James J Going

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint Human breast duct anatomy, the 'sick lobe' hypothesis and intraductal approaches to breast cancer
    James J Going
    Division of Cancer Sciences and Molecular Pathology, University of Glasgow, Glasgow, Scotland, UK
    Breast Cancer Res Treat 97:285-91. 2006
  2. ncbi request reprint Modified classification for adenocarcinoma of the gastro-oesophageal junction
    Christopher J Shearer
    Glasgow Royal Infirmary, University Department of Surgery, Glasgow, UK
    ANZ J Surg 77:544-9. 2007
  3. ncbi request reprint Aberrant expression of TopBP1 in breast cancer
    J J Going
    Faculty of Medicine, Division of Cancer Sciences and Molecular Pathology, Division of Pathological Sciences, Faculty of Veterinary Medicine, University of Glasgow, Glasgow, UK
    Histopathology 50:418-24. 2007
  4. ncbi request reprint Quantifying tumour-infiltrating lymphocyte subsets: a practical immuno-histochemical method
    Paula M Loughlin
    Section of Surgical Sciences and Translational Research, University of Glasgow, UK
    J Immunol Methods 321:32-40. 2007
  5. pmc Ductal-lobar organisation of human breast tissue, its relevance in disease and a research objective: vector mapping of parenchyma in complete breasts (the Astley Cooper project)
    James J Going
    Division of Cancer Sciences and Molecular Pathology, University of Glasgow, Glasgow, UK
    Breast Cancer Res 8:107. 2006
  6. ncbi request reprint Clonal origins of human breast cancer
    J J Going
    Department of Pathology, University of Glasgow, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK
    J Pathol 194:406-12. 2001
  7. ncbi request reprint Stages on the way to breast cancer
    J J Going
    Glasgow University, Department of Pathology, Western Infirmary, Glasgow G11 6NT, UK
    J Pathol 199:1-3. 2003
  8. ncbi request reprint 'Senescence-associated' beta-galactosidase activity in the upper gastrointestinal tract
    James J Going
    Department of Pathology, University of Glasgow, Scotland, UK
    J Pathol 196:394-400. 2002
  9. pmc Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki-67 in dysplastic squamous oesophageal epithelium and Barrett's mucosa
    J J Going
    Department of Pathology, Glasgow University, Glasgow Royal Infirmary, Glasgow, UK
    Gut 50:373-7. 2002
  10. ncbi request reprint Epithelial carcinogenesis: challenging monoclonality
    James J Going
    Department of Pathology, Glasgow University, Glasgow, UK
    J Pathol 200:1-3. 2003

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Human breast duct anatomy, the 'sick lobe' hypothesis and intraductal approaches to breast cancer
    James J Going
    Division of Cancer Sciences and Molecular Pathology, University of Glasgow, Glasgow, Scotland, UK
    Breast Cancer Res Treat 97:285-91. 2006
    ....
  2. ncbi request reprint Modified classification for adenocarcinoma of the gastro-oesophageal junction
    Christopher J Shearer
    Glasgow Royal Infirmary, University Department of Surgery, Glasgow, UK
    ANZ J Surg 77:544-9. 2007
    ..Cytokeratin (CK) 7 and 20 immunophenotypes differentiate Barrett's intestinal metaplasia (IM) from gastric IM. Comparing CK immunostaining with Siewert's classification may establish tumour origin and influence surgical choice...
  3. ncbi request reprint Aberrant expression of TopBP1 in breast cancer
    J J Going
    Faculty of Medicine, Division of Cancer Sciences and Molecular Pathology, Division of Pathological Sciences, Faculty of Veterinary Medicine, University of Glasgow, Glasgow, UK
    Histopathology 50:418-24. 2007
    ..The aim of this study was to determine whether TopBP1 is aberrantly expressed in breast cancer...
  4. ncbi request reprint Quantifying tumour-infiltrating lymphocyte subsets: a practical immuno-histochemical method
    Paula M Loughlin
    Section of Surgical Sciences and Translational Research, University of Glasgow, UK
    J Immunol Methods 321:32-40. 2007
    ..Efficient histological quantification of tumour-infiltrating T and B lymphocyte (TIL) subsets in archival tissues would greatly facilitate investigations of the role of TIL in human cancer biology. We sought to develop such a method...
