J D Glazier

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. doi request reprint eNOS knockout mouse as a model of fetal growth restriction with an impaired uterine artery function and placental transport phenotype
    Laura C Kusinski
    Maternal and Fetal Health Research Centre, School of Biomedicine, Manchester Academic Health Science Centre, The University of Manchester, St Mary s Hospital, Manchester, UK
    Am J Physiol Regul Integr Comp Physiol 303:R86-93. 2012
  2. pmc Isolation of plasma membrane vesicles from mouse placenta at term and measurement of system A and system beta amino acid transporter activity
    L C Kusinski
    Maternal and Fetal Health Research Group, School of Clinical and Laboratory Sciences, University of Manchester, St Mary s Hospital, Oxford Road, Manchester M13 9WL, United Kingdom
    Placenta 31:53-9. 2010
  3. pmc Placental-specific Igf2 knockout mice exhibit hypocalcemia and adaptive changes in placental calcium transport
    M R Dilworth
    Maternal and Fetal Health Research Group, University ofManchester, Manchester, UK
    Proc Natl Acad Sci U S A 107:3894-9. 2010
  4. pmc The SNAT4 isoform of the system A amino acid transporter is functional in human placental microvillous plasma membrane
    M Desforges
    Maternal and Fetal Health Research Group, University of Manchester, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, UK
    J Physiol 587:61-72. 2009
  5. doi request reprint Expression of folate transporters in human placenta and implications for homocysteine metabolism
    N Solanky
    School of Clinical and Laboratory Sciences, University of Manchester, Manchester Academic Health Science Centre, St Mary s Hospital, Manchester, UK
    Placenta 31:134-43. 2010
  6. doi request reprint System A activity and vascular function in the placental-specific Igf2 knockout mouse
    L C Kusinski
    Maternal and Fetal Health Research Centre, School of Biomedicine, Manchester Academic Health Science Centre, The University of Manchester, St Mary s Hospital, Manchester M13 9WL, UK
    Placenta 32:871-6. 2011
  7. ncbi request reprint Characterisation of long term cat placental explant cultures: uptake of taurine by system beta
    E E Champion
    Academic Unit of Child Health, University of Manchester, St Mary s Hospital, Manchester, UK
    Placenta 26:608-16. 2005
  8. ncbi request reprint SNAT4 isoform of system A amino acid transporter is expressed in human placenta
    M Desforges
    Division of Human Development, St Mary s Hospital, The Medical School, University of Manchester, Manchester, United Kingdom
    Am J Physiol Cell Physiol 290:C305-12. 2006
  9. pmc The contribution of SNAT1 to system A amino acid transporter activity in human placental trophoblast
    M Desforges
    Maternal and Fetal Health Research Centre, Developmental Biomedicine, School of Medicine, Manchester Academic Health Sciences Centre, University of Manchester, St Mary s Hospital, Level 5 Research, Oxford Road, Manchester M13 9WL, United Kingdom
    Biochem Biophys Res Commun 398:130-4. 2010
  10. ncbi request reprint Ultrastructural aspects of long-term cat placental explant culture
    C J P Jones
    Academic Unit of Obstetrics and Gynaecology, The University of Manchester, St Mary s Hospital, Manchester M13 0JH, UK
    Placenta 26:585-9. 2005

