meningococcal C conjugate vaccines to induce immunologic memory after a single dose in UK toddlers
    P Richmond
    Immunisation Division, Communicable Disease Surveillance Centre, Public Health Laboratory Service, London, United Kingdom
    J Infect Dis 183:160-3. 2001
    ..This evidence justified the use of a single dose in a catch-up immunization program for children 1-18 years old...
  16. pmc Natural human antibodies to pneumococcus have distinctive molecular characteristics and protect against pneumococcal disease
    H E Baxendale
    Infectious Diseases and Microbiology Unit, Institute of Child Health, University College London, London, UK
    Clin Exp Immunol 151:51-60. 2008
    ..4 (+/-4.2) and selective use of IGHD6 (P < 0.001) and IGHJ6 (P < 0.01) family genes. The clones expressing IGHV1-69 and IGHV 3-21 provided significant passive protection against invasive pneumococcal disease in vivo...
  17. pmc Correlation of molecular characteristics, isotype, and in vitro functional activity of human antipneumococcal monoclonal antibodies
    H E Baxendale
    Infectious Diseases and Microbiology Unit, Institute of Child Health, University of London Medical School, 30 Guilford St, London WC1N 1EH, United Kingdom
    Infect Immun 74:1025-31. 2006
    ..5). These data suggest that the use of canonical genes in the Pnc antibody response is associated with highly functional antibodies and that most somatic mutations seen in these genes are not antigen selected...
  18. ncbi request reprint Persistence of antibody responses to Haemophilus influenzae type b polysaccharide conjugate vaccine in children with vertically acquired human immunodeficiency virus infection
    D Gibb
    Institute of Child Health, London, United Kingdom
    Pediatr Infect Dis J 15:1097-101. 1996
    ..Long term persistence of anti-Hib antibody and the need for, or timing of, a booster dose has not been adequately studied...
  19. doi request reprint Dendritic cell anergy results from endotoxemia in severe malnutrition
    Stephen Miles Hughes
    Immunobiology Unit, Centre for International Health and Development, Institute of Child Health, London, United Kingdom
    J Immunol 183:2818-26. 2009
    ..Defects in DC number and the immunosuppressive phenotype of DCs from severely malnourished children with endotoxemia provide a rational basis for the anergy found in severe malnutrition...
  20. ncbi request reprint Safety and immunogenicity of pneumococcal conjugate vaccine in combination with diphtheria, tetanus toxoid, pertussis and Haemophilus influenzae type b conjugate vaccine
    Stephen K Obaro
    Imperial College School of Medicine, London, United Kingdom
    Pediatr Infect Dis J 21:940-7. 2002
    ..Thus we have evaluated the safety and immunogenicity of a 9-valent PnCV (Wyeth Lederle Pediatrics and Vaccines) mixed with diphtheria, tetanus toxoid, cell pertussis and type b (TETRAMUNE)...
  21. pmc Human dendritic cells infected with an adenoviral vector suppress proliferation of autologous and allogeneic T cells
    Katy R Newton
    Rheumatology Unit, Institute of Child Health, UCL, London, UK
    Immunology 125:469-79. 2008
    ..Together our data suggest that infection of DCs by adenoviral vectors leads to suppression of the resulting immune response...
  22. doi request reprint CD4 counts decline despite nutritional recovery in HIV-infected Zambian children with severe malnutrition
    Stephen Miles Hughes
    Immunobiology Unit, and Centre for International Health and Development, Institute of Child Health, 30 Guilford St, London, United Kingdom, WC1N 1EH
    Pediatrics 123:e347-51. 2009
    ..The objective of this study was to establish the contribution that severe malnutrition makes to CD4 lymphopenia in HIV-infected and uninfected children and to determine the changes in CD4 count during nutritional rehabilitation...
  23. doi request reprint The early kinetics of circulating pneumococcal-specific memory B cells following pneumococcal conjugate and plain polysaccharide vaccines in the elderly
    Helen E Baxendale
    Department of Immunology, University College London Medical School, Royal Free Hospital Campus, London NW3 2PF, UK
    Vaccine 28:4763-70. 2010
    ....
  24. doi request reprint Circulating pneumococcal specific plasma and memory B cells in the elderly two years after pneumococcal conjugate versus polysaccharide vaccination
    Helen E Baxendale
    Department of Immunology, University College London Medical School, Royal Free Hospital Campus, London NW3 2PF, UK
    Vaccine 28:6915-22. 2010
    ..Polysaccharide conjugate vaccines prime for lasting memory responses in children and young adults. The potential value of these vaccines in the elderly is unclear...