  5. pmc Ductal-lobar organisation of human breast tissue, its relevance in disease and a research objective: vector mapping of parenchyma in complete breasts (the Astley Cooper project)
    James J Going
    Division of Cancer Sciences and Molecular Pathology, University of Glasgow, Glasgow, UK
    Breast Cancer Res 8:107. 2006
    ....
  6. ncbi request reprint Clonal origins of human breast cancer
    J J Going
    Department of Pathology, University of Glasgow, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK
    J Pathol 194:406-12. 2001
    ..Further studies using independent analytical techniques are required to test the important possibility that a significant proportion of mammary carcinomas are not monoclonal...
  7. ncbi request reprint Stages on the way to breast cancer
    J J Going
    Glasgow University, Department of Pathology, Western Infirmary, Glasgow G11 6NT, UK
    J Pathol 199:1-3. 2003
    ....
  8. ncbi request reprint 'Senescence-associated' beta-galactosidase activity in the upper gastrointestinal tract
    James J Going
    Department of Pathology, University of Glasgow, Scotland, UK
    J Pathol 196:394-400. 2002
    ..0012). Loss of SAbetaG activity is not, therefore, an early event in glandular dysplasia-neoplasia of the upper gastrointestinal tract...
  9. pmc Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki-67 in dysplastic squamous oesophageal epithelium and Barrett's mucosa
    J J Going
    Department of Pathology, Glasgow University, Glasgow Royal Infirmary, Glasgow, UK
    Gut 50:373-7. 2002
    ..Expression is dysregulated in dysplastic states but data for oesophageal squamous mucosa and Barrett's mucosa have not been published...
  10. ncbi request reprint Epithelial carcinogenesis: challenging monoclonality
    James J Going
    Department of Pathology, Glasgow University, Glasgow, UK
    J Pathol 200:1-3. 2003
    ....
  11. ncbi request reprint Escaping from Flatland: clinical and biological aspects of human mammary duct anatomy in three dimensions
    James J Going
    Department of Pathology, University of Glasgow, Glasgor Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, Scotland, UK
    J Pathol 203:538-44. 2004
    ..While population A ducts appear accessible to duct endoscopy or lavage, population B and population C ducts may be less accessible...
  12. doi request reprint Observer prediction of HER2 amplification in HercepTest 2+ breast cancers as a potential audit instrument
    James J Going
    Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
    Histopathology 59:333-5. 2011
    ..Indeterminate (2+) HER2 immunohistochemistry (IHC) is usually resolved by FISH for HER2 gene amplification. It was hypothesised that predicting HER2 amplification in IHC 2+ cases could improve audit of HER2 IHC and its interpretation...
  13. ncbi request reprint Molecular pathology and future developments
    J J Going
    Department of Pathology, University of Glasgow, Glasgow Royal Infirmary
    Eur J Cancer 35:1895-904. 1999
    ..A further challenge for the biomedical community in the 'genome era' will be to ensure that the benefits of these sophisticated technologies are enjoyed globally...
  14. pmc Zoning of mucosal phenotype, dysplasia, and telomerase activity measured by telomerase repeat assay protocol in Barrett's esophagus
    James J Going
    Department of Pathology, University of Glasgow, Glasgow, Scotland, UK
    Neoplasia 6:85-92. 2004
    ..TRAP activity merits evaluation as a candidate biomarker for increased risk of persistent dysplasia and cancer progression in Barrett's esophagus...
  15. doi request reprint Endoscopic mucosal resection for gastroesophageal cancer in a U.K. population. Long-term follow-up of a consecutive series
    Andrew B C Crumley
    University Department of Surgery, Royal Infirmary, Glasgow, G31 2ER, UK
    Surg Endosc 25:543-8. 2011
    ..We report the long-term results of a consecutive series of 93 endoscopic resections, during a 7-year period, in a U.K. population...
