P J Goadsby

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Early vs. non-early intervention in acute migraine-'Act when Mild (AwM)'. A double-blind, placebo-controlled trial of almotriptan
    P J Goadsby
    Headache Group, Institute of Neurology, London, UK
    Cephalalgia 28:383-91. 2008
  2. ncbi request reprint Another migraine gene
    Peter J Goadsby
    Headache Group, Institute of Neurology, UCL, London WC1N 3BG, UK
    Lancet 366:345-6. 2005
  3. ncbi request reprint Migraine, allodynia, sensitisation and all of that
    Peter J Goadsby
    Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK
    Eur Neurol 53:10-6. 2005
  4. pmc Verapamil induced gingival enlargement in cluster headache
    M S Matharu
    Headache Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 76:124-7. 2005
  5. ncbi request reprint Post-triptan era for the treatment of acute migraine
    Peter J Goadsby
    Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Curr Pain Headache Rep 8:393-8. 2004
  6. ncbi request reprint TRIPSTAR: prioritizing oral triptan treatment attributes in migraine management
    P J Goadsby
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Acta Neurol Scand 110:137-43. 2004
  7. ncbi request reprint The future of headache
    Peter J Goadsby
    Headache Group, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neurol 251:630-6. 2004
  8. ncbi request reprint Diagnostic delays and mis-management in cluster headache
    A Bahra
    Headache Group, Institute of Neurology, Queen Square, London, UK
    Acta Neurol Scand 109:175-9. 2004
  9. ncbi request reprint Evidence for serotonin (5-HT)1B, 5-HT1D and 5-HT1F receptor inhibitory effects on trigeminal neurons with craniovascular input
    P J Goadsby
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Neuroscience 122:491-8. 2003
  10. ncbi request reprint Migraine: diagnosis and management
    P J Goadsby
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, United Kingdom
    Intern Med J 33:436-42. 2003

Collaborators

Detail Information

Publications131 found, 100 shown here

  1. doi request reprint Early vs. non-early intervention in acute migraine-'Act when Mild (AwM)'. A double-blind, placebo-controlled trial of almotriptan
    P J Goadsby
    Headache Group, Institute of Neurology, London, UK
    Cephalalgia 28:383-91. 2008
    ..Treatment with almotriptan while migraine pain is still mild provides statistically significant and clinically relevant enhancements in efficacy compared with treatment when pain has reached higher severity levels...
  2. ncbi request reprint Another migraine gene
    Peter J Goadsby
    Headache Group, Institute of Neurology, UCL, London WC1N 3BG, UK
    Lancet 366:345-6. 2005
  3. ncbi request reprint Migraine, allodynia, sensitisation and all of that
    Peter J Goadsby
    Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK
    Eur Neurol 53:10-6. 2005
    ..Sensitisation may be peripheral, central or disinhibitory. The potential mechanisms of each of these and their possible manipulation by treatments of the acute attack are considered...
  4. pmc Verapamil induced gingival enlargement in cluster headache
    M S Matharu
    Headache Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 76:124-7. 2005
    ....
  5. ncbi request reprint Post-triptan era for the treatment of acute migraine
    Peter J Goadsby
    Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Curr Pain Headache Rep 8:393-8. 2004
    ..Development of one or more such compound offers the exciting prospect of new non-vasoconstrictor treatments for migraine and cluster headache...
  6. ncbi request reprint TRIPSTAR: prioritizing oral triptan treatment attributes in migraine management
    P J Goadsby
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Acta Neurol Scand 110:137-43. 2004
    ..Taken together the findings suggest that some differences amongst triptans may be relevant in clinical practice...
  7. ncbi request reprint The future of headache
    Peter J Goadsby
    Headache Group, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neurol 251:630-6. 2004
  8. ncbi request reprint Diagnostic delays and mis-management in cluster headache
    A Bahra
    Headache Group, Institute of Neurology, Queen Square, London, UK
    Acta Neurol Scand 109:175-9. 2004
    ..Cluster headache is a stereotyped form of primary headache that while common in terms of neurologic illnesses is much less common as a cause of disabling headache than migraine...
