Dervila Glynn

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Depletion of Complexin II does not affect disease progression in a mouse model of Huntington's disease (HD); support for role for complexin II in behavioural pathology in a mouse model of HD
    Dervila Glynn
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, UK
    Brain Res Bull 72:108-20. 2007
  2. ncbi request reprint Profound ataxia in complexin I knockout mice masks a complex phenotype that includes exploratory and habituation deficits
    Dervila Glynn
    Department of Pharmacology, University of Cambridge, UK
    Hum Mol Genet 14:2369-85. 2005
  3. ncbi request reprint Early motor development is abnormal in complexin 1 knockout mice
    Dervila Glynn
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Neurobiol Dis 25:483-95. 2007
  4. doi request reprint Clorgyline-mediated reversal of neurological deficits in a Complexin 2 knockout mouse
    Dervila Glynn
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Hum Mol Genet 19:3402-12. 2010
  5. doi request reprint Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice
    A Jennifer Morton
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Neurobiol Dis 33:331-41. 2009
  6. ncbi request reprint Complexin II is essential for normal neurological function in mice
    Dervila Glynn
    Department of Pharmacology, University of Cambridge, UK
    Hum Mol Genet 12:2431-48. 2003
  7. doi request reprint "Brain training" improves cognitive performance and survival in a transgenic mouse model of Huntington's disease
    Nigel I Wood
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Neurobiol Dis 42:427-37. 2011

Detail Information

Publications7

  1. ncbi request reprint Depletion of Complexin II does not affect disease progression in a mouse model of Huntington's disease (HD); support for role for complexin II in behavioural pathology in a mouse model of HD
    Dervila Glynn
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, UK
    Brain Res Bull 72:108-20. 2007
    ..This indicates that loss of complexin II is part of the mechanism underlying the R6/2 phenotype. Whether it is causal or compensatory remains to be determined...
  2. ncbi request reprint Profound ataxia in complexin I knockout mice masks a complex phenotype that includes exploratory and habituation deficits
    Dervila Glynn
    Department of Pharmacology, University of Cambridge, UK
    Hum Mol Genet 14:2369-85. 2005
    ..These results support the idea that altered expression of complexins in disease states may contribute to the symptomatology of disorders in which they are dysregulated...
  3. ncbi request reprint Early motor development is abnormal in complexin 1 knockout mice
    Dervila Glynn
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Neurobiol Dis 25:483-95. 2007
    ..A role for complexin I depletion should be considered in diseases where deficits in early sensory and motor development exist, such as autism and schizophrenia...
  4. doi request reprint Clorgyline-mediated reversal of neurological deficits in a Complexin 2 knockout mouse
    Dervila Glynn
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Hum Mol Genet 19:3402-12. 2010
    ....
  5. doi request reprint Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice
    A Jennifer Morton
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Neurobiol Dis 33:331-41. 2009
    ..This mouse may represent a better model for adult-onset HD than R6/2 mice with shorter repeats...
  6. ncbi request reprint Complexin II is essential for normal neurological function in mice
    Dervila Glynn
    Department of Pharmacology, University of Cambridge, UK
    Hum Mol Genet 12:2431-48. 2003
    ..Given that decreased expression of CPLXII is seen in HD and schizophrenic patients, a role for CPLXII depletion should be considered in other diseases where motor, cognitive and psychiatric symptoms co-exist...
  7. doi request reprint "Brain training" improves cognitive performance and survival in a transgenic mouse model of Huntington's disease
    Nigel I Wood
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Neurobiol Dis 42:427-37. 2011
    ..While brain training was not beneficial for all mice, it produced no deleterious effects, and so warrants further study in rodent models of HD...