  25. pmc Effects of prior polysaccharide vaccination on magnitude, duration, and quality of immune responses to and safety profile of a meningococcal serogroup C tetanus toxoid conjugate vaccination in adults
    Jo Southern
    Immunisation Department, Communicable Disease Surveillance Centre, Health Protection Agency, 61 Colindale Ave, Colindale, London, United Kingdom
    Clin Diagn Lab Immunol 11:1100-4. 2004
    ..The study shows that MCC-TT is safe and immunogenic in naive and previously MACP-vaccinated adults, though the magnitude and persistence of postvaccination SBA responses in the latter group were lower...
  26. ncbi request reprint Diminished production of anti-inflammatory mediators during neutrophil apoptosis and macrophage phagocytosis in chronic granulomatous disease (CGD)
    Joanne R Brown
    Immunobiology Unit, The Institute of Child Health, Great Ormond Street Hospital, University College London, United Kingdom
    J Leukoc Biol 73:591-9. 2003
    ....
  27. ncbi request reprint The immunogenicity of 7-valent pneumococcal conjugate vaccine versus 23-valent polysaccharide vaccine in adults aged 50-80 years
    David Goldblatt
    Institute of Child Health, University College London, UK
    Clin Infect Dis 49:1318-25. 2009
    ..Although 23-valent pneumococcal polysaccharide vaccine (PPV) is recommended for elderly persons, the potential benefits of conjugate vaccine use in this age group remain unclear...
  28. ncbi request reprint The nature of colitis in chronic granulomatous disease
    Michela G Sch├Ąppi
    Departments of Gastroenterology, dagger Immunology, and double dagger Histopathology, Institute of Child Health and Great Ormond Street Hospital, London, UK
    J Pediatr Gastroenterol Nutr 36:623-31. 2003
    ..Patients with chronic granulomatous disease (CGD) may have gastrointestinal manifestations, commonly colitis. The etiology, prevalence, and inflammatory process of CGD colitis are unclear...
  29. pmc Pneumococcal polysaccharides interact with human dendritic cells
    Ulrike Meltzer
    Immunobiology Unit, The Institute of Child Health, Great Ormond Street Hospital, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom
    Infect Immun 74:1890-5. 2006
    ..This effect was not seen using the control antigen tetanus toxoid. DC-pneumococcus interaction may affect subsequent immune responses to pneumococci, as an altered cytokine balance may have a profound effect on DC-driven T-cell priming...
  30. pmc Human constant regions influence the antibody binding characteristics of mouse-human chimeric IgG subclasses
    N McCloskey
    Institute of Child Health, London, UK
    Immunology 88:169-73. 1996
    ..The exact mechanism for this phenomenon remains obscure but such differences should be taken into account when designing or choosing antibodies for therapeutic use...
  31. pmc Cutaneous and other lupus-like symptoms in carriers of X-linked chronic granulomatous disease: incidence and autoimmune serology
    C M Cale
    Immunology Department, Great Ormond Street Hospital for Children, London, UK
    Clin Exp Immunol 148:79-84. 2007
    ..as symptoms may respond well to appropriate treatment...
  32. ncbi request reprint Lack of association between the nasopharyngeal carriage of Streptococcus pneumoniae and Staphylococcus aureus in HIV-1-infected South African children
    Lisa M McNally
    Centre for International Child Health, Institute of Child Health, University College, London, United Kingdom
    J Infect Dis 194:385-90. 2006
    ..3% vs. 36.0%; P=.11). We did not find a negative association between S. pneumoniae and S. aureus carriage in HIV-1-positive hospitalized children with severe pneumonia...
  33. ncbi request reprint Effect of age, polymicrobial disease, and maternal HIV status on treatment response and cause of severe pneumonia in South African children: a prospective descriptive study
    Lisa M McNally
    Centre for International Child Health and Development, Institute of Child Health, University College London, London WC1N 1EH, UK
    Lancet 369:1440-51. 2007
    ..We aimed to measure predictors of treatment failure and the cause of non-responsive pneumonia in children admitted to hospital with severe pneumonia in Durban, South Africa...