  9. ncbi request reprint Evidence for serotonin (5-HT)1B, 5-HT1D and 5-HT1F receptor inhibitory effects on trigeminal neurons with craniovascular input
    P J Goadsby
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Neuroscience 122:491-8. 2003
    ..5-HT(1B) receptor-mediated inhibition is the most potent of the three in terms of inhibition of trigeminovascular nociceptive traffic...
  10. ncbi request reprint Migraine: diagnosis and management
    P J Goadsby
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, United Kingdom
    Intern Med J 33:436-42. 2003
    ..Chronic daily headache in association with analgesic overuse is probably the major avoidable cause of headache disability in the developed world...
  11. ncbi request reprint Pathophysiology of cluster headache: a trigeminal autonomic cephalgia
    Peter J Goadsby
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Lancet Neurol 1:251-7. 2002
    ..Functional neuroimaging with PET and anatomical imaging with voxel-based morphometry have identified the posterior hypothalamic grey matter as the key area for the basic defect in cluster headache...
  12. ncbi request reprint Zolmitriptan: differences from sumatriptan
    P J Goadsby
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Curr Med Res Opin 17:s46-50. 2001
    ..5 mg was statistically superior to sumatriptan 25 and 50 mg, although at 3.3% not clinically significant. Two comparative studies have found no difference in adverse event frequency between zolmitriptan and sumatriptan...
  13. pmc New daily persistent headache
    Peter J Goadsby
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    J Neurol Neurosurg Psychiatry 72:ii6-ii9. 2002
  14. pmc Chronic daily headache
    Peter J Goadsby
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    J Neurol Neurosurg Psychiatry 72:ii2-ii5. 2002
  15. ncbi request reprint Can we develop neurally acting drugs for the treatment of migraine?
    Peter J Goadsby
    Headache Group, Institute of Neurology, and The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Nat Rev Drug Discov 4:741-50. 2005
    ....
  16. ncbi request reprint Trigeminal autonomic cephalalgias. Pathophysiology and classification
    P J Goadsby
    Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, United Kingdom
    Rev Neurol (Paris) 161:692-5. 2005
    ..Understanding the anatomy and physiology of these disorders has greatly facilitated their management and the development of exciting new strategies such as neuromodulatory approaches to the management of the more intractable cases...
  17. ncbi request reprint Advances in the understanding of headache
    Peter J Goadsby
    Headache Group, Institute of Neurology, Queen Square, London WC1N 3BG UK
    Br Med Bull 73:83-92. 2005
    ..As our understanding of migraine and related syndromes has increased, new therapies have been developed which reduce the significant disability associated with these important neurological disorders...
  18. ncbi request reprint Neurostimulation in primary headache syndromes
    Peter J Goadsby
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Expert Rev Neurother 7:1785-9. 2007
    ..The initial results are encouraging and given the very significant disability of medically intractable primary headaches, this is a very promising area for patients and physicians alike...
  19. ncbi request reprint Emerging therapies for migraine
    Peter J Goadsby
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Nat Clin Pract Neurol 3:610-9. 2007
    ..There is much cause for optimism in this area of neurology and considerable benefit awaits our patients...
  20. ncbi request reprint Neuromodulatory approaches to the treatment of trigeminal autonomic cephalalgias
    P J Goadsby
    The National Hospital for Neurology and Neurosurgery, Institute of Neurology, Queen Square, London, UK
    Acta Neurochir Suppl 97:99-110. 2007
    ..Neuromodulatory procedures are a promising avenue for these highly disabled patients with treatment refractory TACs...
  21. ncbi request reprint Treatment-emergent CNS symptoms following triptan therapy are part of the attack
    P J Goadsby
    Institute of Neurology, London, UK
    Cephalalgia 27:254-62. 2007
    ..The rate of somnolence in placebo responders is comparable to that in responders to E40 and E80, indicating that somnolence is related, at least in some important part, to headache relief and not treatment...
  22. ncbi request reprint Trigeminal autonomic cephalalgias: diagnosis and treatment
    Peter J Goadsby
    Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Curr Neurol Neurosci Rep 7:117-25. 2007
    ..The management of TACs can be very rewarding for physicians and highly beneficial to patients...
