K M Godfrey

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi request reprint Fetal nutrition and adult disease
    K M Godfrey
    MRC Environmental Epidemiology Unit University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Am J Clin Nutr 71:1344S-52S. 2000
  2. pmc Correction of unexpected distributions of P values from analysis of whole genome arrays by rectifying violation of statistical assumptions
    Sheila J Barton
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK
    BMC Genomics 14:161. 2013
  3. pmc Validation of a maternal questionnaire on correlates of physical activity in preschool children
    Alison M McMinn
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0QQ, UK
    Int J Behav Nutr Phys Act 6:81. 2009
  4. pmc Fetal size in the second trimester is associated with the duration of pregnancy, small fetuses having longer pregnancies
    Synnøve L Johnsen
    Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen, Norway
    BMC Pregnancy Childbirth 8:25. 2008
  5. pmc Epigenetic gene promoter methylation at birth is associated with child's later adiposity
    Keith M Godfrey
    Institute of Developmental Sciences, University of Southampton, Southampton, UK
    Diabetes 60:1528-34. 2011
  6. pmc The long-term effects of prenatal development on growth and metabolism
    Keith M Godfrey
    Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom
    Semin Reprod Med 29:257-65. 2011
  7. ncbi request reprint Maternal regulation of fetal development and health in adult life
    K M Godfrey
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Eur J Obstet Gynecol Reprod Biol 78:141-50. 1998
  8. ncbi request reprint The role of the placenta in fetal programming-a review
    Keith M Godfrey
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Placenta 23:S20-7. 2002
  9. ncbi request reprint The 'gold standard' for optimal fetal growth and development
    K M Godfrey
    MRC Environmental Epidemiology Unit University of Southampton, Southampton General Hospital, UK
    J Pediatr Endocrinol Metab 14:1507-13. 2001
  10. ncbi request reprint Neutral amino acid uptake by the microvillous plasma membrane of the human placenta is inversely related to fetal size at birth in normal pregnancy
    K M Godfrey
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, United Kingdom
    J Clin Endocrinol Metab 83:3320-6. 1998

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Fetal nutrition and adult disease
    K M Godfrey
    MRC Environmental Epidemiology Unit University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Am J Clin Nutr 71:1344S-52S. 2000
    ....
  2. pmc Correction of unexpected distributions of P values from analysis of whole genome arrays by rectifying violation of statistical assumptions
    Sheila J Barton
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK
    BMC Genomics 14:161. 2013
    ....
  3. pmc Validation of a maternal questionnaire on correlates of physical activity in preschool children
    Alison M McMinn
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0QQ, UK
    Int J Behav Nutr Phys Act 6:81. 2009
    ..With minor revision, this could be a useful tool for future research in this area. This, in turn, will aid the development of interventions to promote physical activity in this age group...
  4. pmc Fetal size in the second trimester is associated with the duration of pregnancy, small fetuses having longer pregnancies
    Synnøve L Johnsen
    Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen, Norway
    BMC Pregnancy Childbirth 8:25. 2008
    ..Here we test the hypothesis that in low-risk pregnancies fetal growth (expressed by fetal size in the second trimester) is itself a determinant for pregnancy duration with the slower growing fetuses having a longer pregnancy...
  5. pmc Epigenetic gene promoter methylation at birth is associated with child's later adiposity
    Keith M Godfrey
    Institute of Developmental Sciences, University of Southampton, Southampton, UK
    Diabetes 60:1528-34. 2011
    ..In animal models, maternal diet alters offspring body composition, accompanied by epigenetic changes in metabolic control genes. Little is known about whether such processes operate in humans...
  6. pmc The long-term effects of prenatal development on growth and metabolism
    Keith M Godfrey
    Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom
    Semin Reprod Med 29:257-65. 2011
    ..This mismatch may arise through unbalanced diet or body composition of the mother or a change in lifestyle factors between generations. These insights offer new possibilities for the early diagnosis and prevention of chronic disease...