  16. doi request reprint The relationship between genetic profiling, clinicopathological factors and survival in patients undergoing surgery for node-negative colorectal cancer: 10-year follow-up
    Arfon G M T Powell
    Unit of Experimental Therapeutics, Institute of Cancer Science, University of Glasgow, McGregor Building, Western Infirmary Glasgow, Glasgow, G11 6NT, UK
    J Cancer Res Clin Oncol 139:2013-20. 2013
    ..This study aims to identify which clinicopathological factors and genetic profiling markers predict outcome in node-negative disease...
  17. doi request reprint Interrelationships between tumor proliferative activity, leucocyte and macrophage infiltration, systemic inflammatory response, and survival in patients selected for potentially curative resection for gastroesophageal cancer
    Andrew B C Crumley
    University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow, Scotland, UK
    Ann Surg Oncol 18:2604-12. 2011
    ..We examined the interrelationships between standard clinicopathological factors, systemic and local inflammatory responses, tumor proliferative activity, and survival...
  18. doi request reprint Comparison of visual and automated assessment of microvessel density and their impact on outcome in primary operable invasive ductal breast cancer
    Zahra M A Mohammed
    Academic Unit of Surgery, College of Medical, Veterinary and Life of Sciences, University of Glasgow, Royal Infirmary, Glasgow, G31 2ER, UK
    Hum Pathol 44:1688-95. 2013
    ..01). Although automated assessment of microvessel density (CD34(+)) is in reasonable agreement, it poorly predicts outcome in patients with operable invasive ductal breast cancer. ..
  19. pmc Loss of heterozygosity on chromosomes 11 and 17 are markers of recurrence in TCC of the bladder
    J Edwards
    University Department of Surgery, Glasgow Royal Infirmary, Glasgow, G31 2ER, UK
    Br J Cancer 85:1894-9. 2001
    ..These results suggest that loss of these regions is associated with recurrence of TCC. Further investigation is required to identify genes in these regions, which might be responsible for driving recurrence in TCC of the urinary bladder...
  20. pmc IHC for Her2 with CBE356 antibody is a more accurate predictor of Her2 gene amplification by FISH than HercepTest in breast carcinoma
    R Ainsworth
    Department of Pathology, Glasgow Royal Infirmary, Glasgow G4 0SF, UK
    J Clin Pathol 58:1086-90. 2005
    ..When considering patients for trastuzumab treatment, Her2 protein expression is measured by imunohistochemistry (IHC) and, where staining is equivocal, by fluorescence in situ hybridisation (FISH) detection of Her2 gene amplification...
  21. doi request reprint The role of the tumour inflammatory cell infiltrate in predicting recurrence and survival in patients with primary operable breast cancer
    Zahra M A Mohammed
    Academic Unit of Surgery, College of Medical, Veterinary and Life of Sciences, University of Glasgow, Royal Infirmary, Glasgow G31 2ER, United Kingdom
    Cancer Treat Rev 38:943-55. 2012
    ....
  22. doi request reprint Activation of Wnt signalling promotes development of dysplasia in Barrett's oesophagus
    Lisa H Moyes
    University Department of Surgery, Royal Infirmary, Glasgow, UK
    J Pathol 228:99-112. 2012
    ..Based on these results in human tissues and a mouse model, we conclude that abnormal activation of Wnt signalling likely plays only a minor role in initiation of Barrett's metaplasia but a more critical role in progression to dysplasia...
  23. doi request reprint Systematic four-quadrant biopsy detects Barrett's dysplasia in more patients than nonsystematic biopsy
    Jo Etienne Abela
    Department of Surgery, Glasgow Royal Infirmary, Glasgow, United Kingdom
    Am J Gastroenterol 103:850-5. 2008
    ..To compare detection of Barrett's dysplasia and adenocarcinoma by systematic versus nonsystematic surveillance biopsy protocols...