  23. ncbi request reprint Almotriptan and zolmitriptan in the acute treatment of migraine
    P J Goadsby
    Headache Group, Institute of Neurology, Queen Square, London, UK
    Acta Neurol Scand 115:34-40. 2007
    ..To compare almotriptan and zolmitriptan in the treatment of acute migraine...
  24. ncbi request reprint Recent advances in understanding migraine mechanisms, molecules and therapeutics
    Peter J Goadsby
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Trends Mol Med 13:39-44. 2007
    ..These data lead to the view that migraine is a form of sensory dysmodulatio--a system failure of normal sensory processing...
  25. pmc The migrainous brain: what you see is not all you get?
    Peter J Goadsby
    Headache Group, Institute of Neurology, University College London, Queen Square, London, United Kingdom
    PLoS Med 3:e404. 2006
  26. ncbi request reprint Migraine: emerging treatment options for preventive and acute attack therapy
    Peter J Goadsby
    Institute of Neurology, Headache Group, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Expert Opin Emerg Drugs 11:419-27. 2006
    ..Device-based approaches using neurostimulation of the occipital nerve are being studied, although the first study of patent foramen ovale closure for migraine prevention failed...
  27. ncbi request reprint Towards a definition of intractable headache for use in clinical practice and trials
    P J Goadsby
    Headache Group, Institute of Neurology, London, UK
    Cephalalgia 26:1168-70. 2006
  28. pmc Recent advances in the diagnosis and management of migraine
    Peter J Goadsby
    Headache Group, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London WC1N 3BG
    BMJ 332:25-9. 2006
  29. ncbi request reprint Calcitonin gene-related peptide antagonists as treatments of migraine and other primary headaches
    Peter J Goadsby
    Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK
    Drugs 65:2557-67. 2005
    ..The prospect of a non-vasoconstricting therapy for acute migraine offers a real opportunity to patients, and perhaps more importantly, provides a therapeutic rationale to reinforce migraine as a neurological disorder...
  30. ncbi request reprint Headache: a good year for research
    Peter J Goadsby
    Headache Group, Institute of Neurology, University College, Queen Square, London, UK
    Lancet Neurol 5:5-6. 2006
  31. ncbi request reprint Adenosine A1 receptor agonists inhibit trigeminovascular nociceptive transmission
    P J Goadsby
    Headache Group, Institute of Neurology, Queen Square, London, UK
    Brain 125:1392-401. 2002
    ..In this model of trigeminovascular nociception, adenosine A1 receptor activation leads to neuronal inhibition without concomitant vasoconstriction, suggesting a novel avenue for the treatment of migraine and cluster headache...
  32. ncbi request reprint Neurovascular headache and a midbrain vascular malformation: evidence for a role of the brainstem in chronic migraine
    P J Goadsby
    Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK
    Cephalalgia 22:107-11. 2002
    ..Moreover, the patient's lesion provides biologically plausible support that a single entity causes her clinical presentation: chronic migraine, not two-disorders, migraine and tension-type headache...
  33. ncbi request reprint Migraine--current understanding and treatment
    Peter J Goadsby
    Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
    N Engl J Med 346:257-70. 2002
  34. ncbi request reprint Glutamatergic transmission in the trigeminal nucleus assessed with local blood flow
    P J Goadsby
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Brain Res 875:119-24. 2000
    ..NMDA-mediated transmission is likely to be involved in nociceptive trigeminovascular transmission within the trigeminocervical complex and offers a possible target for both acute and preventative treatment of migraine...
  35. pmc Raeder's syndrome [corrected]: paratrigeminal paralysis of the oculopupillary sympathetic system
    P J Goadsby
    Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 72:297-9. 2002
    ..Attaching the eponym Raeder's syndrome or Raeder's paratrigeminal neuralgia to this syndrome adds nothing valuable to the anatomical description (POSS), which might be preferred for clarity...
  36. ncbi request reprint Evidence for postjunctional serotonin (5-HT1) receptors in the trigeminocervical complex
    P J Goadsby
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Ann Neurol 50:804-7. 2001
    ..These data establish the existence of triptan-sensitive (5-HT1) receptors on postsynaptic central trigeminal neurones...