  7. ncbi request reprint Maternal regulation of fetal development and health in adult life
    K M Godfrey
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Eur J Obstet Gynecol Reprod Biol 78:141-50. 1998
    ..Understanding the maternal regulation of human fetal development could lead to public health measures that improve the adult health of future generations...
  8. ncbi request reprint The role of the placenta in fetal programming-a review
    Keith M Godfrey
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Placenta 23:S20-7. 2002
    ..Future interventions to improve placental function are likely to have lifelong health benefits for the offspring...
  9. ncbi request reprint The 'gold standard' for optimal fetal growth and development
    K M Godfrey
    MRC Environmental Epidemiology Unit University of Southampton, Southampton General Hospital, UK
    J Pediatr Endocrinol Metab 14:1507-13. 2001
    ..This acknowledges the importance of developmental adaptations to alterations in the nutrient and hormonal milieu in utero and could have a major impact on human health in the century to come...
  10. ncbi request reprint Neutral amino acid uptake by the microvillous plasma membrane of the human placenta is inversely related to fetal size at birth in normal pregnancy
    K M Godfrey
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, United Kingdom
    J Clin Endocrinol Metab 83:3320-6. 1998
    ..0005); this could reflect important compositional changes in the microvillous plasma membrane, leading in vivo to increased back-diffusion of amino acids out of the syncytiotrophoblast...
  11. ncbi request reprint Fetal programming and adult health
    K M Godfrey
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Public Health Nutr 4:611-24. 2001
    ..Although the influences that impair fetal development and programme adult cardiovascular disease remain to be defined, there are strong pointers to the importance of maternal body composition and dietary balance during pregnancy...
  12. pmc Parental determinants of neonatal body composition
    N C Harvey
    MRC Epidemiology Resource Centre, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Clin Endocrinol Metab 92:523-6. 2007
    ..We used data from the Southampton Women's Survey to investigate parental influences on neonatal body composition ascertained by dual x-ray absorptiometry...
  13. pmc Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass
    R M Lewis
    Institute of Developmental Sciences, University of Southampton and Southampton University Hospitals NHS Trust, UK
    Bone 50:337-42. 2012
    ..The results suggest that placental PHLDA2 may provide a biomarker for suboptimal skeletal growth in pregnancies uncomplicated by overt fetal growth restriction...
  14. ncbi request reprint Placental calcium transporter (PMCA3) gene expression predicts intrauterine bone mineral accrual
    R Martin
    Centre for the Developmental Origins of Health and Disease, University of Southampton, Southampton, UK
    Bone 40:1203-8. 2007
    ..This association may explain, in part, the mechanism whereby a mother's 25(OH)-vitamin D stores influence her offspring's bone mass...
  15. doi request reprint Paternal skeletal size predicts intrauterine bone mineral accrual
    N C Harvey
    Medical Research Council Epidemiology Resource Centre, University of Southampton, and Southampton General Hospital, Southampton, United Kingdom
    J Clin Endocrinol Metab 93:1676-81. 2008
    ..However, the paternal determinants of neonatal bone mass are not known. In this study we explored the relationship between a father's bone mass and that of his offspring...
  16. pmc Placental size at 19 weeks predicts offspring bone mass at birth: findings from the Southampton Women's Survey
    C R Holroyd
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Placenta 33:623-9. 2012
    ..In this study we investigate the relationships between placental size and neonatal bone mass and body composition, in a population-based cohort...
  17. pmc Maternal plasma polyunsaturated fatty acid status in late pregnancy is associated with offspring body composition in childhood
    R J Moon
    Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD, United Kingdom
    J Clin Endocrinol Metab 98:299-307. 2013
    ..Maternal diet during pregnancy has been linked to offspring adiposity, but it is unclear whether maternal polyunsaturated fatty acid (PUFA) status during pregnancy affects offspring body composition...