  34. ncbi request reprint Effect of month of vaccine administration on antibody responses in The Gambia and Pakistan
    Sophie E Moore
    MRC International Nutrition Group, Nutrition and Public Health Intervention Research Unit, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 11:1529-41. 2006
    ..To explore the relationship between calendar month of administration and antibody (Ab) response to vaccination in subjects from The Gambia and Pakistan, two countries with distinct patterns of seasonality...
  35. ncbi request reprint Risk of relapse after meningococcal C conjugate vaccine in nephrotic syndrome
    A S Abeyagunawardena
    Nephrourology Unit, Institute of Child Health, London, UK
    Lancet 362:449-50. 2003
    ..009). The relapse rate of nephrotic syndrome increased significantly after administration of MCCV. Whether to vaccinate such children needs to be carefully considered...
  36. doi request reprint Optimising the use of conjugate vaccines to prevent disease caused by Haemophilus influenzae type b, Neisseria meningitidis and Streptococcus pneumoniae
    Caroline L Trotter
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, UK
    Vaccine 26:4434-45. 2008
    ..The aim of this paper is to review the state of the current evidence on conjugate vaccines and to identify important areas for further study, in order to inform the debate regarding the best use of these vaccines...
  37. ncbi request reprint Conjugate Hib vaccines
    Mark Steinhoff
    Johns Hopkins University School of Medicine, School of Hygiene, Baltimore, MD 21205, USA
    Lancet 361:360-1. 2003
  38. ncbi request reprint Antibody persistence and immunological memory at age 4 years after meningococcal group C conjugate vaccination in children in the United kingdom
    Ray Borrow
    Public Health Laboratory Service Meningococcal Reference Unit, Withington Hospital, Manchester, United Kingdom
    J Infect Dis 186:1353-7. 2002
    ..6; 95% CI, 338.0-2568.1). This is the first demonstration of immunological memory at 4 years of age in children receiving MCC vaccine on the United Kingdom's 2/3/4-month immunization schedule...
  39. pmc Effect of vaccination with carrier protein on response to meningococcal C conjugate vaccines and value of different immunoassays as predictors of protection
    Moya Burrage
    Centre for Applied Microbiology and Research, Porton Down, Salisbury, Wiltshire, United Kingdom
    Infect Immun 70:4946-54. 2002
    ....
  40. ncbi request reprint Avidity maturation following vaccination with a meningococcal recombinant hexavalent PorA OMV vaccine in UK infants
    Emma Longworth
    Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Nell Lane, UK
    Vaccine 20:2592-6. 2002
    ..No increase in avidity was observed in the control group. Antibody avidity indices are useful laboratory markers for the priming of immunological memory following vaccination with meningococcal serogroup B OMV vaccines...
  41. ncbi request reprint Serological criteria for evaluation and licensure of new pneumococcal conjugate vaccine formulations for use in infants
    Luis Jodar
    Department of Vaccines and Biologicals, World Health Organization, CH 1211 27, Geneva, Switzerland
    Vaccine 21:3265-72. 2003
    ..More detailed recommendations for production and control of pneumococcal conjugate vaccines, including criteria for evaluation for licensure, are currently being drafted...
  42. pmc Quality of the Haemophilus influenzae type b (Hib) antibody response induced by diphtheria-tetanus-acellular pertussis/Hib combination vaccines
    Philippe A Denoel
    GlaxoSmithKline Biologicals, Rue de l Institut 89, 1330 Rixensart, Belgium
    Clin Vaccine Immunol 14:1362-9. 2007
    ..In conclusion, in vitro and in vivo data as well as postmarketing vaccine effectiveness data attest to the ability of DTPa-based/Hib combination vaccines to effectively prevent Hib-induced disease in children...
  43. pmc Reduction of antibody response to an 11-valent pneumococcal vaccine coadministered with a vaccine containing acellular pertussis components
    Ron Dagan
    Pediatric Infectious Disease Unit, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University, Beer Sheva 84101, Israel
    Infect Immun 72:5383-91. 2004
    ..With the increasing use of multiple aP-containing vaccines in infancy, novel approaches to adjuvants and carrier protein technology are likely to be required...