  37. ncbi request reprint Neuroimaging in headache
    P J Goadsby
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, United Kingdom
    Microsc Res Tech 53:179-87. 2001
    ..Understanding this neurovascular relationship facilitates an understanding of the pain mechanisms, while characterising the CNS dysfunction will ultimately allow us to dissect out the basic pathogenesis of these disorders...
  38. ncbi request reprint Inhibition of nociceptive dural input in the trigeminal nucleus caudalis by somatostatin receptor blockade in the posterior hypothalamus
    T Bartsch
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Pain 117:30-9. 2005
    ....
  39. ncbi request reprint Modulation of nociceptive dural input to the trigeminal nucleus caudalis via activation of the orexin 1 receptor in the rat
    P R Holland
    Headache Group, Institute of Neurology, Queen Square, London, UK
    Eur J Neurosci 24:2825-33. 2006
    ..The current study demonstrates that orexin A is able to inhibit A-fibre responses to dural electrical stimulation via activation of the OX(1)R...
  40. ncbi request reprint The periaqueductal grey matter modulates trigeminovascular input: a role in migraine?
    Y E Knight
    Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK
    Neuroscience 106:793-800. 2001
    ..Considered with neurosurgical and human functional imaging studies, these data support the notion that brainstem dysfunction might lead to disinhibition of trigeminal afferents and be important in the pain process of migraines...
  41. ncbi request reprint Differential modulation of nociceptive dural input to [hypocretin] orexin A and B receptor activation in the posterior hypothalamic area
    T Bartsch
    Headache Group, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Pain 109:367-78. 2004
    ....
  42. ncbi request reprint Calcium channels modulate nociceptive transmission in the trigeminal nucleus of the cat
    K G Shields
    Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Neuroscience 135:203-12. 2005
    ..We discuss the evidence to suggest a role for VDCCs in the pathophysiology of primary headache disorders, and how abnormalities of function may contribute to their pathogenesis...
  43. ncbi request reprint Differential effects of low dose CP122,288 and eletriptan on fos expression due to stimulation of the superior sagittal sinus in cat
    P J Goadsby
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Pain 82:15-22. 1999
    ..The data suggest that activation of the 5HT(1B/1D) receptor is important for the clinical action of this class of compounds and is consistent with the fact the CP122,288 is ineffective in the treatment of the acute attack of migraine...
  44. ncbi request reprint Eletriptan in acute migraine: a double-blind, placebo-controlled comparison to sumatriptan. Eletriptan Steering Committee
    P J Goadsby
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Neurology 54:156-63. 2000
    ..To compare the efficacy, safety, and tolerability of oral eletriptan (20 mg, 40 mg, and 80 mg) with that of oral sumatriptan (100 mg) and placebo for the acute treatment of migraine...
  45. pmc GABA receptors modulate trigeminovascular nociceptive neurotransmission in the trigeminocervical complex
    R J Storer
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London
    Br J Pharmacol 134:896-904. 2001
    ..GABA(A) receptors may therefore provide a target for the development of new therapeutic agents for primary headache disorders...
  46. ncbi request reprint The clinical characteristics of headache in patients with pituitary tumours
    M J Levy
    Headache Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Brain 128:1921-30. 2005
    ..A proposed modification of the current classification of pituitary-associated headache is given...
  47. ncbi request reprint Occipital afferent activation of second order neurons in the trigeminocervical complex in rat
    K Le Doaré
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Neurosci Lett 403:73-7. 2006
    ....
  48. ncbi request reprint Properties of neurons in the trigeminal nucleus caudalis responding to noxious dural and facial stimulation
    S Bolton
    Headache Group, Institute of Neurology, London, UK
    Brain Res 1046:122-9. 2005
    ....
  49. pmc Vanilloid type 1 receptors (VR1) on trigeminal sensory nerve fibres play a minor role in neurogenic dural vasodilatation, and are involved in capsaicin-induced dural dilation
    S Akerman
    Headache Group, Institute of Neurology, Queen Square, London WCIN 3BG
    Br J Pharmacol 140:718-24. 2003
    ..The data imply that the VR1 receptor plays only a minor role in trigeminovascular-induced dural vessel dilation...