  24. ncbi request reprint Microdissection and extraction of DNA from archival tissue
    Joanne Edwards
    Division of Cancer and Molecular Pathology, University Department of Surgery, Glasgow Royal Infirmary, Scotland, UK
    Methods Mol Med 97:71-5. 2004
  25. pmc Ras p21 in breast tissue: associations with pathology and cellular localisation
    J J Going
    Department of Pathology, University Medical School, Edinburgh, UK
    Br J Cancer 65:45-50. 1992
    ..Expression in carcinomas was inversely related to oestrogen receptor content but independent of the prognosis-associated variables of size, histological type, vascular invasion or lymph node metastasis...
  26. ncbi request reprint Genetic aberrations of NAT2 and chromosome 8: their association with progression in transitional cell carcinoma of the urinary bladder
    A D Watters
    Department of Surgery, Glasgow Royal Infirmary, University of Glasgow, Glasgow G31 2ER, UK
    Urol Int 67:235-9. 2001
    ..This study evaluated NAT2 and chromosome 8 in sequential tumours from bladder cancer patients to determine if NAT2 alterations increase the risk of progression...
  27. ncbi request reprint Evaluating HER2 amplification and overexpression in breast cancer
    J M Bartlett
    University Department of Surgery, Glasgow Royal Infirmary, Glasgow, G31 2ER, UK
    J Pathol 195:422-8. 2001
    ..83% with CB11. Of 174 cases negative by FISH, 96% were negative in the Herceptest and 68% with CB11. In conclusion, FISH is the most accurate, reproducible, and precise predictor of HER2 overexpression in routine diagnostic laboratories...
  28. ncbi request reprint Chromosomal aberrations in transitional cell carcinoma that are predictive of disease outcome are independent of polyploidy
    J M Bartlett
    University Department of Surgery, Glasgow Royal Infirmary, Scotland, UK
    BJU Int 84:775-9. 1999
    ..g. that increased copy numbers for 7 and 17 reflect tumour polyploidy...
  29. ncbi request reprint Comparative genomic hybridization analysis of primary colorectal carcinomas and their synchronous metastases
    F Al-Mulla
    The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Bearsden, Glasgow, United Kingdom
    Genes Chromosomes Cancer 24:306-14. 1999
    ....
  30. doi request reprint The role of lymphatic and blood vessel invasion in predicting survival and methods of detection in patients with primary operable breast cancer
    Fadia J A Gujam
    Academic Unit of Surgery, College of Medical, Veterinary and Life of Sciences, University of Glasgow, Royal Infirmary, Glasgow, UK Electronic address
    Crit Rev Oncol Hematol 89:231-41. 2014
    ..Further work is required using reliable specific staining to establish the routine use of LVI and BVI in the prediction of outcome in patients with primary operable breast cancer. ..
  31. doi request reprint Central obesity in asymptomatic volunteers is associated with increased intrasphincteric acid reflux and lengthening of the cardiac mucosa
    Elaine V Robertson
    Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
    Gastroenterology 145:730-9. 2013
    ..We studied the gastroesophageal junction in asymptomatic volunteers with normal and large waist circumferences (WCs) to determine if central obesity is associated with abnormalities that might predispose individuals to adenocarcinoma...
  32. doi request reprint Breast cancer outcomes by steroid hormone receptor status assessed visually and by computer image analysis
    Zahra M A Mohammed
    Academic Unit of Surgery, College of Medical, Veterinary and Life Sciences, University of Glasgow, Royal Infirmary, Glasgow, UK
    Histopathology 61:283-92. 2012
    ..To compare the assessment of steroid hormone receptor immunohistochemistry by eye and by computer-aided image analysis, and to examine their relationships with survival in breast cancer...
  33. ncbi request reprint E-cadherin mutation-associated diffuse gastric adenocarcinoma: penetrance and non-penetrance
    Daniel R Gaya
    Department of Gastroenterology, Glasgow Royal Infirmary, UK
    Eur J Gastroenterol Hepatol 17:1425-8. 2005
    ..We also speculate on how these patients' undiagnosed genetic haemochromatosis may have influenced the pathology encountered...
