C A Goddard
Affiliation: University of Cambridge
- Genistein activates CFTR-mediated Cl(-) secretion in the murine trachea and colonC A Goddard
Department of Physiology, University of Cambridge, United Kingdom
Am J Physiol Cell Physiol 279:C383-92. 2000..We conclude that genistein activates CFTR-mediated Cl(-) secretion in the murine trachea and distal colon...
- A comparison of linear and branched polyethylenimine (PEI) with DCChol/DOPE liposomes for gene delivery to epithelial cells in vitro and in vivoJ W Wiseman
1Department of Physiology, University of Cambridge, Cambridge, UK
Gene Ther 10:1654-62. 2003..To establish that PEI can be used to deliver a physiologically relevent gene in vivo, we used it to restore Cl(-) secretion by CFTR gene delivery in the airways of a CF mouse model...
- Arrhythmogenic mechanisms in the isolated perfused hypokalaemic murine heartM J Killeen
Physiological Laboratory, University of Cambridge, Cambridge, UK
Acta Physiol (Oxf) 189:33-46. 2007..Hypokalaemia is associated with a lethal form of ventricular tachycardia (VT), torsade de pointes, through pathophysiological mechanisms requiring clarification...
- Optimisation of real-time quantitative RT-PCR for the evaluation of non-viral mediated gene transfer to the airwaysA C Rose
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
Gene Ther 9:1312-20. 2002..Although it remains to be seen if CF patients can tolerate long-term expression of wild-type CFTR, these data demonstrate that TaqMan RT-PCR is an effective tool to accurately quantify transgene expression in the airways...