  50. ncbi request reprint Greater occipital nerve injection in primary headache syndromes--prolonged effects from a single injection
    S K Afridi
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Pain 122:126-9. 2006
    ..It is remarkable that in all conditions in which an effect is observed the response time so much exceeds the local anesthetic effect that the mechanism of action may well be through changes in brain nociceptive pathways...
  51. ncbi request reprint The NMDA receptor antagonist MK-801 reduces Fos-like immunoreactivity within the trigeminocervical complex following superior sagittal sinus stimulation in the cat
    J D Classey
    Headache Group, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK
    Brain Res 907:117-24. 2001
    ..Understanding glutamatergic mechanisms in the trigeminocervical complex offers mechanistic insight and therapeutic possibilities for primary neurovascular headaches, such as migraine...
  52. ncbi request reprint Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception
    P R Holland
    Headache Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Pharmacol Exp Ther 315:1380-5. 2005
    ..The current study demonstrates that orexin A is able to inhibit neurogenic dural vasodilation via activation of the OX1 receptor, resulting in inhibition of prejunctional release of CGRP from trigeminal neurons...
  53. ncbi request reprint Anandamide is able to inhibit trigeminal neurons using an in vivo model of trigeminovascular-mediated nociception
    S Akerman
    Headache Group, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    J Pharmacol Exp Ther 309:56-63. 2004
    ..It can be suggested that anandamide is tonically released to play some form of modulatory role in the trigeminovascular system...
  54. ncbi request reprint 4991W93, a potent blocker of neurogenic plasma protein extravasation, inhibits trigeminal neurons at 5-hydroxytryptamine (5-HT1B/1D) agonist doses
    R J Storer
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK
    Neuropharmacology 40:911-7. 2001
    ..To account for neurogenic dural plasma protein extravasation blockade in animal studies, 4991W93 might have non-5-HT(1B/1D)-based pharmacological targets that are yet to be described...
  55. ncbi request reprint 4991W93 inhibits release of calcitonin gene-related peptide in the cat but only at doses with 5HT(1B/1D) receptor agonist activity?
    Y E Knight
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Neuropharmacology 40:520-5. 2001
    ..Taken with the clinical results, these data emphasise the importance of CGRP release in migraine, and suggest that other non-5HT-based pharmacological targets may account for PPE blockade in animal studies...
  56. ncbi request reprint The effect of adrenergic compounds on neurogenic dural vasodilatation
    S Akerman
    Headache Group, Institute of Neurology, Queen Square, WC1N 3BG, London, UK
    Eur J Pharmacol 424:53-8. 2001
    ..Moreover, the data indicate that the adrenergic system does not play a significant role in neurogenic dural vasodilation...
  57. ncbi request reprint Stimulation of the greater occipital nerve increases metabolic activity in the trigeminal nucleus caudalis and cervical dorsal horn of the cat
    P J Goadsby
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Pain 73:23-8. 1997
    ....
  58. ncbi request reprint Effect of the adenosine A1 receptor agonist GR79236 on trigeminal nociception with blink reflex recordings in healthy human subjects
    N J Giffin
    Headache Group, Institute of Neurology, London, UK
    Cephalalgia 23:287-92. 2003
    ..Furthermore, the adenosine A1 receptor agonist GR79236 inhibits trigeminal nociception in humans. These results support a possible therapeutic role for GR79236 in primary headache disorders...
  59. ncbi request reprint Nociceptive-specific blink reflex and glyceryl trinitrate infusion in healthy volunteers
    F Kowacs
    Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Eur J Neurol 10:295-9. 2003
    ..Although mild headache was induced in six subjects, there was no significant change between the R2 area under the curve before and after drug vs. placebo...
  60. pmc SUNCT syndrome secondary to prolactinoma
    M S Matharu
    Headache Group, Institute of Neurology The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 74:1590-2. 2003
    ....