Collaborators

Detail Information

Publications20

  1. doi request reprint eNOS knockout mouse as a model of fetal growth restriction with an impaired uterine artery function and placental transport phenotype
    Laura C Kusinski
    Maternal and Fetal Health Research Centre, School of Biomedicine, Manchester Academic Health Science Centre, The University of Manchester, St Mary s Hospital, Manchester, UK
    Am J Physiol Regul Integr Comp Physiol 303:R86-93. 2012
    ..We further postulate that this mouse model demonstrates "uteroplacental hypoxia," providing a new framework for understanding the etiology of FGR in human pregnancy...
  2. pmc Isolation of plasma membrane vesicles from mouse placenta at term and measurement of system A and system beta amino acid transporter activity
    L C Kusinski
    Maternal and Fetal Health Research Group, School of Clinical and Laboratory Sciences, University of Manchester, St Mary s Hospital, Oxford Road, Manchester M13 9WL, United Kingdom
    Placenta 31:53-9. 2010
    ..This mirrored the lower expression of TAUT observed in mouse placental vesicles. We conclude that syncytiotrophoblast layer II-derived plasma membrane vesicles can be isolated and used to examine transporter function...
  3. pmc Placental-specific Igf2 knockout mice exhibit hypocalcemia and adaptive changes in placental calcium transport
    M R Dilworth
    Maternal and Fetal Health Research Group, University ofManchester, Manchester, UK
    Proc Natl Acad Sci U S A 107:3894-9. 2010
    ....
  4. pmc The SNAT4 isoform of the system A amino acid transporter is functional in human placental microvillous plasma membrane
    M Desforges
    Maternal and Fetal Health Research Group, University of Manchester, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, UK
    J Physiol 587:61-72. 2009
    ....
  5. doi request reprint Expression of folate transporters in human placenta and implications for homocysteine metabolism
    N Solanky
    School of Clinical and Laboratory Sciences, University of Manchester, Manchester Academic Health Science Centre, St Mary s Hospital, Manchester, UK
    Placenta 31:134-43. 2010
    ..These data support the concept that placental folate transport is established early in pregnancy, providing folate for utilisation in placental Hcy metabolism...
  6. doi request reprint System A activity and vascular function in the placental-specific Igf2 knockout mouse
    L C Kusinski
    Maternal and Fetal Health Research Centre, School of Biomedicine, Manchester Academic Health Science Centre, The University of Manchester, St Mary s Hospital, Manchester M13 9WL, UK
    Placenta 32:871-6. 2011
    ..We tested the hypothesis that FGR in P0 mice is attributable to altered nutrient transport rather than aberrant uteroplacental vascular function...
  7. ncbi request reprint Characterisation of long term cat placental explant cultures: uptake of taurine by system beta
    E E Champion
    Academic Unit of Child Health, University of Manchester, St Mary s Hospital, Manchester, UK
    Placenta 26:608-16. 2005
    ..This model of placental explant culture will provide an important in vitro method for the study of chronic regulation of amino acid transport in the cat...
  8. ncbi request reprint SNAT4 isoform of system A amino acid transporter is expressed in human placenta
    M Desforges
    Division of Human Development, St Mary s Hospital, The Medical School, University of Manchester, Manchester, United Kingdom
    Am J Physiol Cell Physiol 290:C305-12. 2006
    ..This study therefore provides the first evidence of SNAT4 mRNA and protein expression in the human placenta, both at the first trimester and at full term...
  9. pmc The contribution of SNAT1 to system A amino acid transporter activity in human placental trophoblast
    M Desforges
    Maternal and Fetal Health Research Centre, Developmental Biomedicine, School of Medicine, Manchester Academic Health Sciences Centre, University of Manchester, St Mary s Hospital, Level 5 Research, Oxford Road, Manchester M13 9WL, United Kingdom
    Biochem Biophys Res Commun 398:130-4. 2010
    ....
  10. ncbi request reprint Ultrastructural aspects of long-term cat placental explant culture
    C J P Jones
    Academic Unit of Obstetrics and Gynaecology, The University of Manchester, St Mary s Hospital, Manchester M13 0JH, UK
    Placenta 26:585-9. 2005
    ..The cat placenta, therefore, like the human, has the capacity for regrowth in explant culture, including both trophoblast and stromal components...
  11. doi request reprint Aldosterone and cortisol acutely stimulate Na+/H+ exchanger activity in the syncytiotrophoblast of the human placenta: effect of fetal sex
    P F Speake