  18. pmc Increased fat mass is associated with increased bone size but reduced volumetric density in pre pubertal children
    Z A Cole
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Bone 50:562-7. 2012
    ..003; β=-7.7 mg/mm(3) per sd, p=0.02 respectively). These results suggest that fat mass is negatively associated with volumetric bone density at 6 years old, independent of lean mass, despite positive associations with bone size...
  19. doi request reprint Maternal muscle mass may influence system A activity in human placenta
    R M Lewis
    Institute of Developmental Sciences, School of Medicine, University of Southampton, UK
    Placenta 31:418-22. 2010
    ..This alteration may affect fetal development, altering fetal body composition, with long-term consequences...
  20. ncbi request reprint Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study
    M K Javaid
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
    Lancet 367:36-43. 2006
    ..We investigated the effect of maternal vitamin D status during pregnancy on childhood skeletal growth...
  21. pmc Facilitated transporters mediate net efflux of amino acids to the fetus across the basal membrane of the placental syncytiotrophoblast
    J K Cleal
    Institute of Developmental Sciences, University of Southampton, Mail point 887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    J Physiol 589:987-97. 2011
    ..Consistent with a role in placental amino acid transfer capacity and fetal growth TAT1 and LAT3 mRNA expression showed positive associations with infant size at birth...
  22. ncbi request reprint Fetal liver-sparing cardiovascular adaptations linked to mother's slimness and diet
    Guttorm Haugen
    Division of Developmental Origins of Health and Disease, University of Southampton, Southampton, UK
    Circ Res 96:12-4. 2005
    ..Consequences of such "liver-sparing" may underlie the increased cardiovascular risk of people whose mothers were slimmer and had lower body fat stores in pregnancy...
  23. pmc Maternal vitamin D status during pregnancy and child outcomes
    C R Gale
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
    Eur J Clin Nutr 62:68-77. 2008
    ..To investigate whether exposure to high maternal concentrations of 25(OH)-vitamin D in pregnancy poses any risk to the child...
  24. ncbi request reprint Umbilical cord leptin predicts neonatal bone mass
    M K Javaid
    MRC Epidemiology Resource Centre, University of Southampton, Soumampton General Hospital, Southampton, SO16 6YD, UK
    Calcif Tissue Int 76:341-7. 2005
    ..In addition, among previously documented maternal determinants of neonatal bone mass in healthy pregnancies, maternal fat stores may mediate their effect on fetal bone accrual through variation in fetal leptin concentrations...
  25. pmc Physical activity, calcium intake and childhood bone mineral: a population-based cross-sectional study
    N C Harvey
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Osteoporos Int 23:121-30. 2012
    ..Relationships between physical activity and bone indices were stronger when calcium intake was above compared with below median (966 mg/day)...
  26. ncbi request reprint Maternal and seasonal predictors of change in calcaneal quantitative ultrasound during pregnancy
    M K Javaid
    Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Clin Endocrinol Metab 90:5182-7. 2005
    ..However, the environmental determinants of maternal bone resorption during pregnancy in healthy adult mothers have not been previously described...
  27. doi request reprint Comparison of L-serine uptake by human placental microvillous membrane vesicles and placental villous fragments
    A P Brand
    Institute of Developmental Sciences, University of Southampton, School of Medicine, UK
    Placenta 31:456-9. 2010
    ..This study suggests that uptake of L-serine into MVM vesicles and villous fragments via Systems A and L is comparable, but that this is not true for all components of L-serine uptake...
  28. ncbi request reprint High-meat, low-carbohydrate diet in pregnancy: relation to adult blood pressure in the offspring
    A W Shiell
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, United Kingdom
    Hypertension 38:1282-8. 2001
    ..These associations may reflect the metabolic stress imposed on the mother by an unbalanced diet in which high intakes of essential amino acids are not accompanied by the nutrients required to utilize them...