  61. pmc Occipital activation in glyceryl trinitrate induced migraine with visual aura
    S Afridi
    Headache Group, Institute of Neurology, Queen Square, London, WC1, UK
    J Neurol Neurosurg Psychiatry 76:1158-60. 2005
    ..Activation in the primary visual area of the occipital cortex was demonstrated during the aura. This is the first published case of migraine aura triggered reproducibly by GTN...
  62. ncbi request reprint Cerebral vasodilatation in the cat involves nitric oxide from parasympathetic nerves
    P J Goadsby
    Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
    Brain Res 707:110-8. 1996
    ..It may be concluded that the parasympathetic nerves innervating the cerebral circulation contain NOS and furthermore, since blockade of NOS reduces parasympathetic vasodilatation, that NO is one of the transmitters in this system...
  63. ncbi request reprint Are triptans with enhanced lipophilicity used for the acute treatment of migraine associated with an increased consulting rate for depressive illness?
    D Millson
    Primary Care Sciences Research Centre, Keele University, London, UK
    Cephalalgia 20:732-7. 2000
    ..This study highlights the potential to use GPRD to test targeted hypotheses exploring pharmacovigilance issues for patients using new medicines...
  64. ncbi request reprint New targets in the acute treatment of headache
    Peter J Goadsby
    Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK
    Curr Opin Neurol 18:283-8. 2005
    ..The aim of this article is to review recently identified targets for the acute treatment of primary headache disorders...
  65. ncbi request reprint The role of dopamine in a model of trigeminovascular nociception
    S Akerman
    Institute of Neurology, Queen Square, London, WC1N 3BG UK
    J Pharmacol Exp Ther 314:162-9. 2005
    ..Our data do not exclude a role for dopamine receptor modulators in short- or long-term prevention...
  66. ncbi request reprint Increased responses in trigeminocervical nociceptive neurons to cervical input after stimulation of the dura mater
    T Bartsch
    Headache Group, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Brain 126:1801-13. 2003
    ..Understanding this interaction is likely to be pivotal in characterizing the physiology of treatment with manipulations involving cervical input, such as GON injection...
  67. ncbi request reprint Short-lasting primary headaches: focus on trigeminal automatic cephalgias and indomethacin-sensitive headaches
    P J Goadsby
    Institute of Neurology National Hospital for Neurology and Neurosurgery, London, UK
    Curr Opin Neurol 12:273-7. 1999
    ..These headaches tend to be referred to neurologists as they are refractory to other treatments and thus are useful to know about...
  68. ncbi request reprint How do the currently used prophylactic agents work in migraine?
    P J Goadsby
    Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
    Cephalalgia 17:85-92. 1997
    ..The evidence for these mechanisms, except plasma protein extravasation (see Cutrer, this supplement) is examined in the light of current thoughts concerning the pathophysiology of migraine...
  69. ncbi request reprint Direct evidence for central sites of action of zolmitriptan (311C90): an autoradiographic study in cat
    P J Goadsby
    Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
    Cephalalgia 17:153-8. 1997
    ..These receptors may, in part, be responsible for its clinical efficacy and reinforce the importance of central trigeminal neurons as a possible site of action of anti-migraine drugs...
  70. ncbi request reprint Bench to bedside: what have we learnt recently about headache?
    P J Goadsby
    Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
    Curr Opin Neurol 10:215-20. 1997
    ..The anatomy and physiology of pain transmission within the cranium have been elucidated, and advances been made into the pathophysiology of migraine and to a lesser extent cluster headache...
  71. ncbi request reprint The pharmacology of headache
    P J Goadsby
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK
    Prog Neurobiol 62:509-25. 2000
    ....
  72. ncbi request reprint Advances in the pharmacotherapy of migraine. How knowledge of pathophysiology is guiding drug development
    P J Goadsby
    Department of Clinical Neurology, Institute of Neurology, London, England
    Drugs R D 2:361-74. 1999
    ..The future for migraine and cluster headache, the neurovascular headaches, is bright as we unravel their biology and this leads to further therapeutic advances...
  73. pmc The distribution of trigeminovascular afferents in the nonhuman primate brain Macaca nemestrina: a c-fos immunocytochemical study
    P J Goadsby
    Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
    J Anat 190:367-75. 1997
    ..Given the close evolutionary relationship of the monkey to man it is likely that the cells described in this study represent for primates the nucleus that mediates the pain of migraine...