  34. ncbi request reprint What the clinician needs from the pathologist: evidence-based reporting in breast cancer
    J J Going
    Department of Pathology, University of Glasgow, Scotland, UK
    Eur J Cancer 37:S5-17. 2001
    ..Much of the microarray data being put into data-bases has no quality control, and meta-analysis of this data will produce even more conflict than the clinical trials. This can be avoided, as the ability to standardise is available...
  35. pmc Metastatic recurrence of early-stage colorectal cancer is linked to loss of heterozygosity on chromosomes 4 and 14q
    F Al-Mulla
    Department of Pathology, Faculty of Medicine, Molecular Pathology Unit, Kuwait University, Kuwait
    J Clin Pathol 59:624-30. 2006
    ..To investigate the prognostic value for loss of heterozygosity (LOH) of chromosomes 4 and 14q in early-stage colorectal cancer (CRC)...
  36. pmc Is chromosome 9 loss a marker of disease recurrence in transitional cell carcinoma of the urinary bladder?
    J M Bartlett
    Glasgow University Department of Surgery, Glasgow Royal Infirmary, UK
    Br J Cancer 77:2193-8. 1998
    ..It is proposed that loss of chromosome 9 from primary TCC of the urinary bladder identified patients at high risk of recurrence and possible progression...
  37. doi request reprint Specific histological abnormalities are more likely in biopsies of endoscopically normal large bowel after the age of 60 years
    Orla H O'Mahony
    Department of Pathology, Southern General Hospital, Glasgow, UK
    Histopathology 61:1209-13. 2012
    ..The aim of this study was to determine diagnostic yield from mucosal biopsies in patients with normal colonoscopy or sigmoidoscopy, and whether or not diarrhoea is predictive of abnormal histology...
  38. doi request reprint Subgross breast pathology in the twenty-first century
    William A Smith
    Department of Pathology, Glasgow Royal Infirmary, Castle Street, Glasgow G4 OSF, UK
    Virchows Arch 460:489-95. 2012
    ..The hope that the water-miscible thioalcohol, thiodiglycol, might accelerate tissue clearing was not realised. There is scope for further streamlining to make subgross techniques more acceptable in combined research/diagnostic settings...
  39. ncbi request reprint Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer
    Caroline J Witton
    University Department of Surgery, Glasgow Royal Infirmary, Glasgow G31 2ER, UK
    J Pathol 200:290-7. 2003
    ..The development of HER-targeted agents (eg Herceptin, Iressa), and agents targeted at the downstream signalling pathways, therefore provides new possibilities in the treatment of breast cancer...
  40. ncbi request reprint Chromosome 17 aneusomy is associated with poor prognostic factors in invasive breast carcinoma
    A D Watters
    University Department of Surgery, Glasgow Royal Infirmary, Glasgow, Scotland, UK
    Breast Cancer Res Treat 77:109-14. 2003
    ....
  41. pmc A role for BRCA1 in sporadic breast cancer
    J A Fraser
    University Department of Surgery, Glasgow Royal Infirmary, Glasgow, UK
    Br J Cancer 88:1263-70. 2003
    ..BRCA1 protein appears to have a significant role in both sporadic and hereditary breast cancers...
  42. ncbi request reprint Extraction of DNA from microdissected archival tissues
    James J Going
    Department of Pathology, Glasgow Royal Infirmary, UK
    Methods Mol Biol 226:35-42. 2003
  43. ncbi request reprint Genetic profiling of stage I and II colorectal cancer may predict metastatic relapse
    Fahd Al-Mulla
    Molecular Pathology Laboratory, Department of Pathology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    Mod Pathol 19:648-58. 2006
    ..Accordingly, the molecular genetic features of primary tumours should be considered in the mainstream management of patients with this specific stage of the disease...
  44. doi request reprint Positive mobilization margins alone do not influence survival following pancreatico-duodenectomy for pancreatic ductal adenocarcinoma
    Nigel B Jamieson
    West of Scotland Pancreatic Unit, Department of Pancreatico Biliary Surgery, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, United Kingdom
    Ann Surg 251:1003-10. 2010
    ....