  29. pmc Size at birth and its relation to muscle strength in young adult women
    H M Inskip
    MRC Epidemiology Resource Centre, Southampton General Hospital, University of Southampton, Southampton, UK
    J Intern Med 262:368-74. 2007
    ..To assess the relationship between development in utero, assessed by birth weight, and muscle strength in young adult women as assessed by grip strength...
  30. ncbi request reprint Critical periods of brain growth and cognitive function in children
    Catharine R Gale
    MRC Environmental Epidemiology Unit University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Brain 127:321-9. 2004
    ..These results suggest that brain growth during infancy and early childhood is more important than growth during foetal life in determining cognitive function...
  31. ncbi request reprint Developmental mismatch: consequences for later cardiorespiratory health
    K C Pike
    Child Health, University of Southampton, Southampton, UK
    BJOG 115:149-57. 2008
    ....
  32. ncbi request reprint Maternal consumption of a high-meat, low-carbohydrate diet in late pregnancy: relation to adult cortisol concentrations in the offspring
    Kirsten Herrick
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Clin Endocrinol Metab 88:3554-60. 2003
    ....
  33. doi request reprint Maternal dietary patterns during pregnancy and childhood bone mass: a longitudinal study
    Zoe A Cole
    The MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, Untied Kingdom
    J Bone Miner Res 24:663-8. 2009
    ..We conclude that dietary patterns consistent with current advice for healthy eating during pregnancy are associated with greater bone size and BMD in the offspring at 9 yr of age...
  34. ncbi request reprint Umbilical venous IGF-1 concentration, neonatal bone mass, and body composition
    M K Javaid
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    J Bone Miner Res 19:56-63. 2004
    ..However IGF-1 did not explain the relationships of maternal smoking, fat mass, and physical activity with neonatal bone mass. The study supports a direct role for circulating IGF-1 in growth of the fetal skeleton...
  35. ncbi request reprint L-serine uptake by human placental microvillous membrane vesicles
    R M Lewis
    Centre for Developmental Origins of Health and Disease, University of Southampton, Level F MP887, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK
    Placenta 28:445-52. 2007
    ..Further studies are now required to define the fate of L-serine taken up by the placenta and its importance for the fetus...
  36. pmc The relationship between infant lung function and the risk of wheeze in the preschool years
    K C Pike
    Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton, UK
    Pediatr Pulmonol 46:75-82. 2011
    ....
  37. doi request reprint Feeding practices in pregnancy and infancy: relationship with the development of overweight and obesity in childhood
    S M Robinson
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
    Int J Obes (Lond) 32:S4-10. 2008
    ..Further research is needed to gain insight into the evolution of dietary habits in childhood and to determine how these practices influence obesity risk...
  38. pmc Lower maternal folate status in early pregnancy is associated with childhood hyperactivity and peer problems in offspring
    Wolff Schlotz
    MRC Epidemiology Resource Centre, University of Southampton, Southampton SO17 1BJ, UK
    J Child Psychol Psychiatry 51:594-602. 2010
    ..We examined for associations of maternal folate status and dietary intake during pregnancy with brain growth and childhood behavioural difficulties in the offspring...
  39. doi request reprint What do babies eat? Evaluation of a food frequency questionnaire to assess the diets of infants aged 12 months
    Lynne D Marriott
    MRC Epidemiology Resource Centre, University of Southampton, Southampton SO16 6YD, UK
    Public Health Nutr 12:967-72. 2009
    ..To evaluate the relative validity of an FFQ for assessing nutrient intakes in 12-month-old infants...
  40. doi request reprint Cut-off points for anthropometric indices of adiposity: differential classification in a large population of young women
    Sarah L Duggleby
    Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Br J Nutr 101:424-30. 2009
    ..As each index captures different aspects of size in terms of adiposity, there is the need to determine how the three indices relate to function and how they can be of use in defining risk of ill health in women...
  41. ncbi request reprint The ratio of second to fourth digit lengths: a marker of impaired fetal growth?