  74. ncbi request reprint Stimulation of an intracranial trigeminally-innervated structure selectively increases cerebral blood flow
    P J Goadsby
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Brain Res 751:247-52. 1997
    ....
  75. ncbi request reprint Benign paroxysmal torticollis of infancy: four new cases and linkage to CACNA1A mutation
    N J Giffin
    Headache Group, Institute of Neurology, London, UK
    Dev Med Child Neurol 44:490-3. 2002
    ..BPTI may be regarded as a migraine aura equivalent. The syndrome poses interesting questions regarding varying phenotypic expression of calcium channelopathies at different stages of development...
  76. ncbi request reprint Cluster headache: imaging and other developments
    A May
    University Department of Clinical Neurology, National Hospital for Neurology and Neurosurgery, London, UK
    Curr Opin Neurol 11:199-203. 1998
    ..From a physiological viewpoint, therefore, cluster headache should be described as a neurovascular headache, thus placing equal emphasis on its fundamental pathophysiology and clinical expression...
  77. ncbi request reprint Hypothalamic activation in cluster headache attacks
    A May
    University Department of Clinical Neurology, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
    Lancet 352:275-8. 1998
    ..We aimed to assess changes in regional cerebral blood flow (rCBF) in patients with cluster headache...
  78. ncbi request reprint Serotonin receptors and the acute attack of migraine
    P J Goadsby
    Institute of Neurology, Queen Square, London
    Clin Neurosci 5:18-23. 1998
    ..Future drug development will target these individual mechanisms to dissect out which, if any, determines the clinical efficacy of the compounds...
  79. ncbi request reprint Retinal plasma extravasation in animals but not in humans: implications for the pathophysiology of migraine
    A May
    Institute of Neurology, London, UK
    Brain 121:1231-7. 1998
    ..These data raise the possibility that neurogenic inflammation is not a major factor in headache attacks in migraine or cluster headache...
  80. pmc Voltage-dependent calcium channels are involved in neurogenic dural vasodilatation via a presynaptic transmitter release mechanism
    S Akerman
    Headache Group, Institute of Neurology, Queen Square, London, UK
    Br J Pharmacol 140:558-66. 2003
    ..These data suggest that the P/Q-, N- and L-type calcium channels may be involved in trigeminovascular nociception...
  81. pmc Trigeminal autonomic cephalgias
    Manjit S Matharu
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    J Neurol Neurosurg Psychiatry 72:ii19-ii26. 2002
  82. ncbi request reprint New directions in migraine research
    Peter J Goadsby
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    J Clin Neurosci 9:368-73. 2002
  83. ncbi request reprint Functional neuroimaging of primary headache disorders
    Anna S Cohen
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    Expert Rev Neurother 6:1159-71. 2006
    ....
  84. doi request reprint A trans-cultural comparison of the organisation of care at headache centres world-wide
    Ria Bhola
    Headache Service, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Cephalalgia 31:316-30. 2011
    ....
  85. ncbi request reprint The ORL-1 (NOP1) receptor ligand nociceptin/orphanin FQ (N/OFQ) inhibits neurogenic dural vasodilatation in the rat
    T Bartsch
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Neuropharmacology 43:991-8. 2002
    ..ORL-1 (NOP(1)) receptors located on trigeminal sensory fibres may be involved in the regulation of dural vessel diameter and hence may play a role in migraine pathophysiology...
  86. ncbi request reprint The paroxysmal hemicrania-tic syndrome
    C J Boes
    Headache Group, Institute of Neurology, London UK
    Cephalalgia 23:24-8. 2003
    ..We review the six other cases of chronic paroxysmal hemicrania-tic (CPH-tic) reported, and suggest that the term paroxysmal hemicrania-tic syndrome (PH-tic) be used to describe this association...
  87. ncbi request reprint SUNCT syndrome in the elderly
    A S Cohen
    Headache Group, Institute of Neurology, Queen Square, London, UK
    Cephalalgia 24:508-9. 2004
  88. ncbi request reprint Serotonin receptors modulate trigeminovascular responses in ventroposteromedial nucleus of thalamus: a migraine target?