  44. ncbi request reprint Chronic granulomatous disease: from genetic defect to clinical presentation
    Johan Bylund
    Department of Pediatrics, B C Research Institute for Children s and Women s Health, University of British Columbia, Vancouver, Canada
    Adv Exp Med Biol 568:67-87. 2005
  45. pmc Use of opsonophagocytosis for serological evaluation of pneumococcal vaccines
    Sandra Romero-Steiner
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Vaccine Immunol 13:165-9. 2006
  46. pmc Critical differences between pneumococcal polysaccharide enzyme-linked immunosorbent assays with and without 22F inhibition at low antibody concentrations in pediatric sera
    Isabelle Henckaerts
    Research and Development, GlaxoSmithKline Biologicals, Rue de l Institut 89, 1330 Rixensart, Belgium
    Clin Vaccine Immunol 13:356-60. 2006
    ..35 mug/ml determined with the non-22F ELISA corresponded to a concentration of 0.20 mug/ml with the 22F inhibition ELISA. Pneumococcal antipolysaccharide ELISA including 22F inhibition can be recommended as a reference method...
  47. pmc Enzyme-linked immunosorbent assay for quantitation of human antibodies to pneumococcal polysaccharides
    Catherine M Wernette
    Department of Pathology and Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35249 7331, USA
    Clin Diagn Lab Immunol 10:514-9. 2003
  48. pmc Immunogenicity of, and immunologic memory to, a reduced primary schedule of meningococcal C-tetanus toxoid conjugate vaccine in infants in the United kingdom
    Ray Borrow
    PHLS Meningococcal Reference Unit, Withington Hospital, Manchester, United Kingdom
    Infect Immun 71:5549-55. 2003
    ..This study provides the first evidence that the number of doses of MCC-TT used in infant immunization schedules could be decreased...
  49. ncbi request reprint Clinical and immunologic risk factors for meningococcal C conjugate vaccine failure in the United Kingdom
    Cressida Auckland
    Immunisation Department, Centre for Infections, Health Protection Agency, Manchester Royal Infirmary, Manchester, United Kingdom
    J Infect Dis 194:1745-52. 2006
    ..The meningococcal serogroup C conjugate (MCC) vaccine was introduced into the United Kingdom with licensure based on immunogenicity data not efficacy data...
  50. pmc Avidity of the immunoglobulin G response to a Neisseria meningitidis group C polysaccharide conjugate vaccine as measured by inhibition and chaotropic enzyme-linked immunosorbent assays
    Shannon L Harris
    Wyeth Vaccines Research, Pearl River, NY 10965, USA
    Clin Vaccine Immunol 14:397-403. 2007
    ....
  51. pmc Immunogenicity of a fourth dose of Haemophilus influenzae type b (Hib) conjugate vaccine and antibody persistence in young children from the United Kingdom who were primed with acellular or whole-cell pertussis component-containing Hib combinations in inf
    Jo Southern
    Immunisation Department, Centre for Infections, Health Protection Agency, London NW9 5EQ, United Kingdom
    Clin Vaccine Immunol 14:1328-33. 2007
    ..15 microg/ml in about 90% of individuals. A booster dose of Hib vaccine given after the first year of life should provide long-lasting protection...
  52. ncbi request reprint Humoral immunity in children with biliary atresia splenic malformation syndrome
    Rachel M Taylor
    Eur J Pediatr 162:539-40. 2003
  53. pmc Multilaboratory evaluation of a viability assay for measurement of opsonophagocytic antibodies specific to the capsular polysaccharides of Streptococcus pneumoniae
    Sandra Romero-Steiner
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Diagn Lab Immunol 10:1019-24. 2003
    ..75 to 0.85]). All OPA median titers reported for quality control sera were within one dilution of the expected titer. We conclude that this OPA can be done in multiple laboratories with a high degree of interlaboratory reproducibility...
  54. ncbi request reprint Prenatal diagnosis in two families with autosomal, p47(phox)-deficient chronic granulomatous disease due to a novel point mutation in NCF1
    Martin de Boer
    Central Laboratory of the Netherlands Blood Transfusion Service CLB, and Laboratory for Experimental and Clinical Immunology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Prenat Diagn 22:235-40. 2002
    ..Prenatal diagnosis was required in two unrelated families with chronic granulomatous disease (CGD) patients who lacked expression of p47(phox) protein; thus a search for mutations in NCF1 was undertaken...
  55. ncbi request reprint Combined schedules of pneumococcal conjugate and polysaccharide vaccines: is hyporesponsiveness an issue?
    Katherine L O'Brien
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Lancet Infect Dis 7:597-606. 2007
    ..In this Review, we describe the evidence for and against this hyporesponsiveness and explore the possible mechanisms for such an occurrence...