    G Ronalds
    MRC Environmental Epidemiology Unit, Southampton General Hospital, Tremona Road, SO16 6YD, Southampton, UK
    Early Hum Dev 68:21-6. 2002
    ..Recent studies have suggested that the ratio of the length of the second finger relative to the length of the fourth finger (2D:4D ratio) is determined during fetal life and may be such a marker...
  42. pmc Do women change their health behaviours in pregnancy? Findings from the Southampton Women's Survey
    Sarah R Crozier
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Paediatr Perinat Epidemiol 23:446-53. 2009
    ..Although there is encouraging evidence of changed health behaviours in pregnancy, young women and those with few educational qualifications may particularly benefit from targeted health initiatives...
  43. pmc Women's dietary patterns change little from before to during pregnancy
    Sarah R Crozier
    Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    J Nutr 139:1956-63. 2009
    ..Using applied scores, there was a very small mean decrease in prudent diet score in pregnancy and a very small mean increase in high-energy diet score in late pregnancy, indicating little overall change in dietary patterns in pregnancy...
  44. doi request reprint Influences on the quality of young children's diets: the importance of maternal food choices
    Catherine M Fisk
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Br J Nutr 105:287-96. 2011
    ..Our data provide strong evidence of shared family patterns of diet and suggest that interventions to improve the quality of young women's diets could be effective in improving the quality of their children's diets...
  45. doi request reprint Breastfeeding, the use of docosahexaenoic acid-fortified formulas in infancy and neuropsychological function in childhood
    Catharine R Gale
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Arch Dis Child 95:174-9. 2010
    ..To investigate the relation between breastfeeding, use of docosahexaenoic acid (DHA)-fortified formula and neuropsychological function in children...
  46. doi request reprint Breastfeeding and reported morbidity during infancy: findings from the Southampton Women's Survey
    Catherine M Fisk
    MRC Epidemiology Resource Centre, University of Southampton, Southampton SO16 6YD, UK
    Matern Child Nutr 7:61-70. 2011
    ..The graded inverse associations with breastfeeding duration suggest that current efforts to promote breastfeeding and increase duration will have important effects in reducing morbidity in infancy...
  47. doi request reprint Maternal protein restriction with or without folic acid supplementation during pregnancy alters the hepatic transcriptome in adult male rats
    Karen A Lillycrop
    Development and Cell Biology, University of Southampton, Bassett Crescent East, Southampton, UK
    Br J Nutr 103:1711-9. 2010
    ..The present findings show that the pattern of induced changes in the adult liver transcriptome were dependent on maternal protein and folic acid intakes during pregnancy...
  48. pmc Different indices of fetal growth predict bone size and volumetric density at 4 years of age
    Nicholas C Harvey
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    J Bone Miner Res 25:920-7. 2010
    ..These results suggest a discordance between influences on skeletal size and volumetric density...
  49. doi request reprint Variations in infant feeding practice are associated with body composition in childhood: a prospective cohort study
    Sian M Robinson
    Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    J Clin Endocrinol Metab 94:2799-805. 2009
    ..Most studies of infant diet and later body composition focus on milk feeding; few consider the influence of variations in the weaning diet...
  50. ncbi request reprint Is birth weight associated with risk of depressive symptoms in young women? Evidence from the Southampton Women's Survey
    Hazel M Inskip
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, United Kingdom
    Am J Epidemiol 167:164-8. 2008
    ..However, data from this study do not support a major developmental contribution to the etiology of depression in women...
  51. pmc Maternal size in pregnancy and body composition in children
    Catharine R Gale
    Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton SO16 6YD, United Kingdom
    J Clin Endocrinol Metab 92:3904-11. 2007
    ..Evidence suggests that babies' fat mass at birth is greater if their mothers were themselves fatter during pregnancy, but it is unclear whether this association persists into childhood...
  52. ncbi request reprint Fetal growth and the adrenocortical response to psychological stress
    Alexander Jones
    Medical Research Council, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom
    J Clin Endocrinol Metab 91:1868-71. 2006
    ..The extent to which such prenatal hypothalamic-pituitary-adrenal axis adaptations occur in humans is unknown...