    Maternal and Fetal Health Research Group, School of Clinical and Laboratory Sciences, University of Manchester, Manchester Academic Health Sciences Centre, St Mary s Hospital, Manchester M13 9WL, UK
    Placenta 31:289-94. 2010
    ..These non-genomic effects are only evident in placentas from female babies and are mediated by classical mineralocorticoid and/or glucocorticoid receptors...
  12. ncbi request reprint Activity and expression of Na+/H+ exchanger isoforms in the syncytiotrophoblast of the human placenta
    P F Speake
    Human Development and Reproductive Health Academic Group, Academic Unit of Child Health, University of Manchester, St Mary s Hospital, Hathersage Road, Manchester, M13 OJH, UK
    Pflugers Arch 450:123-30. 2005
    ..Overall these data show that under the conditions used NHE activity in the term placental syncytiotrophoblast is absent from BM. NHE activity in the MVM is attributable predominantly to NHE1...
  13. pmc Increased maternofetal calcium flux in parathyroid hormone-related protein-null mice
    H Bond
    Maternal and Fetal Heath Research Group, University of Manchester, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, UK
    J Physiol 586:2015-25. 2008
    ..In situ perfusion of mouse placenta is a robust methodology for allowing detailed dissection of placental transfer mechanisms in genetically modified mice...
  14. ncbi request reprint L-Arginine transport across the basal plasma membrane of the syncytiotrophoblast of the human placenta from normal and preeclamptic pregnancies
    P F Speake
    Academic Unit of Child Health, University of Manchester, St Mary s Hospital, Manchester, United Kingdom M13 0JH
    J Clin Endocrinol Metab 88:4287-92. 2003
    ..If reflected in vivo, a similar increase in transporter activity could alter the delivery of L-arginine to syncytiotrophoblast eNOS...
  15. pmc Activity and expression of Na(+)-K(+)-ATPase in human placental cytotrophoblast cells in culture
    L H Clarson
    Department of Child Health and School of Biological Sciences, University of Manchester, St Mary s Hospital, UK
    J Physiol 497:735-43. 1996
    ..5. It is concluded that N(+)-K(+)-ATPase activity and protein expression does not change during differentiation of cytotrophoblast cells but that there are changes in expression at the transcriptional or post-transcriptional level...
  16. ncbi request reprint Gestational profile of Na+/H+ exchanger and Cl-/HCO3- anion exchanger mRNA expression in placenta using real-time QPCR
    H A Lacey
    Academic Unit of Child Health, University of Manchester, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, UK
    Placenta 26:93-8. 2005
    ..The expression of NHE and AE in the villous placenta is not altered concomitant with the onset of maternal blood flow. However, NHE2 transcripts appear to be gestationally regulated, which may contribute to changes in NHE activity...
  17. ncbi request reprint Localization of alkaline phosphatase and Ca2+-ATPase in the cat placenta
    E E Champion
    Academic Unit of Child Health, University of Manchester, St Mary s Hospital, Manchester, M13 0JH, UK
    Placenta 24:453-61. 2003
    ..We conclude that the plasma membranes of the cat syncytiotrophoblast show a broadly similar functional polarization to the human and that PMCA would prove a useful marker in isolation of the cat syncytiotrophoblast basal plasma membrane...
  18. ncbi request reprint Taurine transporter in fetal T lymphocytes and platelets: differential expression and functional activity
    C G Iruloh
    Academic Unit of Child Health, University of Manchester, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, UK
    Am J Physiol Cell Physiol 292:C332-41. 2007
    ..This study represents the first characterization of amino acid transporters in fetal T lymphocytes...
  19. ncbi request reprint Regulation of placental transfer: the Na(+)/H(+) exchanger--a review
    C P Sibley
    Academic Unit of Child Health, University of Manchester, St Mary s Hospital, Manchester, M13 0JH, UK
    Placenta 23:S39-46. 2002
    ..There is also evidence of acute modulation of NHE activity. Regulation of NHE in syncytiotrophoblast is therefore complex with control at transcription, post transcription and post translational loci...
  20. ncbi request reprint Diabetes in rat pregnancy alters renal calcium and magnesium reabsorption and bone formation in adult offspring
    H Bond
    Academic Unit of Child Health, St Mary s Hospital, University of Manchester, Hathersage Road, Manchester, M13 OJH, UK
    Diabetologia 48:1393-400. 2005
    ..We tested the hypothesis that diabetes in pregnancy can result in the in-utero reprogramming of renal calcium and magnesium handling and of bone formation in the offspring, which persists into adulthood...