Matthew G Gold

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection
    Matthew G Gold
    Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Biol Chem 288:17111-21. 2013
  2. pmc A frontier in the understanding of synaptic plasticity: solving the structure of the postsynaptic density
    Matthew G Gold
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    Bioessays 34:599-608. 2012
  3. pmc AKAP2 anchors PKA with aquaporin-0 to support ocular lens transparency
    Matthew G Gold
    Department of Pharmacology, Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA, USA
    EMBO Mol Med 4:15-26. 2012
  4. pmc An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria
    Christopher K Means
    Department of Pharmacology, Howard Hughes Medical Institute, University of Washington School of Medicine, 1959 Pacific Avenue NE, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 108:E1227-35. 2011
  5. pmc Local cAMP signaling in disease at a glance
    Matthew G Gold
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    J Cell Sci 126:4537-43. 2013
  6. pmc Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex
    Matthew G Gold
    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, 1959 Pacific Avenue NE, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 108:6426-31. 2011

Collaborators

Detail Information

Publications6

  1. pmc Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection
    Matthew G Gold
    Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Biol Chem 288:17111-21. 2013
    ..We propose that this structure-directed evolution strategy might be generally applicable for the investigation of other protein interaction surfaces...
  2. pmc A frontier in the understanding of synaptic plasticity: solving the structure of the postsynaptic density
    Matthew G Gold
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    Bioessays 34:599-608. 2012
    ..The reconstruction of a PSD subcomplex anchored by AKAP79 exemplifies on a small scale how integration can be achieved. With its entire molecular structure coming into focus, this is a unique opportunity to study the PSD...
  3. pmc AKAP2 anchors PKA with aquaporin-0 to support ocular lens transparency
    Matthew G Gold
    Department of Pharmacology, Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA, USA
    EMBO Mol Med 4:15-26. 2012
    ..Thus, anchored PKA modulation of AQP0 is a homeostatic mechanism that must be physically intact to preserve lens transparency...
  4. pmc An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria
    Christopher K Means
    Department of Pharmacology, Howard Hughes Medical Institute, University of Washington School of Medicine, 1959 Pacific Avenue NE, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 108:E1227-35. 2011
    ..Imaging, proteomic analysis, and subcellular fractionation experiments reveal that SKIP is enriched at the inner mitochondrial membrane where it associates with a prominent PKA substrate, the coiled-coil helix protein ChChd3...
  5. pmc Local cAMP signaling in disease at a glance
    Matthew G Gold
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    J Cell Sci 126:4537-43. 2013
    ..The latter sections illustrate the emerging role of local cAMP signaling in four disease areas: cataracts, cancer, diabetes and cardiovascular diseases. ..
  6. pmc Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex
    Matthew G Gold
    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, 1959 Pacific Avenue NE, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 108:6426-31. 2011
    ..This leads to activation of the anchored phosphatases. Our architectural model reveals how dimeric AKAP79 concentrates pockets of second messenger responsive enzyme activities at the plasma membrane...