  53. ncbi request reprint Cohort profile: The Southampton Women's Survey
    Hazel M Inskip
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Int J Epidemiol 35:42-8. 2006
  54. ncbi request reprint Size at birth and motor activity during stress in children aged 7 to 9 years
    Wolff Schlotz
    Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    Pediatrics 120:e1237-44. 2007
    ..Therefore, we investigated associations between size at birth and motor activity during psychosocial stress...
  55. pmc Dietary patterns in pregnant women: a comparison of food-frequency questionnaires and 4 d prospective diaries
    Sarah R Crozier
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Br J Nutr 99:869-75. 2008
    ..The first two dietary patterns identified in this cohort of pregnant women appear to be defined similarly by both FFQ and diary data, suggesting that FFQ data provide useful information on dietary patterns...
  56. ncbi request reprint Low serine hydroxymethyltransferase activity in the human placenta has important implications for fetal glycine supply
    Rohan M Lewis
    Centre for the Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital, SO16 5YA Southampton, United Kingdom
    J Clin Endocrinol Metab 90:1594-8. 2005
    ..The low activity of SHMT in the human and rat placenta suggests that, unlike in the sheep, placental conversion of serine to glycine is not a major source of fetal glycine in these species...
  57. doi request reprint Commentary: Maternal constraint is a pre-eminent regulator of fetal growth
    Mark A Hanson
    Institute of Developmental Sciences, Southampton General Hospital Mailpoint 887, Tremona Road, Southampton SO16 6YD, UK
    Int J Epidemiol 37:252-4. 2008
  58. doi request reprint Oily fish intake during pregnancy--association with lower hyperactivity but not with higher full-scale IQ in offspring
    Catharine R Gale
    MRC Epidemiology Resource Centre University of Southampton, Southampton General Hospital, UK
    J Child Psychol Psychiatry 49:1061-8. 2008
    ..As oily fish is a major dietary source of omega-3 fatty acids, it is possible that low intake of fish during pregnancy may have adverse effects on the developing fetal brain...
  59. pmc Sex-specific programming of cardiovascular physiology in children
    Alexander Jones
    MRC Epidemiology Resource Centre, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Eur Heart J 29:2164-70. 2008
    ..Therefore, we have assessed the relationship between birth weight and cardiovascular physiology in children...
  60. ncbi request reprint Effortful control mediates associations of fetal growth with hyperactivity and behavioural problems in 7- to 9-year-old children
    Wolff Schlotz
    School of Psychology, University ofSouthampton, Southampton SO171BJ, United Kingdom
    J Child Psychol Psychiatry 49:1228-36. 2008
    ..Therefore, we tested for associations of fetal growth with behavioural problems in children and tested if temperament mediated such effects...
  61. pmc Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and
    Karen A Lillycrop
    Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 97:1064-73. 2007
    ..These findings suggest that induction in the offspring of altered epigenetic regulation of the hepatic GR1(10) promoter, and hence metabolic phenotype, may be due to reduced Dnmt1 expression...
  62. pmc Women's compliance with nutrition and lifestyle recommendations before pregnancy: general population cohort study
    Hazel M Inskip
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD
    BMJ 338:b481. 2009
    ..To examine the extent to which women planning a pregnancy comply with recommendations for nutrition and lifestyle...
  63. pmc Dietary patterns in infancy and cognitive and neuropsychological function in childhood
    Catharine R Gale
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    J Child Psychol Psychiatry 50:816-23. 2009
    ..Although many studies have examined the relation between type of milk received in infancy and subsequent cognition, there has been no investigation of the possible effect of variations in the weaning diet...