  45. ncbi request reprint Antigen-driven clonal proliferation, somatic hypermutation, and selection of B lymphocytes infiltrating human ductal breast carcinomas
    Sazini Nzula
    Division of Immunology, Infection and Inflammation, University of Glasgow, Western Infirmary, Glasgow, G11 6NT, Scotland, United Kingdom
    Cancer Res 63:3275-80. 2003
    ....
  46. pmc P-glycoprotein expression in primary breast cancer detected by immunocytochemistry with two monoclonal antibodies
    G C Wishart
    CRC Department of Medical Oncology, University of Glasgow, UK
    Br J Cancer 62:758-61. 1990
    ..Our results suggest that significant levels of P-glycoprotein expression may be present in breast cancer before exposure to drugs associated with multidrug resistance...
  47. ncbi request reprint Expression of telomerase RNA in oesophageal and oral cancer
    M G Downey
    University Departments of Medical Oncology, Pathology and Surgery, University of Glasgow, UK
    J Oral Pathol Med 30:577-81. 2001
    ..Generally concordant hTR status between biopsy and resection suggest that biopsy may have a role in selecting candidates for telomerase inhibition therapy...
  48. ncbi request reprint Radioimmunohistochemistry of epidermal growth factor receptor in breast cancer
    Kevin W Robertson
    Lister Department of Surgery, Glasgow Royal Infirmary, Castle Street, Glasgow G31 2ER, Scotland, UK
    Arch Pathol Lab Med 126:177-81. 2002
    ..Conflicting reports of epidermal growth factor receptor (EGFR) expression in breast cancer and inconstant relationships with established prognostic indicators and outcomes suggest difficulties with EGFR measurement...
  49. ncbi request reprint Human squamous cell carcinomas lose a mortality gene from chromosome 6q14.3 to q15
    S A Fitzsimmons
    Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Glasgow, UK
    Oncogene 22:1737-46. 2003
    ..These results suggest the existence of a suppressor of SCC immortality and tumour development at chromosome 6q14.3-q15, which is important to a subset of human SCCs...
  50. ncbi request reprint Scoring nuclear pleomorphism in breast cancer
    B Dunne
    Department of Pathology, Glasgow University and North Glasgow University Hospitals NHS Trust, Glasgow, UK
    Histopathology 39:259-65. 2001
    ..Specialists tend to allocate higher pleomorphism scores than non-specialists...
  51. ncbi request reprint Androgen receptor gene methylation and exon one CAG repeat length in ovarian cancer: differences from breast cancer
    Samar Kassim
    Oncology Diagnostic Unit, Medical Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    IUBMB Life 56:417-26. 2004
    ..0001), and women homozygous for the AR CAG repeat were over-represented in the ovarian cancer patients but not in the breast cancer series. These findings reinforce recent suggestions that AR may have a role in ovarian carcinogenesis...
  52. ncbi request reprint Progression to detrusor-muscle invasion in bladder carcinoma is associated with polysomy of chromosomes 1 and 8 in recurrent pTa/pT1 tumours
    Amanda D Watters
    University Department of Surgery, Level II Queen Elizabeth Building, Glasgow Royal Infirmary, G31 2ER, Glasgow, UK
    Eur J Cancer 38:1593-9. 2002
    ..009). Investigation of sequential tumours in patients with recurrent and progressive TCC showed that polysomy of chromosomes 1 and 8 were linked to subsequent detrusor muscle invasion, but not recurrence per se...
  53. ncbi request reprint Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients
    Fahd Al-Mulla
    Kuwait University, Faculty of Medicine, Safat, Kuwait
    J Clin Oncol 24:5672-9. 2006
    ..We examined whether RKIP expression in primary colorectal cancers (CRCs) correlates with the risk of metastasis and overall survival...
  54. ncbi request reprint Identification of loci associated with putative recurrence genes in transitional cell carcinoma of the urinary bladder
    Joanne Edwards
    University Department of Surgery, Glasgow Royal Infirmary, Glasgow, G31 2ER, UK
    J Pathol 196:380-5. 2002
    ..Loss of all informative markers, including those residing in the TSC1 region, spanning chromosome 9 was also linked to recurrence...