    Kevin G Shields
    Headache Group, Institute of Neurology, London, UK
    Neurobiol Dis 23:491-501. 2006
    ....
  89. pmc Topiramate inhibits trigeminovascular activation: an intravital microscopy study
    Simon Akerman
    Headache Group, Institute of Neurology, London, UK
    Br J Pharmacol 146:7-14. 2005
    ..The data are consistent with an effect of topiramate on trigeminovascular activation which may form part of its preventive antimigraine mechanisms of action...
  90. ncbi request reprint Effectiveness of intranasal zolmitriptan in acute cluster headache: a randomized, placebo-controlled, double-blind crossover study
    Elizabeth Cittadini
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, England
    Arch Neurol 63:1537-42. 2006
    ..Cluster headache is a form of primary headache in which attacks are rapid in onset with very severe pain. The mainstays of acute therapy are inhaled oxygen and sumatriptan succinate injection...
  91. pmc Basilar artery aneurysm with autonomic features: an interesting pathophysiological problem
    N J Giffin
    Headache Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 71:805-8. 2001
    ..The relevant anatomy and proposed mechanism of autonomic involvement of what may be considered--from a pathophysiological perspective as a secondary trigeminal-autonomic cephalgia--is discussed..
  92. ncbi request reprint Effect of IL-1beta microinjection into the posterior hypothalamic area on trigeminal nociception in the rat
    M J Levy
    Headache Group, Institute of Neurology, Queen Square, London, UK
    J Neural Transm 110:1349-58. 2003
    ..There was no inhibition in the six animals injected with vehicle (saline). If there is an important effect for IL-1beta in the posterior hypothalamus it is likely to be highly somatotopically restricted...
  93. ncbi request reprint A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate
    S K Afridi
    Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Brain 128:932-9. 2005
    ..Consistent with previous work, the activation persisted after pain was controlled by sumatriptan. These results suggest that lateralization of pain in migraine is due to lateralized brain dysfunction...
  94. ncbi request reprint Cluster headache: a prospective clinical study with diagnostic implications
    Anish Bahra
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, United Kingdom
    Neurology 58:354-61. 2002
  95. ncbi request reprint Does chronic daily headache arise de novo in association with regular use of analgesics?
    Anish Bahra
    Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Headache 43:179-90. 2003
    ....
  96. ncbi request reprint Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) or cranial autonomic features (SUNA)--a prospective clinical study of SUNCT and SUNA
    Anna S Cohen
    Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery London, UK
    Brain 129:2746-60. 2006
    ....
  97. ncbi request reprint Functional neuroimaging of primary headache disorders
    Anna S Cohen
    Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Curr Neurol Neurosci Rep 4:105-10. 2004
    ....
  98. ncbi request reprint Trigeminal autonomic cephalalgias: current and future treatments
    Anna S Cohen
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Headache 47:969-80. 2007
    ..The involvement of the hypothalamus in functional imaging studies implies that this may be a substrate for targeting treatment options in the future...
  99. doi request reprint Hemicrania continua: a clinical study of 39 patients with diagnostic implications
    Elisabetta Cittadini
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK
    Brain 133:1973-86. 2010
    ..Since there is no reliable clinical marker of that response, we recommend an indometacin test, either orally or by injection, for any patient with unilateral pain, with or without cranial autonomic symptoms...
  100. ncbi request reprint Central neuromodulation in chronic migraine patients with suboccipital stimulators: a PET study
    Manjit S Matharu
    Headache Group, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Brain 127:220-30. 2004
    ..The dorsal rostral pons may be a locus of neuromodulation by suboccipital stimulation. In addition, suboccipital stimulation modulated activity in the left pulvinar...
  101. doi request reprint Paroxysmal hemicrania: a prospective clinical study of 31 cases
    Elisabetta Cittadini
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Brain 131:1142-55. 2008
    ..Since there is no reliable clinical marker of that response we recommend an indometacin test, either orally or by injection for any patient with lateralized discrete attacks of head pain with associated cranial autonomic symptoms...