  64. ncbi request reprint Maternal diet during pregnancy and carotid intima-media thickness in children
    Catharine R Gale
    MRC Epidemiology Resource Centre, University of Southampton, UK
    Arterioscler Thromb Vasc Biol 26:1877-82. 2006
    ..In animal models, a restricted or unbalanced maternal diet during gestation can influence susceptibility to atherosclerosis, but the relation in humans between maternal diet during pregnancy and atherogenesis is unknown...
  65. pmc Weight gain in pregnancy and childhood body composition: findings from the Southampton Women's Survey
    Sarah R Crozier
    MRC Epidemiology Resource Centre, University of Southampton, United Kingdom
    Am J Clin Nutr 91:1745-51. 2010
    ..Intrauterine life may be a critical period for the programming of later obesity, but there is conflicting evidence about whether pregnancy weight gain is an important determinant of offspring adiposity...
  66. doi request reprint Breast-feeding and adherence to infant feeding guidelines do not influence bone mass at age 4 years
    Nicholas C Harvey
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Br J Nutr 102:915-20. 2009
    ..We observed wide variations in current infant feeding practice, but these variations were not associated with differences in childhood bone mass at age 4 years...
  67. ncbi request reprint Contribution of the umbilical cord and membranes to untrimmed placental weight
    S D Leary
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Placenta 24:276-8. 2003
    ..However, the mode of delivery had a significant effect on this difference; medians for vaginal and Caesarean section deliveries were 19 per cent and 14 per cent respectively...
  68. ncbi request reprint What do babies eat? Evaluation of a food frequency questionnaire to assess the diets of infants aged 6 months
    L D Marriott
    MRC Epidemiology Resource Centre, University of Southampton, Southampton SO16 6YD, UK
    Public Health Nutr 11:751-6. 2008
    ..To evaluate the relative validity of a food frequency questionnaire (FFQ) for assessing nutrient intakes in 6-month-old infants...
  69. doi request reprint Developmental origins of metabolic disease: life course and intergenerational perspectives
    Keith M Godfrey
    University of Southampton School of Medicine, Southampton, UK
    Trends Endocrinol Metab 21:199-205. 2010
    ..Adopting a life course approach that takes into account intergenerational effects has important implications for prevention of non-communicable diseases, particularly in populations undergoing rapid economic transition...
  70. pmc Modification of fetal plasma amino acid composition by placental amino acid exchangers in vitro
    Jane K Cleal
    DOHaD Division, University of Southampton, Southampton, UK
    J Physiol 582:871-82. 2007
    ..This study demonstrates that these transporters have the capacity to exchange micromolar amounts of specific amino acids, and suggests that they play an important role in regulating fetal plasma amino acid composition...
  71. ncbi request reprint Small size at birth and greater postnatal weight gain: relationships to diminished infant lung function
    Jane S Lucas
    B M, MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton SO16 6YD, UK
    Am J Respir Crit Care Med 170:534-40. 2004
    ..001). Lung function measurements were not related to infant feeding. The observations suggest that lower rates of fetal growth and higher rates of early infancy weight gain are associated with impaired lung development...
  72. ncbi request reprint Birth weight and cardiac structure in children
    Benyu Jiang
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, United Kingdom
    Pediatrics 117:e257-61. 2006
    ..The underlying mechanisms are unknown. We investigated whether restricted intrauterine growth affects cardiac structure...
  73. ncbi request reprint Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits
    Mohammad R Abdollahi
    Human Genetics Division, Southampton General Hospital, University of Southampton, Southampton, United Kingdom
    Hum Mutat 28:365-73. 2007
    ..Differential abundance of AGTR1 mRNA haplotypes may mediate clinical phenotypic observations of the AGTR1 genotype...
  74. ncbi request reprint Stress responsiveness in adult life: influence of mother's diet in late pregnancy
    Rebecca M Reynolds
    Endocrinology Unit, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, UK
    J Clin Endocrinol Metab 92:2208-10. 2007
    ..Because raised fasting cortisol concentrations probably reflect a greater response to the stress of fasting and venesection, we suspected that this diet may have led to increased stress responsiveness in the adult offspring...